References of "Lancellotti, Patrizio"
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See detailClinical outcome in asymptomatic severe aortic stenosis: Insights from the new proposed aortic stenosis grading classification
Lancellotti, Patrizio ULg; Magne, Julien ULg; Donal, E. et al

in Journal of the American College of Cardiology (2012), 59(3), 235-243

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See detailEAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography.
Lang, Roberto M.; Badano, Luigi P.; Tsang, Wendy et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2012), 25(1), 3-46

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See detailHeart rate and use of beta-blockers in stable outpatients with coronary artery disease.
Steg, Ph Gabriel; Ferrari, Roberto; Ford, Ian et al

in PLoS ONE (2012), 7(5), 36284

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta ... [more ▼]

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. The goal of the present analysis was to describe HR in such patients, overall and in relation to beta-blocker use, and to describe the determinants of HR. METHODS AND FINDINGS: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis of >50%, or chest pain associated with proven myocardial ischemia. A total of 33,438 patients from 45 countries in Europe, the Americas, Africa, Middle East, and Asia/Pacific were enrolled between November 2009 and July 2010. Most of the 33,177 patients included in this analysis were men (77.5%). Mean (SD) age was 64.2 (10.5) years, HR by pulse was 68.3 (10.6) bpm, and by electrocardiogram was 67.2 (11.4) bpm. Overall, 44.0% had HR >/= 70 bpm. Beta-blockers were used in 75.1% of patients and another 14.4% had intolerance or contraindications to beta-blocker therapy. Among 24,910 patients on beta-blockers, 41.1% had HR >/= 70 bpm. HR >/= 70 bpm was independently associated with higher prevalence and severity of angina, more frequent evidence of myocardial ischemia, and lack of use of HR-lowering agents. CONCLUSIONS: Despite a high rate of use of beta-blockers, stable CAD patients often have resting HR >/= 70 bpm, which was associated with an overall worse health status, more frequent angina and ischemia. Further HR lowering is possible in many patients with CAD. Whether it will improve symptoms and outcomes is being tested. [less ▲]

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See detailPrasugrel versus clopidogrel for acute coronary syndromes without revascularization.
Roe, Matthew T.; Armstrong, Paul W.; Fox, Keith A. A. et al

in New England Journal of Medicine [=NEJM] (2012), 367(14), 1297-309

BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been ... [more ▼]

BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel [less ▲]

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See detailL'atherosclerose: une maladie complexe.
Kulbertus, Henri ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(5-6), 273-8

Atherosclerosis is a complex disease resulting from an interaction between environmental risk factors (diet, smoking habit, lack of exercise, stress) and a favourable genetic profile. In the recent past ... [more ▼]

Atherosclerosis is a complex disease resulting from an interaction between environmental risk factors (diet, smoking habit, lack of exercise, stress) and a favourable genetic profile. In the recent past, the analysis of the genetic factors involved has considerably progressed. A significant number of genetic variants associated with the various phenotypes of atherosclerosis or its risk factors have been identified. Each, taken individually, only exerts a modest influence, but as a group, they play a significant role, albeit as yet not precisely quantified, in the aetiology of atherosclerosis. The individual response to various therapies prescribed in atherosclerosis can also be significantly influenced by genetic factors. In the next future, genetics and pharmacogenetics will represent major determinants of our approach to the prevention and individualized treatment of atherosclerosis and its complications. [less ▲]

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See detailTicagrelor (brilique"): puissant antagoniste oral de l'activite plaquettaire.
LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(9), 485-91

Dual antiplatelet therapy with clopidogrel combined with aspirin reduces ischemic events in acute coronary syndromes (ACS). The individual response to clopidogrel is, however, very variable from one ... [more ▼]

Dual antiplatelet therapy with clopidogrel combined with aspirin reduces ischemic events in acute coronary syndromes (ACS). The individual response to clopidogrel is, however, very variable from one subject to another, and the risk of events seems higher when platelet inhibition is insufficient. Ticagrelor is a potent oral inhibitor of platelet activity. It binds reversibly to the P2Y12 adenosine diphosphate. The platelet inhibition that it induces is faster and more pronounced than that of clopidogrel. In patients who have an ACS (PLATO study) with or without ST-segment elevation, treatment with ticagrelor as compared with clopidogrel significantly reduced the rate of death from vascular causes, myocardial infarction, or stroke, without an increase in the rate of overall major bleeding but with an increase in the rate of non-procedure-related bleeding. In Belgium, Brilique is currently indicated in combination with aspirin for the prevention of atherothrombotic events in patients with ACS. [less ▲]

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See detailThe quest for evidence "Beauty is truth, truth beauty"--that is all ye know on earth, and all ye need to know.
Ector, Hugo; LANCELLOTTI, Patrizio ULg

in Acta Cardiologica (2012), 67(1), 1-2

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See detailRecurrent stress cardiomyopathy with variable pattern of left ventricle contraction abnormality.
Gach, Olivier; Lempereur, Mathieu; Pierard, Luc ULg et al

in Journal of the American College of Cardiology (2012), 60(3), 5

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See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 1: valvulopathies et anticoagulation.
Legrand, D.; Moonen, Marie ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(9), 452-7

In this article, we describe the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of valvular heart disease and ... [more ▼]

In this article, we describe the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of valvular heart disease and anticoagulation.We will also describe cardiologic conditions in which pregnancy is contraindicated and the preferred way of delivery. [less ▲]

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See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 2: Prise en charge de l'hypertension arterielle.
Moonen, Marie ULg; Legrand, D.; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(10), 509-12

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders ... [more ▼]

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders are the most frequent cardiovascular complications in pregnancy. [less ▲]

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See detailRecommandations Europeennes 2011 pour le diagnostic et le traitement des arteriopathies peripheriques.
Brogneaux, C.; Sprynger, M.; Magnee, M. et al

in Revue Médicale de Liège (2012), 67(11), 560-5

In this article, we present the 2011 guidelines on the diagnosis and treatment of peripheral artery diseases. The document covers the diagnostic modalities and therapeutic strategies for the ... [more ▼]

In this article, we present the 2011 guidelines on the diagnosis and treatment of peripheral artery diseases. The document covers the diagnostic modalities and therapeutic strategies for the atherosclerotic disease of the extra-cranial carotid, mesenteric, renal, upper and lower extremity arteries indicating the class and level of evidence of the recommendations. [less ▲]

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See detailEAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography.
Lang, Roberto M.; Badano, Luigi P.; Tsang, Wendy et al

in European Heart Journal - Cardiovascular Imaging (2012), 13(1), 1-46

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See detailEuroEcho and other imaging modalities: highlights.
LANCELLOTTI, Patrizio ULg; Pierard, Luc ULg; Voigt, Jens-Uwe et al

in European Heart Journal - Cardiovascular Imaging (2012), 13(2), 127-31

The annual meeting of the European Association of Echocardiography (EuroEcho and other Imaging Modalities) was held in Budapest, Hungary. In the present paper, we present a summary of the 'Highlights ... [more ▼]

The annual meeting of the European Association of Echocardiography (EuroEcho and other Imaging Modalities) was held in Budapest, Hungary. In the present paper, we present a summary of the 'Highlights' session. [less ▲]

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See detailRecommandations Europeennes 2011 pour la prise en charge du syndrome coronarien aigu sans elevation du segment ST (Partie 2). Revascularisation coronaire: indications.
Lempereur, M.; Moonen, Marie ULg; Gach, O. et al

in Revue Médicale de Liège (2012), 67(1), 8-10

New European guidelines about the management of non-ST elevated acute coronary syndromes emphasize the importance of early risk stratification. This article summarizes the modifications in the guidelines ... [more ▼]

New European guidelines about the management of non-ST elevated acute coronary syndromes emphasize the importance of early risk stratification. This article summarizes the modifications in the guidelines about risk stratification and invasive management of these syndromes. [less ▲]

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See detailMitral valve annuloplasty and papillary muscle relocation oriented by 3-dimensional transesophageal echocardiography for severe functional mitral regurgitation.
Fattouch, Khalil; Murana, Giacomo; Castrovinci, Sebastiano et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2012), 143(4 Suppl), 38-42

OBJECTIVE: The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To ... [more ▼]

OBJECTIVE: The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE). To plan mitral valve repair by annuloplasty and papillary muscle (PPM) relocation, we proposed a valve repair procedure oriented by the new main features obtained by real-time 3D TOE reconstruction of the mitral valve apparatus. METHODS: Since January 2008, 25 patients with severe FMR before mitral valve repair were examined. Mean coaptation depth and mean tenting area were 1.3 +/- 0.2 cm and 3.2 +/- 0.5 cm(2), respectively. Intraoperative 2D and 3D TOE were performed, followed by a 3D offline reconstruction of the mitral valve apparatus. A schematic mitral valve apparatus model was obtained. A geometric model like a truncated cone was traced in according to the preoperative measurements. The size of the prosthetic ring was selected preoperatively according to the anterior leaflet surface. The expected truncated cone after annuloplasty was retraced. A conventional normal coaptation depth about 0.6 cm was used to detect the new position of the PPM tips. RESULTS: Offline reconstruction of the mitral valve apparatus and respective truncated cone were feasible in all patients. The expected position of the PPM tips desirable to reach a normal tenting area with a coaptation depth 0.6 cm or less was obtained in all patients. After surgery, all parameters were calculated and no statistically significant difference was found compared with the expected data. CONCLUSIONS: PPM relocation plus ring annuloplasty reduce mitral valve tenting and may improve mitral valve repair results for patients with severe FMR. This technique may be easily and precisely guided by preoperative offline 3D echocardiographic mitral valve reconstruction. [less ▲]

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See detailRisk stratification in asymptomatic aortic stenosis
Dulgheru, R.; Weisz, S. H.; Magne, Julien ULg et al

in European Cardiology (2012), 8(2), 120-124

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See detailPrognostic importance of exercise brain natriuretic peptide in asymptomatic degenerative mitral regurgitation
Magne, Julien ULg; Mahjoub, H.; Pibarot, P. et al

in European Journal of Heart Failure (2012), 14(11), 1293-1302

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See detailThe importance of exercise echocardiography for clinical decision making in primary mitral regurgitation
Van De Heyning, C. M.; Magne, Julien ULg; Lancellotti, Patrizio ULg et al

in Journal of Cardiovascular Medicine (Hagerstown, Md.) (2012), 13(4), 260-265

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See detailThe role of multi-imaging modality in primary mitral regurgitation
Van de Heyning, C.; Magne, Julien ULg; Vrints, C. et al

in European Journal of Echocardiography (2012), 13(2), 139-151

Primary mitral regurgitation (MR) is the first cause of valvular regurgitation in Western countries. Echocardiography is the cornerstone for diagnosing MR and more specifically for establishing its ... [more ▼]

Primary mitral regurgitation (MR) is the first cause of valvular regurgitation in Western countries. Echocardiography is the cornerstone for diagnosing MR and more specifically for establishing its aetiology and mechanism, for quantifying its severity, progression, and repercussion and for assessing the likelihood of successful of valve repair. Two-dimensional/three-dimensional transthoracic and transoesophageal echocardiography <br />are the most widely used methods. Interest is growing for exercise echocardiography particularly in patients in whom symptoms do not correlate well with MR severity and for risk stratification. The experience of multi-slice computed tomography in primary MR is still limited. Conversely, cardiovascular magnetic resonance has gained progressive relevance and represents the alternative method of choice. [less ▲]

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