Le langage universel de la communication cellulaire et sa pathologie. Les chemins communs du langage intercellulaire

in Revue Médicale de Liège (1992), 47(3), 109-15

Les champs électromagnétiques ELF ont-ils un effet sur la santé? Revue de la littérature

in Psychologie Médicale (1992), 24(11), 1205-1215

De nombreuses études ont été entreprises les dernières décénnies sur les effets des champs électromagnétiques de très basse fréquence (TBF ou ELF). Les rapports publiés sont tantôt optimistes tantôt ... [more ▼]

De nombreuses études ont été entreprises les dernières décénnies sur les effets des champs électromagnétiques de très basse fréquence (TBF ou ELF). Les rapports publiés sont tantôt optimistes tantôt pessimistes. Les auteurs passent en revue les recherches épidémiologiques et expérimentales effectuées chez l'homme avant d'envisager une hypothèse explicative des effets observés, en relation avec le rôle joué par la glande pinéale [less ▲]

Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice

in Pharmacology, Biochemistry & Behavior (1991), 40(2), 261-265

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the ... [more ▼]

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol. [less ▲]

Neuroendocrine-Immunology: from systemic interactions to the immune tolerance of self neuroendocrine functions

in Acta Clinica Belgica (1991), 46

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through ... [more ▼]

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through these interactions, psychological and neurological influences can modulate the immune response (neuroimmunomodulation), while immune cells may communicate to the neuroendocrine system by a regulatory feedback loop. On the basis of our own observations, it has been shown that the neuroendocrine-immune dialogue occurs in the thymus during the early steps of T-cell differentiation, and could be involved both in T-cell positive as well as negative selections. [less ▲]

Thymic cryptocrine signaling and the immune recognition of self neuroendocrine functions

in Progress in NeuroEndocrinImmunology (1991), 4

Neuropeptide signals and receptors in the thymus

in Plotnikoff, Nicholas; Murgo, Anthony; Faith, Robert (Eds.) et al Stress and Immunity (1991)

Expression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymus

in Molecular Endocrinology (1990), 4

The preprotachykinin-A gene, the common gene of mRNAs encoding both substance-P (SP) and neurokinin- A (NKA), was shown to be expressed in Sprague-Dawley rat thymus by detection of specific mRNA in gel ... [more ▼]

The preprotachykinin-A gene, the common gene of mRNAs encoding both substance-P (SP) and neurokinin- A (NKA), was shown to be expressed in Sprague-Dawley rat thymus by detection of specific mRNA in gel-blot analyses. In situ hybridization revealed dispersed PPT-A-labeled cells in sections from rat thymus, with a concentration of grains over a subpopulation of cells in the thymic medulla. Also, neuropeptide-Y mRNA-expressing cells were found in the rat thymus, primarily in the thymic medulla. Rat thymic extracts contained SP-like immunoreactivity (SP-LI), and the major part of the immunoreactivity coeluted with authentic SP and SP sulfoxide standards. SP-LI was also detected in human thymus, which contained between 0.09-0.88 ng SP-LI/ g wet wt. Evidence for translation of preprotachykinin- A mRNA in the rat thymus was obtained from the demonstration of NKA-LI in thymic cells with an epithelial-like cell morphology. Combined with previous observations on the immunoregulatory roles of tachykinin peptides and the existence of specific receptors on immunocompetent cells, the demonstration of intrathymic synthesis of NKA suggests a role for NKA-LI peptides in T-cell differentiation in the thymus. [less ▲]

Interactions neuroendocrino-immunitaires

in Bazin, Hervé; Pastoret, Paul-Pierre; Govaerts, André (Eds.) Immunologie Animale (1990)

Contingent negative variation in psychopharmacology

in Brunia, C. H. M.; Mulder, G.; Verbater, M. N. (Eds.) Event related potentials in brain research (1990)

Neuroendocrine-immune interactions in T cell ontogeny

in Thymus (1989), 13