References of "Louis, Renaud"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailL'omalizumab (Xolair) dans le traitement de l'asthme allergique persistant severe.
Schleich, FLorence ULg; Manise, Maïté ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2009), 64(5-6), 313-7

L’asthme est une maladie chronique des voies aériennes. La plupart des asthmatiques ont une inflammation bronchique liée à un processus immunologique faisant intervenir les immunoglobulines E (IgE). En ... [more ▼]

L’asthme est une maladie chronique des voies aériennes. La plupart des asthmatiques ont une inflammation bronchique liée à un processus immunologique faisant intervenir les immunoglobulines E (IgE). En dépit des thérapeutiques existantes, les patients atteints d’asthme sévère ont une qualité de vie sérieusement altérée et présentent un risque élevé d’exacerbations graves pouvant parfois être fatales. L’omalizumab est un anticorps (Ac) monoclonal humanisé dirigé contre les IgE circulantes, interférant ainsi avec une des cascades moléculaires importantes dans la pathogénie de l’asthme. L’omalizumab a montré qu’il était capable d’améliorer la qualité de vie et de réduire la fréquence des exacerbations ainsi que le recours aux corticoïdes inhalés et systémiques. Selon les nouvelles recommandations de l’asthme du GINA 2006, cet agent biologique est indiqué dans l’asthme allergique persistant sévère. [less ▲]

Detailed reference viewed: 133 (8 ULg)
Full Text
Peer Reviewed
See detailAnalyse de l'expectoration induite dans l'asthme réfractaire
Louis, Renaud ULg; Potmans, Vincent ULg

in Presse Médicale (2008), 37(1, Pt 2), 155-9

Induction of sputum by inhalation of hypertonic or isotonic fluid makes possible the safe and noninvasive harvesting of airway cells from patients with asthma, regardless of disease severity. Analysis of ... [more ▼]

Induction of sputum by inhalation of hypertonic or isotonic fluid makes possible the safe and noninvasive harvesting of airway cells from patients with asthma, regardless of disease severity. Analysis of sputum cells has helped to identify different phenotypes of refractory asthma and shown that such asthma can be eosinophilic, neutrophilic, or both. Elevated eosinophil levels in sputum indicate a risk of exacerbation if the corticosteroid dose is reduced in stabilized patients. Surveillance of eosinophilia levels as an indicator for corticosteroid adjustment in refractory asthma makes it possible to reduce the frequency of severe exacerbations. [less ▲]

Detailed reference viewed: 70 (13 ULg)
Full Text
Peer Reviewed
See detailApport de l'imagerie par tomographie a emission de positons dans la pathologie pleurale. Interet de la TEP en pathologie pleurale.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule et al

in Revue des Maladies Respiratoires (2008), 25(2), 129-38

INTRODUCTION: Positron emission tomography (PET) has a clear role in oncology, particularly in thoracic disease. In the light of our experience and a revue of the literature we define precisely the role ... [more ▼]

INTRODUCTION: Positron emission tomography (PET) has a clear role in oncology, particularly in thoracic disease. In the light of our experience and a revue of the literature we define precisely the role of metabolic imaging in the diagnosis of pleural pathology. BACKGROUND: In particular PET allows characterisation of malignant pleural disease and provides prognostic information in mesothelioma. Metabolic imaging provides clinical information for the staging of pulmonary cancer, in the search for a primary tumour in metastatic pleurisy and also in the follow up of chronic or recurrent pleural pathology. CONCLUSIONS: It is justified, therefore, that PET joins the diagnostic armamentarium of pleural pathology, solid or liquid. [less ▲]

Detailed reference viewed: 52 (13 ULg)
Full Text
Peer Reviewed
See detailComparaison du remodelage tissulaire dans l'asthme et la BPCO.
Godinas, Laurent ULg; Duquenne, Sébastien ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2008), 63(2), 92-6

Asthma and COPD (chronic obstructive pulmonary disease) are two pulmonary obstructive diseases. It is well recognized that inflammation plays a key role in the pathogenesis of these two diseases. However ... [more ▼]

Asthma and COPD (chronic obstructive pulmonary disease) are two pulmonary obstructive diseases. It is well recognized that inflammation plays a key role in the pathogenesis of these two diseases. However, inflammation per se does not entirely account for the progressive loss in pulmonary function. It is admitted that the functional changes partly relate to airway structural alteration called remodeling. In this review we summarize the most frequent tissue abnormalities found in patients with asthma and COPD and report on the relationship between structural alterations and clinical features of the disease. [less ▲]

Detailed reference viewed: 79 (9 ULg)
Full Text
Peer Reviewed
See detailComment j'explore...une pathologie pleurale?
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Nguyen Dang, Delphine ULg et al

in Revue Médicale de Liège (2008), 63(10), 615-23

Pleural involvements are common and various respiratory diseases including inflammatory, infectious, occupational, or neoplastic pathological entities...Pleural thickening and pleurisy are usual ... [more ▼]

Pleural involvements are common and various respiratory diseases including inflammatory, infectious, occupational, or neoplastic pathological entities...Pleural thickening and pleurisy are usual radiological presentation. Etiological diagnosis imposes a vast and sometimes difficult exploration and it, especially since the conventional imaging by radiology, ultrasound, scanning and nuclear magnetic resonance has no specific diagnostic criteria for pleural malignancy. The metabolic imaging by positron emission tomography (PET) has been gradually positioned in the decision-making algorithm exploration of the pleural disease due to its excellent sensitivity in the diagnosis of malignant pleurisy (88.8%-100%). The analysis of chemistry, bacteriology and cytology pleural fluid makes a significant contribution to the diagnostic approach. However, although inescapable, thoracocentesis has a diagnostic sensibility not exceeding 62%. Moreover, the sensibility of the pleural blind needle biopsies does not exceed 51%. So, thoracoscopy, more invasive, is often justified to precise pleural disease with a diagnostic sensitivity greater than 95%. Finally, despite the diagnostic arsenal available, over 10% of pleurisies remain unknown etiology. [less ▲]

Detailed reference viewed: 118 (15 ULg)
Full Text
Peer Reviewed
See detailLa place de l'analyse du condensat de l'air exhalé dans les maladies pulmonaires obstructives.
Renkin, C.; Corhay, Jean-Louis ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2008), 63(4), 193-8

The number of publications on the analysis of the exhaled breath condensate (EBC) has increased considerably over the last five years. The EBC is a new, noninvasive and inexpensive technique which ... [more ▼]

The number of publications on the analysis of the exhaled breath condensate (EBC) has increased considerably over the last five years. The EBC is a new, noninvasive and inexpensive technique which requires a minimum of cooperation on behalf of the patient. The condensate obtained consists of more than 99.99% of water vapour, to which are added various substances which reflect the inflammatory status of the airways. It is now especially used to characterize the inflammatory state of chronic respiratory diseases such as asthma and COPD. This article describes the technique and reviews the main data from the current literature. [less ▲]

Detailed reference viewed: 48 (6 ULg)
Full Text
Peer Reviewed
See detailLe cas clinique du mois. Un cas rare d'épanchement pleural unilatéral: le syndrome d'hyperstimulation des ovaires.
Barile, D.; Bataille, Yoann ULg; Duysinx, Bernard ULg et al

in Revue Médicale de Liège (2008), 63(7-8), 474-9

Ovarian hyperstimulation syndrome is the most severe iatrogenic complication of fertilization modern methods. This syndrome is characterized by a massive cystic ovarian enlargement associated with an ... [more ▼]

Ovarian hyperstimulation syndrome is the most severe iatrogenic complication of fertilization modern methods. This syndrome is characterized by a massive cystic ovarian enlargement associated with an acute body fluid shift. Ascite is the most frequent manifestation of this syndrome. In some rare cases ovarian hyperstimulation syndrome is complicated by massive unilateral pleural effusion without ascite. We describe the case of a 36 year old woman who developed a massive unilateral pleural effusion without ascite. An ovarian hyperstimulation syndrome was diagnosed. Chest tube drainage improved patient parameters and symptoms. We discuss the diagnostic approach of pleural effusions. [less ▲]

Detailed reference viewed: 98 (5 ULg)
Full Text
Peer Reviewed
See detailAsthme réfractaire : mécanismes sous-jacents, diagnostics et nouvelles approches thérapeutiques.
Manise, Maïté ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2008), 63(7-8), 494-499

There has been a recent increase in the prevalence of asthma worldwide. Most cases can be satisfactorily managed with a combination of inhaled corticoids and bronchodilators. However, some 10% of patients ... [more ▼]

There has been a recent increase in the prevalence of asthma worldwide. Most cases can be satisfactorily managed with a combination of inhaled corticoids and bronchodilators. However, some 10% of patients remain symptomatic despite high doses of inhaled corticosteroids and long-acting β-2 agonists. They represent a heterogeneous group consisting of those who are either undertreated, or really refractory to current available treatment. [less ▲]

Detailed reference viewed: 73 (19 ULg)
Full Text
Peer Reviewed
See detailLe mesotheliome: un cancer professionnel encore d'actualite!
Corhay, Jean-Louis ULg; Duysinx, Bernard ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2008), 63(3), 128-35

Mesothelioma is a rare tumour, particularly aggressive, whose incidence increases because of the massive use of asbestos during the last century. Asbestos remains indeed the principal etiologic agent of ... [more ▼]

Mesothelioma is a rare tumour, particularly aggressive, whose incidence increases because of the massive use of asbestos during the last century. Asbestos remains indeed the principal etiologic agent of this cancer. In the event of mesothelioma it is advisable to seek an exposure, even of short duration, often which dates back to several decades. In certain circumstances compensation can be obtained at the Occupational Diseases Found. The renewed interest with regard to this tumour is supported by the improvement of mesothelioma management, the new imaging techniques, the new treatments and the broad diffusion of information related to the risk of developing this tumour following asbestos inhalation. [less ▲]

Detailed reference viewed: 81 (3 ULg)
Full Text
Peer Reviewed
See detailLa rehabilitation pulmonaire dans la bronchopneumopathie chronique obstructive.
Corhay, Jean-Louis ULg; Nguyen Dang, Delphine ULg; Schees, Pierre ULg et al

in Revue Médicale de Liège (2008), 63(11), 677-83

The current treatment of chronic obstructive pulmonary disease (COPD) patients must comprise, in addition to an optimal pharmacological treatment, a pulmonary rehabilitation, if possible multidisciplinary ... [more ▼]

The current treatment of chronic obstructive pulmonary disease (COPD) patients must comprise, in addition to an optimal pharmacological treatment, a pulmonary rehabilitation, if possible multidisciplinary, and a program of post-rehabilitation in order to maintain the outcomes. Today pulmonary rehabilitation has proved to be effective in improving dyspnoea, exercise capacity and quality of life in COPD patients, and reducing the use of health services and thus the cost. In this article we want to present pulmonary rehabilitation, its indications and results, and the way by which it is held in the CHU of Liege. [less ▲]

Detailed reference viewed: 350 (14 ULg)
Full Text
See detailManifestations respiratoires de la rectocolite ulcérohémorragique et de la maladie de Crohn
Guiot, Julien; Louis, Edouard ULg; Belaiche, Jacques ULg et al

in EMC Pneumologie (2008)

Detailed reference viewed: 131 (8 ULg)
Full Text
Peer Reviewed
See detailPrognostic value of metabolic imaging in non-small cell lung cancers with neoplasic pleural effusion.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule ULg et al

in Nuclear Medicine Communications (2008), 29(11), 982-6

BACKGROUND: The intensity of the [F]fluorodeoxyglucose (F-FDG) uptake is an independent prognostic indicator in non-small cell lung cancer (NSCLC). We evaluate the relationship between the metabolic ... [more ▼]

BACKGROUND: The intensity of the [F]fluorodeoxyglucose (F-FDG) uptake is an independent prognostic indicator in non-small cell lung cancer (NSCLC). We evaluate the relationship between the metabolic activity of the primary and the pleurisy in T4 NSCLC. METHODS: 25 patients (16 males, nine females, mean age 63 years, performance status 1) with pathology-proven, T4 NSCLC and malignant pleurisy were included. All were treated by a platinum salt-based chemotherapy regimen. Positron emission tomography (F-FDG-PET) was performed before treatment, according to a routine procedure. Regions of interest were placed over the primary and the pleural effusion on the transaxial slice showing the highest activity. The maximum pixel standard uptake values (SUVs) were calculated. Overall survival was determined by standard Kaplan-Meier survival analysis. All patients were followed up until death. RESULTS: The median survival for the entire population was 83 days (7-988). The SUVs were higher in the primary than in the pleurisy (9.2+/-5.6 and 5.5+/-2.2, respectively). There was no correlation between primary and pleurisy SUVs (r=0.3, P>0.05). The metabolic activity of the primary tumor did not predict the outcome: the median survival was 77.5 days (range 7-988) and 87 days (19-454) in the groups with SUVs lower and higher than the median value (8.7), respectively (P>0.05). By contrast, the metabolic activity of the pleurisy was significantly correlated with the median survival, which was 196 days (40-988) when the SUVs were lower than the median value (5) and 74 days (7-170) when they were higher (P=0.0096). CONCLUSION: Among patients with T4 NSCLC, those with high metabolic activity in the pleural effusion have a dire prognosis, whereas the metabolic activity of the primary fails to predict the survival. [less ▲]

Detailed reference viewed: 32 (12 ULg)
Full Text
Peer Reviewed
See detailDiagnostic value of interleukine-6, transforming growth factor-beta 1 and vascular endothelial growth factor in malignant pleural effusions.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Hubin, Laurent et al

in Respiratory Medicine (2008), 102(12), 1708-14

STUDY OBJECTIVES: We evaluate the accuracy of pleural interleukine-6 (IL-6), transforming growth factor-beta 1 (TGF-beta1), and vascular endothelial growth factor (VEGF) levels for differentiating benign ... [more ▼]

STUDY OBJECTIVES: We evaluate the accuracy of pleural interleukine-6 (IL-6), transforming growth factor-beta 1 (TGF-beta1), and vascular endothelial growth factor (VEGF) levels for differentiating benign from malignant pleural exudates. PATIENTS AND METHODS: Levels of IL-6, TGF-beta1, and VEGF were measured by ELISA in 103 patients with non neutrophilic (<50%) exudative pleurisy including both benign and malignant effusions. Pleurisies were split into benign and malignant according to the pathological diagnosis. RESULTS: Thirty-nine benign (seven infections; 32 inflammatory diseases) and 64 malignant (34 extrathoracic tumors; 25 lung cancers; five mesotheliomas) pleural exudates were diagnosed by thoracoscopy. Pleural reticulo-monocyte count, protein Light's ratio and lactic dehydrogenase Light's ratio were significantly higher in malignant than in benign effusions (p<0.05, p<0.001 and p<0.001, respectively). The median (range) level of VEGF was significantly higher in malignant than in benign effusions (664.50 pg/ml [10-40,143] vs 349 pg/ml [10-8888]) (p<0.05). VEGF levels correlated with pleural LDH (r=0.41, p<0.0001), glucose (r=-0.30, p<0.01) and red cell count (r=0.57, p<0.0001). No significant difference was found between malignant and benign effusions with respect to IL-6 (26.8 ng/ml [1.8-421] vs 18.4 ng/ml [0.45-400], respectively) and TGF-beta1 (1079 pg/ml [18-6206] vs 1123 pg/ml [34-5447]) levels. ROC analysis between benign and malignant pleurisies for VEGF showed an area under the curve of 619 (p=0.03) with a value of 382 pg/ml as the best threshold for distinguishing benign from malignant effusions. CONCLUSIONS: Malignant effusions may enhance the release of VEGF in pleural space and its measurement may help in the diagnosis of malignant effusion. [less ▲]

Detailed reference viewed: 54 (4 ULg)
Full Text
Peer Reviewed
See detailA novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma
Guéders, Maud ULg; Bertholet, P.; Perin, Fabienne ULg et al

in Biochemical Pharmacology (2008), 75(2), 514-26

Background In this study, we assess the effectiveness of inhaled doxycycline, a tetracycline antibiotic displaying matrix metalloproteinases (MMP) inhibitory effects to prevent allergen-induced ... [more ▼]

Background In this study, we assess the effectiveness of inhaled doxycycline, a tetracycline antibiotic displaying matrix metalloproteinases (MMP) inhibitory effects to prevent allergen-induced inflammation, hyperresponsiveness and remodeling. MMPs play key roles in the complex cascade of events leading to asthmatic phenotype. Methods Doxycycline was administered by aerosols by the mean of a novel formulation as a complex with hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) used as an excipient. BALB/c mice (n = 16–24 in each group) were sensitized and exposed to aerosolized ovalbumin (OVA) from day 21 to 27 (short-term exposure protocol) or 5 days/odd weeks from day 22 to 96 (long-term exposure protocol). Results In the short-term exposure model, inhaled doxycycline decreased allergen-induced eosinophilic inflammation in bronchoalveolar lavage (BAL) and in peribronchial areas, as well as airway hyperresponsiveness. In lung tissue, exposure to doxycycline via inhaled route induced a fourfold increase in IL-10 levels, a twofold decrease in IL-5, IL-13 levels and diminished MMP-related proteolysis and the proportion of activated MMP-9 as compared to placebo. In the long-term exposure model, inhaled doxycycline significantly decreased the extent of glandular hyperplasia, airway wall thickening, smooth muscle hyperplasia and subepithelial collagen deposition which are well recognized features of airway remodeling. Conclusion Doxycycline administered by aerosols decreases the allergen-induced airway inflammation and hyperresponsiveness and inhibits the development of bronchial remodeling in a mouse model of asthma by modulation of cytokines production and MMP activity. [less ▲]

Detailed reference viewed: 103 (37 ULg)
Full Text
Peer Reviewed
See detailLe cas clinique du mois. Aspergillose pulmonaire: un cas d'aspergillose necrosante chronique
Golinval, Olivier ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2007), 62(12), 704-6

Pulmonary aspergillosis are uncommon diseases. The clinical expression of which are depending on the immunological status. The spectrum of pulmonary aspergillosis goes from hypersensitization to the ... [more ▼]

Pulmonary aspergillosis are uncommon diseases. The clinical expression of which are depending on the immunological status. The spectrum of pulmonary aspergillosis goes from hypersensitization to the invasive and disseminated aspergillosis. We report here the clinical history of a patient with severe COPD and receiving regular oral corticoids who had a persistent lung infiltration. The infiltration became cavitary and proved to be a chronic necrotizing pneumonia due to Aspegillus fumigatus. The outcome was favourable thank to a treatment with voriconazole. [less ▲]

Detailed reference viewed: 194 (1 ULg)
Full Text
See detailPrise en charge du cancer pulmonaire non a petites cellules
Bosquee, Léon ULg; Frusch, Nicolas ULg; Louis, Renaud ULg

in Revue Médicale Suisse (2007), 3(122), 1890-5

Surgery, chemotherapy, radiotherapy and "biological" treatment are differently used in the treatment of non small cell lung cancer. Surgery is the cornerstone of the stages I-II treatment; chemotherapy is ... [more ▼]

Surgery, chemotherapy, radiotherapy and "biological" treatment are differently used in the treatment of non small cell lung cancer. Surgery is the cornerstone of the stages I-II treatment; chemotherapy is dominant in the treatment of metastatic stage, but is more and more used in earlier stages. A large discussion is still open for advanced non metastatic stages, even if the association of the 3 major modalities is extensively studied. We discuss our position in this setting. [less ▲]

Detailed reference viewed: 120 (5 ULg)
Full Text
Peer Reviewed
See detailPerception of dyspnea in mild smoking asthmatics
Kleis, S.; Chanez, P.; Delvaux, Muriel ULg et al

in Respiratory Medicine (2007), 101(7), 1426-1430

Background: Previous data from the literature reported blunted perception of airway obstruction in severe asthmatics with near fatal asthma. Approximately 25% of patients with asthma are current smokers ... [more ▼]

Background: Previous data from the literature reported blunted perception of airway obstruction in severe asthmatics with near fatal asthma. Approximately 25% of patients with asthma are current smokers. Aim: To determine whether there is an alteration in perception of airway obstruction during a non specific provocative challenge with methacholine in mild controlled asthmatics who smoke. Methods: Enrolled in this study were 50 subjects, including 26 mild asthmatics and 24 healthy subjects, all of them current smokers. The first objective was the sensitivity of airway obstruction calculated by the regression slope linking the change in the visual analogic scale (VAS) assessed by the patient and the fall in FEV1 during a methacholine challenge. Results: Asthmatics who smoke had a blunted perception of airway obstruction during the bronchial challenge significantly different from that seen in healthy smokers (p = 0.03). This impaired dyspnea perception was inversely related to baseline VAS (r = -0.29, p<0.05) and positively related to baseline FEV1 (r = 0.35, p<0.05). Perception of airway obstruction was not correlated with age, sex, atopy or with airway inflammation features such as exhaled NO or sputum eosinophils. Conclusion: Mild asthmatics who smoke display reduced dyspnea perception during a nonspecific provocative challenge with methacholine. This altered perception of airway obstruction does not relate to airway inflammation. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 24 (8 ULg)
Full Text
Peer Reviewed
See detailGranulocyte chemotactic activity in exhaled breath condensate of healthy subjects and patients with COPD
Corhay, Jean-Louis ULg; Hemelaers; Henket, Monique ULg et al

in CHEST (2007), 131(6), 1672-1677

Background. Several chemoattractants have been measured in exhaled breath condensate (EBC) from patients with COPD. The aim of this study was to compare the eosinophil. and neutrophil chemotactic activity ... [more ▼]

Background. Several chemoattractants have been measured in exhaled breath condensate (EBC) from patients with COPD. The aim of this study was to compare the eosinophil. and neutrophil chemotactic activity contained in EBC from healthy subjects and patients with COPD. Methods: EBC collected using a commercially available condenser (EcoScreen; Erich Jaeger Viasys; Hoechberg, Germany) was compared in 45 COPD patients and 65 healthy subjects. EBC chemotactic activity for eosinophils and neutrophils was assessed using microchambers (Boyden; Neuro Probe; Cabin John, MD). Chemotactic index (CI) was used to evaluate cell migration. Results: EBC from patients with COPD (C1, 2.21 +/- 0.16 [mean +/- SEM]) and healthy subjects (CI, 1.67 +/- 0.11) displayed significant neutrophil chemotactic activity (p < 0.0001 for both), which was however higher in patients with COPD (p < 0.001). Healthy smokers had a significantly raised C1 for neutrophils by comparison with healthy nonsmokers (p < 0.01) and ex-smokers (p < 0.05). Ukewise, current COPD smokers tended to have greater neutrophil C1 than COPD who stopped smoking (p = 0.08). COPD ex-smokers had raised chemotactic activity by comparison with healthy ex-smokers (p < 0.05). Anti-interleuldn-8 (10(-6) g/mL) antibodies reduced neutrophil chemotactic activity by 35.2% (p < 0.05). EBC also contained significant eosinophil chemotactic activity in healthy subjects (CI, 1.68 0.09; p < 0.0001) and patients with COPD (CI, 1.23 +/- 0.07; p < 0.01), with a significantly lower CI in patients with COPD as compared to healthy subjects (p < 0.001). Smoking did not influence eosinophil chemotactic activity in healthy subjects or patients with COPD. Conclusions: Current smoking favors neutrophil chemotactic activity. As compared to healthy subjects, EBC from patients with COPD displays a skewed chemotactic activity toward neutrophils vs eosinophils. [less ▲]

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailL'etude clinique du mois. L'etude TORCH (TOwards a Revolution in COPD Health): vers une revolution de la sante des patients souffrant de BPCO
Corhay, Jean-Louis ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2007), 62(4), 230-4

The TORCH study (Towards a Revolution in COPD Health) was a double-blind, randomised, placebo-controlled clinical trial, investigating the combination of salmeterol/fluticasone propionate for 3 years in ... [more ▼]

The TORCH study (Towards a Revolution in COPD Health) was a double-blind, randomised, placebo-controlled clinical trial, investigating the combination of salmeterol/fluticasone propionate for 3 years in COPD. The primary end point was on all-cause mortality. Secondary end points included COPD exacerbation rate, lung function and health status. More than 6000 patients were randomised. In this article, we briefly report the most significant results of the study. The efficacy on mortality (reduction of the risk of death of 17.5%) was near the predetermined level of statistical significance (p = 0.052); the combination had a significant effect on the three pillars of COPD management, that is: improvement of quality of life and respiratory function, and reduction of the rate of exacerbations. In addition to being effective, the combination salmeterol/fluticasone (50/500 microg 2x/day) is well tolerated in COPD and had a favourable benefit/risk ratio. [less ▲]

Detailed reference viewed: 126 (1 ULg)
Full Text
Peer Reviewed
See detailActualites therapeutiques en pneumologie
Louis, Renaud ULg; Bosquee, Léon ULg; DUYSINX, Bernard ULg et al

in Revue Médicale de Liège (2007), 62(5-6, May-Jun), 288-92

We review what we think to be the major advances in the field of respiratory medicine over the last ten years. We concentrate here on four major diseases i.e. asthma, chronic obstructive pulmonary disease ... [more ▼]

We review what we think to be the major advances in the field of respiratory medicine over the last ten years. We concentrate here on four major diseases i.e. asthma, chronic obstructive pulmonary disease (COPD), lung cancer and chronic respiratory insufficiency due to restrictive disorders. Therapeutic advances are based either on new drugs or on new disease management concepts and, in some cases, on new medical devices. These advances have allowed a reduction in mortality and morbidity in aforementioned diseases. [less ▲]

Detailed reference viewed: 104 (5 ULg)