References of "Krzesinski, Jean-Marie"
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See detailL’image du mois. Localisation rénale d’un lymphome
Dispas, Hélène; Delperdange, Mélanie; Meunier, Paul ULg et al

in Revue Médicale de Liège (2010), 65(7-8), 427-429

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See detailInertie thérapeutique en hypertension artérielle: pourquoi et comment combattre cette attitude?
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2010), 65(5-6), 273-277

Therapeutic inertia, i.e. the absence of introduction of an antihypertensive treatment or on adjustment of its intensity by the medical doctor if the blood pressure is elevated or the goal not reached, is ... [more ▼]

Therapeutic inertia, i.e. the absence of introduction of an antihypertensive treatment or on adjustment of its intensity by the medical doctor if the blood pressure is elevated or the goal not reached, is frequent and does play a role in the insufficient control of blood presure in the hypertensive population. The responsibility of the medical doctor is high in this respect. A strict medical approach is required, step by step, to correct this lack of reaction. [less ▲]

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See detailL'observance thérapeutique en transplantation d'organe - L'exemple de la greffe de rein
Milicevic, Martina ULg; Grosch, Stéphanie ULg; Weekers, Laurent ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 386-390

A successful transplantation implies that immunosuppressive drugs will have to be taken during the whole patient’s life. Poor drug compliance is a multifactorial problem, that is particularly dangerous in ... [more ▼]

A successful transplantation implies that immunosuppressive drugs will have to be taken during the whole patient’s life. Poor drug compliance is a multifactorial problem, that is particularly dangerous in organ transplantation as it can lead to loss of graft function and return to dialysis treatment. The medical doctor must stimulate the patient’s adherence to the strict therapeutic drug protocol. The patient must also be reminded at each medical consultation of the importance of such rigorous drug intake. This bad (or non) compliance is particularly well demonstrated a long time after transplantation. The medical staff, all the health participants, but also the family members must continuously fight against non compliance, which is inherent to any chronic disease. [less ▲]

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See detailImportance de la mauvaise adhésion au traitement antihypertenseur
Krzesinski, Jean-Marie ULg; Krzesinski, François ULg

in Revue Médicale de Liège (2010), 65(5-6), 278-284

S’il est unanimement admis que le traitement de l’hypertension artérielle améliore le pronostic cardiovasculaire des patients qui en sont atteints, force est de constater que la moitié des patients ... [more ▼]

S’il est unanimement admis que le traitement de l’hypertension artérielle améliore le pronostic cardiovasculaire des patients qui en sont atteints, force est de constater que la moitié des patients traités n’ont pas leur pression artérielle normalisée. Un des facteurs responsables de ce relatif échec est la mauvaise adhésion au traitement (non médicamenteux et pharmacologique). Ce problème d’observance est multifactoriel. Interviennent le patient, sa maladie, son traitement et l’environnement thérapeutique où la relation médecin-malade joue un grand rôle. Pour améliorer l’observance, comme d’ailleurs la persistance du traitement, il faut d’abord y penser. Le dialogue avec le patient sur l’observance doit être mené à chaque consultation. Une excellente relation médecin-patient, une éducation sur l’hypertension, ses risques et les moyens d’éviter les complications, le choix de schémas de traitement bien tolérés, simplifiés et introduits progressivement, la recherche et la limitation des effets secondaires générés, le partenariat de la famille et du pharmacien dans la prise en charge, la stimulation de l’automesure de la pression artérielle par le patient sont autant de pistes importantes pour améliorer ce paramètre. Ceci permettrait, à coup sûr, de réduire les complications cardiovasculaires liées à l’hypertension et le coût pour la société. [less ▲]

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See detailReference values of central blood pressure and pulse wave velocity in relations with 24 hours ambulatory blood pressure monitoring in Belgian normotensive young subjects
Saint-Remy, Annie ULg; Krzesinski, Jean-Marie ULg

in Journal of Hypertension (2010), 28

The present study aimed to define reference values of central blood pressure (cBP) and Pulse Wave Velocity (PWV) together with 24H APPM in healththy normotensive young adults before starting a follow-up ... [more ▼]

The present study aimed to define reference values of central blood pressure (cBP) and Pulse Wave Velocity (PWV) together with 24H APPM in healththy normotensive young adults before starting a follow-up of their CV profile modifications over time. [less ▲]

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See detailLa vignette thérapeutiqu de l'étudiant Diagnostic différentiel étiologique des oedmes
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2010), 65(11), 655-661

Oedema is a frequent disorder and the easily detectable consequence of an increase of fluid located in the interstitial tissue. It could be localized or generalized and related either to a primary ... [more ▼]

Oedema is a frequent disorder and the easily detectable consequence of an increase of fluid located in the interstitial tissue. It could be localized or generalized and related either to a primary disturbance of hemodynamics at the capillary level, due to a modification of the Starling’s law components with secondary water and saline retention, or to a primary retention of salt and water linked to a kidney abnormality. Generalized forms are pitting oedema, most often painless, white, bilateral and symmetric, distributed at the lower part of the body (localisation according to the gravitation law). They are different in their characteristics from localized oedema or lymphoedema which are tough. We propose a diagnostic approach based on medical history, clinical examination which allows a confident medical diagnosis and so an adapted therapy. [less ▲]

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See detailLa creatinine : d'hier a aujourd'hui.
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Maillard, Nicolas et al

in Annales de Biologie Clinique (2010), 68(5), 531-43

Serum creatinine is certainly one of the most prescribed biological parameters. In this review article, we remind some historical data regarding creatinine. Different methodologies to measure creatinine ... [more ▼]

Serum creatinine is certainly one of the most prescribed biological parameters. In this review article, we remind some historical data regarding creatinine. Different methodologies to measure creatinine in blood and urine are deeply described. We also discuss the physiological reason for its use as a glomerular filtration rate marker. However, analytical and physiological limitations are described and discussed. Creatinine clearance usefulness is finally largely discussed. [less ▲]

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See detailConcepts actuels de l'hyperaldostéronisme primaire
Vroonen, Laurent ULg; Krzesinski, Jean-Marie ULg; Hamoir, Etienne ULg et al

in Revue Médicale de Liège (2010), 65(10), 583-587

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See detailUrinary NGAL: Use of absolute value or ratio to creatinine?
Cavalier, Etienne ULg; Bekaert, Anne-Catherine ULg; Legrand, Delphine ULg et al

in Acta Clinica Belgica (2010), 65-3

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising marker for the detection of acute kidney injury. This marker has been proposed for urinary measurement. However ... [more ▼]

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising marker for the detection of acute kidney injury. This marker has been proposed for urinary measurement. However, in the literature, authors indistinctly use "absolute" value or NGAL to creatinine ratio. Up to now, there are no strong arguments favouring for one. This question is of importance as this marker is sensed to be used only on urine random samples. To find an answer to this very practical matter, one approach could be to compare biological CV(intra-individual variation) of the "absolute" and ratio results. [less ▲]

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See detailUrinary or plasma NGAL?: Analytical point of view
Cavalier, Etienne ULg; Saarbach, D.; Bekaert, Anne-Catherine ULg et al

in Acta Clinica Belgica (2010)

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See detailÉpidémiologie de la maladie rénale chronique en République démocratique du Congo: une revue synthétique des études de Kinshasa, la capitale
Sumaili, E. K.; Krzesinski, Jean-Marie ULg; Cohen, E. P. et al

in Néphrologie & Thérapeutique (2010), 6

Chronic kidney disease (CKD) is a worldwide public health problem. Little is known about its burden in Africa. This paper reviews the knowledge of CKD in Kinshasa, summarizing four studies undertaken in ... [more ▼]

Chronic kidney disease (CKD) is a worldwide public health problem. Little is known about its burden in Africa. This paper reviews the knowledge of CKD in Kinshasa, summarizing four studies undertaken in the general population and traditional health system of Kinshasa. CKD was defined by either kidney damage (proteinuria 300 mg/day) or reduced kidney function (eGFR < 60 ml/min/1.73 m2). In the general population, the prevalence of CKD all stage is 12.4 %. Our work shows also the high prevalence of proteinuria among subjects who do not have diabetes or hypertension, the lack of early detection and management of CKD risk factors in the traditional health care system leading to late referral or premature deaths, and the limits of renal replacement treatment. CKD affects young people in the DRC, in contrast to the United States, where CKD is more prevalent in older people. Major determinants of CKD in our studies were hypertension, diabetes, overweight, age, lower socioeconomic status, and Human immunodeficiency virus (HIV) infection. Glomerular nephropathy (mainly focal segmental glomerulosclerosis) remains the leading cause of end stage renal disease. An annual screening of the population for proteinuria and CKD risk factors is feasible and will, it is hoped, provide the basis for building a nationwide prevention strategy. [less ▲]

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See detailEstimation of the Stability of Parathyroid Hormone when Stored at -80°C for a Long Period
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Hubert, Philippe ULg et al

in Clinical Journal of the American Society of Nephrology (2009), 4(12), 1988-92

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See detailMise au point sur l'hypertension artérielle chez le sujet transplanté
Krzesinski, Jean-Marie ULg

Conference (2009, November 17)

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See detailAvancées concernant l’Aliskiren (Rasilez®), inhibiteur direct de la rénine, et l’Aliskiren-hydrochlorothiazide (Rasilez HCT ®)
Boxho, G.; Krzesinski, Jean-Marie ULg; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(11), 560-565

Aliskiren (Rasilez®), a direct renin inhibitor, is currently indicated for the treatment of essential hypertension, as monotherapy or in combination, especially with hydrochlorothiazide (Rasilez HCT®). It ... [more ▼]

Aliskiren (Rasilez®), a direct renin inhibitor, is currently indicated for the treatment of essential hypertension, as monotherapy or in combination, especially with hydrochlorothiazide (Rasilez HCT®). It may also be use to obtain a more complete blockade of the renin-angiotensin-aldosterone system (RAAS) when it is associated with an angiotensin converting enzyme inhibitor (ACEI) (or an AT1 angiotensin receptor antagonist) (ARA). There is some room for agents that may be more efficacious in reducing the progression of diabetic nephropathy than ACEI or ARA. In this context, the dual blockade of RAAS most probably offers a better efficacy than the simple blockade, but also exposes to a higher risk. Should ongoing trials confirm the preliminary favourable results, aliskiren might reach a forefront position among the armamentarium now available to optimize the RAAS blockade. The present article will summarize advances concerning the biochemical effects of the specific mode of action of aliskiren, especially the potential interferences related to increased renin/pro-renin levels, as well as results of recent clinical trials, not only in hypertension, but also in the fields of diabetes, renal insufficiency and cardiology. The objectives and design of the landmark study ALTITUDE will also be briefly presented. [less ▲]

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