References of "Legros, Jean-Jacques"
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See detailLe langage universel de la communication cellulaire et sa pathologie. Les chemins communs du langage intercellulaire
Geenen, Vincent ULg; Robert, F.; Legros, Jean-Jacques ULg et al

in Revue Médicale de Liège (1992), 47(3), 109-15

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See detailLes champs électromagnétiques ELF ont-ils un effet sur la santé? Revue de la littérature
Crasson, Marion ULg; Timsit-Berthier, Martine; Legros, Jean-Jacques ULg

in Psychologie Médicale (1992), 24(11), 1205-1215

De nombreuses études ont été entreprises les dernières décénnies sur les effets des champs électromagnétiques de très basse fréquence (TBF ou ELF). Les rapports publiés sont tantôt optimistes tantôt ... [more ▼]

De nombreuses études ont été entreprises les dernières décénnies sur les effets des champs électromagnétiques de très basse fréquence (TBF ou ELF). Les rapports publiés sont tantôt optimistes tantôt pessimistes. Les auteurs passent en revue les recherches épidémiologiques et expérimentales effectuées chez l'homme avant d'envisager une hypothèse explicative des effets observés, en relation avec le rôle joué par la glande pinéale [less ▲]

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See detailLa communication cryptocrine et la reconnaissance des fonctions neuroendocrines par les cellules T au cours de leur différenciation
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1992), 33

Le thymus, organe lymphoïde primaire responsable du développement des lymphocytes T, est le site d'expression de différents peptides appartenant à des familles hormonales distinctes. Le modèle classique ... [more ▼]

Le thymus, organe lymphoïde primaire responsable du développement des lymphocytes T, est le site d'expression de différents peptides appartenant à des familles hormonales distinctes. Le modèle classique de la neurosécrétion établi pour l'axe hypothalamo-neurohypophysaire ne peut cependant s'appliquer à la sécrétion de tels signaux par les cellules épithéliales thymiques. Un nouveau modèle de communication cellulaire, celui de la communication cryptocrine, a été proposé par John W. Funder pour décrire les échanges d'information entre une cellule épithéliale fixe et des cellules mobiles en différenciation à leur contact. Dans le thymus, la communication cryptocrine est étroitement associée à la présentation de la structure moléculaire du Soi par les molécules d'histocompatibilité (CMH) aux lymphocytes T au cours de leur différenciation. Sur la base de nos observations, le modèle du répertoire thymique des autoantigènes neuroendocrines permet de transposer au niveau moléculaire le double rôle physiologique du thymus dans les phénomènes de sélections négative et positive des cellules T, et d'apporter un éclairage nouveau sur les mécanismes responsables de la tolérance immunitaire centrale aux fonctions neuroendocrines. [less ▲]

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See detailOxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Jodogne, C.; Tirelli, Ezio ULg; Klingbiel, P. et al

in Pharmacology, Biochemistry & Behavior (1991), 40(2), 261-265

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the ... [more ▼]

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol. [less ▲]

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See detailAt the Cutting Edge. Biosynthesis and Paracrine/Cryptocrine Actions of 'Self' Neurohypophysial-Related Peptides in the Thymus
Geenen, Vincent ULg; Robert, F.; Martens, Henri ULg et al

in Molecular & Cellular Endocrinology (1991), 76(1-3), 27-31

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See detailNeuroendocrine-Immunology: from systemic interactions to the immune tolerance of self neuroendocrine functions
Geenen, Vincent ULg; Robert, Françoise; Legros, Jean-Jacques ULg et al

in Acta Clinica Belgica (1991), 46

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through ... [more ▼]

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through these interactions, psychological and neurological influences can modulate the immune response (neuroimmunomodulation), while immune cells may communicate to the neuroendocrine system by a regulatory feedback loop. On the basis of our own observations, it has been shown that the neuroendocrine-immune dialogue occurs in the thymus during the early steps of T-cell differentiation, and could be involved both in T-cell positive as well as negative selections. [less ▲]

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See detailMonoclonal antibodies to oxytocin: production and characterization
Burgeon, Emmanuel; Chapleur, Michèle; Schoenen, Jean ULg et al

in Journal of Neuroimmunology (1991), 31

To induce a good immune response to oxytocin (OT) we developed a two-step technique to conjugate OT to thyroglobulin (TG) using glutaraldehyde. We obtained 30 hybridomas recognizing OT-ovalbumin ... [more ▼]

To induce a good immune response to oxytocin (OT) we developed a two-step technique to conjugate OT to thyroglobulin (TG) using glutaraldehyde. We obtained 30 hybridomas recognizing OT-ovalbumin conjugates and 16 stable lines. Three monoclonal antibodies were selected for further characterization. One of them (O13) was found to be very specific for OT using three different techniques (EIA, RIA and ICC); it si directed to the C-terminal tripeptide. The other two probably recongize tyrosine-containing epitope(s) also shared by vasopressin and other related nonapeptides. [less ▲]

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See detailThymic cryptocrine signaling and the immune recognition of self neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Progress in NeuroEndocrinImmunology (1991), 4

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See detailNeuroendocrinology of the thymus
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Geenen, Vincent; Maggi, Mario (Eds.) Horizons in Endocrinology, Volume 2 (1991)

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See detailNeuropeptide signals and receptors in the thymus
Geenen, Vincent ULg; Robert, Françoise; Legros, Jean-Jacques ULg et al

in Plotnikoff, Nicholas; Murgo, Anthony; Faith, Robert (Eds.) et al Stress and Immunity (1991)

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See detailThymic cryptocrine signaling and the immune recognition of self neuroendocrine functions
Geenen, Vincent ULg; Martens, Henri ULg; Robert Françoise et al

in Progress in NeuroEndocrinImmunology (1991), 5

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See detailExpression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymus
Ericsson, Anders; Geenen, Vincent ULg; Robert, François et al

in Molecular Endocrinology (1990), 4

The preprotachykinin-A gene, the common gene of mRNAs encoding both substance-P (SP) and neurokinin- A (NKA), was shown to be expressed in Sprague-Dawley rat thymus by detection of specific mRNA in gel ... [more ▼]

The preprotachykinin-A gene, the common gene of mRNAs encoding both substance-P (SP) and neurokinin- A (NKA), was shown to be expressed in Sprague-Dawley rat thymus by detection of specific mRNA in gel-blot analyses. In situ hybridization revealed dispersed PPT-A-labeled cells in sections from rat thymus, with a concentration of grains over a subpopulation of cells in the thymic medulla. Also, neuropeptide-Y mRNA-expressing cells were found in the rat thymus, primarily in the thymic medulla. Rat thymic extracts contained SP-like immunoreactivity (SP-LI), and the major part of the immunoreactivity coeluted with authentic SP and SP sulfoxide standards. SP-LI was also detected in human thymus, which contained between 0.09-0.88 ng SP-LI/ g wet wt. Evidence for translation of preprotachykinin- A mRNA in the rat thymus was obtained from the demonstration of NKA-LI in thymic cells with an epithelial-like cell morphology. Combined with previous observations on the immunoregulatory roles of tachykinin peptides and the existence of specific receptors on immunocompetent cells, the demonstration of intrathymic synthesis of NKA suggests a role for NKA-LI peptides in T-cell differentiation in the thymus. [less ▲]

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See detailNeurophysins as markers of ADH and oxytocin release
Legros, Jean-Jacques ULg; Geenen, Vincent ULg; Carvelli, Thierry ULg et al

in Hormone Research (1990), 34

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See detailInteractions neuroendocrino-immunitaires
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Franchimont, Paul

in Bazin, Hervé; Pastoret, Paul-Pierre; Govaerts, André (Eds.) Immunologie Animale (1990)

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See detailCellular and molecular aspects of the neuroendocrine-immune dialogue in T-cell differentiation
Geenen, Vincent ULg; Robert, Françoise; Martens, Henri ULg et al

in Müller, Eugenio E.; MacLeod, Robert (Eds.) Neuroendocrine Perspectives, Volume 8 (1990)

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See detailContingent negative variation in psychopharmacology
Timsit-Berthier, M.; Ansseau, Marc ULg; Mantanus, H. et al

in Brunia, C. H. M.; Mulder, G.; Verbater, M. N. (Eds.) Event related potentials in brain research (1990)

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See detailNeuroendocrine-Immune Interactions in T Cell Ontogeny
Geenen, Vincent ULg; Robert, Françoise; Fatemi, Marjaneh et al

in Thymus (1989), 13(3-4), 131-140

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See detailNeuroendocrinology of the thymus
Geenen, Vincent ULg; Robert, Françoise; Defresne, Marie-Paule ULg et al

in Hormone Research (1989), 31(1-2), 81-84

The neuropeptides oxytocin (OT) and vasopressin (VP) are synthesized in the human thymus in a similar way as in the hypothalamo-neurophypophyseal system. Immunocytochemistry with polyclonal and monoclonal ... [more ▼]

The neuropeptides oxytocin (OT) and vasopressin (VP) are synthesized in the human thymus in a similar way as in the hypothalamo-neurophypophyseal system. Immunocytochemistry with polyclonal and monoclonal antibodies revealed that immunoreactive OT- and VP-producing cells are localized in the subcapsular cortex and medulla of human and murine thymuses. The epithelial nature of the neuroendocrine thymic cells is demonstrated by their immunostaining with a monoclonal antibody against cytokeratin. An original example of a neuroendocrine-immune microenvironment is given by the thymic nurse cells which are composed of a large neuroendocrine epithelial cell enclosing numerous mitotic immature thymocytes. These observations and the previously reported mitogenic and immunomodulatory properties of VP and OT upon mature T cells and thymocytes strongly support the existence of a neuroendocrine thymo-lymphoid axis and an active role of thymic VP and OT in T cell differentiation and activation. [less ▲]

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See detailNeuroendocrine control of the immune response
Legros, Jean-Jacques ULg; Geenen, Vincent ULg

in Whalley, L. J.; Page, M. L. (Eds.) Stress, immunity and disease (1989)

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