References of "LAMBERMONT, Bernard"
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See detailAlteration of Right Ventricular-Pulmonary Vascular Coupling in a Porcine Model of Progressive Pressure Overloading
Ghuysen, Alexandre ULg; Lambermont, Bernard ULg; Kolh, Philippe ULg et al

in Shock (Augusta, Ga.) (2008), 29(2), 197-204

In acute pulmonary embolism, right ventricular (RV) failure may result from exceeding myocardial contractile resources with respect to the state of vascular afterload. We investigated the adaptation of RV ... [more ▼]

In acute pulmonary embolism, right ventricular (RV) failure may result from exceeding myocardial contractile resources with respect to the state of vascular afterload. We investigated the adaptation of RV performance in a porcine model of progressive pulmonary embolism. Twelve anesthetized pigs were randomly divided into two groups: gradual pulmonary arterial pressure increases by three injections of autologous blood clot (n = 6) or sham-operated controls (n = 6). Right ventricular pressure-volume (PV) loops were recorded using a conductance catheter. Right ventricular contractility was estimated by the slope of the end-systolic PV relationship (Ees). Afterload was referred to as pulmonary arterial elastance (Ea) and assessed using a four-element Windkessel model. Right ventricular-arterial coupling (Ees/Ea) and efficiency of energy transfer (from PV area to external mechanical work [stroke work]) were assessed at baseline and every 30 min for 4 h. Eaincreased progressively after embolization, from 0.26 +/- 0.04 to 2.2 +/- 0.7 mmHg mL (P < 0.05). Ees increased from 1.01 +/-0.07 to 2.35 +/- 0.27 mmHg mL (P < 0.05) after the first two injections but failed to increase any further. As a result, Ees/Ea initially decreased to values associated with optimal SW, but the last injection was responsible for Ees/Ea values less than 1, decreased stroke volume, and RV dilation. Stroke work/PV area consistently decreased with each injection from 79% +/- 3% to 39% +/- 11% (P < 0.05). In response to gradual increases in afterload, RV contractility reserve was recruited to a point of optimal coupling but submaximal efficiency. Further afterload increases led to RV-vascular uncoupling and failure. [less ▲]

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See detailModel-based detection of pulmonary embolism using an extended physiologically relevant, cardiovascular model
Kok, K.; Starfinger, C.; Hann, C. E. et al

in Proceedings of Engineering & Physical Sciences in Medicine and Australian Biomedical Engineering Conference (EPSM ABEC 2008) (2008)

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See detailMaking sense of the Chaos: Model-based CVS monitoring and decision support in critical care
Shaw, G. M.; Chase, J. G.; Hann, C. E. et al

in Proceedings of the NZ Physiological Society 2008 Medical Science Congress (MedSci 2008) (2008)

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See detailModel-based analysis of induced endotoxic shock in pigs with and without hemofiltration,
Kok, K.; Starfinger, C.; Hann, C. E. et al

in Prodeedings of the Engineering & Physical Sciences in Medicine and Australian Biomedical Engineering Conference (EPSM ABEC 2008 (2008)

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See detailImproving model-based cardiac diagnosis with an ECG
Hann, C. E.; Chase, J. G.; Desaive, Thomas ULg et al

in Proceedings (CD) of the 4th European Congress for Medical and Biomedical Engineering (eMBEC 2008), Antwerp, Belgium, Nov 23-27, 2008 (2008)

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See detailModel-Based Assessment of Right Ventricular Arterial Coupling During Septic Shock – Results With a Porcine Model
Desaive, Thomas ULg; Lambermont, Bernard ULg; Janssen, N. et al

in Proceedings of the 21st European Society of Intensive Care Medicine (ESICM) Annual Congress, September 21-24, 2008, Lisbon, Portugal (2008)

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See detailAcetylcysteine and Enzymatic Creatinine: Beware of Laboratory Artefact!
Lognard, Michaël ULg; Cavalier, Etienne ULg; Chapelle, Jean-Paul ULg et al

in Intensive Care Medicine (2007)

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See detailLevosimendan: Right for the right ventricle?
Lambermont, Bernard ULg; Ghuysen, Alexandre ULg; Harstein, Gary et al

in Critical Care Medicine (2007), 35(8), 1995-1996

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See detailL'épuration extrarénale appliquée au patient hospitalisé aux soins intensifs
Delanaye, Pierre ULg; Dubois, Bernard ULg; Lambermont, Bernard ULg et al

in Néphrologie & Thérapeutique (2007), 3(4), 126-32

Mortality remains high in intensive care patients with renal failure requiring extra corporeal blood purification. This article reviews the recent data that have led to the improvement of the care for ... [more ▼]

Mortality remains high in intensive care patients with renal failure requiring extra corporeal blood purification. This article reviews the recent data that have led to the improvement of the care for such patients. We will discuss the criteria to determine the choice of the technique (intermittent or continuous), of the membrane, of the prescribing dose, and the type of anticoagulation and when to initiate such a treatment. [less ▲]

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See detailWhen the book is wrong
Leclercq, Philippe ULg; Betz, Romain ULg; Lambermont, Bernard ULg et al

in Lancet (2007), 369

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See detailCardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion
Lanoye, Lieve; Segers, Patrick; Tchana-Sato, Vincent ULg et al

in Experimental Physiology (2007), 92(1), 127-137

Although reperfusion after coronary occlusion is mandatory for myocardial salvage, reperfusion may trigger a cascade of harmful events (reperfusion injury) adding to myocardial injury. We investigated ... [more ▼]

Although reperfusion after coronary occlusion is mandatory for myocardial salvage, reperfusion may trigger a cascade of harmful events (reperfusion injury) adding to myocardial injury. We investigated effects of reperfusion on left ventricular (LV) haemodynamics and ventriculo-arterial (VA) coupling in pigs following acute myocardial ischaemia induced by coronary artery occlusion. Experiments were performed in six animals, with measurements of cardiac and arterial function at baseline, after 60 min of ischaemia (T60) and after 2 (T180) and 4 h of reperfusion (T300). Ventriculo-arterial coupling was assessed using the ventriculo-arterial elastance ratio of paper, as well as using a 'stiffness coupling' and 'temporal coupling' index. Reperfusion following ischaemia (T180 versus T60) induced a progressive decline in cardiovascular function, evidenced by a decrease in mean arterial blood pressure, cardiac output and ejection fraction which was not restored at T300. Although reperfusion also induced an increase in slope of the end-systolic pressure-volume relationship (ESPVR), the ESPVR curve shifted to the right, associated with a depression of contractile function. Histology demonstrated irreversible myocardial damage at T300. The ventriculo-arterial elastance ratio and the 'stiffness coupling' index were unaffected throughout the protocol, but the 'temporal coupling' parameter indicated a relative shift between heart period and the time constant of the arterial system. It is unlikely that these alterations are attributable to ischaemic injury alone. The combination of both the stiffness and temporal coupling index may provide more information when studying ventriculo-arterial coupling than the more commonly used ventricular end-systolic stiffness/effection arterial elastance (E-es/E-a) ratio. [less ▲]

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See detailFunctional residual capacity measurement as a guide during Peep titration in ARDS
Lambermont, Bernard ULg; Ghuysen, Alexandre ULg; MOMMENS, Véronique et al

in ESICM (2007)

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See detailAcetylcysteine and enzymatic creatinine: take care for interference!
Lognard, Michaël ULg; Cavalier, Etienne ULg; Chapelle, Jean-Paul ULg et al

in Acta Clinica Belgica (2007), 62(6), 462-462

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See detailStudy of ventricular interaction during pulmonary embolism using clinical identification in a minimum cardiovascular system model.
Desaive, Thomas ULg; Ghuysen, Alexandre ULg; Lambermont, Bernard ULg et al

in Proceedings of the IEEE (2007)

Cardiovascular disturbances are difficult to diagnose and treat because of the large range of possible underlying dysfunctions combined with regulatory reflex mechanisms that can result in conflicting ... [more ▼]

Cardiovascular disturbances are difficult to diagnose and treat because of the large range of possible underlying dysfunctions combined with regulatory reflex mechanisms that can result in conflicting clinical data. Thus, medical professionals often rely on experience and intuition to optimize hemodynamics in the critically ill. This paper combines an existing minimal cardiovascular system model with an extended integral based parameter identification method to track the evolution of induced pulmonary embolism in porcine data. The model accounts for ventricular interaction dynamics and is shown to predict an increase in the right ventricle expansion index and a decrease in septum volume consistent with known physiological response to pulmonary embolism. The full range of hemodynamic responses was captured with mean prediction errors of 4.1% in the pressures and 3.1% in the volumes for 6 sets of clinical data. Pulmonary resistance increased significantly with the onset of embolism in all cases, as expected, with the percentage increase ranging from 89.98% to 261.44% of the initial state. These results are an important first step towards model-based cardiac diagnosis in the Intensive Care Unit. [less ▲]

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See detailBeriberi
Moonen, Marie ULg; Lancellotti, Patrizio ULg; Betz, Romain ULg et al

in Revue Médicale de Liège (2007), 62(7-8), 523-530

We discuss here the case of a 49 years old man who is admitted in the emergency department in acute heart failure. He suffers of severe alcoholism and malnutrition. This heart failure is a high-output ... [more ▼]

We discuss here the case of a 49 years old man who is admitted in the emergency department in acute heart failure. He suffers of severe alcoholism and malnutrition. This heart failure is a high-output heart failure. The diagnosis is beriberi, a disease caused by a deficiency of thiamine (vitamin B1). The treatment is intravenous administration of thiamine. Clinical response is spectacular with normalization of the clinical setting within a few hours. [less ▲]

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See detailThe RIFLE criteria: are the foundations robust?
Delanaye, Pierre ULg; Krzesinski, Jean-Marie ULg; Cavalier, Etienne ULg et al

in Critical Care Medicine (2007), 35(11), 26692669-70

Detailed reference viewed: 31 (3 ULg)