References of "MOONEN, Gustave"
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See detailNeurotransmitter phenotype plasticity in adult dorsal root ganglia neurons
Moonen, Gustave ULg; Delrée, P.; Martin, Didier ULg et al

in Restorative Neurology & Neuroscience (1993), 5

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See detailTransplants of syngenic cultured, DRG-derived Schwann cells into the lesioned adult rat spinal cord.
Schoenen, Jean ULg; Martin, Didier ULg; Delrée, D. et al

Conference (1992, September 08)

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See detailExperimental Acute Traumatic Injury of the Adult Rat Spinal Cord by a Subdural Inflatable Balloon: Methodology, Behavioral Analysis, and Histopathology
Martin, Didier ULg; Schoenen, Jean ULg; Delree, P. et al

in Journal of Neuroscience Research (1992), 32(4), 539-50

We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to ... [more ▼]

We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of compression or the volume of saline used to inflate the balloon. The locomotor deficit of animals with various degrees of injury has been assessed at increasing delays after trauma. The parameters generating transient or definitive deficits of varying intensity were defined. Some injured animals underwent nuclear magnetic resonance imaging. Detailed histopathological studies demonstrated that the extent of the spinal lesion was significantly correlated with the physical parameters of compression and with the severity of the behavioral deficit. [less ▲]

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See detailTransplantation of syngenic adult rat DRG-derived Schwann cells to the injured spinal cord.
Martin, Didier ULg; Schoenen, Jean ULg; Delrée, P. et al

Conference (1992, June 14)

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See detailTgf Beta 1 Expression Is Initiated in Adult Auditory Neurons by Sectioning of the Auditory Nerve
LEFEBVRE, Philippe ULg; Martin, Didier ULg; Staecker, H. et al

in Neuroreport (1992), 3(4), 295-8

Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult ... [more ▼]

Neuronotrophic factors (e.g. basic fibroblast growth factor, bFGF and nerve growth factor, NGF) have been demonstrated to respectively promote survival and neuritogenesis in cultures of dissociated adult rat spiral ganglia. Transforming growth factor beta (TGF beta 1) has been shown to modulate the response of cultured auditory neurons to bFGF through the induction of high affinity receptors for bFGF in the neurons. In this study, we show that TGF beta is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve). Based on these in vivo results and on the results from our previous in vitro studies, we propose that TFG beta 1 acts as an early autocrine signal involved in the response to injury by neurons of the peripheral auditor system. [less ▲]

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See detailMécanismes de communication cellulaire dans le système nerveux périphérique en régénération
Leprince, Pierre ULg; Delree, P.; Rogister, Bernard ULg et al

in Revue Médicale de Liège (1992), 47(3), 115-8

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See detailPeripheral and central target-derived trophic factor(s) effects on auditory neurons.
Lefèbvre, Philippe ULg; Weber, T.; Rigo, J. et al

in Hearing Research (1992), 58(2), 185-92

In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of ... [more ▼]

In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants obtained from 5 day postpartum (P5) rat pups were cultured with an intact organ of Corti and in the absence of Corti's organ. Both neuronal survival and neurite extension were influenced by the presence of this peripheral target tissue. Local destruction of Corti's organ caused both neuritic retraction and neuronal cell death to occur in a corresponding portion of the spiral ganglion. This peripheral target-derived neurotrophic effect may be mediated by a diffusible factor(s) since organ of Corti conditioned medium also had a neurotrophic effect on the survival of auditory neurons in cell cultures of dissociated spiral ganglia from P5 rat pups. A component of central target tissue, i.e. astrocytes, was also shown to release a diffusible factor(s) that supported the survival of dissociated P5 rat spiral ganglion neurons. The neurotrophic effects on the in vitro survival of spiral ganglion neurons by both of these conditioned medium factors were concentration dependent. [less ▲]

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See detailNerve growth factor stimulates neurite regeneration but not survival of adult auditory neurons in vitro.
Lefèbvre, Philippe ULg; Van de Water, T. R.; Staecker, H. et al

in Acta Oto-Laryngologica (1992), 112(2), 288-93

Injury to either the peripheral or central nervous system results in the accumulation of growth factors at the wound site. Some of these growth factors have been shown to participate in the neural repair ... [more ▼]

Injury to either the peripheral or central nervous system results in the accumulation of growth factors at the wound site. Some of these growth factors have been shown to participate in the neural repair process. Adult auditory neurons grown in dissociated spiral ganglion cell cultures are injured (i.e. bilateral axotomy) as a result of the initial preparation of these cultures. Therefore, cell cultures of dissociated spiral ganglia provide a model for the study of repair processes of adult auditory neurons (e.g. effects of exogenous growth factors on the process of neuritogenesis by injured neurons). Auditory neurons do not survive in these dissociated ganglion cell cultures when only exogenous NGF is added to the defined culture medium. Previous work has identified substrate bound basic fibroblast growth factor (bFGF) as a survival factor for adult auditory neurons in vitro. Auditory neurons cultured on substrate bound bFGF also do not show increased survival in response to the addition of increasing concentrations of nerve growth factor (NGF) to the defined medium. This is in sharp contrast to the pronounced neurite outgrowth-promoting effects (concentration dependent) observed when exogenous NGF is added to adult auditory neurons cultured on substrate bound bFGF. We propose that several neuronotrophic factors (e.g. TGFB1, bFGF, NGF and other neurotrophins) are active in the spiral ganglions' response to injury. Several of these growth factors (i.e. bFGF, NGF) act in cooperation to promote the regeneration or repair of severed or traumatized neuritic processes. [less ▲]

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See detailThree-dimensional organ culture systems
Rogister, Bernard ULg; Rigo, Jean-Michel; Lefebvre, Philippe ULg et al

in Boulton, Alan; Baker, Glen; Walz, Wolfgang (Eds.) Practical Cell Culture Techniques (1992)

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See detailMri-Pathological Correlations in Acute Traumatic Central Cord Syndrome: Case Report
Martin, Didier ULg; Schoenen, Jean ULg; Lenelle, Jacques ULg et al

in Neuroradiology (1992), 34(4), 262-6

Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who ... [more ▼]

Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who died 60 h later from heart failure. T2-weighted MRI showed a central hyperintense area at C3-4. There were disc protrusions, but no vertebral fracture or displacement. Histopathology disclosed severe axonal swelling and oedema in the dorsolateral fasciculi and, to a lesser degree, in the dorsal columns. In addition, an area of recent necrosis was found in the right anterior horn at C4-5. These findings suggest that the pathological hallmark of typical ATCCS is mechanical axonal disruption at a segmental level, but that more severe trauma may be accompanied by tissue destruction. [less ▲]

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See detailMicroexplants cultures of the cerebellum
Rogister, Bernard ULg; Moonen, Gustave ULg

in Fedoroff, Serguei; Richardson, Anne (Eds.) Protocols for Neural cells Cultures (1992)

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See detailGrowth Factor Interactions in Cultures of Dissociated Adult Acoustic Ganglia: Neuronotrophic Effects
LEFEBVRE, Philippe ULg; Van de Water, T. R.; Weber, T. et al

in Brain Research (1991), 567(2), 306-12

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor ... [more ▼]

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor (bFGF). Nerve growth factor (NGF) is not a survival factor for these neurons in vitro, but when used in combination with substrate bound bFGF, NGF does vigorously stimulate a neuritogenesis response by these neurons. Transforming growth factor beta (TGF beta 1) enhances the survival effect that bFGF has on these adult auditory neurons but does not by itself promote their survival in dissociated acoustic ganglion cultures. We propose that there may be complex interactions and synergy exerted by these growth factors (i.e. bFGF, NGF, TGF beta 1) during injury to the inner ear. [less ▲]

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See detailPlasticité des neurones sensoriels primaires chez le rat adulte. Etude in vitro et in vivo.
Moonen, Gustave ULg; Delrée, P.; Martin, Didier ULg et al

Conference (1991, November 16)

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See detailMR of radiation induced myelopathy.
Collignon, F.; Flandroy, P.; Martin, Didier ULg et al

Conference (1991, October 06)

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See detailIn vitro and in vivo modulation of transmitter phenotype in adult rat DRG neurons.
Moonen, Gustave ULg; Schoenen, Jean ULg; Delrée, P. et al

Conference (1991, August 11)

Detailed reference viewed: 1 (0 ULg)