References of "Kaux, Jean-François"
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See detailPathologie du handball
Kaux, Jean-François ULg

Learning material (2015)

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See detailPathologies du rugbyman
Kaux, Jean-François ULg

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See detailTraumatologie du volleyball
Kaux, Jean-François ULg

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See detailTraumatologie du basketball
Kaux, Jean-François ULg

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See detailNotions de pharmacologie
Kaux, Jean-François ULg

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See detailLe dopage
Kaux, Jean-François ULg

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See detailEvidence based medicine - Tendon and platelet-rich plasma (PRP)
Kaux, Jean-François ULg

in Annual Congress RSBPRM (2014, December 06)

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines ... [more ▼]

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines and growth factors (VEGF, PDGF, TGF-B, IGF-I, and HGF) that promote angiogenesis, tissue remodeling (bone, skin, muscle, tendon, etc.), and wound healing. PRP is obtained by centrifuging autologous blood to obtain a concentration of platelets, usually between 3 and 10 times that of whole blood, depending on the isolation method. For this reason, different PRP preparation techniques cannot provide a consistently identical final product, but there is currently no international consensus on this issue. Overall, PRP could be an attractive therapeutic option for treating chronic musculoskeletal conditions, such as tendinopathy or plantar fasciitis. Tendons do not have a high metabolic index. Growth factors released by platelets promote tenocyte proliferation, stimulate angiogenesis and have analgesic properties. Thus it could stimulate and accelerate tissue regeneration in animal models. In addition to PRP, optimal tissue quality requires the application of mechanical loads. PRP should be considered for chronic tendinopathies. Indeed, the goal is to initiate an acute inflammatory reaction that quickly moves on to the proliferative phase that involves collagen synthesis. The latter is necessary for appropriate tendon healing. PRP should therefore not be used for acute tendinitis or tenosynovitis. Even if most of the preclinical studies showed that PRP stimulates the tendon healing process, clinical series remain more controversial. Based on literature and our clinical experience, we suggest some ideas for improving this treatment. Optimization of the technique for collecting the PRP is paramount. Different risk factors must be corrected before infiltration, and chronic tendinopathies must be carefully selected. Finally, post-infiltration rehabilitation remains absolutely necessary. Standardisation of the use of PRP remains necessary in order to optimise the results. [less ▲]

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See detailPlasma riche en plaquettes et tendinopathies
KAUX, Jean-François ULg; Crielaard, Jean-Michel ULg

in Ortho-Rhumato (2014), 12(6), 35-39

Certaines tendinopathies présentent une évolution désespérément chronique malgré l’instauration d’un traitement conservateur bien conduit. Diverses études soulignent les propriétés réparatrices des ... [more ▼]

Certaines tendinopathies présentent une évolution désespérément chronique malgré l’instauration d’un traitement conservateur bien conduit. Diverses études soulignent les propriétés réparatrices des plaquettes qui pourraient accélérer la cicatrisation de différents tissus. Le plasma riche en plaquettes (platelet-rich plasma ou PRP) représenterait une thérapeutique d’avenir. Les plaquettes libéraient, lors de leur dégranulation, divers facteurs de croissance. Ceux-ci favoriseraient la cicatrisation tendineuse. Actuellement, les effets du PRP restent toujours discutés voire controversés : les résultats cliniques sont parfois contradictoires même si son efficacité in vitro et sur animal apparait plus franche. Cette variabilité pourrait s’expliquer par l’absence de consensus relatif au mode de préparation du PRP, à la concentration plaquettaire, à la présence ou non de leucocytes, à la technique d’infiltration et au protocole post-infiltration. [less ▲]

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See detailCalcifications des tissus mous des jambes
COLLIN, Romain ULg; ANDRE, Béatrice ULg; Crielaard, Jean-Michel ULg et al

in Revue Médicale de Liège (2014), 69(12), 641-643

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See detailEvaluation de la fatigue musculaire des membres supérieurs
Forthomme, Bénédicte ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Abstract Book des XVIèmes Rencontres isocinétiques de Médimex (2014, November 28)

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See detailIsocinétisme et tendinopathies
Croisier, Jean-Louis ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Abstract Book des XVIèmes Rencontres isocinétiques de Médimex (2014, November 28)

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See detailTraitements conservateurs de la gonarthrose
Kaux, Jean-François ULg

Conference (2014, November 20)

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See detailPlasma riche en plaquettes et lésions tendineuses
KAUX, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Revue Médicale de Liège (2014), 69(Synthèse 2014), 72-77

Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of ... [more ▼]

Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of Platelet-Rich Plasma (PRP) is still discussed or even controversial. Our researches have evaluated the effectiveness of PRP on the healing of animal tendons and human suffering from chronic jumper's knee. [less ▲]

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See detailTendon et tendinopathie
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

in Journal de Traumatologie du Sport (2014), 31(4), 235-240

The tendon, connective fibrous tissue, mechanically responsible for the transmission of strength of muscles to bones, is a dynamic entity which, according to the constraints, restructures permanently and ... [more ▼]

The tendon, connective fibrous tissue, mechanically responsible for the transmission of strength of muscles to bones, is a dynamic entity which, according to the constraints, restructures permanently and, thanks to various metabolic and mechanical changes. This review describes the histology, vascularization and innervation of the healthy tendon. In addition, the biomechanics and tendinous physiological responses, as well as the pathophysiology of tendinopathy are exposed. © 2014 Elsevier Masson SAS. [less ▲]

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See detailInjections de PRP et tendinopathies
Kaux, Jean-François ULg

Conference (2014, October 30)

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See detailContribution à l’étude du Plasma Riche en Plaquettes (PRP) dans le traitement des lésions tendineuses
Kaux, Jean-François ULg

Doctoral thesis (2014)

Platelet-rich plasma (PRP) may represent a new therapeutic option for chronic tendinopathies. Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and ... [more ▼]

Platelet-rich plasma (PRP) may represent a new therapeutic option for chronic tendinopathies. Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and wound healing. We made an extended literature review of the use of PRP in chronic tendinopathies. Despite the proven efficacy of PRP on tissue regeneration in experimental studies, there is currently scanty tangible clinical evidence with respect to its efficacy in chronic tendon disorders. The few studies that have been performed appear unlikely to be comparable. Randomized controlled studies with appropriate placebo groups are needed to determine the real effectiveness of PRP for treating chronic musculoskeletal injuries. After, we made a study to compare the platelet concentrations using 5 techniques of preparation of PRP and observed that each provides a very different PRP, with variations in the platelet concentrations and of the amount (if any) of erythrocytes and leucocytes. White blood cells could adversely affect wound healing through the release of proinflammatory factors responsible for extracellular matrix degradation. In addition, erythrocyte lysis releases free radicals that harm tissue structures. We thus think that ideal PRP should not contain any erythrocytes or leucocytes, and that the quality of the PRP could perhaps partially explain the variable results observed in the literature. The aim of our next study was to determine if an injection of PRP could improve the healing of sectioned Achilles tendons of rats. After surgery, rats received an injection of PRP (n = 60) or a physiological solution (n = 60) in situ. After 5, 15, and 30 days, 20 rats of both groups were euthanized and 15 collected tendons were submitted to a biomechanical test using cryo-jaws before performing transcriptomic analyses. Histological and biochemical analyses were performed on the five remaining tendons in each group. Tendons in the PRP group were more resistant to rupture at 15 and 30 days. The mechanical stress was significantly increased in tendons of the PRP group at day 30. Histological analysis showed a precocious deposition of fibrillar collagen at day 5 confirmed by a biochemical measurement. The expression of tenomodulin was significantly higher at day 5. The messenger RNA levels of type III collagen, matrix metalloproteinases 2, 3, and 9, were similar in the two groups at all time points, whereas type I collagen was significantly increased at day 30 in the PRP group. We concluded that an injection of PRP in sectioned rat Achilles tendon influences the early phase of tendon healing and results in an ultimately stronger mechanical resistance. Vascular endothelial growth factor (VEGF) is a platelet growth factor known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. We made a study with the aim of evaluating whether VEGF-111 could have a therapeutic interest in tendon pathologies with the same rat protocol as our previous study. The force necessary to induce tendon rupture was greater for tendons of the VEGF-111 group (but less than the results obtained with the PRP in our previous study), while the section areas of the tendons were similar. The mechanical stress was similar at 5 and 15 days in both groups but was improved for the VEGF-111 group at day 30. No differences were observed in the mRNA expression of collagen III, tenomodulin and MMP-9. Finally, we made a study, the aim of which was to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies, up to one year after a single infiltration of PRP. Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks, 3 months and 1 year after the infiltration, using a 10-point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. We observed that with time, during the 1-year follow-up, VAS dropped significantly and both IKDC and VISA-P scores improved also significantly. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have a relief of pain by the PRP infiltration. Seventy percent of the patients reported a favourable evolution with decrease of pain, 15% reported no improvement and 15% were treated surgically. Seventy percent returned to sports activities, 64,3% without any pain and 50% recovered the same sports level. Even if 1 infiltration seems to be efficient in the indication of patellar tendinopathies, most studies evaluated the effects of 3 successive infiltrations. However, the multiplication of infiltrations risks increasing complications, and this treatment can be expensive. It seemed relevant to evaluate if 2 infiltrations of PRP would be more effective than only 1.Twenty patients suffering from jumper’s knee for more than 3 months were enrolled and randomized in 2 groups (1 or 2 infiltrations of PRP). The follow-up was made as follows: VAS, IKDC and VISA-P scores, algometer, isokinetic and ultrasounds evaluations. The concentration of the PRP used for each infiltration was similar in both groups, without any red or white blood cells. Results for all the evaluations did not show any difference between the groups. The comparison of 1 or 2 infiltrations of PRP did not show any difference between the 2 groups after a follow-up of 3 months. A second close infiltration of PRP to treat upper patellar tendinopathies is not necessary to improve the efficacy of this treatment in the short term. However, these results must be evaluated at a longer term. [less ▲]

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See detailIsocinétisme et muscles rotateurs d'épaule
Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg; Kaux, Jean-François ULg et al

in Innovations technologiques et préhension (2014, October)

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