Wath’s new in the management of spinal cord injury ?
Conference (2006, October 13)Detailed reference viewed: 5 (1 ULg)
Nonlésional central lobule seizures : use of awake cortical mapping and subdural grid monitoring for resection of seizure focus
; ; et al
Conference (2006, March)
Long-term outcome of Epilepsy surgery among 399 patients with non-lesional pathology including mesial temporal lobe sclerosis.
; ; Martin, Didier et al
Conference (2006, March)Detailed reference viewed: 3 (0 ULg)
Alteration in expression of connexin subtypes may play a role in human mesial temporal lobe epilepsy
; Martin, Didier ;
Conference (2006, March)Detailed reference viewed: 1 (0 ULg)
Extensive epidural and paraspinal follicular Non-Hodgkin lymphoma
Scholtes, Félix ; ; et al
Conference (2006, March)Detailed reference viewed: 25 (0 ULg)
Initial outcome and efficacy of kyphoplasty in the treatment of painful osteoporotic vertebral compression fractures
Scholtes, Félix ; Martin, Didier ; et al
Conference (2006, March)Detailed reference viewed: 2 (0 ULg)
Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas.
; ; Hennuy, Benoît et al
in BMC Bioinformatics (2006), 7
BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that ... [more ▼]
BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for mathematical approaches to exploit this dependency for the analysis of expression data-sets. RESULTS: We have devised a novel mathematical technique (CHROMOWAVE) based on the Haar wavelet transform and applied it to a dataset obtained with the Affymetrix HG-U133_Plus_2 array in 27 gliomas. CHROMOWAVE generated multi-chromosomal pattern featuring low expression in chromosomes 1p, 4, 9q, 13, 18, and 19q. This pattern was not only statistically robust but also clinically relevant as it was predictive of favourable outcome. This finding was replicated on a data-set independently acquired by another laboratory. FISH analysis indicated that monosomy 1p and 19q was a frequent feature of tumours displaying the CHROMOWAVE pattern but that allelic loss on chromosomes 4, 9q, 13 and 18 was much less common. CONCLUSION: The ability to detect expression changes of spatially related genes and to map their position on chromosomes makes CHROMOWAVE a valuable screening method for the identification and display of regional gene expression changes of clinical relevance. In this study, FISH data showed that monosomy was frequently associated with diffuse low gene expression on chromosome 1p and 19q but not on chromosomes 4, 9q, 13 and 18. Comparative genomic hybridisation, allelic polymorphism analysis and methylation studies are in progress in order to identify the various mechanisms involved in this multi-chromosomal expression pattern. [less ▲]Detailed reference viewed: 26 (5 ULg)
A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].
Robe, Pierre ; Martin, Didier ; Albert, Adelin et al
in BMC Cancer (2006), 6
BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median ... [more ▼]
BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median survival of glioblastoma multiforme (WHO grade 4) patients is at best 14.6 month with only 26.5 percent of the patients still alive after 2 years and the median survival of anaplastic astrocytomas (WHO grade 3) is 19.2 month. Recent evidence suggests that the transcription factor NF-kappaB is constitutively expressed in malignant gliomas and that its inhibition by drugs like Sulfasalazine may block the growth of astrocytic tumors in vitro and in experimental models of malignant gliomas. DESIGN: ULg_GBM_04/1 is a prospective, randomized, double blind single-center phase 1-2 study. A total of twenty patients with progressive malignant glioma despite surgery, radiation therapy and a first line of chemotherapy will be recruited and assigned to four dosage regimen of Sulfasalazine. This medication will be taken orally t.i.d. at a daily dose of 1.5-3-4 or 6 g, continuously until complete remission, evidence of progression or drug intolerance. Primary endpoints are drug safety in the setting of malignant gliomas and tumor response as measured according to MacDonald's criteria. An interim analysis of drug safety will be conducted after the inclusion of ten patients. The complete evaluation of primary endpoints will be conducted two years after the enrollment of the last patient or after the death of the last patient should this occur prematurely. DISCUSSION: The aim of this study is to evaluate the safety and efficacy of Sulfasalazine as a treatment for recurring malignant gliomas. The safety and efficacy of this drug are analyzed as primary endpoints. Overall survival and progression-free survival are secondary endpoint. [less ▲]Detailed reference viewed: 69 (16 ULg)
Spontaneous pneumocephalus caused by the association of pneumosinus dilatans and meningioma. Case illustration.
; ; Deprez, Manuel et al
in Journal of Neurosurgery (2006), 105(6), 934Detailed reference viewed: 18 (0 ULg)
Correlation of postmortem 9.4 tesla magnetic resonance imaging and immunohistopathology of the human thoracic spinal cord 7 months after traumatic cervical spine injury.
Scholtes, Félix ; ; et al
in Neurosurgery (2006), 59(3), 671-8671-8
OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as ... [more ▼]
OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as standard histology and immunohistochemistry, were performed on an excised specimen of human high thoracic spinal cord, obtained 7 months after the initial trauma, several segments below a severe spinal cord lesion (C5). RESULTS: A precise correlation is described between MRI and immunohistochemistry of the long white matter tracts undergoing Wallerian degeneration and of an extension of the cervical lesion into the high thoracic cord. CONCLUSION: MRI, the only imaging technique that currently provides useful information on the spinal cord parenchyma after trauma, is rapidly evolving. High-field scanners of up to 9.4 T are being clinically tested. The present postmortem investigation of an isolated spinal cord specimen demonstrates the precise correlation that can be achieved between imaging and pathology. In future investigations, this type of technique can lead to a more precise description of spinal cord injuries and their consequences in remote tissue. Translation into the clinical setting will improve diagnosis and follow-up of spinal cord injured patients. [less ▲]Detailed reference viewed: 39 (11 ULg)
Transsphenoidal surgery for Cushing’s disease. Early and long-term results in 106 patients
Stevenaert, Achille ; Robe, Pierre ; Martin, Didier et al
Conference (2005, October 07)Detailed reference viewed: 5 (0 ULg)
35. Stimulateur du nerf vague et autres attitudes pratiques face aux épilepsies rebelles.
Conference (2005, June 11)Detailed reference viewed: 2 (0 ULg)
Nouvelles techniques d'imagerie du système nerveux central
Scientific conference (2005, June)Detailed reference viewed: 1 (0 ULg)