References of "Martin, Didier"
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See detailPreparation of a Macroporous Biodegradable Polylactide Implant for Neuronal Transplantation
Schugens, C.; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Biomedical Materials Research (1995), 29(11), 1349-62

This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an ... [more ▼]

This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an original method consisting of the aggregation of calibrated poly-D,L-lactide microparticles. The size of the interstices between the aggregated microspheres was in a direct relationship to the microsphere diameter. A first approach was based on coating the microspheres with poly(vinyl alcohol) followed by chemically crosslinking the coating layers that were in mutual contact. This method was disregarded because of the acute cytotoxicity of glutaraldehyde used as the crosslinking agent, the absence of macroporosity, and the complete lack of flexibility. A physical technique of aggregation was then tested, which relied on the plasticization of poly-D,L-lactide microspheres with triethylcitrate to the point where microspheres strongly adhered to each other when they were in contact. This method has proved to be straightforward and definitely superior to the chemical approach, particularly with respect to cytotoxicity, control of macroporosity, and flexibility. A polymer support was thus successfully which was biodegradable, macroporous( interconnected pores of 10-100 microns in diameter), and flexible. This potential medical device is presently being used for neuronal transplantation in the central nervous system. [less ▲]

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See detailA model of spinal cord injury: the balloon-compressive model
Martin, Didier ULg; Franzen, R.; Robe, Pierre ULg et al

Conference (1995, September 03)

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See detailSpinal cord trauma:approaches and perspectives
Martin, Didier ULg

Scientific conference (1995, September)

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See detail132. Intrasellar arachnoïd cysts: diagnosis and treatment
Dubuisson, Annie ULg; Martin, Didier ULg; Bruggeman, L. et al

Conference (1995, May 07)

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See detailIntrasellar Arachnoïd Cysts: Diagnosis, Management, and Pathophysiology.
Dubuisson, Annie ULg; Martin, Didier ULg; Bruggeman, L. et al

Conference (1995, April 22)

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See detailTraitement préchirurgical par octréolide dans l'acromégalie.
Stevenaert, Achille ULg; Lenelle, Jacques ULg; Martin, Didier ULg et al

Conference (1995, March 11)

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See detailLe kyste arachnoïdien spinal extradural : une cause rare de douleur vertébrale isolée
Martin, Didier ULg; Bruggeman, L.; Collignon, F.

Conference (1995, March 11)

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See detailPresurgical Octreotide Treatment in Acromegaly : does it improve surgical cure rate?
Stevenaert, Achille ULg; Lenelle, Jacques ULg; Martin, Didier ULg et al

in 10th European Congress of Neurosurgery - Abstract book (1995)

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See detailLes lésions de la moelle épinière : du modèle expérimental aux transplantations.
Martin, Didier ULg

Conference (1994, November 23)

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See detailRadiation-Induced Myelopathy and Vertebral Necrosis
Martin, Didier ULg; Delacollette, Mireille ULg; Collignon, Jacques ULg et al

in Neuroradiology (1994), 36(5), 405-7

Radiation-induced myelopathy is often a diagnosis of exclusion. In addition to the classic criteria needed to support the diagnosis, the presence of another radiation-induced lesion, such as aseptic ... [more ▼]

Radiation-induced myelopathy is often a diagnosis of exclusion. In addition to the classic criteria needed to support the diagnosis, the presence of another radiation-induced lesion, such as aseptic vertebral necrosis, is useful to confirm the cause of the spinal cord lesion. [less ▲]

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See detailSpinal cord stimulation for ischemic rest pain. The Belgian randomized study.
Suy, R.; Gybels, J.; Van Damme, Hendrik ULg et al

in Horsch, S.; Clayes, L. (Eds.) Spinal cord stimulation (1994)

Detailed reference viewed: 35 (0 ULg)
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See detailLes transplantations de cellules de Schwann syngéniques dans les lésions médullaires: résultats, limitations et perspectives
Martin, Didier ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1994), 149(5-7), 279-89289-91

After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at ... [more ▼]

After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at least in part, to the existence in the periphery of Schwann cells and of growth promoting proteins they synthetize. One strategy to promote regrowth of central axons can be therefore, to modify (i.e. "peripheralize") the microenvironment by transplanting biologically active Schwann cells into the lesion site. In a rat model of traumatic paraplegia by inflation of a subdural microballoon, we performed syngeneic transplants of Schwann cells. These cells are cultured from adult dorsal root ganglia and can be kept in vitro for several months. They are transplanted in the injured spinal cord. The grafted Schwann cells are well integrated in the host tissue without detectable inflammatory reaction. Cystic cavitation and astrogliosis are reduced in grafted animals as compared to injured, non-grafted animals. The transplant is invaded by abundant, mainly unmyelinated axons which are immunoreactive for substance P, VIP or CGRP, i.e. transmitters known to be present in DRG afferents. Supraspinal afferents containing 5HT, TH or CCK accumulate at the rostral margin of the graft. Experimental procedures trying to stimulate the invasion of the graft by descending fibers, i.e. by inducing a chemoattraction are therefore of crucial importance for functional recovery. [less ▲]

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