Spinal cord trauma:approaches and perspectives

Scientific conference (1995, September)

Presurgical octreolide treatment in acromegaly: does it improve surgical cure?

Conference (1995, May 07)

Intrasellar Arachnoïd Cysts: Diagnosis, Management, and Pathophysiology.

Conference (1995, April 22)

Le kyste arachnoïdien spinal extradural : une cause rare de douleur vertébrale isolée

Conference (1995, March 11)

Tumeur à cellules géantes du rachis lombaire : traitement chirurgical par vertébrectomie complète en deux temps, y compris la reconstruction

Conference (1994, December 05)

Les transplantations de cellules de Schwann syngéniques dans les lésions médullaires : résultats, limitations et perspectives

Conference (1994, November 06)

Les transplantations de cellules de Schwann syngéniques dans les lésions médullaires: résultats, limitations et perspectives.

Conference (1994, June 25)

Les transplantations de cellules de Schwann syngéniques dans les lésions médullaires: résultats, limitations et perspectives

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1994), 149(5-7), 279-89289-91

After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at ... [more ▼]

After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at least in part, to the existence in the periphery of Schwann cells and of growth promoting proteins they synthetize. One strategy to promote regrowth of central axons can be therefore, to modify (i.e. "peripheralize") the microenvironment by transplanting biologically active Schwann cells into the lesion site. In a rat model of traumatic paraplegia by inflation of a subdural microballoon, we performed syngeneic transplants of Schwann cells. These cells are cultured from adult dorsal root ganglia and can be kept in vitro for several months. They are transplanted in the injured spinal cord. The grafted Schwann cells are well integrated in the host tissue without detectable inflammatory reaction. Cystic cavitation and astrogliosis are reduced in grafted animals as compared to injured, non-grafted animals. The transplant is invaded by abundant, mainly unmyelinated axons which are immunoreactive for substance P, VIP or CGRP, i.e. transmitters known to be present in DRG afferents. Supraspinal afferents containing 5HT, TH or CCK accumulate at the rostral margin of the graft. Experimental procedures trying to stimulate the invasion of the graft by descending fibers, i.e. by inducing a chemoattraction are therefore of crucial importance for functional recovery. [less ▲]

Transplantations syngéniques de neurones et de cellules de Schwann dans la moelle épinière

Conference (1993, November 22)

Stabilité du rachis cervical lors de l'abord antérieur des myélopathies cervicarthrosiques

Conference (1993, September 24)