Régulation du magnésium

Conference (2011, November 29)

Régulation du potassium

Conference (2011, October 25)

Reproducibility of blood pressure (BP) measurement techniques in late kidney transplantation (KT): the EPARA study

Conference (2011, October 08)

There has been a long debate about appropriate BP measurement techniques for evaluating the quality of BP control, especially in kidney transplantation (KT). Thus, one aim of the present study was to ... [more ▼]

There has been a long debate about appropriate BP measurement techniques for evaluating the quality of BP control, especially in kidney transplantation (KT). Thus, one aim of the present study was to examine 3 methods of BP measurement and their reproducibility over a short period of 8 weeks. Conclusion: Home blood pressure monitoring (HBPM) and ambulatory blood pressure monitoring (ABPM) should be applied more often also in KT, among others for reasons of better reproducibility over time than office blood pressure monitoring (OBPM). [less ▲]

Tumor-induced osteomalacia: The tumor may stay hidden!

in Clinical Biochemistry (2011), 44(14-15), 1264-6

We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth ... [more ▼]

We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) was abnormally high and the diagnostic of tumor-induced osteomalacia was made. Despite multiple tests, the tumor was not localized. In this report, we discuss different possible investigations to localize the tumor. Lastly, we review the potential therapy available when tumor is not found and can thus not be excised. [less ▲]

Détection de la maladie rénale chronique dans la population générale: créatinine ou cystatine C?

in Néphrologie & Thérapeutique (2011, September), 7(5), 298

Suivi longitudinal des concentrations de PTH et de phosphatase alcaline osseuse chez le sujet hémodialysé: mesure-t-on la même chose?

in Néphrologie & Thérapeutique (2011, September), 7(5), 324

Trimethoprim, creatinine and creatinine-based equations

in Kidney International (2011), 80(5), 439-40

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis ... [more ▼]

Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis jirovecii infections. The Sfx component appears to be nephrotoxic at high doses or doses inappropriately adjusted for glomerular filtration rate (GFR). The trimethoprim component, even at recommended doses, inhibits tubular creatinine secretion, leading to a rapid but ultimately reversible increase in serum creatinine independent of any changes in GFR. This translates into a falsely low estimated GFR when creatinine-based equations are used. This review focuses on evidence of the differential effects of trimethoprim and Sfx on serum creatinine concentrations and GFR and their relevance to clinical practice, with particular attention to kidney transplantation. [less ▲]

Hypophosphatémie et ostéomalacie oncogénique

in Revue Médicale Suisse (2011), 7

In this article, we will discuss about hypophosphatemia due to tumor-induced osteomalacia. This disease is characterized by severe muscular and articular tenderness inducing profound walking limitation ... [more ▼]

In this article, we will discuss about hypophosphatemia due to tumor-induced osteomalacia. This disease is characterized by severe muscular and articular tenderness inducing profound walking limitation. Clinical chemistry results show severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGG-23) is abnormally high. Physiological role of FGF-23 is examined. We also consider the pathophysiology of tumor induced osteomalacia, the use of different investigations to localize the tumor and therapies available to treat this rare disease. [less ▲]

Native vitamin D in dialysis patients : safety and biological effects

Conference (2011, June 25)

Native vitamine D (VTD) supplementation is recommended by the last KDIGO guidelines in CKD patients including dialysis patients. However, this recommendation is based on a low level of evidence. We ... [more ▼]

Native vitamine D (VTD) supplementation is recommended by the last KDIGO guidelines in CKD patients including dialysis patients. However, this recommendation is based on a low level of evidence. We designed a randomized double-blind prospective study comparing the effects of VTD and placebo in dialysis patients on mortality, vascular calcifications and different paremeters: 25-OH vitamine D- 25(OH)D -, parathormone (PTH), calcium and phosphorus. [less ▲]

Practical issues in medication compliance in hypertensive patients

in Research Reports in Clinical Cardiology (2011), 2

Unsatisfactory compliance in the treatment of high blood presure is frequently due to sequential barriers, such as insufficient patient education about the illness and low motivation to receive any ... [more ▼]

Unsatisfactory compliance in the treatment of high blood presure is frequently due to sequential barriers, such as insufficient patient education about the illness and low motivation to receive any treatment, existence of a large gap between physicians'perceptions of the problem and clinical reality, complexity of the treatment potentially generating adverse effects, and a health care environment with few public education compaigns and incentives for better coordinated supportive care. In order to improve drug compliance, establishment of personalized plans adapted to each patient is required. First, a good doctor-patient relationship is mandatory, with regular education of the patient about hypertension and its risks, discussion about adverse drug effects, and the complexity and cost of treatment. Second, to have any chance of success, the provider should offer convenient appointments and tailor the treatment regimen to the patient's lifestyle and needs, with written instructions. Third, there is a need to promote active patient collaboration with treatment. An innovative combination of home self-measurement of blood pressure, use of new technology options, eg, texting or telemedicine, and creation of a multi-disciplinary working team can offer new, effective opportunities. This approach could reduce cardiovascular complications by improving the control of high blood pressure, and thereby the overall costs of hypertension to the health care system. [less ▲]