Synthesis, purification and kinetic properties of fluorescein-labelled penicillinsLakaye, Bernard ; Damblon, Christian ; et alin Biochemical Journal (1994), 300 Detailed reference viewed: 8 (1 ULg) A New, Highly Sensitive Method for the Detection and Quantification of Penicillin-Binding ProteinsGalleni, Moreno ; Lakaye, Bernard ; et alin Biochemical Journal (1993), 291((Pt 1)), 19-21 A new method for the identification and quantification of penicillin-binding proteins is described which uses fluorescein-coupled penicillins. It allows the rapid detection of 0.2 pmol with the naked eye ... [more ▼] A new method for the identification and quantification of penicillin-binding proteins is described which uses fluorescein-coupled penicillins. It allows the rapid detection of 0.2 pmol with the naked eye and 2 fmol with the help of an A.L.F. automatic DNA sequencer. Direct labelling can also be performed on whole bacterial cells. [less ▲] Detailed reference viewed: 23 (3 ULg) Cloning, Nucleotide Sequence and Amplified Expression of the Gene Encoding the Extracellular Metallo (Zn) Dd-Peptidase of Streptomyces Albus GDuez, Colette ; Lakaye, Bernard ; et alin FEMS Microbiology Letters (1990), 71(1-2), 215-219 The gene encoding the extracellular metallo (Zn) DD-peptidase of Streptomyces albus G has been cloned in Escherichia coli DH5 alpha MCR via pBR322 or 325, and then transferred into Streptomyces lividans ... [more ▼] The gene encoding the extracellular metallo (Zn) DD-peptidase of Streptomyces albus G has been cloned in Escherichia coli DH5 alpha MCR via pBR322 or 325, and then transferred into Streptomyces lividans TK24 via pIJ486, with substantial amplification of the expressed DD-peptidase. The gene has the information for the synthesis of a 255 amino acid precursor, the amino terminal region of which has the characteristic features of a signal peptide. The primary structure as deduced from nucleotide sequencing confirms that previously determined by chemical methods except for the occurrence of an Asp instead of Asn at position 1 and an additional Ala immediately downstream of Pro67. [less ▲] Detailed reference viewed: 6 (0 ULg) |
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