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See detailPlatelet-rich plasma (PRP) increases healing process of rats' Achilles tendons
Kaux, Jean-François ULg; Drion, Pierre ULg; Pascon, Frédéric ULg et al

Conference (2010, March 20)

Introduction Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy ... [more ▼]

Introduction Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy, physiotherapy, corticosteroid infiltrations, extracorporeal shock waves… Recently, several studies, essentially in vitro, demonstrated the positive effects of platelets on the healing process of different tissues: bones, muscles and tendons. Objectives The aim of our experiment was to ascertain whether the use of platelet-rich plasma (PRP) was of interest for accelerating the healing process of Achilles tendon after surgical induced lesion. Methods A 5mm defect was surgically induced in rat Achilles tendon after resection of plantaris tendon. Rats were divided into 2 groups: A: control (no injection) and B: PRP injection. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cage without immobilization. After 5, 15 and 30 days, rats were euthanized. The traumatized Achilles tendon of each rat was removed and dissected during this healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Results We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile test study was more important for tendons which had been submitted to an injection of PRP. These results were noticed from day 5 onwards. Discussion – Conclusion This experimentation has shown that PRP injections could accelerate tendons healing process and increase the force needed to break tendons in their healing process. This “accelerating” process can be observed as early as day 5. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

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See detailLe PRP (Platelet-Rich Plasma) peut-il favoriser la régénération tendineuse ?
Kaux, Jean-François ULg; Drion, Pierre ULg; Pascon, Frédéric ULg et al

in Annales de Réadaptation et de Médecine Physique (2009, October), 52(Sup. 1), 109-110

Introduction : Certaines tendinopathies (l’épicondylite, la tendinopathie rotulienne supérieure ou encore la tendinopathie d’Achille) demeurent rebelles malgré un traitement « classique » bien conduit ... [more ▼]

Introduction : Certaines tendinopathies (l’épicondylite, la tendinopathie rotulienne supérieure ou encore la tendinopathie d’Achille) demeurent rebelles malgré un traitement « classique » bien conduit : repos, orthèse, AINS, électrothérapie, kinésithérapie, infiltrations de corticoïdes, ondes de choc... Certains travaux, essentiellement in vitro, soulignent les potentialités réparatrices des plaquettes qui présentent la capacité d’accélérer la cicatrisation de différents tissus : os, muscles et tendons. Objectifs : Le but de notre étude préliminaire est d’objectiver l’effet « accélérateur » sur la réparation tendineuse suite à l’emploi d’injection de plasma enrichi en plaquettes (platelet-rich plasma ou PRP) car cette technique pourrait représenter une thérapeutique d’avenir en médecine physique et en traumatologie du sport. Méthodes : Nous avons sectionné et réalisé un défect de 5mm dans le tendon d’Achille de rats (N = 12). Quatre rats ont bénéficié d’une injection in loco de PRP et remis en liberté comme les autres dans leur cage. Trois rats (2 sans PRP et 1 avec PRP) sont euthanasiés à J5, J10, J20 et J30 et le tendon d’Achille en cours de régénération est disséqué et prélevé. Une étude biomécanique de traction jusqu’à rupture est réalisé à l’aide de « Cryo-jaw ». Résultats : L’analyse des résultats montre que la force développée pour obtenir la rupture tendineuse doit être plus importante pour les tendons ayant bénéficié d’une injection de PRP et ce dès J5. Discussion – Conclusion : Cette série préliminaire permet de montrer que les injections de PRP permettent une accélération de la cicatrisation tendineuse et une augmentation des valeurs de résistances à la traction. Une étude avec un plus grand nombre de sujets est en cours. [less ▲]

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See detailViscoelastic Modeling of Brain Tissue: A Fractional Calculus-Based Approach
Libertiaux, Vincent ULg; Pascon, Frédéric ULg

in Ganghoffer, Jean-François; Pastrone, Franco (Eds.) Mechanics of Microstructured Solids Cellular Materials, Fibre Reinforced Solids and Soft Tissues (2009)

In recent years, the mechanical study of the brain has become a major topic in the field of biomechanics. A global biomechanical model of the brain could find applications in neurosurgery and haptic ... [more ▼]

In recent years, the mechanical study of the brain has become a major topic in the field of biomechanics. A global biomechanical model of the brain could find applications in neurosurgery and haptic device design. It would also be useful for car makers, who could then evaluate the possible trauma due to impact. Such a model requires the design of suitable constitutive laws for the different tissues that compose the brain (i.e. for white and for gray matters, among others). Numerous constitutive equations have already been proposed, based on linear elasticity, hyperelasticity, viscoelasticity and poroelasticity. Regarding the strong strain-rate dependence of the brain’s mechanical behaviour, we decided to describe the brain as a viscoelastic medium. The design of the constitutive law was based on the Caputo fractional derivation operator. By definition, it is a suitable tool for modeling hereditary materials. Indeed, unlike integer order derivatives, fractional (or real order) operators are non-local, which means they take the whole history of the function into account when computing the derivative at current time t. The model was calibrated using experimental data on simple compression tests performed by Miller and Chinzei. A simulated annealing algorithm was used to ensure that the global optimum was found. The fractional calculus-based model shows a significant improvement compared to existing models. This model fits the experimental curves almost perfectly for natural strains up to − 0.3 and for strain-rates from 0.64s − 1 to 0.64 10− 2 s − 1. [less ▲]

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See detailProblems and Challenges of Image-Guided Neurosurgical Navigation and Intervention
Verly, Jacques ULg; Kavec, Martin; Vigneron, Lara et al

in Lecture Notes in Computer Science (2006, November), 4263

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