Tgf Beta 1 Expression Is Initiated in Adult Auditory Neurons by Sectioning of the Auditory Nerve
; Martin, Didier ; et al
in Neuroreport (1992), 3(4), 295-8
Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult ... [more ▼]
Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGF beta 1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGF beta is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFG beta 1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system. [less ▲]Detailed reference viewed: 15 (1 ULg)
Etude des activateurs du plasminogène et de leurs inhibiteurs dans le système nerveux en développement.
Schoenen, Jean ; ; et al
Conference (1992)Detailed reference viewed: 8 (2 ULg)
Mri-Pathological Correlations in Acute Traumatic Central Cord Syndrome: Case Report
Martin, Didier ; Schoenen, Jean ; Lenelle, Jacques et al
in Neuroradiology (1992), 34(4), 262-6
Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who ... [more ▼]
Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who died 60 h later from heart failure. T2-weighted MRI showed a central hyperintense area at C3-4. There were disc protrusions, but no vertebral fracture or displacement. Histopathology disclosed severe axonal swelling and oedema in the dorsolateral fasciculi and, to a lesser degree, in the dorsal columns. In addition, an area of recent necrosis was found in the right anterior horn at C4-5. These findings suggest that the pathological hallmark of typical ATCCS is mechanical axonal disruption at a segmental level, but that more severe trauma may be accompanied by tissue destruction. [less ▲]Detailed reference viewed: 17 (1 ULg)
Paraplégie traumatique expérimentale chez le rat. Effets de greffes syngéniques de neurones et de cellules de Schwann
Doctoral thesis (1992)Detailed reference viewed: 15 (5 ULg)
Plasticité des neurones sensoriels primaires chez le rat adulte. Etude in vitro et in vivo.
Moonen, Gustave ; ; Martin, Didier et al
Conference (1991, November 16)
Experimental spinal cord injury and grafts of syngenic cultured DRG-derived cells.Traumatic experimental paraplegia in the rat by inflatable subdural balloon. Morphological and behavioural studies. Effects of syngenic grafts of DRG neurons and of Schwann cells
Schoenen, Jean ; Martin, Didier ; et al
Conference (1991, October 18)Detailed reference viewed: 3 (0 ULg)
In vitro and in vivo modulation of transmitter phenotype in adult rat DRG neurons.
Moonen, Gustave ; Schoenen, Jean ; et al
Conference (1991, August 11)Detailed reference viewed: 1 (0 ULg)
A model of traumatic paraplegia in the rat : behavioral and anatomical studies; preliminary results of neuronal and non-neuronal transplants.
Schoenen, Jean ; Moonen, Gustave ; Martin, Didier et al
Conference (1991, August 11)Detailed reference viewed: 2 (0 ULg)
Grafts of Syngenic Cultured, Adult Dorsal Root Ganglion-Derived Schwann Cells to the Injured Spinal Cord of Adult Rats: Preliminary Morphological Studies
Martin, Didier ; Schoenen, Jean ; et al
in Neuroscience Letters (1991), 124(1), 44-8
Highly enriched cultures of Schwann cells were obtained from adult rat dorsal root ganglia and implanted (5 x 10(5) -9 x 10(5) cells) in the spinal cord of syngenic adult rats at the site of an acute ... [more ▼]
Highly enriched cultures of Schwann cells were obtained from adult rat dorsal root ganglia and implanted (5 x 10(5) -9 x 10(5) cells) in the spinal cord of syngenic adult rats at the site of an acute compression lesion produced by a subdural inflatable microballoon. These autografts survived and invaded the host tissue, reducing central cavitation and astrocytic gliosis. They dramatically promoted ingrowth of axons, the majority of which appeared to come from the dorsal roots as judged by their neuropeptide content. Invasion of the transplants by descending, e.g. aminergic fibers, was negligible at survival times of up to 4 months. Nonetheless, autologous Schwann cells, which are readily available in the host, represent a promising material for grafts into the injured spinal cord. [less ▲]Detailed reference viewed: 18 (3 ULg)
La neurostimulation épidurale pour le stade ultime de l'artérite chronique des membres inférieurs.
Van Damme, Hendrik ; Martin, Didier ; Creemers, Etienne et al
Conference (1991, March 09)Detailed reference viewed: 13 (1 ULg)
Protéases et inhibiteurs de protéases : implications multiples dans le développement et le vieillissement cérébral
Leprince, Pierre ; Rogister, Bernard ; et al
in Revue d'Oto-Neuro-Ophtalmologie (1991), 12(13), 30-38Detailed reference viewed: 13 (2 ULg)
Transplants of syngenic adult dorsal root ganglion neurons to the spinal cord of rats with acute traumatic paraplegia: morphological analyses.
Martin, Didier ; ; Schoenen, Jean et al
in Restorative Neurology & Neuroscience (1991), 2Detailed reference viewed: 48 (13 ULg)
Transforming growth factor-ß : a novel neuronal mediator of Schwann cell reaction after peripheral nerve injury.
Leprince, Pierre ; ; Rogister, Bernard et al
Conference (1990, December 10)Detailed reference viewed: 3 (0 ULg)
Lésion traumatique expérimentale de la moelle épinière. Réalisation de greffes intra-médullaires neuronales et non neuronales.
Conference (1990, November 22)Detailed reference viewed: 31 (8 ULg)
Neuronotrophic factors involvement in the regeneration of adult afferent auditory neurons.
; ; et al
Conference (1990, November 10)Detailed reference viewed: 1 (0 ULg)
Effets de facteurs neuronotrophiques sur la régénération des neurones auditifs adultes in vitro
Lefebvre, Philippe ; ; et al
Conference (1990, November)Detailed reference viewed: 12 (1 ULg)