References of "Lancellotti, Patrizio"
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See detailThe Dual Role of Neutrophils in Inflammatory Bowel Diseases
Wéra, Odile ULiege; Lancellotti, Patrizio ULiege; Oury, Cécile ULiege

in Journal of clinical medicine (2016), 5(12),

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration ... [more ▼]

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration. These two diseases are considered distinct entities, and there is some evidence that neutrophil behaviour, above all other aspects of immunity, clearly separate them. Neutrophils are the first immune cells recruited to the site of inflammation, and their action is crucial to limit invasion by microorganisms. Furthermore, they play an essential role in proper resolution of inflammation. When these processes are not tightly regulated, they can trigger positive feedback amplification loops that promote neutrophil activation, leading to significant tissue damage and evolution toward chronic disease. Defective chemotaxis, as observed in Crohn's disease, can also contribute to the disease through impaired microbe elimination. In addition, through NET production, neutrophils may be involved in thrombo-embolic events frequently observed in IBD patients. While the role of neutrophils has been studied in different animal models of IBD for many years, their contribution to the pathogenesis of IBD remains poorly understood, and no molecules targeting neutrophils are used and validated for the treatment of these pathologies. Therefore, it is crucial to improve our understanding of their mode of action in these particular conditions in order to provide new therapeutic avenues for IBD. [less ▲]

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See detailP2X1 ion channel is critical for vascular integrity in inflammation
Wéra, Odile ULiege; Delierneux, Céline; Servais, Laurence ULiege et al

Poster (2016, November)

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See detailProspective, long-term study of the effect of cabergoline on valvular status in patients with prolactinoma and idiopathic hyperprolactinemia.
VROONEN, Laurent ULiege; Lancellotti, Patrizio ULiege; Garcia, Monica Tome et al

in Endocrine (2016)

Since the 1990's cabergoline has been the treatment of choice in prolactinoma, as it permits rapid and effective hormonal and tumor control in most cases. Evidence of cardiac valvulopathy was demonstrated ... [more ▼]

Since the 1990's cabergoline has been the treatment of choice in prolactinoma, as it permits rapid and effective hormonal and tumor control in most cases. Evidence of cardiac valvulopathy was demonstrated in Parkinson's disease patients treated with dopamine agonists. Retrospective studies in prolactinoma patients treated with cabergoline at lower doses did not show such an effect. However, few prospective data with long-term follow-up are available. The aim of this study was to assess the safety of cabergoline regarding cardiac valvular status during prospective follow-up in patients treated for prolactinoma or idiopathic hyperprolactinemia. We report here a series of 100 patients (71F; median age at diagnosis: 41.5 years) treated with cabergoline for endocrine diseases (prolactinoma n = 89, idiopathic hyperprolactinemia n = 11). All patients underwent complete transthoracic echocardiographic studies at baseline and during long-term prospective surveillance using the same equipment and performed by the same technicians. The median interval between baseline and last follow-up echocardiographic studies while on cabergoline was 62.5 months (interquartile range: 34.75-77.0). The median total duration of cabergoline treatment was 124.5 months (interquartile range: 80.75-188.75) and the median cumulative total dose of cabergoline was 277.8 mg (interquartile range : 121.4-437.8 mg) at last follow-up. We found no clinically relevant alterations in cardiac valve function or valvular calcifications with cabergoline treatment. Our data suggest that findings from retrospective analyses are correct and that cabergoline is a safe chronic treatment at the doses used typically in endocrinology. [less ▲]

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See detailQuantitative Three-Dimensional Color Flow Echocardiography of Chronic Mitral Regurgitation: New Methods, New Perspectives, New Challenges
zhou, x; vannan, m; LANCELLOTTI, Patrizio ULiege

in Journal of the American Society of Echocardiography (2016), 29(10), 935-937

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See detailP2X1 ion channel is critical for vascular integrity in inflammation
Wéra, Odile ULiege; Delierneux, Céline; Hego, Alexandre ULiege et al

Conference (2016, September)

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See detailHeart Team Liege - Session Video Link
PIERARD, Luc ULiege; vahanian, Alec; LANCELLOTTI, Patrizio ULiege et al

Conference (2016, September)

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See detailHeart Team Session
PIERARD, Luc ULiege; LANCELLOTTI, Patrizio ULiege; PETERMANS, Jean ULiege et al

Conference (2016, August)

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See detail2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, Massimo F.; Hoes, Arno W.; Agewall, Stefan et al

in European Heart Journal (2016), 37(29), 2315-2381

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See detail2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, Piotr; Voors, Adriaan A.; Anker, Stefan D. et al

in European Journal of Heart Failure (2016), 18(8), 891-975

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See detailRecommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
Nagueh, Sherif F.; Smiseth, Otto A.; Appleton, Christopher P. et al

in European Heart Journal - Cardiovascular Imaging (2016)

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See detailPulmonary pressures and outcome in primary mitral regurgitation. Paradigm shift from Rung to Ladder
LANCELLOTTI, Patrizio ULiege; MARTINEZ, Christophe ULiege; Bernard, Alice ULiege

in Journal of the American College of Cardiology (2016), 67(25), 2962-2964

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See detail2015 ESC Guidelines on the management of infective endocarditis: a big step forward for an old disease.
Habib, Gilbert; Lancellotti, Patrizio ULiege; Iung, Bernard

in Heart (British Cardiac Society) (2016), 102(13), 992-4

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See detailTricuspid Annular Size and Regurgitation Progression After Surgical Repair for Degenerative Mitral Regurgitation.
Sordelli, Chiara; Lancellotti, Patrizio ULiege; Carlomagno, Guido et al

in American Journal of Cardiology (2016)

The late worsening of nonsevere tricuspid regurgitation (TR) after mitral valve surgery is a relevant clinical problem that can lead to high-risk reoperation. Although tricuspid annulus (TA) dilatation ... [more ▼]

The late worsening of nonsevere tricuspid regurgitation (TR) after mitral valve surgery is a relevant clinical problem that can lead to high-risk reoperation. Although tricuspid annulus (TA) dilatation has been proposed for prophylactic annuloplasty to prevent TR worsening, prospective data in degenerative mitral regurgitation (MR) are lacking. The aim of this prospective cohort study was to evaluate TA dimension to predict TR progression after valve repair for degenerative MR. Clinical and echocardiographic evaluation of 706 patients with degenerative MR and no significant TR was obtained preoperatively and at follow-up after isolated mitral valve repair. Together with standard cardiac chamber and valve analysis, 3-dimensional (3D) transesophageal echocardiography was performed to evaluate TA, including the anteroposterior and septolateral diameters. After a mean follow-up of 24 +/- 15 months (range 6 to 60), 2 patients died while 14 developed severe MR. Compared with preoperative values, TR decreased (</=1 degree) in 227 patients, was unchanged in 437, and increased (>/=1 degree) in 39 patients, with the development of significant TR (3 to 4 degree) in 3 patients. Receiver-operating characteristic curve analysis did not identify significant TA values predicting postoperative TR worsening. On multivariate regression analysis, recurrent MR and pulmonary hypertension at follow-up emerged as significant positive predictors of TR progression. Newly developed significant TR is a rare event after successful repair of degenerative MR. Although more accurate than conventional 2D measurement, 3D analysis of TA does not predict early to midterm subsequent TR progression. [less ▲]

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See detailJoint EACVI HIT/EAPCI young survey/ESC CoT survey: training and education for 'multimodality imaging in structural interventions': the rise of a new sub-specialty?
Grapsa, Julia; Kunadian, Vijay; Capodanno, Davide et al

in European Heart Journal - Cardiovascular Imaging (2016)

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See detailAortic Stenosis Grading and Outcome: New Categories, New Therapeutic Challenges.
Lancellotti, Patrizio ULiege; Davin, Laurent; Dulgheru, Raluca

in JACC. Cardiovascular Imaging (2016)

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See detailCriteria for recommendation and expert consensus papers: from the European Association of Cardiovascular Imaging Scientific Documents Committee.
Edvardsen, Thor; Cardim, Nuno; Cosyns, Bernard et al

in European Heart Journal - Cardiovascular Imaging (2016)

The recommendations given in this document are intended as a guide for the writing committees with the aim to harmonize the style and content of EACVI expert consensus and recommendation documents.

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See detailPulmonary Hypertension in Aortic Stenosis and Mitral Regurgitation: Rest and Exercise Echocardiography Significance.
Martinez, Christophe; Bernard, Anne; Dulgheru, Raluca et al

in Progress in Cardiovascular Diseases (2016), 59(1), 59-70

Valvular heart disease is a common cause of increased mean pulmonary artery pressure (PAP). Aortic stenosis and mitral regurgitation are frequently accompanied by pulmonary hypertension (PH), especially ... [more ▼]

Valvular heart disease is a common cause of increased mean pulmonary artery pressure (PAP). Aortic stenosis and mitral regurgitation are frequently accompanied by pulmonary hypertension (PH), especially when they are severe and symptomatic. In asymptomatic patients, PH is rare, though the exact prevalence is unknown and mainly stems from the severity of the valvular heart disease and the presence of diastolic dysfunction. Exercise echocardiography has recently gained interest in depicting PH. In these asymptomatic patients, exercise PH is observed in about >40%. Either PH at rest (systolic PAP >50 mmHg) or during exercise (systolic PAP >60 mmHg) is a powerful determinant of outcome and is independently associated with reduced survival, regardless of the severity of the underlying valvular pathology. [less ▲]

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