References of "Kaux, Jean-François"
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See detailValidation of the French translation of the VISA-A
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 112-113

Introduction : The Victorian Institute of Sports Assessment– Achilles (VISA-A) was designed to evaluate the clinical severity of Achilles tendinopathy. It has been developed in English and therefore is ... [more ▼]

Introduction : The Victorian Institute of Sports Assessment– Achilles (VISA-A) was designed to evaluate the clinical severity of Achilles tendinopathy. It has been developed in English and therefore is not adapted for French-speaking patients. Although this questionnaire has already been translated into different languages but not in French. French is spoken by most than 275 millions of people and is one of the 2 official languages of the International Olympic Committee, and one of the 6 official languages and one of the 2 working languages of the United Nation Organisation. The aim of this study was to translate this questionnaires into French and to study its reliability and validity. Methods : The questionnaire was translated into French (VISA-AF) according to the "guidelines for the process of cross-cultural adaptation of self-report measures" using six steps: translation, synthesis, back translation, expert committee review, pretesting, and appraisal of the adaptation process by the expert committee. Once the final versions obtained, several psychometric proprieties such as test-retest fidelity, internal coherence, construct validity and floor and ceiling effects were evaluated. We recruited 116 subjects who were distributed in 3 groups: pathological patients (n=31), at risk athletes (n=63), healthy people (n=22). Results : The questionnaire was approved by the expert committee after the pre-final version test. On a scale ranging from 0 (theoretical minimum) to 100 (asymptomatic subject), the average scores of the VISA-PF obtained were 59 (± 18) for the pathological group, 99 (± 1) for the healthy group and 94 (± 7) for the sports-risk group. The VISA-A-F shows excellent reliability. The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion : The French versions of the VISA-A is equivalent to its original version and is reliable and valid questionnaire for French speaking patients with Achilles tendinopathy. [less ▲]

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (2015), 55(9), 953-61

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailExploring the effect of a second closely-timed infiltration of PRP to treat proximal patellar tendinopathy
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 54

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative ... [more ▼]

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. The aim of this study was to evaluate whether 2 infiltrations of PRP proves more effective than a single treatment. Material and methods: Twenty patients suffering from chronic proximal patellar tendinopathy were enrolled into the study and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. Discussion and conclusion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat chronic proximal patellar tendinopathy is not necessary to improve the efficacy of this treatment in the short term. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies
Kaux, Jean-François ULg; Bruyère, Olivier ULg; Croisier, Jean-Louis ULg et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 113

Introduction: Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the ... [more ▼]

Introduction: Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies. Material and methods : Twenty subjects with chronic upper patellar tendinopathy benefited from 1 infiltration of PRP. The follow-up (up to 1 year) was assessed by means of a Visual Anologue Scale (VAS), the International Knee Documentation Committee (IKDC) form and the Victorian Institute of Sport Assessment (VISA-P) score. Moreover, subjects had to answer an information questionnaire concerning their life and sports activities. Results : Seventy percents of the patients reported a favourable evolution with decrease of pain, and returned to sports activities. With time, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. Conclusion : This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation for treating a chronic jumper's knee, improves pain symptoms and the functionalities of the subjects’ knee up to 1 year after injection. [less ▲]

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See detailEffectiveness of High Intensity Radial Shock Wave Therapy in The Treatment of Chronic Plantar Fasciitis
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Fromm, Aurélien et al

in Jacobs Journal of Physical Rehabilitation Medicine (2015), 1(3), 0117

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See detailImpact of an ultra-trail of 330 km on plasma levels of cardiac biomarkers
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Gergelé, Laurent et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 77

Introduction/Aim: While a moderate exercise produces beneficial effects on the cardiovascular system, consequences of a supraphysiological effort are not yet clear. The aim of our study was to evaluate ... [more ▼]

Introduction/Aim: While a moderate exercise produces beneficial effects on the cardiovascular system, consequences of a supraphysiological effort are not yet clear. The aim of our study was to evaluate the consequences of such an effort on cardiac markers, markers of inflammation but also markers of renal function. This project also studied the evolution of new biomarkers of cardiac fibrosis such as the ST2 and galectin-3. Material and Methods: 51 people attending the Tor des Géants (330 km, with an altitude range of 24,000 meters) have been followed. The study is conducted on 33 participants having reached at least half of the race (148.7 km). Blood and urine samples were collected at four different times: before the race, halfway, at the finish and three days after arrival. Several biomarkers were assayed on different analyzers such COBAS®, KRYPTOR®, VIDAS® and ETIMAX®. Meanwhile, the ST2 was measured manually. Results: During this ultra-endurance effort, the plasma levels of cardiac markers (hsTnT, NT-proBNP, copeptin, H-FABP, ST2, Gal-3), muscle (CK, myoglobin) and inflammation (CRP DFO, GB) have increased significantly to halfway (148.7 km). Meanwhile, the markers of renal function (urinary NGAL and plasma and urinary creatinine) have only slightly varied, excepting plasma creatinine. Conclusions: The study suggests that there is no permanent structural damage at the myocardium level. However, the low pace adopted by the runners, due to fatigue, caused an inflammatory response as well as muscle damage less important than a shorter race. Nevertheless, an endurance race as the Tor des Géants means an intense physical and psychological effort. [less ▲]

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See detailEfficacité du traitement des tendinopathies chroniques par infiltration de plasma riche en plaquettes
Kaux, Jean-François ULg; Sancerne, Audrey; Libertiaux, Vincent ULg

in 8ème Congrès Commun SFMES - SFTS (2015, September)

Introduction: Les tendinopathies sont des pathologies d’hyperutilisation essentiellement présentent chez les sportifs ainsi que les travailleurs manuels. Elles représentent près de 20% des troubles ... [more ▼]

Introduction: Les tendinopathies sont des pathologies d’hyperutilisation essentiellement présentent chez les sportifs ainsi que les travailleurs manuels. Elles représentent près de 20% des troubles musculo-squelettiques et plus de 30% des consultations en médecine générale et en médecine sportive. Ces tendinopathies peuvent être rebelles aux traitements conservateurs, raison pour laquelle de nouveaux traitements sont développés parmi lesquels figurent les infiltrations de plasma riche en plaquettes (PRP). L’objectif de notre étude est d’évaluer l’effet d’une injection de PRP suivie d’un protocole de rééducation standardisé chez des patients présentant différentes tendinopathies : épicondylites, tendinopathies du moyen glutéus, patellaires, calcanéennes et fasciites plantaires. Enfin, nous souhaitons mettre en évidence des facteurs biologiques de bon pronostic suite à un traitement par PRP. Matériels et méthodes : 51 patients atteints de différentes tendinopathies, réfractaires aux traitements de kinésithérapie classique depuis au moins 3 mois, ont reçu une injection de PRP sous contrôle échographique sans anesthésie locale. Par la suite, ils ont bénéficié d’une rééducation excentrique standardisée. Aux trois temps de l’étude (pré-injection, 6 semaines et 12 semaines), ils ont reçu une évaluation algo-fonctionnelle (EVA, PRTEE, HOOS, VISA-P, VISA-A, FAAM) en fonction de la localisation de la tendinopathie et une évaluation de la douleur par un algomètre de pression. Résultats : Les résultats montrent d’une manière générale une amélioration significative de l’EVA (p=0,01) après 3 mois de suivi et une amélioration de l’algomètre de pression entre 6 et 12 semaines (p=0,05). Pour les épicondylites, les améliorations sont significatives pour l’EVA (p=0,017) et le PRTEE (p=0,0036) au terme de l’étude. Les tendinopathies du moyen glutéus, patellaires et les fasciites plantaires montrent également une amélioration clinique mais non significative (nombre de sujets trop faible). Concernant les tendinopathies d’Achille, l’EVA (p<0.001) et le VISA-A (p=0,018) évoluent de manière significative après les 6 premières semaines. Aucune relation n’a été mise en évidence entre l’évolution de l’EVA et de l’algomètre de pression et les paramètres biologiques. Conclusions : Une injection de PRP couplée à un programme de rééducation excentrique présente des effets positifs au niveau de la symptomatologie douloureuse et la fonctionnalité pour les épicondylites et les tendinopathies d’Achille. Malgré l’absence de résultats significatifs, la tendance est à l’amélioration clinique concerne également les tendinopathies du moyen glutéal, patellaires et les fasciites plantaires. [less ▲]

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See detailEfficacité à long terme d’une infiltration de plasma riche en plaquettes pour traiter une tendinopathie patellaire proximale
Kaux, Jean-François ULg; Honoré, Morgan; Evrard, Frédéric

in 8ème Congrès Commun SFMES - SFTS (2015, September)

Introduction: Les tendinopathies sont des pathologies d’hyper-utilisation très fréquentes, tant chez des sujets sportifs ou non-sportifs. Leur incidence est actuellement en augmentation. La tendinopathie ... [more ▼]

Introduction: Les tendinopathies sont des pathologies d’hyper-utilisation très fréquentes, tant chez des sujets sportifs ou non-sportifs. Leur incidence est actuellement en augmentation. La tendinopathie patellaire proximale est une des tendinopathies les plus réfractaires au traitement conservateur et peut affecter la qualité de vie en limitant les activités sportives qu'elles soient récréationnelles ou professionnelles. Objectifs : L’objectif de cette étude est d’évaluer les effets à long terme du PRP pour traiter les tendinopathies patellaires proximales et éventuellement d’en identifier des facteurs de bon pronostic. Matériel et méthodes: 25 tendinopathies patellaires proximales ont été traités par PRP et ont été suivie à plus d’un an (dont 9 sujets sont suivi jusque 48 mois post-infiltration). Les patients sont évalués selon les questionnaires VISA-P, IKDC et un questionnaire reprenant leurs habitudes. Les scores VISA-P et IKDC sont croisés avec le troisième questionnaire afin d’obtenir des moyennes en rapport avec les réponses de ce dernier. Résultats : Aucun patient n’a été traité par chirurgie après l’infiltration. L’évolution des patients a tendance à être toujours positive jusqu’à 48 mois. Les facteurs semblant être bénéfiques sur l’évolution des patients sont : l’activité sportive à une fréquence de six à huit heures de sport par semaine, la réalisation d’exercices excentriques à domicile, une hydratation de plus d’un litre et demi par jour, un échauffement de plus de dix minutes ainsi que l’âge des patients (<30 ans). Conclusion : Le traitement d’une tendinopathie patellaire proximale par infiltration de PRP est efficace à long terme (jusque 4 ans). La réalisation d’exercices excentriques réguliers semble nécessaire et permet d’observer la poursuite de l’amélioration clinique des patients. [less ▲]

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See detailRelation entre hygiène bucco-dentaire et tendinopathies chez les sportifs
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in 8ème Congrès Commun SFMES - SFTS (2015, September)

Intoduction : De nos jours, la majorité des patients consultent un dentiste pour des problèmes dentaires stricto senso et fort peu pour des pathologies liées au parodonte. Ce dernier est pourtant leur ... [more ▼]

Intoduction : De nos jours, la majorité des patients consultent un dentiste pour des problèmes dentaires stricto senso et fort peu pour des pathologies liées au parodonte. Ce dernier est pourtant leur structure d’ancrage permettant le maintien des dents et donc de l’appareil manducateur. La présence d’un saignement gingival au brossage quotidien, étant la plupart du temps non douloureux, ne déclenche souvent aucune inquiétude ni demande de consultation. Il s'agit pourtant d'un des signes cliniques les plus évidents des parodontopathies qui affectent, à des degrés divers, pratiquement 90% de la population en France dans toutes les tranches d'âge et cause la perte de 30 à 40% des dents. Objectif : Le parodonte représente un des points fragiles de notre corps permettant facilement l’entrée de bactéries dans la circulation sanguine et expliquant une relation entre la maladie parodontale et certaines maladies systémiques. Qu’en est-t-il des tendinopathies? Cette étude a pour objectif de mettre en évidence les relations entre l’hygiène bucco-dentaire et ses répercussions sur les tendinopathies. Matériel & méthode : Soixante-quatre sportifs réguliers ont participé à un examen parodontal complet au cours duquel les paramètres cliniques suivants ont été enregistrés: indices de plaque (PI), indice gingival (GI) et indice de saignement papillaire (PBI). Les athlètes ont été répartis en trois groupes en fonction de leur état de santé : « athlètes non blessés » (ANB), « athlètes blessés » (AB) et « athlètes régulièrement blessés » (ARB). Résultats : En comparant les groupes ANB et AB on remarque une différence significative entre les trois valeurs enregistrées (IP : p=0.023 ; IG : p<0.0001 ; PBI : p<0.0001). Le groupe ARB ne montre pas de différences significatives avec les deux autre groupes. Discussion et Conclusion : Notre étude montre une relation entre les parodontopathies et les tendinopathies mais le modèle ne permet pas à déterminer l’origine ni l’importance de cette relation. Il est recommandé aux athlètes de prêter suffisaient attention à leur hygiène de vie générale et de ne pas négliger leur hygiène dentaire. [less ▲]

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See detailComparison between VeinoPlus Sport and TENS on the recovery on young soccer players
God, Maxime; LE GOFF, Caroline ULg; Evrard, Frédéric et al

in European Journal of Sports Medicine (2015, September), 3(Suppl 1), 106

Introduction Every physical activity is tiresome for the body; muscles produce metabolites and lactic acid which limit its working ability. It is then necessary to efficiently and quickly recover after ... [more ▼]

Introduction Every physical activity is tiresome for the body; muscles produce metabolites and lactic acid which limit its working ability. It is then necessary to efficiently and quickly recover after the effort. In fact, a bad recovery could bring prejudice to the following performance and the athlete's physical state. Active recovery and balneotherapy together with new techniques such as cryotherapy and electro stimulation are upcoming tools to recover better. The goal of this study was to compare the impact of 2 types of electro stimulator : « VeinoPlus Sport » (VPS) and « TENS » on amateur soccer players after Yo-Yo-type effort. Material and methods In an identical context, each athlete (20 soccer players; average age 17,1 ± 0,79) benefited from VPS and TENS during 2 different treatment sessions after 2 Yo-Yo-type efforts. Four blood samples were taken (lactate, blood gases, ions, cardiac markers,...) and an explosiveness Myotest evaluation was conducted respectively before effort, just after effort, after recovery, and after the second effort. A questionnaire on the fatigue state was filled out by each athlete. For the statistical analysis, we used the Anova algorithm of the StatPlus system and a Scheffé test. Results All athletes have ran a greater distance in their second effort especially in the VPS group but differences were insignificant. The test lead to a significant variation of lactate, HCO3- ions and myoglobin. The study of other blood parameters and of the explosiveness parameters didn't show any significant variations. Nevertheless according to the subjective athlete's opinion the VPS group has noted less legs pain, less overall fatigue, less diminishment of strength and fitter than the TENS group between 12 and 24 hours after effort. Finally all athletes have said to like the use of a electro-stimulation recovery device better than their normal daily recovery techniques without expressing any preferences between VPS and TENS. Discussion - Conclusion This comparative study only shows minor differences, non significant, between the two devices. The two groups have ran the greatest distance during the second effort which suggests that the test wasn't tiresome despite biological signs of "fatigue". However on subjective criteria of recovery and well-being a slight preference was shown for the VPS device. The results should be taken into consideration in a other comparative study of the recovery devices with more tiresome effort. [less ▲]

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See detailAnalyse critique des traitements conservateurs classiques des tendinopathies
KAUX, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Revue Médicale de Liège (2015), 70(9), 456-460

Les thérapeutiques «passives» classiques (anti-inflammatoires, infiltrations de corticoïdes…) des tendinopathies, utilisées de manière relativement empirique, réduisent la douleur et l’inflammation, sans ... [more ▼]

Les thérapeutiques «passives» classiques (anti-inflammatoires, infiltrations de corticoïdes…) des tendinopathies, utilisées de manière relativement empirique, réduisent la douleur et l’inflammation, sans modifier fondamentalement la structure du tendon, expliquant leur vocable et caractère «passif». La rééducation excentrique a été appliquée aux tendinopathies chroniques, non seulement de par l’échec des traitements classiques, mais aussi en raison d’une meilleure compréhension physiopathologique des tendinopathies. Diverses études soulignent l’efficacité de la rééducation excentrique qui, après 20-30 séances, entraîne la guérison et surtout prévient le risque de chronicité. Les ondes de choc, modifiant la structure tendineuse, permettraient une guérison à plus long terme. [less ▲]

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See detailPlasma riche en plaquettes pour le traitements de lésions tendineuses
Kaux, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Journal de Réadaptation Médicale (2015), 35(3), 181-191

Objectives: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to ... [more ▼]

Objectives: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to platelet-rich plasma applied to tendinous lesions. Materials and method: Articles in French and English, published between 1 January 2012 and 30 September 2014 dealing with PRP and tendons were searched for using the Medline and Scopus data bases. Results: Forty-seven articles were identified which addressed pre-clinical and clinical studies: 27 relating to in vitro and in vivo animal studies and 20 relating to human studies. Of these, 5 addressed lateral epicondylitis, 2 addressed rotator cuff tendinopathies, 10 dealt with patellar tendinopathies and 3 looked at Achilles tendinopathies. Conclusions: The majority of pre-clinical studies show that PRP stimulates the tendon's healing process. However, clinical series remain more controversial and level 1, controlled, randomised studies are still needed. [less ▲]

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See detailIdentification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Couffignal, Vincent et al

in Clinical physiology and functional imaging (2015), 35(5), 368-375

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among ... [more ▼]

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks. MATERIALS AND METHODS: Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes. CONCLUSION: Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies. [less ▲]

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See detailOne-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies
Kaux, Jean-François ULg; Bruyère, Olivier ULg; Croisier, Jean-Louis ULg et al

in Acta Orthopaedica Belgica (2015), 81(2), 251-256

Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports ... [more ▼]

Infiltration of Platelet-Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of this study is to evaluate the clinical status and the return to sports activities in patients with chronic proximal patellar tendinopathies. Twenty subjects with chronic proximal patellar tendinopathy benefited from 1 infiltration of PRP coupled with a standardized eccentric rehabilitation. The follow-up (up to 1 year) was assessed by means of a Visual Anologue Scale (VAS), the International Knee Documentation Committee (IKDC) form and the Victorian Institute of Sport Assessment (VISA-P) score. Moreover, subjects had to answer an information questionnaire concerning their life and sports activities. Seventy percents of the patients reported a favourable evolution with decrease of pain, and returned to sports activities. With time, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. This study confirms that a local injection of PRP coupled with a program of eccentric rehabilitation for treating a chronic jumper’s knee, improves pain symptoms and the functionaliti [less ▲]

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See detailLe syndrome tarsien antérieur
MILANTS, Christophe ULg; WANG, François-Charles ULg; Gomulinski, Léon et al

in Revue Médicale de Liège (2015), 70(7-8), 400-404

The anterior tarsal tunnel syndrome is a rare entrapment neuropathy of the deep peroneal nerve beneath the inferior extensor retinaculum of the ankle. It is unrecognized and may lead to misdiagnosis and ... [more ▼]

The anterior tarsal tunnel syndrome is a rare entrapment neuropathy of the deep peroneal nerve beneath the inferior extensor retinaculum of the ankle. It is unrecognized and may lead to misdiagnosis and delayed treatment. We report the case of a 77 years old patient complaining of anterior tarsal tunnel syndrome’s symptoms with neuropathic pain located at the dorsal part of the foot without any sensorimotor loss. The electroneuromyography was in favour of the motor impairment of the deep peroneal nerve. MRI exploration of the ankle showed a millimetric bony overgrowth of the upper pole of the navicular irritative to the deep peroneal nerve. Infiltration at overgrowth of the navicular provided a partial and temporary decrease in pain symptoms. Surgical nerve decompression was then considered. [less ▲]

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See detailNo interest for a second closely-timed infiltration of platelet-rich plasma (PRP) to treat jumper’s knees
Kaux, Jean-François ULg; CROISIER, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Radmann, A; Hedenborg, S; Tsolakidis, E (Eds.) 20th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS (2015, June)

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to ... [more ▼]

Introduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. The aim of this study was to evaluate whether 2 infiltrations of PRP proves moreeffective than a single treatment. Methods: Twenty patients suffering from chronic jumper’s knee were enrolled into our prospective, randomized and comparative study of level 2, and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups.Discussion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat jumper’s knees is not necessary to improve the efficacy of this treatment in the short term. References: Kaux JF, Croisier JL, Bruyere O, Rodriguez de la Cruz C, Forthomme B, Brabant G et al. One injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper’s knee. J Sports Med Phys Fitness. 2014 Jun 19. [Epub ahead of print]. Kaux JF, Croisier JL, Forthomme B, Le Goff C, Buhler F, Savanier C et al. Using platelet-rich plasma to treat jumper’s knees: exploring the effect of a second closely-timed infiltration. J Sci Med Sport. Submitted. Kaux JF, Bruyère O, Croisier JL, Forthomme N, Le Goff C, Rohr N et al. One-year follow-up of platelet-rich plasma infiltration to treat chronic upper patellar tendinopathies. Acta Orthop Belg. In press. [less ▲]

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See detailGalectin-3 and Suppression of Tumorigenicity 2 measurement in participants at the “Tor des Géants”
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Gergelé, Laurent et al

in Radmann, A; Hedenborg, S; Tsolakidis, E (Eds.) 20th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS0th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS (2015, June)

Introduction: Gal-3 is a carbohydrate binding lectin produced by macrophages, upregulated in hypertrophied heart, emerging as a mediator for fibrosis development and cardiac remodeling. ST2 is a family ... [more ▼]

Introduction: Gal-3 is a carbohydrate binding lectin produced by macrophages, upregulated in hypertrophied heart, emerging as a mediator for fibrosis development and cardiac remodeling. ST2 is a family member of IL-1 receptors initially known for its role in immunological processes. It has a potential role in the cardiac pathogenesis. These receptors are led in cardiomyocytes and fibroblasts due to a mechanical stress. We aimed to examine the evolution of Gal-3 and ST2 in trailers who ran one of the most challenging ultra-marathon in the world: the Tor des Géants (330 km, altitude range: 24000m). Methods: Levels of plasma Gal-3 and ST2 were determined at 4 times: before the start, after 158km, at the end and 3 days after the end of the race in 33 trailers. Samples were directly centrifuged and frozen at -80°C. Gal-3 measurement was performed on the VIDAS (Biomerieux) and ST2 was analyzed with the Presage ST2 Assay (Critical Diagnostic). The reference values are <17.8ng/mL for Gal-3 and <35ng/mL for ST2. Statistica was used for the statistical analysis (ANOVA). We calculated the difference between the different time and expressed in delta: Δ1=(T2-T1)/T1*100, Δ2=(T3-T2)/T2*100, Δ3=(T4-T3)/T3*100, Δ4=(T3-T1)/T1*100, Δ5=(T4-T1)/T1*100. After that, we tried to correlate the delta between them (results= R(p-value)). Results were considered as significant with p<0.05. Results: Plasmatic levels of Gal-3 did never exceed the cut-off of 17.8ng/mL, except for 1 trailer in T2. A slight increase of levels of Gal-3 was observed at T2 (min-max:7.5-17.6ng/mL). These ones did not vary a lot at T3 (min-max:7.0- 18.8ng/mL) but return to normality at T4 (min-max:6.0-12.8ng/mL). For ST2, at T1, 12 subjects had plasmatic levels above the reference value of 35ng/ml. At T2, only 2 trailers blood samples were still in the reference interval. Indeed, a great increase of ST2 plasmatic levels observed (min-max:18.8-158.8ng/mL). A slight decrease of ST2 levels was observed at T3, but only one subject had a value below 30ng/ml (min-max:20.1-182.7ng/mL). However, a subject had still plasmatic levels above T2 values. A return to normality was observed at T4 with 16 trailers blood levels in the reference interval (min-max:12.0-56.4ng/mL). We observed an increase for Gal-3 and ST2, above the reference values only for ST2. We noted for both a decrease up to the normal values 3 days after the trail. For the correlation between deltas, we observed that Gal-3 and ST2 are correlated for each delta. Discussion: A logical correlation is observed between Gal-3 andST2 as they are involved in cardiac fibrosis and inflammation. But we do not known why it is not in the same proportion. We know that some trailers take NSAIDs and painkillers during the race. The results of this study demonstrate that this exercise was associated with biochemical abnormalities that may reflect adverse consequences on cardiac structure as fibrosis. However, ST2 values were higher, perhaps due to a mechanical stress more than a cardiac stress. Gal-3 is perhaps then more cardiospecific than ST2. [less ▲]

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See detailTendinopathies and platelet-rich plasma (PRP): from pre-clinical experiments to therapeutic use
KAUX, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Journal of Stem Cell & Regenerative Medicine (2015), 11(1), 7-17

Objectives: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to ... [more ▼]

Objectives: The restorative properties of platelets, through the local release of growth factors, are used in various medical areas. This article reviews fundamental and clinical research relating to platelet-rich plasma applied to tendinous lesions. Materials and method: Articles in French and English, published between 1 January 2012 and 31 December 2014 dealing with PRP and tendons were searched for using the Medline and Scopus data bases. Results: Forty-seven articles were identified which addressed pre-clinical and clinical studies: 27 relating to in vitro and in vivo animal studies and 20 relating to human studies. Of these, five addressed lateral epicondylitis, two addressed rotator cuff tendinopathies, ten dealt with patellar tendinopathies and three looked at Achilles tendinopathies. Conclusions: The majority of pre-clinical studies show that PRP stimulates the tendon's healing process. However, clinical series remain more controversial and level 1, controlled, randomised studies are still needed. [less ▲]

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See detailCardiac Biomarkers and Cycling Race
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Goffaux, Sébastien et al

in Journal of Sports Science & Medicine (2015), 14(2 (eCollection 2015 Jun)), 475-476

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See detailTendon et acide hyaluronique
Kaux, Jean-François ULg; Samson, Antoine; Crielaard, Jean-Michel ULg

in Science & Sports (2015), 30(2), 57-65

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