References of "Martin, Didier"
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See detailIntrasellar arachnoid cysts.
Dubuisson, Annie ULg; Stevenaert, Achille ULg; Martin, Didier ULg et al

in Neurosurgery (2007), 61(3), 505-13513

OBJECTIVE: To evaluate the clinical, endocrinological, and radiological presentation of nine cases of surgically verified intrasellar arachnoid cysts and to discuss the physiopathological mechanisms of ... [more ▼]

OBJECTIVE: To evaluate the clinical, endocrinological, and radiological presentation of nine cases of surgically verified intrasellar arachnoid cysts and to discuss the physiopathological mechanisms of formation of these cysts. METHODS: Among 1540 patients presenting with pituitary lesions, nine presented with an intrasellar arachnoid cyst. Their charts were retrospectively reviewed. RESULTS: Presenting symptoms included headache (n = 2), visual symptoms (n = 3), menstrual irregularities (n = 2), rapid weight gain (n = 1), vertigo (n = 1), and/or confusion (n = 1). Two cysts were discovered incidentally. T1-weighted magnetic resonance imaging scans showed an intrasellar cystic lesion in all cases, with a huge suprasellar extension in six cases. The cyst was of the same intensity as the cerebrospinal fluid (CSF) in only two patients. A transsphenoidal approach allowed the transdural aspiration of fluid and injection of a water-soluble contrast agent under mild pressure. In three patients, the contrast infiltrated along the pituitary stalk toward the subarachnoid spaces; in the other patients, it remained in the intrasellar compartment. Cyst membranes were removed as completely as possible with fenestration toward the subarachnoid spaces in communicating cysts. In spite of tight packing of the sella and sphenoid sinus, CSF fistulae requiring reoperation developed in two patients. CONCLUSION: The clinical picture of an intrasellar arachnoid cyst resembles that of a nonfunctional pituitary adenoma. Magnetic resonance imaging scans typically show a cystic intrasellar lesion with suprasellar extension, containing isointense or, more often, hyperintense fluid on T1-weighted sequences. In spite of the risk of CSF fistulae, the preferred surgical approach is transsphenoidal. A physiopathological mechanism is proposed according to anatomic variations of the sellar diaphragma allowing penetration of subarachnoid spaces into the sellar compartment and their enlargement by a ball-valve mechanism. [less ▲]

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See detailLe cas clinique du mois. Le syndrome lissencephalique de Miller-Dieker.
Cremers, Julien ULg; Scholsem, Martin; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2007), 62(3), 139-43

We present the case of a 10-year-old boy who presents with a severe epilepsy resistant to medical treatment in the context of a Miller-Dieker syndrome. This patient underwent the implantation of a ... [more ▼]

We present the case of a 10-year-old boy who presents with a severe epilepsy resistant to medical treatment in the context of a Miller-Dieker syndrome. This patient underwent the implantation of a pneumogastric nerve stimulator. We describe the patient's clinical history and the main characteristics of lissencephaly syndrome. [less ▲]

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See detailActualites neurochirurgicales dans le traitement des tumeurs cerebrales
Robe, Pierre ULg; Martin, Didier ULg

in Revue Médicale de Liège (2007), 62(5-6, May-Jun), 405-409

Neuronavigation is a tool for image guidance surgery. Based on the principle of the GPS, it is notably used for the ablation of brain tumors. Because of their millimetre precision, neuronavigation devices ... [more ▼]

Neuronavigation is a tool for image guidance surgery. Based on the principle of the GPS, it is notably used for the ablation of brain tumors. Because of their millimetre precision, neuronavigation devices bring more safety and effectiveness due to the ever increasing performances of medical imaging. However, neuronavigation presents a major pitfall as it uses a static support (the images acquired preoperatively) to perform a dynamic process (the surgical ablation). To preserve the performance of neuronavigation, it is mandatory to update the images during surgery. This is now achievable by interventional MRI, intra-operative ultrasound and the incorporation of fluorescent tracers by the tumor cells. These major tools, now available at Sart Tilman University Hospital of combined with state-of-the-art chemotherapy, radiotherapy and experimental protocols (including gene therapy) will undoubtedly improve the prognosis of brain tumors. [less ▲]

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See detailAnisocoria and Cerebro-Vascular Diseases
Martin, Didier ULg

Conference (2006, November 22)

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See detailEffects of vagal nerve stimulation in the rat orofacial formalin model of pain
Multon, S.; Scholsem, M.; Legrain, C. et al

Conference (2006, November 10)

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See detailEffects of vagal nerve stimulation in the rat orofacial formalin model of pain
Multon, Sylvie ULg; Scholsem, Martin; LEGRAIN, Caroline ULg et al

Poster (2006, November)

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See detailNeuroanesthésie
Martin, Didier ULg

Scientific conference (2006, November)

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See detailWath’s new in the management of spinal cord injury ?
Martin, Didier ULg

Conference (2006, October 13)

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See detailEffects of vagal nerve stimulation in the rat orofacial formalin model of pain
Multon, Sylvie ULg; Scholsem, Martin; LEGRAIN, Caroline ULg et al

in Book of Abstracts of the 36th Annual Meeting Society for Neuroscience (Oct 2006) (2006, October)

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See detailPathologie cérébro-vasculaire
Martin, Didier ULg

Scientific conference (2006, June)

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See detailNonlésional central lobule seizures : use of awake cortical mapping and subdural grid monitoring for resection of seizure focus
Collignon, F.; Cohen-Gadol, A.; Meyer, F. et al

Conference (2006, March)

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See detailLong-term outcome of Epilepsy surgery among 399 patients with non-lesional pathology including mesial temporal lobe sclerosis.
Scholsem, M.; Cohen-Gadol, A.; Martin, Didier ULg et al

Conference (2006, March)

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See detailAlteration in expression of connexin subtypes may play a role in human mesial temporal lobe epilepsy
Collignon, F.; Martin, Didier ULg; Wetjen, N.

Conference (2006, March)

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See detailExtensive epidural and paraspinal follicular Non-Hodgkin lymphoma
Scholtes, Félix ULg; Scholsem, M.; Matus, G. et al

Conference (2006, March)

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See detailChirurgie du système nerveux périphérique
Martin, Didier ULg

Scientific conference (2006, March)

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See detailSpinal cord trauma
Martin, Didier ULg

Conference (2006, February 24)

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See detailTips and tricks about aneurysm clipping
Martin, Didier ULg

Conference (2006, February 10)

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See detailSpontaneous pneumocephalus caused by the association of pneumosinus dilatans and meningioma. Case illustration
Scholsem, Martin; Collignon, Frederic; Deprez, Manuel ULg et al

in Journal of Neurosurgery (2006), 105(6), 934

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See detailChromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas.
Turkheimer, Federico E; Roncaroli, Federico; Hennuy, Benoît ULg et al

in BMC Bioinformatics (2006), 7

BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that ... [more ▼]

BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for mathematical approaches to exploit this dependency for the analysis of expression data-sets. RESULTS: We have devised a novel mathematical technique (CHROMOWAVE) based on the Haar wavelet transform and applied it to a dataset obtained with the Affymetrix HG-U133_Plus_2 array in 27 gliomas. CHROMOWAVE generated multi-chromosomal pattern featuring low expression in chromosomes 1p, 4, 9q, 13, 18, and 19q. This pattern was not only statistically robust but also clinically relevant as it was predictive of favourable outcome. This finding was replicated on a data-set independently acquired by another laboratory. FISH analysis indicated that monosomy 1p and 19q was a frequent feature of tumours displaying the CHROMOWAVE pattern but that allelic loss on chromosomes 4, 9q, 13 and 18 was much less common. CONCLUSION: The ability to detect expression changes of spatially related genes and to map their position on chromosomes makes CHROMOWAVE a valuable screening method for the identification and display of regional gene expression changes of clinical relevance. In this study, FISH data showed that monosomy was frequently associated with diffuse low gene expression on chromosome 1p and 19q but not on chromosomes 4, 9q, 13 and 18. Comparative genomic hybridisation, allelic polymorphism analysis and methylation studies are in progress in order to identify the various mechanisms involved in this multi-chromosomal expression pattern. [less ▲]

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