References of "Lekeux, Pierre"
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See detailCould pulmonary inertance be a limiting factor of ventilation during exercise in the equine species ?
Art, Tatiana ULg; Lekeux, Pierre ULg; Gustin, Pascal ULg et al

in Proceedings of the 7th Comparative Respiratory Society Meeting (1988)

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See detailStudy of the airflow patterns in healthy and diseased cattle
Lekeux, Pierre ULg; Art, Tatiana ULg

in Proceedings of the Sixth Veterinary Respiratory Symposium (1987, November)

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See detailMechanics of breathing and gas exchanges in healthy cattle: effect of somatic growth
Lekeux, Pierre ULg

in Archives Internationales de Physiologie et de Biochimie (1987, November), 95(2), 5

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See detailFunctional Changes Induced by Necrotic Laryngitis in Double Muscled Calves
Lekeux, Pierre ULg; Art, Tatiana ULg

in Veterinary Record : Journal of the British Veterinary Association (1987), 121(15), 353-355

The effects of necrotic laryngitis on the mechanics of breathing and gas exchange were investigated in five Belgian blue double muscled calves two to three months old. All the animals showed the typical ... [more ▼]

The effects of necrotic laryngitis on the mechanics of breathing and gas exchange were investigated in five Belgian blue double muscled calves two to three months old. All the animals showed the typical clinical picture of the respiratory syndrome associated with naturally occurring necrotic laryngitis. Highly significant increases in total pulmonary resistance, minute viscous work of breathing and alveolar-arterial oxygen gradient, and highly significant decreases in dynamic lung compliance and arterial oxygen tension were recorded in the infected animals, when compared to reference values for healthy cattle. The ratio of inspiratory to expiratory viscous work of breathing was also significantly increased probably because of a partial collapse of the extrathoracic trachea during inspiration. It was concluded that necrotic laryngitis disturbs pulmonary function to such an extent that it impedes the growing process and predisposes the infected animals to secondary bronchopneumonia and ventilatory failure due to respiratory muscle fatigue. [less ▲]

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See detailPartitioning of pulmonary resistance in calves
Gustin, Pascal ULg; Lomba, F.; Bakima, J. et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1987), 62(5), 1826-1831

Nine right apical lobes of healthy Friesian calves and 10 right apical lobes of double-muscled calves of Belgian White and Blue (BWB) breed were suspended in an airtight box, inflated at a constant ... [more ▼]

Nine right apical lobes of healthy Friesian calves and 10 right apical lobes of double-muscled calves of Belgian White and Blue (BWB) breed were suspended in an airtight box, inflated at a constant transpulmonary pressure (Ptp), and subjected to quasi-sinusoidal pressure changes (amplitude: 0.5 kPa) at a frequency of 30 cycles/min. Lobar resistance (RL) was partitioned at six different lung volumes into three components: central airway resistance (Rc), small airway resistance (Rp), and tissue resistance (Rt). Pressure in small airways (2-3 mm ID) was measured with a retrograde catheter. Alveolar pressure was sampled in capsules glued onto the punctured pleural surface. RL was minimal at values of Ptp comprised between 0.5 and 0.7 kPa and increased at higher and lower values of Ptp. At a Ptp of 0.5 kPa, Rc, Rp, and Rt represented 30, 15, and 55% of RL, respectively, in Friesian calves and 25, 25, and 50% in BWB calves. Rp increased markedly at low lung volumes. Rt was responsible for the increase of RL at high Ptp. Rc tended to decrease at high Ptp. The significantly higher values of Rp in BWB calves (P less than 0.05) might explain the sensitivity of this breed to severe bronchopneumonia [less ▲]

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See detailInertance pressures and their implications in pulmonary function testing in cattle
Lekeux, Pierre ULg; Art, Tatiana ULg

in Archives Internationales de Physiologie et de Biochimie (1987), 95(4), 74

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See detailMechanisms of breathing and gas exchanges in healthy cattle: effect of somatic growth
Lekeux, Pierre ULg

in Archives Internationales de Physiologie et de Biochimie (1987), 95(2), 5

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See detailEffet des pathologies respiratoires sur la fonction pulmonaire des bovins à l'engraissement
Lekeux, Pierre ULg; Art, Tatiana ULg; Gustin, Pascal ULg et al

in Annales de Médecine Vétérinaire (1987), 131

Clinical, serological and physiological values were measured during and after naturally occuring respiratory disease in fattening cattle. Clinical and serological findings were in agreement with the ... [more ▼]

Clinical, serological and physiological values were measured during and after naturally occuring respiratory disease in fattening cattle. Clinical and serological findings were in agreement with the description of the Shipping Fever syndrome. Pulmonary function values recorded during the initial stage of the disease showed a significant increase in respiratory rate, total pulmonary resistance, minute viscous work of breathing and alveolo-arterial oxygen gradient and a significant decrease in tidal volume and arterial oxygen tension. None of these values was still abnormal 2 weeks later. It was concluded that moderate Shipping Fever induce an acute obstructive disease located mainly at the level of large airways. On the other hand, the complete reversibility of the clinical and functional changes indicates that accurate preventive and curative treatments may avoid the onset of severe pulmonary dammage and may reduce the economical losses induced by the Shipping Fever syndrome. [less ▲]

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See detailFunktioneller Zugang zu den Respirationskrankheiten der Doppellender-Rinder der Rasse Weiss-Blaue Belgier.
Gustin, Pascal ULg; Bakima, M.; Lekeux, Pierre ULg et al

in Deutsche Tierarztliche Wochenschrift (1987), 94(5), 261-264

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See detailMechanical properties of excised calf lungs: effects of airway obstruction with beads
Gustin, Pascal ULg; Lekeux, Pierre ULg; Lomba, F. et al

in Research in Veterinary Science (1987), 42(3), 277-279

Isolated lungs of five calves were suspended in an airtight box used as a ventilator. Lungs were ventilated from the outside at different levels of transpulmonary pressure. Dynamic compliance (Cdyn) and ... [more ▼]

Isolated lungs of five calves were suspended in an airtight box used as a ventilator. Lungs were ventilated from the outside at different levels of transpulmonary pressure. Dynamic compliance (Cdyn) and total pulmonary resistance (RL) were measured. These pulmonary function values were also measured during central and peripheral airway obstructions. It was demonstrated that both central and peripheral obstructions induced significant variations of Cdyn and RL. However, decrease of Cdyn was greater and increase of RL was smaller during a peripheral obstruction than during a central one [less ▲]

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See detailMechanical properties of excised calf lungs
Gustin, Pascal ULg; Lekeux, Pierre ULg; Lomba, F. et al

in Research in Veterinary Science (1987), 42(3), 272-276

Five isolated calf lungs were suspended in an airtight box used as a ventilator. Lungs were ventilated from the outside at different levels of transpulmonary pressure (Ptp). The static pressure-volume ... [more ▼]

Five isolated calf lungs were suspended in an airtight box used as a ventilator. Lungs were ventilated from the outside at different levels of transpulmonary pressure (Ptp). The static pressure-volume curve characteristics of the lungs were measured. Static compliance (Cstat) was 1.9 +/- 0.37 litres kPa-1 or 25 +/- 5 per cent of total lung capacity kPa-1. At a Ptp of 0.7 kPa, dynamic compliance (Cdyn) and lung resistance (RL) were 1.1 +/- 0.1 litres kPa-1 and 0.126 +/- 0.02 kPa litres sec-1, respectively. Both an increase and a decrease of this level of Ptp induced an increase of RL and a decrease of Cdyn. The ratio Cdyn/Cstat averaged 57 +/- 0.8 per cent. It was concluded that in excised lungs, Cdyn is lower in the calf than in a number of other species and that pulmonary function values measured in vitro are optimum at values of Ptp close to values recorded in vivo in healthy cattle [less ▲]

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See detailPartitioning of pulmonary resistance in Friesian calves
Gustin, Pascal ULg; Bakima, M.; Lekeux, Pierre ULg et al

in Research in Veterinary Science (1987), 42(3), 313-317

Eight right cranial lobes of healthy Friesian calves were suspended in an airtight box. They were inflated at a constant transpulmonary pressure (Ptp) and ventilated from the outside by modifying ... [more ▼]

Eight right cranial lobes of healthy Friesian calves were suspended in an airtight box. They were inflated at a constant transpulmonary pressure (Ptp) and ventilated from the outside by modifying pressures in the box with a quasi-sinusoidal pump at a frequency of 30 counts per minute. Peak-to-peak changes were 0.5 kPa. Lobar resistance (Rl) was partitioned into three components: central airway resistance (Rc), small airway resistance (Rp) and tissue resistance (Rt). Partitioning of R1 was realised at six different lung volumes. Minimal R1 was observed for a value of Ptp between 0.5 and 0.7 kPa. At a Ptp of 0.5 kPa, Rc, Rp, Rt represent 30, 15 and 55 per cent of R1, respectively. Lobar resistance increases at high and low lung volumes. Small airway resistance is small and independent of the level of lung inflation, except at low lung volumes where a marked increase is observed. Tissue resistance is relatively high and responsible for the increase of R1 at high lung volumes. Central airway resistance does not change significantly with lung volumes [less ▲]

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See detailPartitioning of upper airway resistance in Friesian and double-muscled calves.
Gustin, Pascal ULg; Bakima, M.; Lekeux, Pierre ULg et al

in Respiration Physiology (1987), 69(3), 299-306

Respiratory resistance in calves was partitioned in two components: upper airway resistance and pulmonary resistance. The former one was divided into naso-pharyngeal and laryngeal resistance. A comparison ... [more ▼]

Respiratory resistance in calves was partitioned in two components: upper airway resistance and pulmonary resistance. The former one was divided into naso-pharyngeal and laryngeal resistance. A comparison between seven healthy unsedated double-muscled calves of the Belgian White and Blue breed (BWB) and five healthy unsedated Friesian (F) calves was performed. Respiratory resistance was significantly greater in the BWB calves, due to the significantly higher values of the naso-pharyngeal and the laryngeal resistances. This finding might be related to the higher prevalence of laryngitis in this breed [less ▲]

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See detailPulmonary function and tracheal dynamics during upper airway obstructive diseases in cattle
Lekeux, Pierre ULg; Art, Tatiana ULg

in Proceedings of the Fifth Veterinary Respiratory Symposium (1986, November 15)

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See detailEfficacy of ivermectin and levamisole against immature Dictyocaulus viviparus in cattle
Pouplard, L.; Lekeux, Pierre ULg; Detry, M.

in Veterinary Record : Journal of the British Veterinary Association (1986), 118

Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six ... [more ▼]

Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six animals. Calves of group 1 were controls. Calves of group 2 were given levamisole at a dose rate of 10 mg/kg and calves of group 3 were given ivermectin at a dose rate of 200 micrograms/kg. The anthelmintic activity of these two drugs was compared using clinical, functional, parasitological and pathological parameters. The results showed that the efficacy of ivermectin, given at a therapeutic dose, against immature D viviparus was higher than that of levamisole, given at double the recommended dose [less ▲]

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See detailEtude des arythmies cardiaques chez 159 chevaux de selle belges
Gabriel, F.; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1986), 130

A resting electrocardiogram was performed in 159 healthy belgian saddle horses (5 stallions, 98 castrated horses and 56 females) aged from 2 to 20 years. Technics and methods of recording were ... [more ▼]

A resting electrocardiogram was performed in 159 healthy belgian saddle horses (5 stallions, 98 castrated horses and 56 females) aged from 2 to 20 years. Technics and methods of recording were standardized. The most frequent cardiac arrhythmias were second degree atrioventricular block (37 cases), wandering pace¬maker (16 cases), first degree atrioventricular block (7 cases) and second degree sinoatrial block (2 cases). Atrial fibrillation and sinus arrhythmia was also once recorded. Four horses showed simultaneously atrioventri¬cular block and wandering pacemaker. Vagal arrhythmias were significantly more frequent in castrated horses than in females. The age of the horse had little effect on the frequency of these arrhythmias. On the other hand, a study of the T wave suggested that the clinical interpretation of its morphological changes is highly hasardous, because of our poor knowledge of the ventricular repolarization in horses. [less ▲]

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See detailPulmonary function changes induced by experimental dichlorvos toxicosis in calves
Lekeux, Pierre ULg; Kyavu, A.; Clercx, Cécile ULg et al

in Research in Veterinary Science (1986), 40(3), 318-321

Clinical and pulmonary function changes induced by intravenous dichlorvos (2,2-dichlorvinyldimethyl phosphate) (DDVP) toxicosis, and reversibility of these changes after atropine treatment were ... [more ▼]

Clinical and pulmonary function changes induced by intravenous dichlorvos (2,2-dichlorvinyldimethyl phosphate) (DDVP) toxicosis, and reversibility of these changes after atropine treatment were investigated in six Friesian calves one to three months old. From one minute after dosage, all animals showed severe respiratory distress, excitation, weakness, muscle fasciculation and cholinesterase inhibition. Decrease in dynamic lung compliance and arterial oxygen tension and increase in total pulmonary resistance, viscous work of breathing and alveolar arterial oxygen gradient were highly significant (P less than 0.01). On the other hand, body secretions, heart rate, respiratory rate, tidal volume and arterial carbon dioxide tension were not significantly affected by DDVP injection. Atropine promptly and completely reversed these changes, except for muscle fasciculations, central depression and cholinesterase inhibition which disappeared progressively within 24 hours. [less ▲]

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See detailRole of inertia in the measurement of dynamic compliance in adult cattle
Lekeux, Pierre ULg; Clercx, Cécile ULg; Gustin, Pascal ULg

in 4th Comparative Respiratory Society meeting - Anaheim California - USA - 10-11 novembre 1985 (1985, November 10)

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See detailHigh-frequency ventilation in cats: technical data
Clercx, Cécile ULg; Lekeux, Pierre ULg; Degroote, A. et al

in 4th Comparative Respiratory Society meeting - Anaheim California - USA (1985)

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