The Liege Acromegaly Survey (LAS) : A new software tool for the study of acromegaly
PETROSSIANS, Patrick ; ; Stevenaert, Achille et al
in Annales d'Endocrinologie (2012), 73Detailed reference viewed: 21 (5 ULg)
Spinal cord injury and its treatment:current management and experimental perspectives
SCHOLTES, Félix ; ; MARTIN, Didier
in Advances and Technical Standards in Neurosurgery (2012), 38Detailed reference viewed: 38 (3 ULg)
Atteinte des nerfs crâniens par les anévrismes intracrâniens : implications stratégiques.
SCHOLTES, Félix ; Martin, Didier
in Neuro-Chirurgie (2012)Detailed reference viewed: 11 (3 ULg)
Strategical implications of aneurysmal cranial nerve compression
SCHOLTES, Félix ; Martin, Didier
in Neuro-Chirurgie (2012)Detailed reference viewed: 9 (1 ULg)
La Toxine Botulinique : applications cliniques en ophtalmologie.
MARTIN, Didier ; ANDRIS, Cécile
Conference (2011, October 19)Detailed reference viewed: 10 (1 ULg)
Waterjet dissection and vacuum-assisted resection of supratentorial meningioma
Conference (2011, September 15)Detailed reference viewed: 4 (0 ULg)
Traumatic aneurysm of the distal anterior cerebral artery in the adult. Case report describing an anatomical explanation.
HENROTEAUX, Adrienne ; SCHOLTES, Félix ; MARTIN, Didier
Poster (2011, March 26)Detailed reference viewed: 49 (0 ULg)
Is paralysing lumbar disc herniation a surgical emergency ?
DUBUISSON, Annie ; BORLON, Sarah ; NGUYEN KHAC, Minh-Tuan et al
Conference (2011, March 26)Detailed reference viewed: 48 (7 ULg)
Post-mortem assessment of rat spinal cord injury and white matter sparing using inversion recovery-supported proton density magnetic resonance imaging
Scholtes, Félix ; ; Phan Ba, Remy et al
in Spinal Cord : The Official Journal of the International Medical Society of Paraplegia (2011)Detailed reference viewed: 21 (11 ULg)
Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection.
Kroonen, Jérôme ; Nassen, Jessica ; et al
in International Journal of Cancer = Journal International du Cancer (2011), 129(3), 574-585
This study reports the subsequent isolation of human glioblatoma cells able to initiate experimental brain tumors, specifically and repeatedly found in the subventricular zones and olfactory bulbs ... [more ▼]
This study reports the subsequent isolation of human glioblatoma cells able to initiate experimental brain tumors, specifically and repeatedly found in the subventricular zones and olfactory bulbs following xenograft in the caudate putamen of immunodeficient mice.In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate towards the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer-initiating cells. [less ▲]Detailed reference viewed: 65 (28 ULg)
Atrophie de la main sur syndrome de défilé cervicothoracique neurogène. A propos de 7 cas opérés.
Dubuisson, Annie ; Nguyen Khac, Minh-Tuan ; Scholtes, Félix et al
Poster (2010, December)Detailed reference viewed: 59 (2 ULg)
Données chirurgicales récentes - adénomes hypophysaires
Conference (2010, November 19)Detailed reference viewed: 10 (0 ULg)
Traumatisme médullaire : de la Clinique à la Recherche Fondamentale.
Conference (2010, October 25)Detailed reference viewed: 9 (0 ULg)
Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
Gangolf, Marjorie ; ; Radermecker, Marc et al
in PLoS ONE (2010), 5(10), 13616
Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine ... [more ▼]
Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations. This is the first comprehensive study on the distribution of thiamine derivatives in human biopsies, body fluids and cell lines. Methodology and Principal Findings Thiamine derivatives were determined by HPLC. In human tissues, the total thiamine content is lower than in other animal species. ThDP is the major thiamine compound and tissue levels decrease at high age. In semen, ThDP content correlates with the concentration of spermatozoa but not with their motility. The proportion of ThTP is higher in humans than in rodents, probably because of a lower 25-kDa ThTPase activity. The expression and activity of this enzyme seems to correlate with the degree of cell differentiation. ThTP was present in nearly all brain and muscle samples and in ~60% of other tissue samples, in particular fetal tissue and cultured cells. A low ([ThTP]+[ThMP])/([Thiamine]+[ThMP]) ratio was found in cardiovascular tissues of patients with cardiac insufficiency. AThTP was detected only sporadically in adult tissues but was found more consistently in fetal tissues and cell lines. Conclusions and Significance The high sensitivity of humans to thiamine deficiency is probably linked to low circulating thiamine concentrations and low ThDP tissue contents. ThTP levels are relatively high in many human tissues, as a result of low expression of the 25-kDa ThTPase. Another novel finding is the presence of ThTP and AThTP in poorly differentiated fast-growing cells, suggesting a hitherto unsuspected link between these compounds and cell division or differentiation. [less ▲]Detailed reference viewed: 52 (22 ULg)