References of "Martin, Didier"
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See detailNonlésional central lobule seizures : use of awake cortical mapping and subdural grid monitoring for resection of seizure focus
Collignon, F.; Cohen-Gadol, A.; Meyer, F. et al

Conference (2006, March)

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See detailLong-term outcome of Epilepsy surgery among 399 patients with non-lesional pathology including mesial temporal lobe sclerosis.
Scholsem, M.; Cohen-Gadol, A.; Martin, Didier ULg et al

Conference (2006, March)

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See detailAlteration in expression of connexin subtypes may play a role in human mesial temporal lobe epilepsy
Collignon, F.; Martin, Didier ULg; Wetjen, N.

Conference (2006, March)

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See detailExtensive epidural and paraspinal follicular Non-Hodgkin lymphoma
Scholtes, Félix ULg; Scholsem, M.; Matus, G. et al

Conference (2006, March)

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See detailChirurgie du système nerveux périphérique
Martin, Didier ULg

Scientific conference (2006, March)

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See detailSpinal cord trauma
Martin, Didier ULg

Conference (2006, February 24)

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See detailTips and tricks about aneurysm clipping
Martin, Didier ULg

Conference (2006, February 10)

Detailed reference viewed: 3 (0 ULg)
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See detailSpontaneous pneumocephalus caused by the association of pneumosinus dilatans and meningioma. Case illustration
Scholsem, Martin; Collignon, Frederic; Deprez, Manuel ULg et al

in Journal of Neurosurgery (2006), 105(6), 934

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See detailChromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas.
Turkheimer, Federico E; Roncaroli, Federico; Hennuy, Benoît ULg et al

in BMC Bioinformatics (2006), 7

BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that ... [more ▼]

BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for mathematical approaches to exploit this dependency for the analysis of expression data-sets. RESULTS: We have devised a novel mathematical technique (CHROMOWAVE) based on the Haar wavelet transform and applied it to a dataset obtained with the Affymetrix HG-U133_Plus_2 array in 27 gliomas. CHROMOWAVE generated multi-chromosomal pattern featuring low expression in chromosomes 1p, 4, 9q, 13, 18, and 19q. This pattern was not only statistically robust but also clinically relevant as it was predictive of favourable outcome. This finding was replicated on a data-set independently acquired by another laboratory. FISH analysis indicated that monosomy 1p and 19q was a frequent feature of tumours displaying the CHROMOWAVE pattern but that allelic loss on chromosomes 4, 9q, 13 and 18 was much less common. CONCLUSION: The ability to detect expression changes of spatially related genes and to map their position on chromosomes makes CHROMOWAVE a valuable screening method for the identification and display of regional gene expression changes of clinical relevance. In this study, FISH data showed that monosomy was frequently associated with diffuse low gene expression on chromosome 1p and 19q but not on chromosomes 4, 9q, 13 and 18. Comparative genomic hybridisation, allelic polymorphism analysis and methylation studies are in progress in order to identify the various mechanisms involved in this multi-chromosomal expression pattern. [less ▲]

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See detailA phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].
Robe, Pierre ULg; Martin, Didier ULg; Albert, Adelin ULg et al

in BMC Cancer (2006), 6

BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median ... [more ▼]

BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median survival of glioblastoma multiforme (WHO grade 4) patients is at best 14.6 month with only 26.5 percent of the patients still alive after 2 years and the median survival of anaplastic astrocytomas (WHO grade 3) is 19.2 month. Recent evidence suggests that the transcription factor NF-kappaB is constitutively expressed in malignant gliomas and that its inhibition by drugs like Sulfasalazine may block the growth of astrocytic tumors in vitro and in experimental models of malignant gliomas. DESIGN: ULg_GBM_04/1 is a prospective, randomized, double blind single-center phase 1-2 study. A total of twenty patients with progressive malignant glioma despite surgery, radiation therapy and a first line of chemotherapy will be recruited and assigned to four dosage regimen of Sulfasalazine. This medication will be taken orally t.i.d. at a daily dose of 1.5-3-4 or 6 g, continuously until complete remission, evidence of progression or drug intolerance. Primary endpoints are drug safety in the setting of malignant gliomas and tumor response as measured according to MacDonald's criteria. An interim analysis of drug safety will be conducted after the inclusion of ten patients. The complete evaluation of primary endpoints will be conducted two years after the enrollment of the last patient or after the death of the last patient should this occur prematurely. DISCUSSION: The aim of this study is to evaluate the safety and efficacy of Sulfasalazine as a treatment for recurring malignant gliomas. The safety and efficacy of this drug are analyzed as primary endpoints. Overall survival and progression-free survival are secondary endpoint. [less ▲]

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See detailCorrelation of postmortem 9.4 tesla magnetic resonance imaging and immunohistopathology of the human thoracic spinal cord 7 months after traumatic cervical spine injury.
Scholtes, Félix ULg; Adriaensens, Peter; Storme, Liesbet et al

in Neurosurgery (2006), 59(3), 671-8671-8

OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as ... [more ▼]

OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as standard histology and immunohistochemistry, were performed on an excised specimen of human high thoracic spinal cord, obtained 7 months after the initial trauma, several segments below a severe spinal cord lesion (C5). RESULTS: A precise correlation is described between MRI and immunohistochemistry of the long white matter tracts undergoing Wallerian degeneration and of an extension of the cervical lesion into the high thoracic cord. CONCLUSION: MRI, the only imaging technique that currently provides useful information on the spinal cord parenchyma after trauma, is rapidly evolving. High-field scanners of up to 9.4 T are being clinically tested. The present postmortem investigation of an isolated spinal cord specimen demonstrates the precise correlation that can be achieved between imaging and pathology. In future investigations, this type of technique can lead to a more precise description of spinal cord injuries and their consequences in remote tissue. Translation into the clinical setting will improve diagnosis and follow-up of spinal cord injured patients. [less ▲]

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See detailHypertension intra-crânienne et hydrocéphalie
Martin, Didier ULg

Scientific conference (2005, December)

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See detailPrise en charge de la douleur chronique
Martin, Didier ULg

Scientific conference (2005, November)

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See detailNouvelles techniques d'imagerie du système nerveux central
Martin, Didier ULg

Scientific conference (2005, June)

Detailed reference viewed: 2 (0 ULg)
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See detailPathologie neurochirurgicale
Martin, Didier ULg

Conference (2005, May 21)

Detailed reference viewed: 3 (0 ULg)
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See detailTwo stages total vertebrectomy : about a series of 16 patients.
Lenelle, Jacques ULg; Collignon, F.; Dubuisson, Annie ULg et al

Conference (2005, March)

Detailed reference viewed: 8 (0 ULg)