References of "Linden, Annick"
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See detailBluetongue virus in wild deer, Belgium, 2005-2008
Linden, Annick ULg; Grégoire, Fabien ULg; Nahayo, A. et al

in Emerging Infectious Diseases (2010), 16(5), 833-836

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See detailCause of mortality and diseases in hare (Lepus europaeus) in Southern Belgium
Grégoire, F; Hanrez, D; Mousset, B et al

Conference (2009, October 16)

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See detailA three-year on Anaplasma phagocytophilum in wild cervids populations in Southern Belgium.
Nahayo, A; Heyman, P; Cochez, C et al

Conference (2009, October)

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See detailComparative intradermal tuberculin test in dairy cattle in the north of Ecuador and risk factors associated with bovine tuberculosis
Proano-Perez, F.; Benitez-Ortiz, Washington; Celi-Erazo, M. et al

in American Journal of Tropical Medicine and Hygiene (The) (2009), 81(6), 1103-1109

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See detailA case of a periarticular abscess and suppurative arthritis of the atlanto-occipital joint
Van Galen, Gaby ULg; Busoni, Valeria ULg; Sandersen, Charlotte ULg et al

in Equine Veterinary Education (2009), 21(7), 340-343

This case report describes a periarticular abscess and a suppurative arthritis of the atlanto-occipital joint in an adult horse. The horse showed a painful swelling localized on the atlanto-occipital ... [more ▼]

This case report describes a periarticular abscess and a suppurative arthritis of the atlanto-occipital joint in an adult horse. The horse showed a painful swelling localized on the atlanto-occipital region and ataxia in all four limbs. During his hospitalization the horse developed recumbency, dysphagia, facial paralysis and seizures. With the use of ultrasonography of the atlanto-occipital region a tentative diagnosis was made which was later confirmed by autopsy. Culture of the abscess revealed a Staphylococcus aureus. However, the horse had a history of recurrent fever, hypertrophy and abcessation of the submandibular lymph nodes, neck pain and dyspnoea for 2 months, suggestive for strangles. [less ▲]

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See detailAtypical Myopathy In Grazing Horses: A First Exploratory Data Analysis
Votion, Dominique ULg; Linden, Annick ULg; Delguste, Catherine ULg et al

in Veterinary Journal (2009), 180(1),

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See detailImprovement of the organisation of wildlife disease surveillance in Belgium : The WildSurv project
Tavernier, P; Linden, Annick ULg; Pirot, P et al

Conference (2008, October)

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See detailBluetongue in wild ruminants (Cervus elaphus) in southern Belgium
Linden, Annick ULg; Mousset, B; Grégoire, F et al

Conference (2008, October)

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See detailEvidence of European Brown Hare Syndrome in Southern Belgium
Grégoire, F; Hanrez, D; Mousseet, B et al

Conference (2008)

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See detailCavernous hemangiosarcoma in a free-living red deer (Cervus elaphus)
Grégoire, Fabien ULg; Mousset, Bénédicte ULg; Hanrez, David ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 162

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See detailEvidence for transplacental transmission of the current wild-type strain of bluetongue virus serotype-8 in cattle
Desmecht, Daniel ULg; Vanden Bergh, Raphaël ULg; Sartelet, Arnaud ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 163

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See detailBluetongue virus antibodies in wild red deer in southern Belgium
Linden, Annick ULg; Mousset, B.; Grégoire, Fabien ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008)

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See detailPurification of the recombinant beta2 toxin (CPB2) from an enterotoxaemic bovine Clostridium perfringens strain and production of a specific immune serum
Lebrun, Maud; Filée, Patrice ULg; Galleni, Moreno ULg et al

in Protein Expression & Purification (2007), 55(1), 119-131

Overgrowth of Clostridium perfringens clones with production of one or more of its toxin(s) results in diverse digestive and systemic pathologies in human and animals, such as cattle enterotoxaemia. The ... [more ▼]

Overgrowth of Clostridium perfringens clones with production of one or more of its toxin(s) results in diverse digestive and systemic pathologies in human and animals, such as cattle enterotoxaemia. The so-called beta2 toxin (CPB2) is the most recently described major toxin produced by C perfringens. In this study, the cpb2 ORF (cpb2FM) from a cattle C perfringens-associated enterotoxaemia was cloned and sequenced. The cpb2FM and its deduced nucleotide sequence clearly corresponded to the epb2 allele considered as "consensus" and not to "atypical" allele, despite its "non-porcine" origin. Expression assays of the recombinant toxin CPB2FM were performed in Escherichia coli and Bacillus subtilis with the expression vector pBLTS72, and by genomic integration by double recombination in B. subtilis. Highest level of production was obtained with the expression vector in B. subtilis 168 strain. The recombinant CPB2FM protein was purified and a specific rabbit polyclonal antiserum was produced. Polyclonal antibodies could detect CPB2 production in supernatants of C. perfringens from enterotoxaemic cattle. (C) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailDifferential anti-influenza activity among allelic variants at the Sus scrofa Mx1 locus
Palm, Mélanie; Leroy, Michael; Thomas, Anne et al

in Journal of Interferon & Cytokine Research (2007), 27(2), 147-155

A promising way to oppose infectious challenges would be to improve the resistance of the target species through genetic selection. Theoretically, a candidate gene is available against influenza viruses ... [more ▼]

A promising way to oppose infectious challenges would be to improve the resistance of the target species through genetic selection. Theoretically, a candidate gene is available against influenza viruses since a resistance trait was fortuitously discovered in the A2G mouse strain. This trait was demonstrated to be correlated with the expression of a specific isoform of the type I interferon (IFN)-dependent protein MX, an isoform coded by a specific allele at the mouse Mx1 locus. Two allelic polymorphisms were described recently in the Sus scrofa homologous gene. In this study, the frequencies and distribution of both alleles were evaluated among European domestic pig and wild boar populations by PCR-RFLP, and the anti-influenza activity conferred by both MX1 isoforms was evaluated in vitro using transfection of Vero cells followed by flow cytometric determination of the fraction of influenza virus-infected cells among MX-producing and MX-nonproducing cell populations. A significant difference in the anti-influenza activity brought by the two MX1 isoforms was demonstrated, which suggests that a significant improvement of innate resistance of pigs by genetic selection might be feasible provided the differences found here in vitro are epidemiologically relevant in vivo. [less ▲]

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See detailMorphological alterations in oxidative muscles and mitochondrial structure associated with equine atypical myopathy
Cassart, Dominique ULg; Baise, Etienne ULg; Cherel, Yann et al

in Equine Veterinary Journal (2007), 39(1), 26-32

REASONS FOR PERFORMING STUDY: There is a lack of well documented studies about muscular lesions in equine atypical myopathy (EAM). <br /> <br />OBJECTIVES: To characterise morphopathological changes of ... [more ▼]

REASONS FOR PERFORMING STUDY: There is a lack of well documented studies about muscular lesions in equine atypical myopathy (EAM). <br /> <br />OBJECTIVES: To characterise morphopathological changes of striated muscles and myocardium, to progress understanding of this disease. <br /> <br />METHODS: Thirty-two horses age 0.5-7 years kept on pasture were referred for a sudden ataxia/myoglobinuria syndrome. Clinical examination (stiffness, muscle pain, muscle fasciculations, abnormal gait, recumbency, myoglobinuria, tachycardia, sweating) and plasma CPK, LDH and AST levels were consistent with extensive myonecrosis and, together with anamnestic data, with so-called 'equine atypical myopathy' (EAM), a disease of unknown aetiology reported since 1939. Macroscopic and microscopic (histology, histoenzymology, ultrastructure) lesions were evaluated. <br /> <br />RESULTS: Necropsic examination revealed large areas of muscle necrosis, the extent and severity of which varied between cases and muscles, but which were clearly more constant and severe in respiratory and postural muscles and in the myocardium. Histology highlighted a multifocal and monophasic process compatible with Zenker degeneration/necrosis that mostly and segmentally affected type 1 fibres. Histochemical evaluation revealed a weak and disorganised pattern of NADH tetrazolium reductase staining, the absence of calcium salts precipitates and a dramatic accumulation of lipid droplets. Ultrastructural examination often revealed fibres of which the sole modifications were altered mitochondria and sarcoplasmic lipidosis. <br /> <br />CONCLUSIONS: Taken together, the data suggest that a primary alteration of mitochondria should be considered, although secondary mitochondrial abnormalities have yet to be ruled out. <br /> <br />POTENTIAL RELEVANCE: The morphological features gathered here reveal that EAM shares most of the characteristics of toxic myopathies. [less ▲]

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See detailHaemangiosarcoma in a wild red deer (Cervus elaphus)
Grégoire, F; Mousset, Bénédicte ULg; Hoyoux, A et al

Conference (2007)

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See detailThe expression of Clostridium perfringens consensus beta2 toxin is associated with bovine enterotoxaemia syndrome
Lebrun, Maud; Filée, Patrice ULg; Mousset, Bénédicte ULg et al

in Veterinary Microbiology (2007), 120(1-2), 151-157

Clostridium perfringens has been implicated in a broad array of enteric infections including the fatal haemorrhagic enteritis/enterotoxaemia syndrome in cattle. The beta2 toxin (CPB2), encoded by cpb2, is ... [more ▼]

Clostridium perfringens has been implicated in a broad array of enteric infections including the fatal haemorrhagic enteritis/enterotoxaemia syndrome in cattle. The beta2 toxin (CPB2), encoded by cpb2, is suspected to be implicated in this syndrome. However, among C. perfringens isolates from cattle suspected of clostridial disease, an atypical allele was recently found to predominate at the cpb2 locus and atypical corresponding CPB2 proteins were shown to be poorly expressed, thus arguing against a biologically significant role of the beta2 toxin in clostridial diseases in cattle. This study compared genotype and phenotype of the beta2 toxin between C. perfringens isolates from a group of healthy calves (n = 14, 87 isolates) and from a group of enterotoxaemic calves (n = 8,41 isolates). PCR results revealed the exclusive presence of the typical "consensus" cpb2 in the enterotoxaernic group. Western blot analysis demonstrated that the typical variant of CPB2 was often expressed in isolates from enterotoxaemic calves (43.9%) and infrequently in isolates from healthy cattle (6.9%). These data suggest that the typical variant of the CPB2 toxin may play a role in the pathogenesis of cattle enterotoxaemia. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailIsolation and Characterisation of a Ruminant Alphaherpesvirus Closely Related to Bovine Herpesvirus 1 in a Free-Ranging Red Deer
Thiry, Julien ULg; Widen, F.; Grégoire, Fabien ULg et al

in BMC Veterinary Research (2007), 3

BACKGROUND: The genus Varicellovirus of the Herpesviridae subfamily Alphaherpesvirinae includes a cluster of viruses antigenically and genetically related to bovine herpesvirus 1 (BoHV-1): namely bovine ... [more ▼]

BACKGROUND: The genus Varicellovirus of the Herpesviridae subfamily Alphaherpesvirinae includes a cluster of viruses antigenically and genetically related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5 (BoHV-5), bubaline herpesvirus 1 (BuHV-1), caprine herpesvirus 1 (CpHV-1), cervid herpesviruses 1 (CvHV-1) and 2 (CvHV-2) and elk herpesvirus 1 (ElkHV-1). Considering the serological relationship between these ruminant alphaherpesviruses, several surveys have studied the occurrence of BoHV-1 related virus infection in wild and domestic ruminant species. In this way, a recent investigation has indicated, in Belgium, a high increase in the serological prevalence of BoHV-1 related virus infection in free-ranging red deer population. In this context, it has been decided to investigate the presence of an alphaherpesvirus spreading in the Belgian free-ranging red deer population. RESULTS: The current study reports the first isolation in a free-ranging red deer of a BoHV-1 closely related virus. The isolate was antigenically, genomically and genetically characterised by comparison with several ruminant alphaherpesvirus. Immunofluorescence assays revealed the isolate was antigenically distinct from bovine and caprine alphaherpesviruses. Similarly, BamHI and BstEII restriction analyses demonstrated the genomic difference between the isolate and the other ruminant alphaherpesviruses. Next, the sequencing of selected parts of UL27 and US8 genes showed a high degree of homologies between each BoHV-1 related ruminant alphaherpesvirus and the isolate. Besides the close relationship between all ruminant alphaherpesviruses, the phylogenetic analysis revealed that the isolate clustered with CvHV-1. CONCLUSION: The first isolation of a virus closely related to BoHV-1 in a free-ranging red deer is reported. Data demonstrate that a CvHV-1 strain, named Anlier, circulates in wild red deer in continental Europe. Anlier strain show consistent differences with the virus isolated from Scottish farmed red deer. All together, these results improve our understanding of ruminant alphaherpesviruses. [less ▲]

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See detailHistory and clinical features of atypical myopathy in horses in Belgium (2000-2005)
Votion, D. M.; Linden, Annick ULg; Saegerman, Claude ULg et al

in Journal of Veterinary Internal Medicine (2007), 21(6, Nov-Dec), 1380-1391

Background: The emergent nature of atypical myopathy or atypical myoglobinuria (AM) necessitates precise description of its clinical and epidemiologic features. Purpose: To define key features of AM to ... [more ▼]

Background: The emergent nature of atypical myopathy or atypical myoglobinuria (AM) necessitates precise description of its clinical and epidemiologic features. Purpose: To define key features of AM to help practitioners recognize the disease and to advise owners to take preventive measures. Animals: Belgian cases of AM confirmed by histology (CC horses; n = 57) from autumn 2000 to spring 2005 were included in the study. Co-grazing horses (Co-G horses; n = 77) that remained free of any abnormal clinical signs constituted a control croup. Methods: History, environmental characteristics, clinical signs, and laboratory results associated with AM were determined by a retrospective case series study. Results: Young horses in poor or normal body condition were found to be at risk for AM. Pastures were characterized by poor natural drainage and vegetation of low nutritional value. Features of AM were seasonal occurrence, apparent link with weather conditions fie, lack of solar radiation with no heavy frost and an excess of precipitation or relative humidity), sudden onset of clinical signs, and rapid death. Evaluation of serum creatine kinase activity indicated severe muscle destruction in CC horses and subclinical disease in a few Co-G horses. Conclusions: The association of AM with specific environmental conditions and individual animals suggests that young horses should not be pastured on bare premises subject to humidity when the weather has been very wet and cold for several days. Management of AM outbreaks should include control of Co-G horses who are apparently healthy. [less ▲]

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