References of "Kaux, Jean-François"
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See detailEvaluation of the use of VEGF111 for the treatment of tendon lesions.
Janssen, Lauriane ULg; Kaux, Jean-François ULg; Drion, Pierre ULg et al

Poster (2011, May 20)

Alterations of tendons are common pathologies resulting from repetitive or abnormal mechanical sollicitations. Very frequently lesions become chronic and may even lead to rupture. As there is no current ... [more ▼]

Alterations of tendons are common pathologies resulting from repetitive or abnormal mechanical sollicitations. Very frequently lesions become chronic and may even lead to rupture. As there is no current efficient treatment for curing this type of diseases, new therapeutic approaches are being tested and developed. Injection of platelet-rich plasma (PRP) seems to be a promising treatment by local release of growth factors. Among these factors, VEGF-A is known to induce positive effects on vascular functions and angiogenesis, and could be implicated in the healing process of tendons. Several isoforms of VEGF-A have been described in literature, including VEGF165 and 121. VEGF111 is encoded by exons 1-4 and 8a. The lack of exon 5 enables VEGF111 to resist to proteolytic degradation and the absence of exons 6 and 7 reduces its affinity for several macromolecules present on the cell surface and in the extracellular matrix. In vivo, it has been shown to be highly proangiogenic and diffusible. A 5mm defect was surgically performed in the Achilles tendon of 60 rats. Two hours after closure of the fascia and the skin, an injection within the wound was performed with PBS alone (n=30) or with PBS containing 100 ng of VEGF111 (n=30). 10 rats of each group were sacrificed at days 5, 15 and 30. The operated tendon was then carefully removed and collected for either immunohistochemical analyses or mechanical testing. At each time point, the section and the overall appearance of the repairing tendons were similar for PBS and VEGF111-injected tendon. As compared to controls, injection of VEGF111 seemed to promote a faster angiogenesis, although the number of samples was at this stage too low for performing reliable statistical analysis. Mechanical resistance to rupture of the repairing tendons was also measured. No difference between the two groups was observed after 5 or 15 days. By contrast, increased tensile strength was clearly evidenced in the VEGF-treated group after 30 days. These preliminary data seem to indicate a positive effect of a single VEGF111 injection for restoring the mechanical properties of tendons after their section. Additional experiments are planned for confirmation purposes and for further characterizing the model. It includes a “dose- response” analysis, the use of VEGF165 as an additional control and a study evaluating the effect of several injections. [less ▲]

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See detailMetastase unique cervicale d'un cancer du sein
Courtois, Anne-Catherine ULg; COLLIGNON, Joëlle ULg; Bruyère, Pierre-Julien et al

in Revue Médicale de Liège (2011), 66(5-6), 285-287

We report a rare case of single cervical metas- tasis of breast cancer. Bone metastases are the most frequent in breast cancer. early diagnosis combined with the new the- rapeutic advances have ... [more ▼]

We report a rare case of single cervical metas- tasis of breast cancer. Bone metastases are the most frequent in breast cancer. early diagnosis combined with the new the- rapeutic advances have considerably improved the quality of life and increased the survival. imaging plays a great role in the diagnosis, particularly scintigraphy and radiography, but sometimes also ct and Mri. the treatment is currently not standardized and it combines hormone therapy, chemotherapy, radiotherapy, and / or surgery. [less ▲]

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See detailElevation of cardiac and oxidative stress biomarkers after a running activity in sedentary subjects
LE GOFF, Caroline ULg; Bury, Thierry ULg; Rodriguez de la Cruz, Carlos ULg et al

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(Special Suppl), 313

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See detailFatty acids and cardiovascular risk
LE GOFF, Caroline ULg; Leroy, Ludovic; Kaux, Jean-François ULg et al

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(Special Suppl), 313

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See detailPlatelet-rich plasma and tendons healing: rat model
Kaux, Jean-François ULg; Drion, Pierre ULg; Colige, Alain ULg et al

in Biomedica Life Science Summit (2011, April 07)

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See detailFatty acids determinations: an cardiovascular risk? Preliminary results
LE GOFF, Caroline ULg; Leroy, Ludovic; Pincemail, Joël ULg et al

in Biomedica - Life Science Summit (2011, April 07)

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See detailOndes de choc et pathologies abarticulaires
Kaux, Jean-François ULg

Conference (2011, April 06)

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See detailPrévention des lésions tendineuses : mythe ou réalité ?
Delvaux, François ULg; Forthomme, Bénédicte ULg; Kaux, Jean-François ULg et al

in Julia, M.; Hirt, D.; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendino-musculaire - De la biomécanique aux applications thérapeutiques (2011)

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See detailDonnées scientifiques actuelles concernant le traitement par injection de concentré plaquettaire
Kaux, Jean-François ULg; LE GOFF, Caroline ULg; Drion, Pierre ULg et al

in Julia, Marc; Hirt, Daniel; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendino-musculaire (2011)

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See detailFacteurs plaquettaires et traitement des lésions tendino-musculaires
Sanchez, Mikel; Kaux, Jean-François ULg; Anitua, Ernesto et al

in Julia, Marc; Hirt, Daniel; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendinomusculaire (2011)

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See detailAnalyse critique des traitements conservateurs des tendinopathies
Kaux, Jean-François ULg; Forthomme, Bénédicte ULg; LE GOFF, Caroline ULg et al

in Julia, Marc; Hirt, Daniel; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendino-musculaire (2011)

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See detailProgramme excentrique et tendinopathie : quels outils, quel programme ?
Forthomme, Bénédicte ULg; KAUX, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Julia, M.; Hirt, D.; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendino-musculaire - De la biomécanique aux applications thérapeutiques (2011)

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See detailQuels critères de retour au sport après tendinopathie ?
Croisier, Jean-Louis ULg; Delvaux, François ULg; Kaux, Jean-François ULg et al

in Julia, M.; Hirt, D.; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendino-musculaire - De la biomécanique aux applications thérapeutiques (2011)

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See detailInfluence sur le tissu tendino(-musculaire) du mode de contraction en entraînement : modèle animal
Kaux, Jean-François ULg; Drion, Pierre ULg; Croisier, Jean-Louis ULg et al

in Julia, Marc; Hirt, Daniel; Croisier, Jean-Louis (Eds.) et al Tendon et jonction tendino-musculaire - De la biomécanique aux applications thérapeutiques (2011)

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See detailLa bonne prescription de kinésithérapie
Kaux, Jean-François ULg; BAUVIR, Philippe ULg

Conference (2011, February 17)

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See detailPlatelet-rich plasma (PRP) and tendon healing: animal model
Kaux, Jean-François ULg; Drion, Pierre ULg; Renouf, Julien et al

in British Journal of Sports Medicine (2011, February), 45(2), 1

Introduction: The tendon is a tissue which does not heal easily. Recently, several studies have demonstrated the positive effects of platelets on the healing process of tendons. A local injection of ... [more ▼]

Introduction: The tendon is a tissue which does not heal easily. Recently, several studies have demonstrated the positive effects of platelets on the healing process of tendons. A local injection of platelet–rich plasma (PRP), which releases in situ many growth factors, has the potentiality to enhance the tendon healing process. The aim of our experiment was to ascertain by an original mechanical measure whether the use of PRP was of interest for accelerating the healing process of rats’ Achilles tendons after surgical induced lesion. Methods: A 5mm defect was surgically induced in 90 rats’ Achilles tendon. Rats were divided into 2 groups of 45: (A) control (no treatment) and (B) PRP treatment. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cages without immobilization. After 5, 15 and 30 days, 10 traumatized Achilles tendons of each group were dissected and removed. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. After that, transcriptomic analyses were made on the tendon samples, to study the expression of type III collagen, matrix metalloproteases and tenomodulin. A hydroxyproline dosage was done to quantify the collagen in the tendon during its healing process. Tendons of the 15 remaining rats of each group were subjected to a histological study, respectively at day 5, 15 and 30 (5 rats for each time). Results: We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile test study was greater for tendons which had been submitted to an injection of PRP compared to the control group: +19% (day 5), +30% (day 15) and +43% (day 30). Histological study showed that PRP could enhance cells proliferation, angiogenesis and collagen organisation. Our biochemical analyses did not explain beneficial effects of PRP. Indeed, there was no significant difference neither between the expression of different studied genes, nor in the quantity of hydroxyproline between both groups. Conclusion: This experimentation has shown that a PRP injection could accelerate the tendons healing process and improve its quality. [less ▲]

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See detailL’image du mois. Exostose douloureuse de la métaphyse distale du fémur
Hogge, Martine; Kurth, William ULg; Crielaard, Jean-Michel ULg et al

in Revue Médicale de Liège (2011), 66(1), 4-6

Cartilaginous exostosis, a frequent benign bone tumour, develops mainly during the growth. Often asymptomatic, it can be painful, compressive or unsightly, involving a surgical treatment. The diagnostic ... [more ▼]

Cartilaginous exostosis, a frequent benign bone tumour, develops mainly during the growth. Often asymptomatic, it can be painful, compressive or unsightly, involving a surgical treatment. The diagnostic is based on radiological imaging. At adulthood, pains, a growth of the exostosis volume or characteristic imaging modifications lead to a resection in order to exclude a sarcomatous transformation. We report the case of a patient showing a painful exostosis of the femur distal metaphysis. [less ▲]

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See detailLatence du potentiel global d’action musculaire du muscle 1er interosseux dorsal de la main
Kaux, Jean-François ULg; Dive, Dominique ULg; Wang, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2011), XV(1), 21-23

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See detailL'onde F dans tous ses états
Wang, François-Charles ULg; Massart, Nicolas ULg; Kaux, Jean-François ULg et al

in Journées de la Société Francophone du Nerf Périphérique - Livre des Résumés (2011, January)

C’est Magladery et McDougal (1950) qui, les premiers, ont constaté l’existence des réponses F au niveau du pied (F pour foot) chez l’homme. Dawson et Merton (1956) ont ensuite démontré que celles-ci ne ... [more ▼]

C’est Magladery et McDougal (1950) qui, les premiers, ont constaté l’existence des réponses F au niveau du pied (F pour foot) chez l’homme. Dawson et Merton (1956) ont ensuite démontré que celles-ci ne résultent pas d’un réflexe, mais de la décharge des motoneurones suite à leur activation rétrograde par des volées d’influx centripètes. L’onde F se traduit au niveau musculaire, par une réponse indirecte (dont la latence diminue lorsque le site de stimulation nerveuse s’éloigne du site de détection musculaire), tardive (survenant après la réponse M), de longue latence. Lors d’une stimulation nerveuse supramaximale, une ou plusieurs unités motrices participent à la formation de la réponse F. Lorsque la stimulation nerveuse est répétée, les unités motrices, générant l’onde F, changent d’une stimulation à l’autre, induisant une variabilité en latence, durée, amplitude et forme de la réponse tardive. Cette variabilité est principalement liée au niveau d’excitabilité des motoneurones α. En clinique, le paramètre le plus utile est la latence minimale, à condition qu’au moins 7 ondes F distinctes soient évoquées. Lorsque l’analyse est relative soit au côté controlatéral, soit à un examen antérieur, ce paramètre est un des plus sensibles en électroneuromyographie. [less ▲]

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