References of "Kirschvink, N."
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See detailEffect of obesity in dogs on airway reactivity measured by barometric whole body plethysmography
Bernaerts, Frederique ULg; Bolognin, M.; Dehard, S. et al

in 16th ECVIM Meeting - Amsterdam - Nederlands - Septembre 2006 (2006, September)

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See detailInhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis
Kirschvink, N; Leemans, Jérôme ULg; Delvaux, François et al

in Journal of Feline Medicine and Surgery (2006), 8(1), 45-54

This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were ... [more ▼]

This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were compared with healthy cats serving as controls (n = 6). Chest radiographs, BR tests performed non-invasively by barometric whole body plethysmography (BWBP) and bronchoalveolar lavage (BAL) were performed before and after treatment. BR was quantified by calculating the concentration of carbachol inducing bronchoconstriction (C-Penh300%), defined as a 300% increase of baseline Penh, an index of bronchoconstriction obtained by BWBP. BAL fluid was analyzed cytologically and the oxidant marker 8-iso-PGF2α was determined. At test 1, healthy cats and cats with bronchitis were untreated, whereas for test 2 inhalant fluticasone (250 μg once daily) was administrated for 2 consecutive weeks to cats with bronchitis. Control cats remained untreated. Inhaled fluticasone induced a significant increase in C-Penh300% and a significant decrease of BAL fluid total cells, macrophages, neutrophils and 8-iso-PGF2α in cats with bronchitis, whilst untreated control cats did not show significant changes over time. This study shows that a 2-week fluticasone treatment significantly reduced lower airway inflammation in very mild bronchitis. BR could be successfully monitored in cats using BWPB and decreased significantly in response to inhaled fluticasone. 8-Iso-PGF2α in BAL fluid was responsive to treatment and appeared as a sensitive biomarker of lower airway inflammation in cats. [less ▲]

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See detailEvaluation of respiratory function by barometric whole-body plethysmography in healthy dogs
Talavera, J.; Kirschvink, N.; Schuller, S. et al

in Veterinary Journal (2006), 172(1), 67-77

The objective of the present study was to assess the validity of barometric whole-body plethysmography (BWBP), to establish reference values, and to standardise a bronchoprovocative test to investigate ... [more ▼]

The objective of the present study was to assess the validity of barometric whole-body plethysmography (BWBP), to establish reference values, and to standardise a bronchoprovocative test to investigate airway responsiveness using BWBP in healthy dogs. BWBP measurements were obtained from six healthy beagle dogs using different protocols: (1) during three consecutive periods (3.5 min each) in two morning and two evening sessions; (2) before and after administration of two protocols of sedation; (3) before and after nebulisation of saline and increasing concentrations of carbachol and histamine both in conscious dogs and in dogs under both protocols of sedation. Enhanced pause (PENH) was used as index of bronchoconstriction. Basal BWBP measurements were also obtained in 22 healthy dogs of different breeds, age and weight. No significant influence of either time spent in the chamber or daytime was found for most respiratory variables but a significant dog effect was detected for most variables. A significant body weight effect was found on tidal volume and peak flow values (P < 0.05). Response to carbachol was not reproducible and always associated with side effects. Nebulisation of histamine induced a significant increase in respiratory rate, peak expiratory flow, peak expiratory flow/peak inspiratory flow ratio and PENH (P < 0.05). The response was reproduced in each dog at different concentrations of histamine. Sedation with acepromazine + buprenorphine had little influence on basal measurements and did not change the results of histamine challenge. It was concluded that BWBP is a safe, non invasive and reliable technique of investigation of lung function in dogs which provides new opportunities to characterise respiratory status, to evaluate airway hyperresponsiveness and to assess therapeutic interventions. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEffect of water intake on dietary mannitol, sodium chloride and food frequency in healthy cats
Kirschvink, N.; Lhoest, E.; Leemans, J. et al

in Proceedings of the 10th Congress ESVCN (2006)

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See detailInvestigation of blood oxidant/antioxidant markers in healthy competition horses : effect of discipline and gender.
Kirschvink, N.; De Moffarts, Brieuc; Farnir, Frédéric ULg et al

in 7th International Conference on Equine Exercise Physiology (2006)

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See detailWhole body barometric plethysmography measurements in dogs with brachycephalic airway obstruction syndrome : preliminary results
Bernaerts, Frederique ULg; Talavera, J.; Le Garrérès, A. et al

in 15th ESVIM Meeting - Glasgow - Ecosse - Septembre 2005 (2005, September)

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See detailWhole-body barometric plethysmography in healthy dogs : influence of jet nebulizer and bias flow rate on the results of a bronchoprovocative test
Talavera, J.; Bernaerts, Frederique ULg; Schuller, S. et al

in ACVIM Meeting - Baltimore (USA) - juin 2005 (2005, June)

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See detailEffects of feeding frequency on water intake in cats
Kirschvink, N.; Lhoest, E.; Leemans, J. et al

in Journal of Veterinary Internal Medicine (2005, May)

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See detailCollection of exhaled breath condensate and analysis of hydrogen peroxide as a potential marker of lower airway inflammation in cats
Kirschvink, N.; Marlin, D.; Castermans, Françoise ULg et al

in Veterinary Journal (2005), 169(3), 385-396

The objective of this study was to describe a standardised and non-invasive method for exhaled breath condensate (EBC) collection in cats and to test whether determination of hydrogen peroxide (H2O2) in ... [more ▼]

The objective of this study was to describe a standardised and non-invasive method for exhaled breath condensate (EBC) collection in cats and to test whether determination of hydrogen peroxide (H2O2) in EBC might be used as marker of lower airway inflammation. The technique of barometric whole body plethysmography for cats was combined with a system to condense the effluent air from the plethysmograph, allowing simultaneous EBC collection and respiratory pattern measurement. H2O2 was determined spectrophotometrically. Eighteen experimental cats were used to investigate the impact on EBC volume and EBC H2O2 of plethysmograph ventilation rate, collection duration, sample stability, within-day and day-to-day variability. After determination of a standardised EBC collection procedure, correlation analyses between EBC H2O2 and bronchoalveolar lavage (BAL) cytology of healthy and allergen-challenged Ascaris suum (AS)-sensitised cats were performed. A significant and positive correlation between EBC H2O2 and bronchoalveolar lavage (BAL) neutrophil% was found in healthy cats (P < 0.001, r = 0.55), whereas in AS-sensitised cats, correlation with BAL eosinophil% was significant (P < 0.005, r = 0.61). H2O2 was increased after an allergen challenge in AS-sensitised cats (n = 6, 0.56 ± 0.12 versus 1.08 ± 0.35 μ mol/L, P < 0.05). This study proposes a non-invasive, well tolerated and repeatable method of EBC collection for cats and suggests that EBC H2O2 might be used as non-invasive biomarker for monitoring lower airway inflammation. [less ▲]

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See detailOxidants and airway inflammation
Kirschvink, N.; Lekeux, Pierre ULg

in 3rd World Equine Airways Symposium (WEAS) (2005)

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See detailWater intake is influenced by feeding frequency and energy allowance in cats
Kirschvink, N.; Lhoest, E.; Leemans, J. et al

in Proceedings of the 9th Congress ESVCN (2005)

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See detailComparison between Pulmonary Resistance and Penh in Anaesthetised Rats with Tracheal Diameter Reduction and after Carbachol Inhalation
Kirschvink, N.; Vincke, G.; Onclinx, C. et al

in Journal of Pharmacological & Toxicological Methods (2005), 51(2, Mar-Apr), 123-128

Introduction: Single-chambered barometric whole-body plethysmography is frequently used as a noninvasive lung function test. However, the validity of the enhanced Pause (Penh), an index of airflow ... [more ▼]

Introduction: Single-chambered barometric whole-body plethysmography is frequently used as a noninvasive lung function test. However, the validity of the enhanced Pause (Penh), an index of airflow limitation, remains controversial. We compared Penh with pulmonary resistance (R(L)) to test whether Penh detects tracheal subobstruction and carbachol-induced airflow limitation in spontaneously breathing, anaesthetised rats. Methods: Fourteen male Sprague-Dawley rats underwent tracheal catheterisation, followed by measurements of R(L) and Penh. Six rats underwent tracheal subobstruction by the consecutive insertion into the lumen of the tracheal tube of two catheters of decreasing diameter. Eight rats received an inhaled saline challenge, followed by two noncumulative nebulizations of carbachol (1.25 mg/mL, 1 min). Results: In rats with tracheal calibre reductions, R(L) significantly increased at each reduction (0.218+/-0.052 vs. 0.417+/-0.058 vs. 0.820+/-0.258 cm H(2)O/mL s, p<0.05), whereas Penh only increased after the last reduction (1.88+/-0.25 vs. 2.47+/-0.26, p<0.05). Increases (Delta) of R(L) and Penh were not correlated. In comparison to postsaline values, carbachol induced a significant increase of Penh (1.93+/-0.44 vs. 4.05+/-1.45, p<0.005) and R(L) (0.137+/-0.04 vs. 0.284+/-0.084 cm H(2)O/mL.s, p<0.005). DeltaPenh and DeltaR(L) were significantly correlated (r=0.80, p<0.05). Discussion: This study showed, by comparing Penh with R(L), that single-chambered plethysmography measuring Penh allows to detect carbachol-induced airflow limitation in spontaneously breathing, anaesthetised Sprague-Dawley rats, but poorly detects an increase in R(L) due to tracheal calibre reductions. These findings suggest that Penh might be only be used as an index of airflow limitation under well-defined experimental conditions. [less ▲]

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See detailCadmium inhalation-induced emphysema is resistant to glucocorticoids
Fievez, Laurence ULg; Kirschvink, N.; Belleflamme, M. et al

in European Respiratory Journal (2005)

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See detailEffect of substance 101333-3 on emphysema and MMP activity in a model of cadmium-induced emphysema
Fievez, Laurence ULg; Kirschvink, N.; Provins, L. et al

in European Respiratory Journal (2005), 579s

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See detailEffect of inhaled fluticasone on airway reactivity and 8-Iso-PGF2 in bronchoalveolar lavage fluid of cats
Kirschvink, N.; Leemans, J.; Delvaux, François ULg et al

in 5th China - France Pharmacological Joint Symposium - Beijing - France - Octobre 2004 (2004, October)

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See detailEffect of inhaled fluticasone on airway reactivity and inflammation in cats.
Kirschvink, N.; Leemans, J.; Delvaux, F. et al

in 22nd Veterinary and Comparative Respiratory Society Symposium - Montreal- Canada - Octobre 2004 (2004, October)

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See detailBronchial reactivity assessed by whole body barometric plethymography is correlated with lower airway inflammation in cats
Kirschvink, N.; Leemans, J.; Delvaux, François ULg et al

in 14th ESVIM Meeting - Barcelona - Espagne (2004, September)

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See detailWhole-body barometric plethysmography in healthy dogs: effect of sedation on basal respiratory variables and during histamine challenge
Talavera, J.; Kirschvink, N.; Clercx, Cécile ULg

in 14th ESVIM Meeting - Barcelona - Espagne (2004, September)

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See detailPreventive use of bronchodilators reduces bronchoscopy-induced airflow limitation in cats
Kirschvink, N.; Leemans, J.; Delvaux, F. et al

in ACVIM Meeting - Minneapolis - USA - Juin 2004 (2004, June)

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See detailCharakterisierung des bronchialen “remodellings” in einem Modell von felinem Asthma
Kirschvink, N.; Delvaux, François ULg; Vincke, G. et al

in 45. Kongress der Deutschen Gesellschaft für Pneumologie - Frankfurt - Allemangne - Mars 2004 (2004, March)

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