References of "MARTIN, Didier"
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See detailThiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
Gangolf, Marjorie ULg; Czerniecki, Jan; Radermecker, Marc ULg et al

in PLoS ONE (2010), 5(10), 13616

Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine ... [more ▼]

Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations. This is the first comprehensive study on the distribution of thiamine derivatives in human biopsies, body fluids and cell lines. Methodology and Principal Findings Thiamine derivatives were determined by HPLC. In human tissues, the total thiamine content is lower than in other animal species. ThDP is the major thiamine compound and tissue levels decrease at high age. In semen, ThDP content correlates with the concentration of spermatozoa but not with their motility. The proportion of ThTP is higher in humans than in rodents, probably because of a lower 25-kDa ThTPase activity. The expression and activity of this enzyme seems to correlate with the degree of cell differentiation. ThTP was present in nearly all brain and muscle samples and in ~60% of other tissue samples, in particular fetal tissue and cultured cells. A low ([ThTP]+[ThMP])/([Thiamine]+[ThMP]) ratio was found in cardiovascular tissues of patients with cardiac insufficiency. AThTP was detected only sporadically in adult tissues but was found more consistently in fetal tissues and cell lines. Conclusions and Significance The high sensitivity of humans to thiamine deficiency is probably linked to low circulating thiamine concentrations and low ThDP tissue contents. ThTP levels are relatively high in many human tissues, as a result of low expression of the 25-kDa ThTPase. Another novel finding is the presence of ThTP and AThTP in poorly differentiated fast-growing cells, suggesting a hitherto unsuspected link between these compounds and cell division or differentiation. [less ▲]

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See detailSpinal Cord Research on the Way to Translation
Martin, Didier ULg

Conference (2010, August 26)

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See detailPlace de la chimiothérapie dans le traitement des gliomes
Martin, Didier ULg

Scientific conference (2010, June 02)

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See detailLa S-3D et réalité augmentée au service de la médecine et de la science
Audrit, Pierre; Martin, Didier ULg

Conference (2010, June 01)

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See detailPostoperative sialadenitis with chronic brachial plexopathy
Reuter, Gilles; Racaru, Tudor ULg; Nguyen khac, Minh-Tuan et al

Poster (2010, March 20)

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See detailLes critères médicaux d'aptitude à la conduite automobile dans les affections neurologiques
Martin, Didier ULg

Scientific conference (2010, March 10)

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See detailInternational Foundation for Research in Paraplegia
Martin, Didier ULg

Conference (2010, January 26)

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See detailNew developments in medical imaging applied to Neurosurgery
Martin, Didier ULg

Scientific conference (2010, January 20)

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See detailEncéphalocèle orbitaire post-traumatique bilatéral
Racaru, Tudor ULg; Nguyen Khac, Minh-Tuan ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2010), 65

L'encéphalocèle orbitaire aigu traumatique est une entité rare. Selon Pubmed moins de 25 cas ont été raportés. Nous présentons le premier cas d'encéphalocèle post-traumatique bilatéral provoqué par une ... [more ▼]

L'encéphalocèle orbitaire aigu traumatique est une entité rare. Selon Pubmed moins de 25 cas ont été raportés. Nous présentons le premier cas d'encéphalocèle post-traumatique bilatéral provoqué par une fracture enfoncement du toit de l'orbite. Un traitement rapide est nécessaire pour éviter l'hypertension intra-orbitaire qui peut être responsable de lésions dégénératives du nerf optique. La réparation du toit de l'orbite nécessite une reconstruction rigide pour éviter la transmission de variations de la pression intra-crânienne. Dans le cas rapporté, la reconstruction du toit de l'orbite a été effectuée par voie crânienne sous-frontale à l'aide d'un mélange de poudre d'os à la colle biologique soutenu par un treillis en titane fixé avec des vis [less ▲]

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See detailComment j'explore... les troubles dystoniques : un guide simple et pratique
JEDIDI, Zayd ULg; Scholtes, Félix ULg; Kaschten, Bruno ULg et al

in Revue Médicale de Liège (2009), 64

La rencontre d'une dystonie, que ce soit en tant que symptôme entrant dans un cadre nosologique plus large ou en tant qu’anomalie isolée, n’est pas exceptionnelle en pratique clinique. La dystonie peut se ... [more ▼]

La rencontre d'une dystonie, que ce soit en tant que symptôme entrant dans un cadre nosologique plus large ou en tant qu’anomalie isolée, n’est pas exceptionnelle en pratique clinique. La dystonie peut se produire à tous âges de la vie. Un diagnostic précis est important afin d’optimiser la prise en charge de ces affections souvent chroniques et invalidantes. Les divers examens complémentaires devront inclure la résonance magnétique nucléaire, incontournable dans le diagnostic et le suivi des patients dystoniques. Nous présentons ici un aperçu des troubles dystoniques les plus fréquents et des solutions thérapeutiques appropriées, ainsi qu’une proposition de classification afin d’en simplifier le diagnostic. [less ▲]

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See detailDoes radiation treatment delay affect survival in glioblastoma
Robe, Pierre ULg; Nguyen-Khac, Minh-Tuan ULg; Lenelle, Jacques ULg et al

in Surgical Neurology (2009), 72(5), 519

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See detailIntérêt de la réadaptation en Neurochirurgie
Martin, Didier ULg

Scientific conference (2009, October 28)

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See detailWorld Federation of Neurosurgical Societies
Martin, Didier ULg

Conference (2009, August 30)

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See detailLes infections du rachis
Martin, Didier ULg

Scientific conference (2009, June 03)

Detailed reference viewed: 12 (0 ULg)