References of "Martens, Henri"
     in
Bookmark and Share    
Peer Reviewed
See detailLa communication cryptocrine et la reconnaissance des fonctions neuroendocrines par les cellules T au cours de leur différenciation
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1992), 33

Le thymus, organe lymphoïde primaire responsable du développement des lymphocytes T, est le site d'expression de différents peptides appartenant à des familles hormonales distinctes. Le modèle classique ... [more ▼]

Le thymus, organe lymphoïde primaire responsable du développement des lymphocytes T, est le site d'expression de différents peptides appartenant à des familles hormonales distinctes. Le modèle classique de la neurosécrétion établi pour l'axe hypothalamo-neurohypophysaire ne peut cependant s'appliquer à la sécrétion de tels signaux par les cellules épithéliales thymiques. Un nouveau modèle de communication cellulaire, celui de la communication cryptocrine, a été proposé par John W. Funder pour décrire les échanges d'information entre une cellule épithéliale fixe et des cellules mobiles en différenciation à leur contact. Dans le thymus, la communication cryptocrine est étroitement associée à la présentation de la structure moléculaire du Soi par les molécules d'histocompatibilité (CMH) aux lymphocytes T au cours de leur différenciation. Sur la base de nos observations, le modèle du répertoire thymique des autoantigènes neuroendocrines permet de transposer au niveau moléculaire le double rôle physiologique du thymus dans les phénomènes de sélections négative et positive des cellules T, et d'apporter un éclairage nouveau sur les mécanismes responsables de la tolérance immunitaire centrale aux fonctions neuroendocrines. [less ▲]

Detailed reference viewed: 53 (1 ULg)
Peer Reviewed
See detailImmunomodulatory properties of cyclic hexapeptide oxytocin antagonists
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Thymus (1992), 20

A pharmacological manipulation of cryptocrine cell-to-cell signaling was tested by the investigation of the immunomodulatory properties of novel cyclic hexapeptide oxytocin (OT) antagonists (MSD Research ... [more ▼]

A pharmacological manipulation of cryptocrine cell-to-cell signaling was tested by the investigation of the immunomodulatory properties of novel cyclic hexapeptide oxytocin (OT) antagonists (MSD Research Laboratories). The compounds were found to significantly inhibit the productions of IL-1ß and IL-6 elicited by anti-CD3 treatment oh human whole blood cells cultures (WBC). Cytokine productions were more significantly reduced by OT antagonists in WBC derived from female volunteers than in those obtained from male donors, suggesting an influence of sex steroids on the expression of NHP receptors by immune cells. These observations support the concept of novel immunomodulating approaches through immune-specific neuropeptide antagonists, as well as the pharmacological value of such strategies in selective immunotherapy. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Peer Reviewed
See detailExpression of functional neurohypophysial peptide receptors by murine immature and cytotoxic T-cell lines
Martens, Henri ULg; Robert, Françoise; Geenen, Vincent ULg et al

in Progress in NeuroEndocrinImmunology (1992), 5

In order to demonstrate the cryptocrine model of neuroendocrine-immune interactions, specific neurohypophysial (NHP) receptors were detected on murine immature pre-T and cytotoxic T cell lines. A computer ... [more ▼]

In order to demonstrate the cryptocrine model of neuroendocrine-immune interactions, specific neurohypophysial (NHP) receptors were detected on murine immature pre-T and cytotoxic T cell lines. A computer analysis (LIGAND) revealed the heterogeneity of the binding sites. The Kd of Highest affinity were equivalent in both cell lines (0.15 nM), but the capacity (Bmax) of both low and high affinity sites was higher in the immature thymic lymphoma-derived pre-T-cell line. The functionality of these receptors was evidenced by their transduction of NHP-related ligands as an increase in intracellular inositol phosphates. These transductory properties were inhibited by a V1 receptor antagonist in pre-T cells, and by an oxytocin (OT) receptor antagonist in cytotoxic T cells. This work supports the involvement of NHP-related ligands and receptors in a process of cryptocrine signaling in the thymus, where the peptide concentration and the receptor affinity are in appropriate concordance. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Peer Reviewed
See detailAt the Cutting Edge. Biosynthesis and Paracrine/Cryptocrine Actions of 'Self' Neurohypophysial-Related Peptides in the Thymus
Geenen, Vincent ULg; Robert, F.; Martens, Henri ULg et al

in Molecular & Cellular Endocrinology (1991), 76(1-3), 27-31

Detailed reference viewed: 16 (2 ULg)
Peer Reviewed
See detailThymic cryptocrine signaling and the immune recognition of self neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Progress in NeuroEndocrinImmunology (1991), 4

Detailed reference viewed: 6 (2 ULg)
See detailNeuroendocrinology of the thymus
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Geenen, Vincent; Maggi, Mario (Eds.) Horizons in Endocrinology, Volume 2 (1991)

Detailed reference viewed: 14 (5 ULg)
Peer Reviewed
See detailThymic cryptocrine signaling and the immune recognition of self neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Robert Françoise et al

in Progress in NeuroEndocrinImmunology (1991), 5

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailThymic cryptocrine signalling and the immune recognition of neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Benhida, Abdellah et al

in Proceedings of the Joint Meeting (1991)

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailNeurophysins as markers of vasopressin and oxytocin release. A study in carcinoma of the lung.
Legros, Jean-Jacques ULg; Geenen, Vincent ULg; Carvelli, T et al

in Hormone Research (1990), 34(3-4), 151-5

Vasopressin-neurophysin (hNpI), oxytocin-neurophysin (hNpII) and blood osmolality were assayed before any treatment in basal conditions in 35 patients suffering from lung carcinoma (20 oat cell, 6 ... [more ▼]

Vasopressin-neurophysin (hNpI), oxytocin-neurophysin (hNpII) and blood osmolality were assayed before any treatment in basal conditions in 35 patients suffering from lung carcinoma (20 oat cell, 6 undifferentiated and 9 well-differentiated epidermoid cell carcinomas). Plasma vasopressin (antidiuretic hormone, ADH) was also assayed in 7 of the 20 patients suffering from oat cell carcinoma. We found a close correlation (r = 0.98) between plasma ADH and hNpI levels in the 7 patients. Further, hNpI was elevated in 13 out of the 20 oat cell carcinoma patients and in none of the epidermoid-cell carcinoma group; however, searching for an abnormality of ADH secretion as reflected by a detectable plasma hNpI level together with subnormal plasma osmolality revealed 2 additional positive results in the oat cell carcinoma group, and 2 out of the 6 in the undifferentiated-cell carcinoma group. hNpII was increased together with an increase in hNpI in 6 oat cell carcinoma patients; it was specifically increased without hNpI increment in 2 additional oat cell carcinoma patients and in 2 patients of the undifferentiated-cell carcinoma group (different from the 2 positive for the hNpI-osmolality ratio). hNpI and hNpII were normal in the majority of undifferentiated and all of the differentiated epidermoid-cell carcinoma group. Hence, our results show that simultaneous measurements of hNpI, hNpII, and blood osmolality could detect abnormalities in 17 out of 20 oat cell carcinoma patients, in 4 of the 9 undifferentiated-cell carcinoma patients, but in none of the differentiated epidermoid-cell carcinoma patients, suggesting that the neurophysin assay can be used for the early detection of oat cell- and possibly other neuroendocrine-derived carcinomas. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailNeurophysins as markers of ADH and oxytocin release
Legros, Jean-Jacques ULg; Geenen, Vincent ULg; Carvelli, Thierry ULg et al

in Hormone Research (1990), 34

Detailed reference viewed: 19 (1 ULg)
See detailCellular and molecular aspects of the neuroendocrine-immune dialogue in T-cell differentiation
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Müller, Eugenio E.; MacLeod, Robert (Eds.) Neuroendocrine Perspectives, Volume 8 (1990)

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailNeuroendocrine-Immune Interactions in T Cell Ontogeny
Geenen, Vincent ULg; Robert, Françoise; Fatemi, Marjaneh et al

in Thymus (1989), 13(3-4), 131-140

Detailed reference viewed: 10 (0 ULg)