References of "Maquet, Pierre"
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See detailModulating effect of COMT Val158Met polymorphism on interference resolution during a working memory task
Jaspar, Mathieu ULg; DIDEBERG, Vinciane ULg; Bours, Vincent ULg et al

in Brain & Cognition (2015), 95

Genetic variability related to the catechol-O-methyltransferase (COMT) gene has received increasing attention in the last 15 years, in particular as a potential modulator of the neural substrates ... [more ▼]

Genetic variability related to the catechol-O-methyltransferase (COMT) gene has received increasing attention in the last 15 years, in particular as a potential modulator of the neural substrates underlying inhibitory processes and updating in working memory (WM). In an event-related functional magnetic resonance imaging (fMRI) study, we administered a modified version of the Sternberg probe recency task (Sternberg, 1966) to 43 young healthy volunteers, varying the level of interference across successive items. The task was divided into two parts (high vs. low interference) to induce either proactive or reactive control processes. The participants were separated into three groups according to their COMT Val158Met genotype [Val/Val (VV); Val/Met (VM); Met/Met (MM)]. The general aim of the study was to determine whether COMT polymorphism has a modulating effect on the neural substrates of interference resolution during WM processing. Results indicate that interfering trials were associated with greater involvement of frontal cortices (bilateral medial frontal gyrus, left precentral and superior frontal gyri, right inferior frontal gyrus) in VV homozygous subjects (by comparison to Met allele carriers) only in the proactive condition of the task. In addition, analysis of peristimulus haemodynamic responses (PSTH) revealed that the genotype-related difference observed in the left SFG was specifically driven by a larger increase in activity from the storage to the recognition phase of the interfering trials in VV homozygous subjects. These results confirm the impact of COMT genotype on inhibitory processes during a WM task, with an advantage for Met allele carriers. Interestingly, this impact on frontal areas is present only when the level of interference is high, and especially during the transition from storage to recognition in the left superior frontal gyrus. [less ▲]

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See detailRelation entre fatigue et travail chez des patients atteints de sclérose en plaques
DELRUE, Gaël ULg; Blavier, Adelaïde ULg; Hennen, Julie et al

Poster (2014, December 15)

Fatigue is one of the most frequent symptom in multiple sclerosis patients (MS patients). We showed significant correlations between fatigue levels and difficulties encountered by our patients at work ... [more ▼]

Fatigue is one of the most frequent symptom in multiple sclerosis patients (MS patients). We showed significant correlations between fatigue levels and difficulties encountered by our patients at work evaluated through a specific questionnaire we already validated . This complaint must be carefully managed by professionnals in order to help the patients cope with it in the best way for maintaining work situation. [less ▲]

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See detailAbility to Maintain Internal Arousal and Motivation Modulates Brain Responses to Emotions
Sterpenich, Virginie; Schwartz, Sophie; MAQUET, Pierre ULg et al

in PLoS ONE (2014)

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See detailValidation d’un questionnaire d’ergonomie cognitive relatif au travail chez des patients atteints de sclerose en plaques
Blavier, Adelaïde ULg; DELRUE, Gaël ULg; HENNEN, Julie et al

Poster (2014, December)

We present datas validating the use of our QUIPSEP questionnaire among multiple sclerosis patients actually employed.

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See detailFatigue et auto-évaluation chez des patients atteints de sclérose en plaques
DELRUE, Gaël ULg; Blavier, Adelaïde ULg; HENNEN, Julie et al

Poster (2014, December)

Different fatigue scales specific for multiple sclerosis patients correlate quite differently with other psychological measures which gives rise to a necessary reflexion about the tools used in clinical ... [more ▼]

Different fatigue scales specific for multiple sclerosis patients correlate quite differently with other psychological measures which gives rise to a necessary reflexion about the tools used in clinical practice and their meanings. [less ▲]

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See detailHuman cortical excitability depends on time spent awake and circadian phase
Ly, Julien ULg; Gaggioni, Giulia ULg; Chellappa, Sarah Laxhmi ULg et al

Scientific conference (2014, October 04)

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking ... [more ▼]

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking period. But what’s happen at the cortical cerebral level? We used a novel technique coupling transcranial magnetic stimulation with electroencephalography (TMS/EEG) to assess the influence of time spent awake and circadian phasis on human cortical excitability. Twenty-two healthy young men underwent 8 TMS/EEG sessions during a 28 hour sleep deprivation protocole. We found that cortical excitability depends on both time spent awake and circadian phasis. [less ▲]

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See detailAutomatic artifact detection for whole-night polysomnographic sleep recordings
Coppieters't Wallant, Dorothée ULg; Chellappa, Sarah Laxhmi ULg; Gaggioni, Giulia ULg et al

Poster (2014, September 17)

Detecting of bad channels and artifacts for whole-night polysomnographic recordings is very time consuming and tedious. We therefore developed an automatic procedure to automatize this job.

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See detailHuman cortical excitability depends on time awake and circadian phase
Ly, Julien ULg; Chellappa, Sarah Laxhmi ULg; Gaggioni, Giulia ULg et al

Conference (2014, September 17)

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking ... [more ▼]

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking period. But what’s happen at the cortical cerebral level? We used a novel technique coupling transcranial magnetic stimulation with electroencephalography (TMS/EEG) to assess the influence of time spent awake and circadian phasis on human cortical excitability. Twenty-two healthy young men underwent 8 TMS/EEG sessions during a 28 hour sleep deprivation protocole. We found that cortical excitability depends on both time spent awake and circadian phasis. [less ▲]

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See detailHuman cortical excitability depends on time spent awake and circadian phase
Ly, Julien ULg; Chellappa, Sarah Laxhmi ULg; Gaggioni, Giulia ULg et al

Conference (2014, September 17)

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking ... [more ▼]

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking period. But what’s happen at the cortical cerebral level? We used a novel technique coupling transcranial magnetic stimulation with electroencephalography (TMS/EEG) to assess the influence of time spent awake and circadian phasis on human cortical excitability. Twenty-two healthy young men underwent 8 TMS/EEG sessions during a 28 hour sleep deprivation protocole. We found that cortical excitability depends on both time spent awake and circadian phasis. [less ▲]

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See detailDiagnosing multiple sclerosis with a gait measuring system, an analysis of the motor fatigue, and machine learning
Pierard, Sébastien ULg; Azrour, Samir ULg; Phan-Ba, Rémy et al

in Multiple Sclerosis Journal (2014, September 11), 20(S1), 171

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See detailAutomatic biorythms description from actigraphic data
González y Viagas, Miguel ULg; Ly, Julien ULg; Gaggioni, Giulia ULg et al

Poster (2014, September)

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See detailCortical excitability dynamics of during sleep deprivation set PVT performance
Borsu, Chloé; Gaggioni, Giulia ULg; Ly, Julien ULg et al

Poster (2014, September)

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See detailThe circadian system sets the temporal organization of basic human neuronal function
Chellappa, Sarah Laxhmi ULg; Ly, Julien; Gaggioni, Giulia ULg et al

Conference (2014, June 16)

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See detailMemory reactivation during rapid eye movement sleep promotes its generalization and integration in cortical stores.
Sterpenich, Virginie; Schmidt, Christina ULg; Albouy, Genevieve et al

in Sleep (2014), 37(6), 1061-751075-1075

STUDY OBJECTIVES: Memory reactivation appears to be a fundamental process in memory consolidation. In this study we tested the influence of memory reactivation during rapid eye movement (REM) sleep on ... [more ▼]

STUDY OBJECTIVES: Memory reactivation appears to be a fundamental process in memory consolidation. In this study we tested the influence of memory reactivation during rapid eye movement (REM) sleep on memory performance and brain responses at retrieval in healthy human participants. PARTICIPANTS: Fifty-six healthy subjects (28 women and 28 men, age [mean +/- standard deviation]: 21.6 +/- 2.2 y) participated in this functional magnetic resonance imaging (fMRI) study. METHODS AND RESULTS: Auditory cues were associated with pictures of faces during their encoding. These memory cues delivered during REM sleep enhanced subsequent accurate recollections but also false recognitions. These results suggest that reactivated memories interacted with semantically related representations, and induced new creative associations, which subsequently reduced the distinction between new and previously encoded exemplars. Cues had no effect if presented during stage 2 sleep, or if they were not associated with faces during encoding. Functional magnetic resonance imaging revealed that following exposure to conditioned cues during REM sleep, responses to faces during retrieval were enhanced both in a visual area and in a cortical region of multisensory (auditory-visual) convergence. CONCLUSIONS: These results show that reactivating memories during REM sleep enhances cortical responses during retrieval, suggesting the integration of recent memories within cortical circuits, favoring the generalization and schematization of the information. [less ▲]

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See detailNeuroimaging, cognition, light and circadian rhythms
Gaggioni, Giulia ULg; Maquet, Pierre ULg; Schmidt, Christina ULg et al

in Frontiers in Systems Neuroscience [=FNSYS] (2014)

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See detailLa Narcolepsie-Cataplexie aujourd'hui
DEPIERREUX, Frédérique ULg; FANIELLE, Julien ULg; Martin-Lecomte, Marianne ULg et al

in Revue Médicale de Liège (2014), 69(2), 72-81

Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue ... [more ▼]

Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue Médicale de Liège, in 2002, is based, in human beings, <br />on a destruction of specific cells located in the lateral and <br />posterior part of the hypothalamus (the perifornical nuclei, <br />containing some 70,000 neurons), producing peptides which <br />stimulate the central nervous system; they are called hypocretins <br />or orexins. The role of autoimmunity in their disappearance <br />becomes more evident. The treatment is simplified but <br />remains symptomatic. It is mainly based on Sodium Oxybate <br />or Gamma-Hydroxybutyrate, syrup, prescribed for the night. <br />The authors report on their own experience in this regard and <br />on future therapeutics more targeted towards the cause of the <br />disease. [less ▲]

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