References of "Lancellotti, Patrizio"
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See detailThe role of stress testing in evaluation of asymptomatic patients with aortic stenosis.
Lancellotti, Patrizio ULg; Magne, Julien ULg; Pierard, Luc ULg

in Current opinion in cardiology (2013), 28(5), 531-9

PURPOSE OF REVIEW: The emerging role of exercise and especially exercise echocardiography in aortic stenosis has been recently emphasized. In this clinical setting, stress testing can help identify ... [more ▼]

PURPOSE OF REVIEW: The emerging role of exercise and especially exercise echocardiography in aortic stenosis has been recently emphasized. In this clinical setting, stress testing can help identify patients who are falsely asymptomatic, unmask those who will rapidly become symptomatic and appraise the true haemodynamic consequences of aortic stenosis. RECENT FINDINGS: Both exercise stress test and exercise stress echocardiography are strictly contraindicated in symptomatic patients. In contrast, exercise testing is recommended by current guidelines in asymptomatic patients with aortic stenosis. During exercise, either the development of symptoms or an abnormal blood pressure response is associated with a poor outcome and should be considered as an indication for surgery. Exercise echocardiography permits stratification and identification of asymptomatic patients at a higher risk of a cardiac event: exercise-induced increase of more than 18-20 mmHg in mean pressure gradient, absence of left ventricular contractile reserve and/or exercise pulmonary hypertension are suggestive features of an advanced disease process. SUMMARY: Exercise echocardiography has the advantage of its wide availability, low cost and versatility. In asymptomatic severe aortic stenosis, exercise echocardiography can help unmask patients at a more advanced stage of the disease and could aid in identifying those who may benefit from an early elective aortic valve surgery. [less ▲]

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See detailStress echocardiography in regurgitant valve disease.
Lancellotti, Patrizio ULg; Magne, Julien ULg

in Circulation. Cardiovascular imaging (2013), 6(5), 840-9

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See detailEuroEcho and other imaging modalities: highlights.
Lancellotti, Patrizio ULg; Magne, Julien ULg; Sicari, Rosa et al

in European heart journal cardiovascular Imaging (2013), 14(3), 195-200

The annual meeting of the European Association of Echocardiography (Euroecho and other Imaging Modalities) was held in Athens, Greece. In the present paper, we present a summary of the 'Highlights ... [more ▼]

The annual meeting of the European Association of Echocardiography (Euroecho and other Imaging Modalities) was held in Athens, Greece. In the present paper, we present a summary of the 'Highlights' session. [less ▲]

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See detailL'image du mois. La sequestration pulmonaire.
Delcour, A.; Peters, J.-L.; Lancellotti, Patrizio ULg

in Revue médicale de Liège (2013), 68(9), 433-5

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See detailThe role of statin treatment in valvular heart disease: is the jury still out?
Antonini-Canterin, Francesco; Mateescu, Anca D.; Nicolosi, Gian Luigi et al

in Acta cardiologica (2013), 68(4), 403-11

Valvular heart disease (VHD) represents a significant burden within the spectrum of cardiovascular diseases. In recent years, there has been a great interest in finding medical treatments able to slow the ... [more ▼]

Valvular heart disease (VHD) represents a significant burden within the spectrum of cardiovascular diseases. In recent years, there has been a great interest in finding medical treatments able to slow the progression ofVHD. The negative results of several large randomized trials failing to demonstrate a benefit of such therapies, has led to a decrease of interest in this field. However, finding a medical treatment capable of preventing VHD progression is still a hot topic, due to the important clinical implications. We believe that the jury is still out on the debate about the role of statin therapy in VHD, considering also recently published studies providing new information with future implications for the treatment of this disease process. This article gives an overview of the published evidence about the role of hydroxymethylglutaryl coenzyme-A reductase inhibitors on delaying progressive valve dysfunction. A preventive therapy, which could influence not only the haemodynamic progression of valve disease, but also the cardiovascular outcome, is warranted. Large, prospective, randomized trials are needed to properly evaluate the role of statins in the early stages of valvular heart disease. [less ▲]

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See detailLinee guida per il trattamento delle valvulopatie (versione 2012). Task Force congiunta per il Trattamento delle Valvulopatie della Societa Europea di Cardiologia (ESC) e dell'Associazione Europea di Chirurgia Cardiotoracica (EACTS).
Vahanian, Alec; Alfieri, Ottavio; Andreotti, Felicita et al

in Giornale Italiano di Cardiologia (2006) (2013), 14(3), 167-214

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See detailAssessment of left ventricular volumes and primary mitral regurgitation severity by 2D echocardiography and cardiovascular magnetic resonance.
Van De Heyning, Caroline M.; Magne, Julien ULg; Pierard, Luc ULg et al

in Cardiovascular ultrasound (2013), 11

BACKGROUND: Two-dimensional transthoracic echocardiography (2DTTE) remains the first-line diagnostic imaging tool to assess primary mitral regurgitation although cardiovascular magnetic resonance (CMR ... [more ▼]

BACKGROUND: Two-dimensional transthoracic echocardiography (2DTTE) remains the first-line diagnostic imaging tool to assess primary mitral regurgitation although cardiovascular magnetic resonance (CMR) has proven to establish left ventricular function more accurately and might evaluate mitral regurgitation severity more reliably. We sought to compare routine evaluation of left ventricular function and mitral regurgitation severity by 2DTTE with assessment by CMR in moderate to severe primary mitral regurgitation without overt left ventricular dysfunction. METHODS: We prospectively included 38 patients (79% of male, age 57 +/- 14 years) with at least moderate primary mitral regurgitation, a left ventricular ejection fraction >/=60% and a left ventricular end-systolic diameter </=45 mm. Patients with evidence of coronary artery disease, arrhythmias or significant concomitant valvular disease were excluded. All patients were scheduled for 2DTTE and CMR. RESULTS: Left ventricular end-diastolic and end-systolic volumes were significantly underestimated by 2DTTE in comparison with CMR, although there was a strong correlation (Pearson r = 0.81, p < 0.00001 and r = 0.7, p < 0.00001, respectively). Measurement of the regurgitant orifice was similar between 2DTTE PISA method and planimetry by CMR (47 +/- 24 vs. 42 +/- 16 mm2, p = 0.12) with a strong correlation between both imaging techniques (Pearson r = 0.76, p < 0.0001). By contrast, assessment of the regurgitant volume by 2DTTE and by phase contrast velocity mapping by CMR showed poor agreement. CONCLUSIONS: In moderate to severe primary mitral regurgitation without overt left ventricular dysfunction, 2DTTE significantly underestimates left ventricular remodelling in comparison to CMR. Measurement of the regurgitant orifice with planimetry by CMR shows good agreement with the PISA method by 2DTTE and thus may be a valuable alternative to assess mitral regurgitation severity. [less ▲]

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See detailPrognostic value of low-dose dobutamine stress echocardiography in patients with aortic stenosis and impaired left ventricular function.
Plonska-Gosciniak, Edyta; Lipiec, Piotr; LANCELLOTTI, Patrizio ULg et al

in Archives of Medical Science (2013), 9(3), 434-9

INTRODUCTION: The aim of this multicenter, prospective study was to evaluate the long-term prognostic value of low-dose dobutamine stress echocardiography (LDDSE) in patients with aortic stenosis (AS) and ... [more ▼]

INTRODUCTION: The aim of this multicenter, prospective study was to evaluate the long-term prognostic value of low-dose dobutamine stress echocardiography (LDDSE) in patients with aortic stenosis (AS) and depressed left ventricular (LV) function. MATERIAL AND METHODS: The study group comprised 39 patients (34 male, mean age 59 +/-13 years) with AS (peak gradient > 25 mm Hg), LV ejection fraction (LVEF) </= 45% and low transaortic gradient (peak gradient </= 45 mm Hg, mean gradient </= 35 mm Hg). The qualification for subsequent therapeutic procedures was based on generally accepted indications. All patients underwent LDDSE and coronary angiography. Twelve months after LDDSE patients underwent control resting echocardiography and clinical evaluation. RESULTS: Twenty-seven (69.2%) patients had preserved contractile reserve. In this subgroup, true-severe AS was diagnosed in 12 patients, whereas pseudo-severe AS was found in 15 patients. Nine patients with true-severe AS, 2 patients with pseudo-severe AS and 7 patients without contractile reserve were referred for surgical treatment. The independent risk factors of death during follow-up were: aortic valve area (AVA) at peak stress < 0.8 cm(2) (OR 1.4; p = 0.003) and LVEF at rest < 35% (OR 6.8; p = 0.05). The independent risk factors of composite end-point (death or myocardial infarctions or pulmonary edema) were: AVA at stress < 0.8 cm(2) (OR 4.0; p = 0.03), absence of AVA increase during LDDSE (OR 5.7; p = 0.005), absence of contractile reserve (OR 4.5; p = 0.01) and presence of significant CAD (OR 6.9; p = 0.02). CONCLUSIONS: In patients with AS and depressed LVEF, LDDSE is a useful tool for long-term risk stratification. [less ▲]

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See detailGrupo de Trabajo para el manejo del infarto agudo de miocardio con elevacion del segmento ST de la Sociedad Europea de Cardiologia (ESC).
Steg, Gabriel; James, Stefan K.; Atar, Dan et al

in Revista Espanola de Cardiologia (2013), 66(1), 531-5346

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See detailUpdate of the Echocardiography Core Syllabus of the European Association of Cardiovascular Imaging (EACVI).
Cosyns, Bernard; Garbi, Madalina; Separovic, Jadranka et al

in European Heart Journal - Cardiovascular Imaging (2013), 14(9), 837-9

The update of the Echocardiography Core Syllabus of European Association of Cardiovascular Imaging (EACVI) is now available online. The Echocardiography Core Syllabus enumerates the elements of knowledge ... [more ▼]

The update of the Echocardiography Core Syllabus of European Association of Cardiovascular Imaging (EACVI) is now available online. The Echocardiography Core Syllabus enumerates the elements of knowledge to be taught, represents a framework for the development of local training curricula and provides expected learning outcomes to the echocardiography learner. [less ▲]

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See detailIntracardiac flow visualization: current status and future directions.
Rodriguez Munoz, Daniel; Markl, Michael; Moya Mur, Jose Luis et al

in European Heart Journal - Cardiovascular Imaging (2013)

Non-invasive cardiovascular imaging initially focused on heart structures, allowing the visualization of their motion and inferring its functional status from it. Colour-Doppler and cardiac magnetic ... [more ▼]

Non-invasive cardiovascular imaging initially focused on heart structures, allowing the visualization of their motion and inferring its functional status from it. Colour-Doppler and cardiac magnetic resonance (CMR) have allowed a visual approach to intracardiac flow behaviour, as well as measuring its velocity at single selected spots. Recently, the application of new technologies to medical use and, particularly, to cardiology has allowed, through different algorithms in CMR and applications of ultrasound-related techniques, the description and analysis of flow behaviour in all points and directions of the selected region, creating the opportunity to incorporate new data reflecting cardiac performance to cardiovascular imaging. The following review provides an overview of the currently available imaging techniques that enable flow visualization, as well as its present and future applications based on the available literature and on-going works. [less ▲]

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See detail2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology.
Montalescot, Gilles; Sechtem, Udo; Achenbach, Stephan et al

in European heart journal (2013), 34(38), 2949-3003

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See detailWytyczne ESC dotyczace cukrzycy, stanu przedcukrzycowego i chorob ukladu sercowo-naczyniowego opracowane we wspolpracy z EASD.
Ryden, Lars; Grant, Peter J.; Anker, Stefan D. et al

in Kardiologia polska (2013), 71 Suppl 11

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See detailL'imagerie cardiovasculaire multimodalites avant l'implantation d'une prothese valvulaire aortique par voie percutanee.
DAVIN, Laurent ULg; BRUYERE, Pierre-Julien ULg; LANCELLOTTI, Patrizio ULg et al

in Revue Médicale de Liège (2013), 68(2), 86-93

Calcified aortic valve stenosis is the most frequent valvular heart disease in developed countries with a very poor outcome when symptoms develop. However, several of these patients are denied for surgery ... [more ▼]

Calcified aortic valve stenosis is the most frequent valvular heart disease in developed countries with a very poor outcome when symptoms develop. However, several of these patients are denied for surgery. The main reasons are their advanced age (elderly patient), co-morbidities, technical limitations and a very high surgical risk. It is currently possible to propose a Transcatheter Aortic Valve Implantation (TAVI). After selection of candidates, the feasibility of the intervention is analysed. The size of the aortic bioprosthesis must be selected according to the cardiac anatomy. Several cardiac imaging modalities (echocardiography, computed tomography and cardiac MRI) can be used to identify unsuitable situations. Heavy calcifications or tortuosity can thwart the retrograde approach use. The sub-clavian arteries (for the CoreValve) and trans-apical approach (for the Edwards-Sapien) constitute alternatives ways. [less ▲]

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See detailExpert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.
LANCELLOTTI, Patrizio ULg; Nkomo, Vuyisile T.; Badano, Luigi P. et al

in European Heart Journal - Cardiovascular Imaging (2013), 14(8), 721-40

Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality ... [more ▼]

Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors. A comprehensive review of potential cardiac complications related to radiotherapy is warranted. An evidence-based review of several imaging approaches used to detect, evaluate, and monitor RIHD is discussed. Recommendations for the early identification and monitoring of cardiovascular complications of radiotherapy by cardiac imaging are also proposed. [less ▲]

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See detailSubacute Transcatheter CoreValve Thrombotic Obstruction.
LANCELLOTTI, Patrizio ULg; Radermecker, Marc ULg; Weisz, Sara H et al

in Circulation: Cardiovascular Interventions (2013), 6(3), 32-3

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See detailStress echocardiography and mitral valvular heart disease.
Magne, Julien ULg; LANCELLOTTI, Patrizio ULg; Pierard, Luc ULg

in Cardiology Clinics (2013), 31(2), 311-21

The European Society of Cardiology's updated guidelines emphasize the usefulness of exercise stress echocardiography in patients with valvular heart disease. Exercise-induced changes in valve hemodynamics ... [more ▼]

The European Society of Cardiology's updated guidelines emphasize the usefulness of exercise stress echocardiography in patients with valvular heart disease. Exercise-induced changes in valve hemodynamics should be assessed in patients with mitral valve disease. In asymptomatic patients with moderate or severe mitral regurgitation without left ventricular dysfunction/dilatation, exercise stress echocardiography may identify a subset of patients with reduced cardiac event-free survival who are at a higher risk of developing symptoms. In patients with mitral stenosis who are asymptomatic, the development of symptoms during exercise is strongly related to the kinetics of the changes in the systolic pulmonary arterial pressure. [less ▲]

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See detailLe cas clinique du mois. Le tetanos existe toujours !
Legrand, D.; Delcour, A.; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2013), 68(4), 157-9

We report the dramatic story of a 81 year old patient admitted to the intensive care unit following the development of tetanus. This man, perfectly autonomous, used to workin his garden without anti ... [more ▼]

We report the dramatic story of a 81 year old patient admitted to the intensive care unit following the development of tetanus. This man, perfectly autonomous, used to workin his garden without anti-tetanus immunization coverage. In this article, we report the therapeutic management of tetanus. We emphasize the importance of vaccination which permits to avoid the disease, the mortality and morbidity of which remain high. [less ▲]

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