References of "Kirschvink, N."
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See detailDéficience du système glutathion chez le cheval de course
De Moffarts, Brieuc; Kirschvink, N.; Art, Tatiana ULg et al

in 30ème Journée de la Recherche Equine, Les Haras Nationaux (2004)

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See detailSpécificités cardiorespiratoires des ânes
Delvaux, Véronique ULg; Kirschvink, N.; Amory, Hélène ULg et al

in Proceedings: Congrès de l'Association Vétérinaire Equine Française (AVEF) (2004)

A group of 22 donkeys underwent a series of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For ... [more ▼]

A group of 22 donkeys underwent a series of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For particular tests (haematology, measurement of arterial blood gases, electrocardiogram width phonocardiogram, thoracic radiographs, cardiac echocardiography), no major différences were found. However, the mechanical ventilation parameters differed from those for horses and were similar to those for food-producing animals (cattle). The conformation of the pharynx and larynx is slightly différent to that of horses making it more difficult to pass an endoscope through this area. The differencial leukocyte count from tracheal lavage includes a number of epithelial cells, and a higher percentage of eosinophils and neutrophils for donkeys compared to horses. These similarities and différences between donkeys and horses should be taken into account when performing ancillary tests. [less ▲]

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See detailEffet d’un complément antioxydant sur les marqueurs sanguins du stress oxydant chez des galopeurs entraînés
De Moffarts, Brieuc; Kirschvink, N.; Art, Tatiana ULg et al

in Congrès de l'Association Vétérinaire Equine Française (AVEF) (2003)

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See detailImpaired Accumulation of Granulocytes in the Lung During Ozone Adaptation
Fievez, Laurence ULg; Kirschvink, N.; Dogne, S. et al

in Free Radical Biology & Medicine (2001), 31(5), 633-641

Respiratory alterations induced by an acute exposure to ozone (O(3)) paradoxically resolve during multiday exposure. This adaptation is characteristically accompanied by a gradual attenuation of lung ... [more ▼]

Respiratory alterations induced by an acute exposure to ozone (O(3)) paradoxically resolve during multiday exposure. This adaptation is characteristically accompanied by a gradual attenuation of lung neutrophilia. As maintenance of neutrophilia at the site of inflammation is due to cytokine-mediated delayed neutrophil apoptosis, which is associated with reduced levels of Bax, a proapoptotic protein, we sought to determine whether defects in these mechanisms could account for O(3) adaptation. Lung granulocytes obtained at different time points from calves exposed to 0.75 ppm O(3) for 12 h/d for 7 consecutive days neither showed enhancement of survival nor Bax deficiency, when compared to blood granulocytes. To further investigate the effects of an exogenous oxidative stress on neutrophil survival, human granulocytes were treated with hydrogen peroxide alone, or in combination with granulocyte/macrophage colony-stimulating factor, an antiapoptotic cytokine. Both treatments led to rapid apoptosis associated with downregulation of Bcl-x(L) and Bcl-2, two antiapoptotic proteins. This study shows that O(3) adaptation is associated with a failure in the mechanisms leading to accumulation of neutrophils at the site of inflammation, and suggests that this defect is due to direct proapoptotic effects of exogenous oxidative stress on granulocytes [less ▲]

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See detailP65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
Sandersen, Charlotte ULg; Bureau, Fabrice ULg; Turlej, R. et al

in Veterinary Immunology and Immunopathology (2001), 80(3-4), 315-26

Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity ... [more ▼]

Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity-associated inflammatory condition of the lung). To determine whether this increased activity extends to distal airways and to other pulmonary cells, cells recovered by broncho-alveolar lavage (BAL) in healthy and heaves-affected horses were assessed for NF-kappaB activity. NF-kappaB activity was much higher in BAL cells from heaves-affected horses, especially during crisis (disease exacerbation), than in cells from healthy horses. Moreover, the level of NF-kappaB activity found in BAL cells was positively correlated to total lung resistance and to the proportion of neutrophils present in BAL fluid. Finally, prototypical p65-p50 NF-kappaB heterodimers were absent from BAL cells, which mostly contained p65 homodimers. These results (1) show that increased NF-kappaB activity is a general feature of heaves lung; (2) demonstrate the importance of p65 homodimers in neutrophilic inflammation; and (3) suggest that the use of specific NF-kappaB inhibitors could improve lung function in heaves-affected horses. [less ▲]

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See detailMechanisms of inflammation in equine airways
Lekeux, Pierre ULg; Bureau, Fabrice ULg; Art, Tatiana ULg et al

in Proceedings : 3er Congreso Iberoamericano de Veterinarios Especializados en Equinos, Montevideo (2001)

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See detailCorrelation between Nuclear Factor-Kappab Activity in Bronchial Brushing Samples and Lung Dysfunction in an Animal Model of Asthma
Bureau, Fabrice ULg; Bonizzi, G.; Kirschvink, N. et al

in American Journal of Respiratory & Critical Care Medicine (2000), 161(4, Pt 1), 1314-1321

Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the ... [more ▼]

Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the transcriptional initiation of inflammatory genes, has been poorly investigated in asthma. In the present report, bronchial cells (BCs), recovered by bronchial brushing in healthy and heaves-affected horses (i.e., an animal model of asthma), were assessed for NF-kappaB activity. Small amounts of active NF-kappaB were present in BCs of healthy horses, whereas high levels of NF-kappaB activity was found during crisis (i.e., acute airway obstruction) in all heaves-affected horses. Three weeks after the crisis, the level of NF-kappaB activity found in BCs of heaves-affected horses was highly correlated (p < 0.01) to the degree of residual lung dysfunction. Unexpectedly, active NF- kappaB complexes found in BCs of heaves-affected horses were mainly p65 homodimers, rather than classic p65-p50 heterodimers. At last, intercellular adhesion molecule-1 (ICAM-1) expression paralleled p65 homodimers activity in these cells. These results demonstrate that the kinetics of NF-kappaB activity is strongly related to the course of the disease and confirm the relevance of NF-kappaB as a putative target in asthma therapy. Moreover, uncommon p65 homodimers could transactivate, in BCs, a subset of genes, such as ICAM-1, characteristic of chronic airway inflammation. [less ▲]

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See detailGranulocyte macrophage-colony stimulating factor delay granulocytic apoptosis in heaves-affected horses
Turlej, R. K.; Sandersen, Charlotte ULg; Fievez, Laurence ULg et al

in Pflügers Archiv : European Journal of Physiology (2000)

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See detailNuclear factor kappaB activity and characterization in lung cells from heaves affected horses
Sandersen, Charlotte ULg; Turlej, R. K.; Fievez, Laurence ULg et al

in Pflügers Archiv : European Journal of Physiology (2000), 440(R217),

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