References of "Linden, Annick"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailA role for the Clostridium perfringens beta 2 toxin in bovine enterotoxaemia?
Manteca, Christophe; Daube, Georges ULg; Jauniaux, Thierry ULg et al

in Veterinary Microbiology (2002), 86(3), 191-202

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and ... [more ▼]

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and haemorrhagic enteritis. The purpose of this study was to investigate the putative role of the more recently described beta2 toxin. Seven hundred and fourteen non-enterotoxigenic type A C. perfringens isolated from 133 calves with lesions of enterotoxaemia and high clostridial cell counts (study population) and 386 isolated from a control population of 87 calves were tested by a colony hybridisation assay for the beta2 toxin. Two hundred and eighteen (31%) C perfringens isolated from 83 calves (62%) of the study population and 113 (29%) C. perfringens isolated from 51 calves (59%) of the control population tested positive with the beta2 probe. Pure and mixed cultures of four C perfringens (one alpha+beta2+, one alpha+enterotoxin-1 and two alpha+) were tested in the ligated loop assay in one calf. Macroscopic haemorrhages of the intestinal wall, necrosis and haemorrhages of the intestinal content, and microscopic lesions of necrosis and polymorphonuclear and mononuclear cell infiltration of the intestinal villi were more pronounced in loops inoculated with the a and beta2-toxigenic C. perfringens isolate. These results suggest in vivo synergistic role of the alpha and beta2 toxins in the production of necrotic and haemorrhagic lesions of the small intestine in cases of bovine enterotoxaemia. However, isolation of beta2-toxigenic C. perfringens does not confirm the clinical diagnosis of bovine enterotoxaemia and a clostridial cell counts must still be performed. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

Detailed reference viewed: 133 (25 ULg)
See detailRésistances aux antibiotiques des principaux pathogènes respiratoires chez les bovins
Linden, Annick ULg

Article for general public (2001)

Detailed reference viewed: 9 (0 ULg)
Peer Reviewed
See detailBactériologie comparée des liquides de lavage pulmonaire obtenus par voie transtrachéale ou par voie nasotrachéale chez le veau
Schreiber, P.; Thomas, A.; Linden, Annick ULg et al

in Annales de Médecine Vétérinaire (2000), 144

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailStudy of the Virulence of Five Strains of Amyxomatous Myxoma Virus in Crossbred New Zealand White/Californian Conventional Rabbits, with Evidence of Long-Term Testicular Infection in Recovered Animals
Marlier, Didier ULg; Mainil, Jacques ULg; Sulon, Joseph ULg et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 101-13

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by ... [more ▼]

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by inoculation of five groups of 10 crossbred New Zealand White/Californian conventional rabbits. A much more acute myxomatosis syndrome was produced in conventional rabbits than that reproduced previously in SPF animals. However, the main clinical signs were of the respiratory type. The MV strains MYX 254/95 and 801 appeared very virulent, killing all the inoculated animals. The strains MYX 217/95, MYX 555/94 and Saint Benoist were somewhat attenuated, killing only seven, six and six rabbits, respectively. Extensive lung lesions due to supervening bacterial infections were observed in 36 of the 39 rabbits that died. Lethality was found to be a better estimate of virulence than mean survival time. By 98 days after viral inoculation, all the surviving animals had completely recovered. At that time, they were immunosuppressed by treatment with adrenocorticotrophic hormone (ACTH) for 10 days to determine whether they still harboured the virus. After the ACTH treatment, eight of the 11 surviving rabbits showed clinical signs that resembled amyxomatous myxomatosis. All the virological examinations performed on naso-conjunctival exudate, on mononuclear cells, on eyelids and on ovaries remained negative but infectious virus was isolated from the testes of three of six surviving male rabbits. [less ▲]

Detailed reference viewed: 39 (10 ULg)
Full Text
Peer Reviewed
See detailInfectious Agents Associated with Rabbit Pneumonia: Isolation of Amyxomatous Myxoma Virus Strains
Marlier, Didier ULg; Mainil, Jacques ULg; Linden, Annick ULg et al

in Veterinary Journal (2000), 159(2), 171-8

Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for ... [more ▼]

Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for bacteriological examinations. At post mortem, the diagnoses based on observed lesions were as follows: acute haemorrhagic pneumonia (38%); acute suppurative bronchopneumonia (35%); and fibrinohaemorrhagic bronchopneumonia with fibrinous pleuritis (27%). MV was isolated from 10% of the rabbits, mainly from those with acute haemorrhagic pneumonia. Serological evidence of MV infection was demonstrated in 44% of rabbits. Pathogenic bacteria species isolated from lungs were Pasteurella (spp. and multocida), Escherichia coli, Bordetella bronchiseptica and Pseudomonas aeruginosa, respectively, from 41, 11, 7 and 6% of samples. No relationship could be established between the presence of specific antibodies to MV and the observed pulmonary lesions or the results of the bacteriological examinations. A significant trend was established between the severity of the lesions and the results of the bacteriological examinations. [less ▲]

Detailed reference viewed: 31 (7 ULg)
Full Text
Peer Reviewed
See detailThe Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Marlier, Didier ULg; Mainil, Jacques ULg; Boucraut-Baralon, C. et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 115-22

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An ... [more ▼]

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against challenge with either a virulent amyxomatous MV strain or a virulent nodular MV strain. Apart from a difference in the cutaneous expression of the disease, the two challenge strains resembled each other in respect of mortality rate, naso-conjunctival shedding of virus, and tissue infection. Vaccination with SFV alone failed to prevent clinical signs, naso-conjunctival shedding or tissue infection. Vaccination with SFV followed by a booster inoculation with SG33 protected rabbits against the development of clinical signs and significantly reduced both viral shedding in naso-conjunctival exudates and viral infection of eyelids, lungs and testes; virus was, however, isolated from testes of some surviving animals. [less ▲]

Detailed reference viewed: 28 (3 ULg)
Peer Reviewed
See detailEndocardite végétante dans l’espèce équine : revue de littérature à partir de 2 cas cliniques
Amory, Hélène ULg; Christmann, U.; Cassart, Dominique ULg et al

in Annales de Médecine Vétérinaire (2000), 144

Detailed reference viewed: 31 (0 ULg)
Peer Reviewed
See detailLa pleuropneumonie contagieuse bovine
Linden, Annick ULg; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailEtude du rôle présomptif des souches atypiques du virus de la myxomatose dans l’étiologie des lésions du système respiratoire chez le lapin
Marlier, Didier ULg; Linden, Annick ULg; Mainil, Jacques ULg et al

in Proceedings of the 8èmes Journées de la Recherche Cunicole (1999, June 09)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailCardiovascular Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade, by Metrenperone, in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Veterinary Journal (1999), 157(1), 31-37

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and ... [more ▼]

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and pulmonary hypertension were the major changes elicited by 5-HT. The purpose of the present study was to determine whether the cardiovascular response to 5-HT in calves was attributable to 5-HT2 receptors. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg) was administered intramuscular to six unsedated Friesian calves 30 min before the animals were given a 5-min intravenous 5-HT infusion. Mean systemic arterial (SAP), mean pulmonary arterial (PAP), pulmonary capillary wedge (PW) pressures were obtained by means of fluid-filled catheters, and cardiac output (CO) was measured by the thermodilution technique. Heart rate, stroke volume, systemic (SVR) and pulmonary (PVR) vascular resistances were calculated. Administration of 5-HT after metrenperone induced a short-lasting period of severe bradycardia followed by tachycardia and increased CO. The systemic blood pressure response was exclusively hypotensive and associated with a decrease in SVR. Conversely, PAP, PW, and PVR were not modified by 5-HT administration. The results establish that 5-HT induced systemic as well as pulmonary hypertension is mediated through the activation of type-2 serotonergic or alpha-adrenergic receptors, or both. In contrast, neither apnoea, bradycardia and hypotension, nor the positive chronotropic effect induced by 5-HT in cattle are mediated through such receptors. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Peer Reviewed
See detailVegetative endocarditis in 2 young horses
Amory, Hélène ULg; Christmann, U; Cassart, Dominique ULg et al

in Journal of Equine Veterinary Science (1999), 19

Detailed reference viewed: 9 (0 ULg)
Peer Reviewed
See detailEndocardite végétante dans l’espèce équine : revue de littérature à partir de 2 cas cliniques
Amory, Hélène ULg; Christmann; Cassart, Dominique ULg et al

in Annales de Médecine Vétérinaire (1998), 144

Detailed reference viewed: 22 (5 ULg)
Peer Reviewed
See detailLes mycoplasmes respiratoires des bovins : II. Propriétés de virulence et vaccination
Mainil, Jacques ULg; Thomas, A.; Linden, Annick ULg

in Annales de Médecine Vétérinaire (1998), 142

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailLes mycoplasmes respiratoires des bovins : I. Clinique, diagnostic et traitement
Linden, Annick ULg; Thomas, A.; Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (1998), 142

Detailed reference viewed: 17 (1 ULg)
Peer Reviewed
See detailPulmonary Function Values in Friesian and Double-Muscled Calves During Acute Poikilocapnic Hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(2), 79-90

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian ... [more ▼]

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves. [less ▲]

Detailed reference viewed: 43 (4 ULg)
Peer Reviewed
See detailVentilatory Effects of the Single-Breath Co2 Test, Compared with Eructation, in Cattle
Rollin, Frédéric ULg; Desmecht, Daniel ULg; Genicot, B. et al

in American Journal of Veterinary Research (1997), 58(3), 310-6

OBJECTIVE: To assess the peripheral chemoreceptor-induced ventilatory response to single tidal-breath CO2 (SB CO2) tests, compared with eructations, in 2 breeds of calves. ANIMALS: 13 conscious unsedated ... [more ▼]

OBJECTIVE: To assess the peripheral chemoreceptor-induced ventilatory response to single tidal-breath CO2 (SB CO2) tests, compared with eructations, in 2 breeds of calves. ANIMALS: 13 conscious unsedated Holstein-Friesian and 8 Belgian White and Blue hypermuscled calves. PROCEDURE: An SB of +/- 50% CO2 in equal parts of O2 and N2 was inhaled. Ventilatory response was determined from the increase in ventilation (delta Ve) during the first 20 seconds after the test breath or eructation and from the difference in end-tidal PCO2 between the stimulus and preceding control breaths. RESULTS: Because no difference was found between the 2 breeds of calves, all data were pooled. The increase in Ve peaked during the fifth breath after the SB CO2 test on average, corresponding to a delay of 12.4 seconds. The SB CO2 responses ranged from 0.037 to 0.151 L/min.mm of Hg.m2, with a mean +/- SD of 0.082 +/- 0.032 L/min.mm of Hg.m2 for all calves. The SB CO2 tests, similar to eructations, modified the breathing pattern significantly and in the same direction, by principally shortening expiratory time and increasing mean inspiratory flow. After eructations, Ve peak increase was more important for lower difference in end-tidal PCO2 between the stimulus and preceding control breaths and took place more rapidly than after SB CO2 tests. Accordingly, eructation responses were more marked than SB CO2 responses and averaged 0.925 +/- 0.276 L/min.mm of Hg.m2. CONCLUSIONS AND CLINICAL RELEVANCE: In cattle, the pattern of breathing and ventilation under basal conditions is characterized by a cyclic variability coupled to eructation. [less ▲]

Detailed reference viewed: 25 (0 ULg)
Full Text
Peer Reviewed
See detailEffects of Growth and Breed on Direct Static Measurements of Chest Wall Compliance in Cattle
Desmecht, Daniel ULg; Rollin, Frédéric ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1997), 62(1, Jan-Feb), 1-5

Chest wall compliance (CW) was measured in 59 conscious standing calves, aged six to 162 days, which were breathing air spontaneously through a face mask. The airways were occluded at the end of ... [more ▼]

Chest wall compliance (CW) was measured in 59 conscious standing calves, aged six to 162 days, which were breathing air spontaneously through a face mask. The airways were occluded at the end of inspiration in order to elicit the Hering-Breuer reflex, the effectiveness of which was ensured by the presence of a plateau on the tracings of airway opening and oesophageal pressure (Pes). CW was measured directly from the inspired volume of the occluded breath and changes in Pes generated by the recoil of the relaxed chest wall. This airway-occlusion technique yielded reproducible CW values similar to those measured by classical invasive methods. The ratio of CW to bodyweight in the growing calves (sCW) ranged from 2.2 to 11.5 ml cmH2O-1 kg-1 and was correlated negatively with age: (log sCW = 0.91-0.003 x age, r = 0.68), the rate of decline corresponding well to the multispecies allometric growth relationship. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailParasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in health calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1996), 57(6), 896-901

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailCardiovascular response to exogenous serotonin in healthy calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1996), 57(5), 731-738

OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT ... [more ▼]

OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT administrations were performed: II slow infusions (duration, 5 minutes) and 30 bolus infusions (duration, 5 seconds). Cardiovascular function values were recorded before, during, and after the infusion. RESULTS: Slow infusion of 5HT first resulted in a brief period of severe bradycardia, then in sustained tachycardia with a concomitant increase in cardiac output. Systemic initial hypotension concomitant with bradycardia, then a pressor phase associated with an increase in systemic vascular resistance, and finally, a long-lasting hypotensive phase associated with decreased systemic vascular resistance. Pulmonary hypertension was associated with increased pulmonary vascular resistance, reflecting intense pulmonary vasoconstriction. Bolus infusion at increasing dosages resulted in dose-dependent bradycardia and systemic hypotension, followed by dose-dependent systemic hypertension. Unlike with slow infusion, neither the second tachycardiac nor the third systemic hypotensive phases were evident. CONCLUSIONS: 5-HT induces dose-dependent cardiovascular responses, including a reflex response followed by pulmonary and systemic vasoconstriction, in healthy calves. CLINICAL RELEVANCE: Determining the type of serotonergic receptors responsible for these responses may help to determine whether 5-HT is involved in the mechanisms underlying brisket disease in cattle. [less ▲]

Detailed reference viewed: 8 (0 ULg)