References of "Krzesinski, Jean-Marie"
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See detailPlasma Na-K ATPase inhibitor activity and intracellular ions during hemodialysis
Krzesinski, Jean-Marie ULg; Du, F.; Pequeux, M. L. et al

in International Journal of Artificial Organs (1993), 16(1), 23-30

We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic ... [more ▼]

We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic controls (NC). As compared with the NC population, significantly enhanced values for erythrocyte (RBC) Na, Ca, platelet cytosolic Ca and EDLS were observed in all the uremic patients tested just before a dialysis session, as well as a decrease in RBC Ca ATPase and in the platelet pH. In uremia, significant correlations have been noted between RBC Na and platelet Ca (r = 0.6) or systolic BP (r = 0.45); between platelet Ca and systolic blood pressure (r = 0.8) or diastolic BP (r = 0.5) and between EDLS and RBC Na, Ca or platelet Ca (r = 0.5). Anti-hypertensive treatment has no influence on these parameters. During dialysis, a significant decrease has been noted in RBC Na, Ca, platelet Ca, SBP (only in untreated patients) and EDLS and an increase in RBC Ca ATPase and platelet pH. These modifications are significantly correlated with the weight change. [less ▲]

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See detailApport de la mesure ambulatoire de la pression artérielle dans une consultation d'hypertension artérielle
Saint-Remy, Annie ULg; Dubois, Bernard ULg; Krzesinski, Jean-Marie ULg et al

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (1993), 5(1), 6-13

La fréquence du syndrome de la blouse blanche, l'importance de la charge tensionnelle et de la variabilité de la pression artérielle au cours du nycthémère ont été analysées dans une population de 181 ... [more ▼]

La fréquence du syndrome de la blouse blanche, l'importance de la charge tensionnelle et de la variabilité de la pression artérielle au cours du nycthémère ont été analysées dans une population de 181 patients ayant bénéficié d'un enregistrement de la pression artérielle en ambulatoire pendant 24 heures. En dépit d'une bonne corrélation entre la mesure clinique de la pression artérielle et la pression moyenne de jour ou de 24 heures, on observe une discordance entre les niveaux de pression fournis par les deux méthodes (la pression clinique étant supérieure à la pression en ambulatoire et cela d'autant plus que la pression clinique est élevée). Lors de l'évaluation de l'efficacité du traitement antihypertenseur, l'analyse des tracés montre qu'un tiers des patients traités ont des pressions normalisées, alors que deux tiers d'entre eux conservent des pressions de jour et de 24 heures nettement supérieures aux critères définissant l'hypertension artérielle. Par ailleurs, cette étude souligne également la supériorité des valeurs de pression en ambulatoire (surtout la pression systolique) par rapport à la pression clinique comme prédicteur d'une hypertrophie ventriculaire gauche. Ces observations confirment l'intérêt de cette technique non invasive de mesure de la pression artérielle moyenne tant pour objectiver l'effet blouse blanche, et ainsi préciser le diagnostic d'une hypertension artérielle, que pour s'assurer du contrôle de la pression par les thérapeutiques antihypertensives. [less ▲]

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See detailRed Blood Cell Na-Li Countertransport, Hypertensive Heredity, and Cardiovascular Risk in Young Adults
Krzesinski, Jean-Marie ULg; Saint-Remy, Annie ULg; Du, F. et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (1993), 6(4), 314-316

The erythrocyte Na-Li countertransport (CT) has been considered as a marker of genetic propension to essential hypertension, but also to be linked to atherosclerosis risk factors. We have evaluated these ... [more ▼]

The erythrocyte Na-Li countertransport (CT) has been considered as a marker of genetic propension to essential hypertension, but also to be linked to atherosclerosis risk factors. We have evaluated these relationships by measuring the Na-Li CT, blood pressure levels, the family predisposition to hypertension, body mass index, subscapular skin-fold thickness, waist/hip ratio, and plasma lipids in 43 young adults (22 to 23 years; 13 with a positive family history of hypertension), followed since adolescence (+/- 10 years) to analyze the natural history of blood pressure in this period of life. The Na-Li CT was negatively correlated with the HDL cholesterol (r = -0.37) and the HDL cholesterol/total cholesterol ratio (r = -0.44). This transport system was positively correlated to family history of hypertension (r = 0.38), waist/hip ratio, and the diastolic blood pressure. When the family history of hypertension was present, Na-Li CT and diastolic blood pressure were higher (P < .05), but the HDL cholesterol was lower (P < .01). After separating people according to the blood pressure level during adolescence in two groups, one lower than the 75th percentile (P75), and one higher, we notice that the latter remains characterized by a higher systolic blood pressure. But neither the Na-Li CT nor family history of hypertension and plasma lipids could explain the difference in the blood pressure behavior during this period. Thus, an increase of RBC Na-Li CT activity in young adults would suggest a higher cardiovascular risk rather than to be a simple marker of a hypertensive risk. [less ▲]

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See detailBiometrical evaluation of the stratum corneum texture in patients under maintenane hemodialysis
Deleixhe-Mauhin, F.; Pierard, Claudine ULg; Krzesinski, Jean-Marie ULg et al

in Nephron (1993), 64

Xerosis and hydration of the stratum corneum were evaluated in 60 hemodialyzed patients. Xerosis and a low capacitance of the stratum corneum were evidenced in more than 80% of the patients. Pruritus was ... [more ▼]

Xerosis and hydration of the stratum corneum were evaluated in 60 hemodialyzed patients. Xerosis and a low capacitance of the stratum corneum were evidenced in more than 80% of the patients. Pruritus was present in two third of the subjects. We failed to disclose any significant relationship between severity of these three parameters. [less ▲]

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See detailImportance of Weight Loss and Sodium Restriction in the Treatment of Mild and Moderate Essential Hypertension
Krzesinski, Jean-Marie ULg; Janssens, Marion; Vanderspeeten, Francine et al

in Acta Clinica Belgica (1993), 48(4), 234-245

The effectiveness of non pharmacological treatment of chronic arterial hypertension has been evaluated in 116 treated or not primary hypertensive out-patients. Those receiving diuretics were however ... [more ▼]

The effectiveness of non pharmacological treatment of chronic arterial hypertension has been evaluated in 116 treated or not primary hypertensive out-patients. Those receiving diuretics were however excluded. This population was requested to follow for 3 months a modification of their usual diet characterized by salt restriction combined with energy intake restriction when the patients were above their ideal body weight. Only 62 patients (53%) completed the study. However, this approach was effective by decreasing blood pressure and total cholesterol. The weight loss appears the most effective way to decrease blood pressure in untreated patients, but needs 3 months to be significant. In drug-treated patients, the sodium restriction significantly influences the blood pressure level, already after 1 month. However, salt sensitivity has been noted, especially in the most severe forms of the hypertensive disease. The combination of both modifications (weight loss and sodium restriction) does not appear to be more effective than each separate dietary measure. [less ▲]

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See detailA sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties
Masereel, B.; Schynts, M.; Krzesinski, Jean-Marie ULg et al

in Journal of Pharmacy & Pharmacology (1993), 45

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé ... [more ▼]

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide. [less ▲]

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See detailL'hémofiltration continue
Krzesinski, Jean-Marie ULg; Theelen, Bernadette ULg

in Néphrologie, Dialyse et Transplantation (1993)

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See detailL'anticoagulation en hémodialyse
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Néphrologie, Dialyse et Transplantation (1993)

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See detailRelation between sodium balance and cellular calcium in hypertension
Krzesinski, Jean-Marie ULg; Pequeux, M. L.; Rorive, Georges ULg

in American Journal of Hypertension : Journal of the American Society of Hypertension (1993), 6

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See detailPlasma influence on cellular calcium (Ca IC) regulation in chronic renal failure (CRF) and essential hypertension
Krzesinski, Jean-Marie ULg; Pequeux, M. L.; Rorive, Georges ULg

in Abstract book of XII International Congress of Nephrology (1993)

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See detailSodium et hypertension artérielle essentielle. Nouveau refrain pour une vieille chanson
Krzesinski, Jean-Marie ULg

in L'Information Cardiologique (1993), 17(7), 299-304

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See detailNut van ambulante bloeddrukmeting bij arteriële hypertensie
Saint-Remy, Annie ULg; Dubois, Bernard ULg; Krzesinski, Jean-Marie ULg et al

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (1993), 1

De frequentie van het 'witte-jassen' syndroom en het belang van dit fenomeen op de bloeddrukbelasting en de variabiliteit van de arteriële bloeddruk over 24 uur werden bij 181 patiënten onderzocht ... [more ▼]

De frequentie van het 'witte-jassen' syndroom en het belang van dit fenomeen op de bloeddrukbelasting en de variabiliteit van de arteriële bloeddruk over 24 uur werden bij 181 patiënten onderzocht gedurende een 24 uur durende ambulante bloeddrukmeting. Ondanks een goede correlatie tussen de klinische meting van de arteriële bloeddruk en de gemiddelde bloeddruk overdag of gedurende 24 uur, is er toch een tegenstrijdigheid tussen de .bloeddrukwaarden die met beide methoden worden gemeten (de klinische bloeddruk is hoger dan de ambulant gemeten bloeddruk, des te meer naarmate de klinische bloeddruk hoger is). Bij de beoordeling van de werkzaamheid van antihypertensiva blijkt uit het beloop van de bloeddruk dat een derde van de behandelde patiënten normale bloeddrukwaarden heeft, terwijl bij twee derden van de patiënten de gemiddelde bloeddruk overdag en gedurende 24 uur duidelijk hoger is dan per definitie is toegestaan. Dit onderzoek toont ook aan dat de ambulant gemeten bloeddrukwaarden (vooral de systolische bloeddruk) een beter voorspellend vermogen voor linker-ventrikelhypertrofie hebben dan de klinisch gemeten bloeddrukwaarden. Deze waarnemingen bevestigen het belang van deze niet-invasieve techniek van meting van de gemiddelde bloeddruk, zowel om het 'witte-jassen' effect te objectiveren en aldus de diagnose arteriële hypertensie te preciseren, als om na te gaan of de bloeddruk met antihypertensiva goed is ingesteld. [less ▲]

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See detailQuantification of skin color in patients undergoing maintenance hemodialysis
Deleixhe-Mauhin, F.; Krzesinski, Jean-Marie ULg; Rorive, Georges ULg et al

in Journal of the American Academy of Dermatology (1992), 27(6), 950-953

Background: In patients undergoing long-term hemodialysis, a peculiar hyperpigmentation develops, the intensity of which may or may not be related to the duration of treatment and use of erythropoietin ... [more ▼]

Background: In patients undergoing long-term hemodialysis, a peculiar hyperpigmentation develops, the intensity of which may or may not be related to the duration of treatment and use of erythropoietin. Objective: Our purpose was to conduct a comparative cross-sectional study of white patients with distinct diseases that modify their skin color. Methods: A reflected-light colorimeter was used to compare the color of the forehead and forearms of 61 white patients receiving hemodialysis with that of matched controls and of patients with anemia or icterus. Results: Significant differences were found in both reflectance and chromaticity between these groups of patients. Duration of hemodialysis and use of erythropoietin did not significantly influence the colorimetric measurements. Conclusion: The use of a color-reflectance meter allows precise evaluation of subtle changes in skin color and may be used to monitor several diseases. [less ▲]

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See detailLow sodium diet in essential hypertension- Effect on blood cell ions and hemodynamic parameters
Krzesinski, Jean-Marie ULg; Du, Fenghe; Pequeux, Marie-Louise et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (1992), 5

The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight ... [more ▼]

The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight untreated essential hypertensive patients. A low salt diet decreases blood pressure, vascular resistances, erythrocyte sodium, and platelet calcium, but not platelet pH. A strong positive correlation was noted between baseline platelet calcium and vascular resistances (r=0.95, P < .01). But during the salt restriction period, a negative correlation has been observed between the changes in these parameters, which casts doubt on the use of the platelet as a mode of the smooth muscle cell. [less ▲]

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See detailThe red blood cell Na-Li countertransport, hypertensive heredity and the cardiovascular risk in young adults
Krzesinski, Jean-Marie ULg; Saint-Remy, Annie ULg; Rorive, Georges ULg

in American Journal of Hypertension : Journal of the American Society of Hypertension (1992), 5(part 2), 21

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See detailInfluence du sodium alimentaire chez l'hypertendu essentiel non traité par médicament
Krzesinski, Jean-Marie ULg; Du, F.; Pequeux, Marie-Louise et al

in Archives Maladie du Coeur (1992), 85

Le traitement de l'hypertension artérielle passe par l'application des conseils hygiéno-diététiques. A ce propos, la place de la restriction sodée est discutée, notamment chez les sujets hypertendus ... [more ▼]

Le traitement de l'hypertension artérielle passe par l'application des conseils hygiéno-diététiques. A ce propos, la place de la restriction sodée est discutée, notamment chez les sujets hypertendus obèses. Le but de cette étude est de tester l'effet d'un régime hyposodé personnalisé sur la pression artérielle chez des hypertendus essentiels ne recevant pas de médicament antihypertenseur. Une supplémentation sodée est ensuite appliquée pour vérifier cette influence. Nous avons voulu apprécier le rôle éventuel joué par une hérédité hypertensive positive ou négative (H+, H-) et par des modifications dans certains paramètres érythrocytaires au niveau de l'importance de cette réponse. [less ▲]

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See detailDoes salt restriction lower the intracellular calcium concentration in essential hypertension?
Krzesinski, Jean-Marie ULg; Du, F.; Rorive, Georges ULg

in Journal of Hypertension (Supplement) (1992), 10

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See detailInfluence of salt restriction in untreated essential hypertension patients
Krzesinski, Jean-Marie ULg; Du, F.; Pequeux, L. et al

in Journal of Hypertension (1992), 10(10), 1297-1298

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See detailLes inhibiteurs de l'enzyme de conversion: la molécule a-t-elle de l'importance?
Rorive, Georges ULg; Krzesinski, Jean-Marie ULg

in Médecine et Hygiène (1991), 49

De nombreuses, peut-être de trop nombreuses molécules, dotées d'un pouvoir d'inhibition de l'enzyme de conversion ont été introduites ces dix dernières années pour le traitement de l'hypertension ... [more ▼]

De nombreuses, peut-être de trop nombreuses molécules, dotées d'un pouvoir d'inhibition de l'enzyme de conversion ont été introduites ces dix dernières années pour le traitement de l'hypertension artérielle et de l'asystolie. Les différences entre ces molécules sont peu importantes et sont fonction de leur structure moléculaire. Le captopril, seul dérivé doté d'un groupe sulfhydrile, a un effet rapide et de durée assez brève; son utilisation s'accompagne par ailleurs de certains effets secondaires propres au groupe SR. Par contre, le délai d'action des dérivés dont le ligand est un groupe carboxyle est généralement plus tardif, leur durée d'action plus longue, justifiant une prise par jour. Il reste difficile d'affirmer que le groupe SR confère des propriétés cardioprotectrices plus importantes que celles dont jouissent les autres molécules de cette classe thérapeutique. De la même manière, à ce stade, les différences démontrées concernant la diffusion tissulaire des inhibiteurs de l'enzyme de conversion n'ont pas pu être illustrées par des observations cliniques. [less ▲]

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