References of "MAGIS, Delphine"
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See detailNeurostimulation for headaches
MAGIS, Delphine ULg

Conference (2012, October 07)

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See detailAnodal transcranial direct current stimulation over the visual cortex as a preventive treatment of migraine: a proof-of-concept study.
Sasso d'Elia, Tullia; Vigano, Alessandro; SAVA, Simona Liliana ULg et al

in Frontiers in Human Neuroscience (2012, September)

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See detailA novel CACNA1A mutation results in episodic ataxia with migrainous features without headache
MAGIS, Delphine ULg; Boon, Elles; Coppola, Gianluca et al

in Cephalalgia : An International Journal of Headache (2012)

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See detailAdvances and challenges in neurostimulation for headaches
MAGIS, Delphine ULg; Schoenen, Jean ULg

in Lancet Neurology (2012), 11(8), 708-719

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See detailNeurostimulation therapies for primary headache disorders: present and future
MAGIS, Delphine ULg; JENSEN, Rigmor; Schoenen, Jean ULg

in Current Opinion in Neurology (2012), 25(3), 269-276

Purpose of review Most pharmacological treatments of primary headache disorders are partially effective and have cumbersome side effects. Therapies with better efficacy and tolerance are needed ... [more ▼]

Purpose of review Most pharmacological treatments of primary headache disorders are partially effective and have cumbersome side effects. Therapies with better efficacy and tolerance are needed. Neurostimulation techniques may have this potential. This is an attempt to summarize the latest clinical trial results published in the field. Recent findings Hypothalamic deep brain stimulation is effective in drug-resistant chronic cluster headache (drCCH) but not riskless. Recent anatomical MRI studies indicate that the effective stimulation sites are rather widespread. Occipital nerve stimulation (ONS) seems to be effective in up to 76% of drCCH patients and its benefit long-lasting. A minority of patients are able to abandon preventive drugs. Its mechanism of action appears nonspecific. In chronic migraine, randomized controlled trials of ONS showed recently encouraging results, but long-term studies are missing. An ongoing sham-controlled trial suggests sphenopalatine ganglion neurostimulation (SPGS) efficacy in drCCH acute treatment, but possibly also in preventive therapy. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) modulate cortical excitability and connectivity. TMS could prevent headache when applied over the occipital cortex during the migraine aura. Repetitive TMS and tDCS have provided mixed results in a few small studies and warrant further trials. Summary Neurostimulation therapies inaugurate a new era in headache management and offer a promising alternative to medications. Future studies are necessary to provide evidence-based efficacy data, knowledge on their mode of action and information about their pharmaco-economic advantages. [less ▲]

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See detailLes migraines: des gènes à l'environnement
MAGIS, Delphine ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (2012), 67(5-6), 349-358

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See detailNeurosurgery for headaches
MAGIS, Delphine ULg

Conference (2012, March)

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See detailNon invasive neurostimulation for headaches.
MAGIS, Delphine ULg

Conference (2012, March)

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See detailNeurostimulation dans l’algie vasculaire de la face.
MAGIS, Delphine ULg; FONTAINE, Denys

Conference (2011, October)

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See detailCase report discussion.
MAGIS, Delphine ULg

Conference (2011, October)

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See detailSustained effeciveness of occipital nerve stimulation in drug-resistant chronic cluster headache
MAGIS, Delphine ULg; Gerardy, Pierre-Yves; Remacle, Jean-Michel et al

in Headache (2011)

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See detailTeaching course: Pearls and pitfalls in headache electrophysiology
MAGIS, Delphine ULg

Conference (2011, June)

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See detailHabituation of evoked responses is greater in patients with familial hemiplegic migraine than in controls: a contrast with the common forms of migraine.
Hansen, Jacob Moller; Bolla, Monica; Magis, Delphine ULg et al

in European Journal of Neurology (2011)

Background: Familial hemiplegic migraine (FHM) is a rare, dominantly inherited subtype of migraine with transient hemiplegia during the aura phase. Mutations in at least three different genes can produce ... [more ▼]

Background: Familial hemiplegic migraine (FHM) is a rare, dominantly inherited subtype of migraine with transient hemiplegia during the aura phase. Mutations in at least three different genes can produce the FHM phenotype. The mutated FHM genes code for ion transport proteins that animal and cellular studies have associated with disturbed ion homeostasis, altered cellular excitability, neurotransmitter release, and decreased threshold for cortical spreading depression. The common forms of migraine are characterized interictally by a habituation deficit of cortical and subcortical evoked responses that has been attributed to neuronal dysexcitability. FHM and the common forms of migraine are thought to belong to a spectrum of migraine phenotypes with similar pathophysiology, and we therefore examined whether an abnormal habituation pattern would also be found in FHM patients. Methods: In a group of genotyped FHM patients (five FHM-1, four FHM-2), we measured habituation of visual evoked potentials (VEP), auditory evoked potentials including intensity dependence (IDAP), the nociception-specific blink reflex (nsBR) and compared the results to a group of healthy volunteers (HV). Results: FHM patients had a more pronounced habituation during VEP (P = 0.025) and nsBR recordings (P = 0.023) than HV. There was no difference for IDAP, but the slope tended to be steeper in FHM. Conclusion: Contrary to the common forms of migraine, FHM patients are not characterized by a deficient, but rather by an increased habituation in cortical/brain stem evoked activities. These results suggest differences between FHM and the common forms of migraine, as far as central neuronal processing is concerned. [less ▲]

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See detailNeurostimulation therapy in intractable headaches
Schoenen, Jean ULg; Allena, M; MAGIS, Delphine ULg

in Nappi; Moskowitz (Eds.) Handbook of Clinical Neurology (2011)

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See detailTreatment of migraine: update on new therapies.
MAGIS, Delphine ULg; Schoenen, Jean ULg

in Current Opinion in Neurology (2011)

PURPOSE OF REVIEW: This review provides a comprehensive selection of the latest clinical trial results in antimigraine treatment. RECENT FINDINGS: The oral calcitonine gene-related peptide antagonist ... [more ▼]

PURPOSE OF REVIEW: This review provides a comprehensive selection of the latest clinical trial results in antimigraine treatment. RECENT FINDINGS: The oral calcitonine gene-related peptide antagonist telcagepant is efficacious in acute treatment. Compared to triptans, its efficacy is almost comparable but its tolerance is superior. The same is true for the 5HT-1F agonist lasmiditan, another agent devoid of vascular effects. Triptans, as other drugs, are more efficient if taken early but nonsteroidal anti-inflammatory drugs and analgesics remain useful for acute treatment, according to several meta-analyses. Single-pulse transcranial magnetic stimulation during the aura rendered more patients pain-free (39%) than sham stimulation (22%) in one study. Topiramate could be effective for migrainous vertigo, but it did not prevent transformation to chronic migraine in patients with high attack frequency. Onabotulinumtoxin A was effective for chronic migraine and well tolerated, but the therapeutic gain over placebo was modest; the clinical profile of responders remains to be determined before widespread use. Occipital nerve stimulation was effective in intractable chronic migraine with 39% of responders compared to 6% after sham stimulation. This and other neuromodulation techniques, such as sphenopalatine ganglion stimulation, are promising treatments for medically refractory patients but large controlled trials are necessary. One study suggests that outcome of patent foramen ovale closure in migraine might depend on anatomic and functional characteristics. SUMMARY: Drugs with a better efficacy or side-effect profile than triptans may soon become available for acute treatment. The future may also look brighter for some of the very disabled chronic migraineurs thanks to novel drug and neuromodulation therapies. [less ▲]

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