References of "Lecomte, Philippe"
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See detailStainless steel with robust anibacterial activiy based on a versatile and bio-inspired strategy
Faure, Emilie ULg; Lecomte, Philippe ULg; Vreuls, Christelle ULg et al

Conference (2011, September 01)

The synthesis of a poly(methacrylamide) bearing 3,4-dihydroxyphenylalanine inspired from the chemical composition of mussel adhesives will be presented. This homopolymer is designed to insure a multilayer ... [more ▼]

The synthesis of a poly(methacrylamide) bearing 3,4-dihydroxyphenylalanine inspired from the chemical composition of mussel adhesives will be presented. This homopolymer is designed to insure a multilayer film growth by covalent coupling during the layer-by-layer building with a homopolymer containing amino groups. The film cross-linking is initiated by adequately controlling both the redox state of the polymer and the pH of the solutions. This cross-linking is evidenced by solid-state 13C NMR with the occurrence of a typical signal of imine, traducing the Schiff base formation during film growth. The same coupling reaction is implemented for grafting an antibacterial peptide, Nisin, on a stainless steel substrate. Antibacterial activity against Bacillus subtilis is preserved even after long immersion time, as the result of the peptide covalent anchoring on the surface. All the processing steps, including the synthesis of the polymers and the peptide grafting, are performed in aqueous solutions under mild conditions. [less ▲]

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See detailSustainable and bio-inspired chemistry for robust antibacterial activity of stainless steel
Faure, Emilie ULg; Lecomte, Philippe ULg; Lenoir, Sandrine et al

in Journal of Materials Chemistry (2011), 21(22), 7901-7904

We report on the original synthesis of a poly(methacrylamide) bearing (oxidized) 3,4-dihydroxyphenylalanine specially designed to (i) insure film growth by covalent coupling, (ii) covalently bind an ... [more ▼]

We report on the original synthesis of a poly(methacrylamide) bearing (oxidized) 3,4-dihydroxyphenylalanine specially designed to (i) insure film growth by covalent coupling, (ii) covalently bind an antibacterial peptide and (iii) contribute to the film cross-linking that is essential for the durability of the properties. [less ▲]

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See detailPreparation of pH-sensitive star-shaped aliphatic polyesters as precursors of polymersomes
Riva, Raphaël ULg; Lazzari, Wenda; Billiet, Leen et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2011), 49(7), 1552-1563

The synthesis of a new pH-sensitive amphiphilic A2B mikto-arm star-shaped aliphatic copolyester (with A = PCL and B = tertiary amine-bearing PCL) with two hydrophobic arms and one hydrophilic arm when ... [more ▼]

The synthesis of a new pH-sensitive amphiphilic A2B mikto-arm star-shaped aliphatic copolyester (with A = PCL and B = tertiary amine-bearing PCL) with two hydrophobic arms and one hydrophilic arm when protonated at pH = 5.5. The copper mediated azide-alkyne cycloaddition was used for the synthesis of the star copolyester and to impart the pH sensitivity to the hydrophilic arm by grafting of tertiary amine groups onto azide bearing PCL chain. The formation of polymersomes in water at pH 5 was assessed by DLS and TEM analyses. [less ▲]

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See detailFluorescent labeling of degradable poly(lactide-co-glycolide) for cellular nanoparticles tracking in living cells
Freichels, Hélène; Danhier, Fabienne; Préat, Véronique et al

in International Journal of Artificial Organs (2011), 34(2), 152-160

Fluorescent-labeled aliphatic polyesters are essential materials for in vitro and in vivo studies of the behavior of these biodegradable polymers in interaction with cells or in a body. In particular, the ... [more ▼]

Fluorescent-labeled aliphatic polyesters are essential materials for in vitro and in vivo studies of the behavior of these biodegradable polymers in interaction with cells or in a body. In particular, the direct cellular localization of drug delivery systems based on these materials allows better understanding of the internalization mechanism and determination of the pharmacokinetics. Polylactide-co-glycolide (PLGA) is a rapidly degradable copolymer widely used in pharmaceutics and nanomedecine. It was prepared by ring-opening polymerization of lactide and glycolide in order to obtain a well-defined material to investigate conditions allowing the covalent linkage of a fluorescent dye (fluorescein) while preserving the macromolecular characteristics of the polymer. The success of the functionalization was ascertained by proton nuclear magnetic resonance (1H NMR), size-exclusion chromatography (SEC) and fluorescence spectroscopy. [less ▲]

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See detailStainless steel with robust antibacterial activity based on a versatile and bio-inspired strategy
Faure, Emilie; Lecomte, Philippe ULg; Vreuls, Christelle et al

in Polymer Preprints (2011), 52(2), 193-194

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See detailContribution of "click chemistry" to the macromolecular engineering of aliphatic polyesters
Riva, Raphaël ULg; Schmeits, Stephanie ULg; Croisier, Florence ULg et al

Poster (2010, July 13)

In this work, click chemistry was sucessfully applied to the chemical modification of aliphatic polyesters with the purpose to tailor their physical properties. The developped strategy was then applied to ... [more ▼]

In this work, click chemistry was sucessfully applied to the chemical modification of aliphatic polyesters with the purpose to tailor their physical properties. The developped strategy was then applied to the synthesis of materials, such as smart partially degradable hydrogels or antibacterial polyesters. Last, the synthesis of amphiphilic star-shaped copolyester was investigated. [less ▲]

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See detailRecent development in the macromolecular engineering of functionalized aliphatic polyesters
Lecomte, Philippe ULg

Scientific conference (2009, December 16)

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See detailSynthesis of novel amphiphilic mikto-arm star-shaped copolymers
Riva, Raphaël ULg; Lazarri, Wenda; Billiet, Leen et al

Poster (2009, December 14)

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See detailControlled Synthesis of AB2 amphiphilic triarm star-shaped block copolymers by ring-opening polymerization
Petrova, Svetla; Riva, Raphaël ULg; Jérôme, Christine ULg et al

in European Polymer Journal (2009), 45(12), 3442-3450

This paper describes the synthesis of a novel amphiphilic AB2 triarm star-shaped copolymer with A = non-toxic and biocompatible hydrophilic poly(ethylene oxide) (PEO) and B = biodegradable and hydrophobic ... [more ▼]

This paper describes the synthesis of a novel amphiphilic AB2 triarm star-shaped copolymer with A = non-toxic and biocompatible hydrophilic poly(ethylene oxide) (PEO) and B = biodegradable and hydrophobic poly(ε-caprolactone) (PCL). A series of AB2 triarm star-shaped copolymers with different molecular weights for the PCL block were successfully synthesized by a three-step procedure. α-methoxy-ω-epoxy-poly(ethylene oxide) (PEO-epoxide) was first synthesized by the nucleophilic substitution of α-methoxy-ω-hydroxy-poly(ethylene oxide) (MPEO) on epichlorohydrin. In a second step, the α-methoxy-ω,ω’-dihydroxy-poly(ethylene oxide) (PEO(OH)2) macroinitiator was prepared by the selective hydrolysis of the ω-epoxy end-group of the PEO-epoxide chain. Finally, PEO(OH)2 was used as a macroinitiator for the ring-opening polymerization (ROP) of ε-caprolactone (εCL) catalyzed by tin octoaote (Sn(Oct)2). PEO-epoxide, PEO(OH)2 and the AB2 triarm star-shaped copolymers were assessed by 1H NMR spectroscopy, size exclusion chromatography (SEC) and MALDI-TOF. The behavior of the AB2 triarm star-shaped copolymer in aqueous solution was studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). [less ▲]

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See detailFunctionlization and grafting of polylactide by click chemistry
Riva, Raphaël ULg; Croisier, Florence ULg; Jérôme, Christine ULg et al

Conference (2009, November 19)

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See detailNouveaux développements pour la synthèse des matériaux polymères du futur
Lecomte, Philippe ULg

Conference (2009, November 11)

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See detailFirst example of “click” copper(I) catalyzed azide-alkyne cycloaddition in supercritical carbon dioxide: Application to the functionalization of aliphatic polyesters
Grignard, Bruno ULg; Schmeits, Stephanie ULg; Riva, Raphaël ULg et al

in Green Chemistry (2009), 11

The modification of aliphatic polyesters by the copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) was successfully implemented in supercritical carbon dioxide (scCO2). Due to the remarkable ... [more ▼]

The modification of aliphatic polyesters by the copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) was successfully implemented in supercritical carbon dioxide (scCO2). Due to the remarkable properties of scCO2, the CuAAC reaction turned out to be quantitative even though the aliphatic polyesters used in this work were insoluble in scCO2. Interestingly enough, the conditions were mild enough to prevent polymer degradation from occurring and finally, efficient removal of the catalyst (>96%) was achieved by scCO2 extraction. [less ▲]

Detailed reference viewed: 113 (35 ULg)