References of "Lemaire, Christian"
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See detailMetabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in free mooving rats.
Aerts, Joël ULg; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

in Society for Neuroscience / Abstracts (1998), 24

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See detailHigh-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635.
Le Bars, Didier; Lemaire, Christian ULg; Ginovart, N. et al

in Nuclear Medicine & Biology (1998), 25(4), 343-50

No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the ... [more ▼]

No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the presence of Kryptofix 222 and K2CO3 by microwave heating (3 min, 500 W) using a remotely controlled radiosynthesis. Baseline separation of p-[18F]MPPF from the nitro derivative was performed on a semipreparative HPLC C18 column. After Sep-Pak formulation, the radiopharmaceutical was obtained with a radiochemical yield of 25% (EOS) in about 70 min. Specific radioactivity averaged between 1-5 Ci/micromol EOS. Labelling of the ortho and meta derivatives was also attempted. Brain uptake of p-[18F]MPPF was studied with PET on fluothane-anesthetized cats. Following intravenous injection of p-[18F]MPPF, high accumulation of radioactivity was observed in the hippocampus and cerebral cortex. Low levels of radioactivity were observed in cerebellum. At 30 min, the mean hippocampus/cerebellum and cortex/cerebellum ratios were 5 and 3.8, respectively. The accumulation of the tracer was blocked by prior administration of reference WAY-100635, demonstrating the specificity of the ligand. [less ▲]

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See detailMethod and device for synthesizing labeled compounds
Lemaire, Christian ULg; Damhaut, Philippe; Monclus, Michel et al

Patent (1997)

A method for synthesizing compds. labeled with any isotopic element is disclosed. The method comprises the steps of prepg. the labeling agent, labeling a precursor in the form of a protected substrate ... [more ▼]

A method for synthesizing compds. labeled with any isotopic element is disclosed. The method comprises the steps of prepg. the labeling agent, labeling a precursor in the form of a protected substrate, pre-​purifying and deprotecting same, and forming a final soln. of the resulting compd. The deprotection step, in which the labeled precursor is converted into a labeled compd., is performed directly on a solid medium in a column or a cartridge. A device for synthesizing the labeled compd. according to said method is also disclosed. Thus, 2-​[18F]​fluoro-​2-​deoxy-​D-​glucose and 1,​3,​4,​6-​tetra-​O-​acetyl-​2-​trifluoromethanesulfonyl-​β-​D-​mannopyranose were prepd. [less ▲]

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See detailMétabolisme du p-[18]MPPF (antagoniste 5-HT1A) chez le rat
Plenevaux, Alain ULg; Aerts, Joël ULg; Lemaire, Christian ULg et al

Poster (1997, May 29)

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See detailMétabolisme de la 6-fluoro-L-tyrosine chez le rat
Aerts, Joël ULg; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

Poster (1997, May 29)

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See detailLe p-[18F]MPPF: un nouveau ligand pour l'étude par TEP des récepteurs 5-HT1A
Ginovart, Nathalie; Le Bars, Didier; Lemaire, Christian ULg et al

Poster (1997, May 25)

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See detailMicrowave improved synthesis of p-[18F]MPPF, 5-HT1A antagonist and PET sudies on cat brain.
Le Bars, D.; Ginovart, N.; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1997), 40

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See detailSynthesis of a fluorinated analogue of L-threo-3-(3,4-dihydroxyphenyl)serine: 6-fluoro-L-threo-DOPS.
Lambin, D.; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1997), 40

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See detailSynthesis of [18F]FDG with alkaline hydrolysis on a low polarity solid phase support.
Lemaire, Christian ULg; Damhaut, Ph.; Lauricella, Benjamino ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1997), 40

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See detailMetabolism of no carrier added 2-[18F]fluoro-L-tyrosine in free moving rats.
Aerts, Joël ULg; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1997), 40

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See detailTissue distribution, autoradiography and metabolism in rats of p-[18F]MPPF: 5-HT1A antagonist.
Plenevaux, Alain ULg; Aerts, Joël ULg; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1997), 40

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See detailHigh yield radiosynthesis of p-[F-18]MPPF, 5-HT1A antagonist, and PET studies in cat brain.
Le Bars, D.; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1997), 38

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See detailEvaluation of p-[F-18]MPPF, 5-HT1A antagonist, in rats: tissue distribution, autoradiography and metabolism.
Plenevaux, Alain ULg; Aerts, Joël ULg; Lemaire, Christian ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1997), 38

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See detailNo-carrier-added asymmetric synthesis of alpha-methyl-alpha-amino acids labelled with fluorine-18
Damhaut, Philippe; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Tetrahedron (1997), 53(16), 5785-5796

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential ... [more ▼]

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential inhibitors of enzymatic functions, were regiospecifically labelled by nucleophilic substitution on trimethylammoniumbenzaldehyde triflate precursors 9. The [18F]fluoro aromatic aldehydes 12 obtained were easily converted to the corresponding [18F]fluorobenzyl halides [13 (X = 1)]. After alkylation of the lithium enolate of (2S,5S)-l-tert-Boc-2-tert-butyl-3,5-dimethyl-imidazolidin-4-one 2, the adducts were cleaved to give, after HPLC purification, various [18F]fluoro-α-methyl amino acid analogs with radiochemical yields of 10% (End of Bombardment, EOB) after a synthesis time of 120 min. The corresponding [19F]fluorinated amino acids 4 and [19F]fluoro intermediates were also prepared. [less ▲]

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See detailCombined study of cerebral glucose metabolism and [11C] methionine accumulation in probable Alzheimer's disease using positron emission tomography
Salmon, Eric ULg; Grégoire, M. C.; Delfiore, Guy et al

in Journal of Cerebral Blood Flow & Metabolism (1996), 16(3), 399-408

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result ... [more ▼]

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result from local neuronal loss or from a decrease of synaptic activity. We measured in vivo [11C]methionine accumulation into proteins with positron emission tomography (PET) to assess cortical tissue loss in AD. Both global regional activity and compartmental analysis were used to express [11C]methionine accumulation into brain tissue. Glucose metabolism was measures with [18F]fluorodeoxyglucose and autoradiographic method. Combined studies were performed in 10 patients with probable AD, compared to age-matched healthy volunteers. There was a significant 45% decrease of temporo-parietal glucose metabolism in patients with AD, and frontal metabolism was lowered in most patients. Temporo-parietal metabolism correlated to dementia severity. [11C]methionine incorporation into temporo-parietal and frontal cortices was not significantly decreased in AD. There was no correlation with clinical symptoms. Data suggest that regional tissue loss, assessed by the decrease of [11C]methionine accumulation, is not sufficient to explain cortical glucose hypometabolism, which reflects, rather, reduced synaptic connectivity. [less ▲]

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See detailEnantioselective syntheses of no-carrier-added (nca) (S)-4-chloro-2 F-18 fluorophenylalanine and (S)-(alpha-methyl)-4-chloro-2 F-18 fluorophenylalanine
Al-Darwich, M. J.; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

in Journal of Fluorine Chemistry (1996), 80(2), 117-124

(S)-4-Chloro-2-fluorophenylalanine and (S)-( a-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on ... [more ▼]

(S)-4-Chloro-2-fluorophenylalanine and (S)-( a-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F] fluorobenzyl iodide and the lithium enolate of (2s) -1-( tert-butyloxycarbonyl) -2-( tert-butyl)-3-methyl- 1,3-imidazolidine-4-one for (S) -4-chloro-2- [18F] fluorophenylalanine and (2S,5S)-1-( tert-butyloxycarbonyl) -2-( tert-butyl) -3,5-dimethyl- 1,3-imidazolidine-4-one for (S) -( a-methyl) -4-chloro-2- [18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F] fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better. [less ▲]

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See detailFluorine-18 labeling of radiopharmaceuticals for PET studies: main aspects and problems encountered in chemical syntheses
Lemaire, Christian ULg

in Emran, A (Ed.) Chemists' Views of Imaging Centers (1995)

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See detailS-, N- and O-[11C]methylations of a Nor precursor adsorbed on Al2O3/KF.
Schmitz, F.; Plenevaux, Alain ULg; Del Fiore, G. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1995), 37

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See detail[1-11C]Bromoethane: an alternative to the use of [1-11C]iodoethane.
Schmitz, F.; Del Fiore, G.; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1995), 37

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