References of "Llabres, Gabriel"
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See detailDevelopment of a parenteral and of an oral formulation of albendazole with cyclodextrins
Piel, Géraldine ULg; Evrard, Brigitte ULg; Van Hees, Thierry ULg et al

in STP Pharma Sciences (1999), 3

L'albendazole est une dérivé benzimidazole à large spectre d'activité contre les parasites helminthiques de l'homme et de l'animal. L'albendazole est très faiblement soluble dans l'eau. Il a été démontré ... [more ▼]

L'albendazole est une dérivé benzimidazole à large spectre d'activité contre les parasites helminthiques de l'homme et de l'animal. L'albendazole est très faiblement soluble dans l'eau. Il a été démontré que les cyclodextrines sont capables de former des complexes d'inclusion avec l'albendazole et d'en augmenter la solubilité. La solubilité aqueuse de l'albendazole est dépendante du pH. Le but de ce travail est d'étudier l'influence combinée des cyclodextrines et de différents acides sur la solubilité de l'albendazole. Il a été démontré qu'il existe un véritable effet synergique entre les cyclodextrines et les différents acides. L'utilisation combinée d'hydroxypropyl-b-cyclodextrine (200 mM) et d'acide lactique ou acide citrique (50 mM) permet de dissoudre plus de 1 mg/ml d'albendazole. Des études RMN ont démontré l'inclusion de l'albendazole dans la b-cyclodextrine en milieu acide. Ces résultats montrent qu'il est possible de réaliser une solution injectable et une solution orale d'albendazole grâce aux cyclodextrines. [less ▲]

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See detailStrychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos Nux-Vomica
Biala, Rose Gadi; Tits, Monique ULg; Penelle, Jacques et al

in Journal of Natural Products (1998), 61(1), 139-41

The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was ... [more ▼]

The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was defined by detailed spectroscopic methods. [less ▲]

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See detailDevelopment of a non-surfactant parenteral formulation of miconazole by the use of cyclodextrins
Piel, Géraldine ULg; Evrard, Brigitte ULg; Fillet, Marianne ULg et al

in International Journal of Pharmaceutics (1998), 169

Miconazole is an antimycotic drug exhibiting a very poor water solubility (B1.03 mg:ml). It has been shown that cyclodextrins (CDs) are able to form inclusion complexes with miconazole and that they are ... [more ▼]

Miconazole is an antimycotic drug exhibiting a very poor water solubility (B1.03 mg:ml). It has been shown that cyclodextrins (CDs) are able to form inclusion complexes with miconazole and that they are able to increase its aqueous solubility. Miconazole is a weak base whose solubility depends of the pH. The purpose of this study was to investigate the influence of both CDs and different acids on the solubility of miconazole. It was found that a synergistic effect existed between CDs and different acids. The combination of hydroxypropyl-bCD (HP-bCD) (100 mM) or sulfobutylether 7-bCD (SBE7-bCD) (50 mM) and lactic acid (50 mM) allowed to dissolve more than 10 mg of miconazole per ml. NMR studies confirmed the formation of an inclusion complex miconazole–CD in an acidic medium. It was also shown by the NMR studies that the complex formed was a 1:1 complex. These results demonstrate that it is possible to develop a parenteral aqueous solution of miconazole without surfactant. [less ▲]

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See detailStudy of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide-L-Lysine-Cyclodextrin Complexes
Piel, Géraldine ULg; Pirotte, Bernard ULg; Delneuville, Isabelle et al

in Journal of Pharmaceutical Sciences (1997), 86(4), 475-80

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 ... [more ▼]

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 has an aqueous solubility of approximately 16 mg.mL-1 of nimesulide. A nimesulide-L-lysine salt has also been prepared and increases the aqueous solubility of nimesulide to approximately 5.0-7.5 mg.mL-1. The purpose of the present study was to investigate the interaction of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide. Nimesulide-L-lysine-beta- or gamma-cyclodextrin complexes were prepared by spray-drying. The inclusion of the nimesulide-L-lysine salt into the cyclodextrin cavity was confirmed by differential scanning calorimetry and proton nuclear magnetic resonance spectroscopy. These complexes offered remarkable aqueous solubility. The incorporation of nimesulide in a nimesulide-L-lysine-beta-cyclodextrin complex increased its water solubility by a factor of 10 at pH 1.5 (0.050 mg.mL-1 for the complex versus 0.005 mg.mL-1 for nimesulide), 160 at pH 6.8 (2.373 mg.mL-1 for the complex versus 0.015 mg.mL-1 for nimesulide), and 3600 in purified water (36.400 mg.mL-1 for the complex versus 0.01 mg.mL-1 for nimesulide). [less ▲]

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See detailGlucoindole Alkaloids from Stem Bark of Strychnos Mellodora
Tits, Monique ULg; Brandt, V.; Wauters, Jean-Noël ULg et al

in Planta Medica (1996), 62(1), 73-4

Three glucoindole alkaloids, dolichantoside (1), strictosidine (2), and palicoside (3), have been identified in the stem bark of Strychnos mellodora (Loganiaceae), collected in Zimbabwe. The chiroptical ... [more ▼]

Three glucoindole alkaloids, dolichantoside (1), strictosidine (2), and palicoside (3), have been identified in the stem bark of Strychnos mellodora (Loganiaceae), collected in Zimbabwe. The chiroptical (CD) data are compared. [less ▲]

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See detail9-Methoxygeissoschizol, an alkaloid from bark of strychnos guianensis
Mavar-Manga, Hélène; Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg et al

in Phytochemistry (1996), 43(5), 1125-1127

The isolation and structure determination of 9-methoxygeissoschizol from the stem bark of Strychnos guianensis is described. Elucidation of its structure is mainly based on NMR studies.

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See detailGuianensine, a zwitterionic alkaloid from Strychnos guianensis
Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg; Warin, Roger et al

in Phytochemistry (1995), 40(5), 1557-1560

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new ... [more ▼]

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new alkaloid has a zwitterionic asymmetrical bis-indole structure and is named guianensine. [less ▲]

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See detailStudy of residual water types in freeze-dried Lactobacillus acidophilus by nuclear magnetic resonance
Hodzic, D.; Llabres, Gabriel ULg; Zgoulli, S. et al

in Lebensmittel-Wissenschaft & -Technologie = Food Science & Technology (1995), 28

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See detailDirect n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase.
Jamin, M.; Damblon, Christian ULg; Bauduin-Misselyn, A. M. et al

in Biochemical Journal (1994), 301 ( Pt 1)

Cefoxitin and other beta-lactam antibiotics with a methoxy group on the alpha-face behave as very poor substrates of the Bacillus licheniformis beta-lactamase. The kinetic properties of the enzyme ... [more ▼]

Cefoxitin and other beta-lactam antibiotics with a methoxy group on the alpha-face behave as very poor substrates of the Bacillus licheniformis beta-lactamase. The kinetic properties of the enzyme-cefoxitin system made it theoretically suitable for a detailed structural study of the acyl-enzyme. Unfortunately, soaking the crystals in cefoxitin solution did not allow detection of a crystalline acyl-enzyme complex. In contrast, direct observation by n.m.r. of the stable acyl-enzyme formed with cefoxitin and moxalactam indicated clear modifications of the enzyme structure, which were reflected in the aromatic and high-field methyl regions of the spectrum. The return to the initial free enzyme spectrum was concomitant with the hydrolysis of the acyl-enzyme, the process being slow enough to allow multidimensional n.m.r. experiments. [less ▲]

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See detailNMR study of ginkgolides by a suited ROESY approach
Grodent, Denis ULg; Llabres, Gabriel ULg

Poster (1992, August 15)

Detailed reference viewed: 4 (0 ULg)