References of "Joris, Jean"
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See detailLes morphinomimétiques en réanimation
Lamy, Maurice ULg; Joris, Jean ULg; Damas, Pierre ULg et al

in Réan urg (1993), 2(4bis), 488-494

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See detailClonidine and ketanserin both are effective treatment for postanesthetic shivering.
Joris, Jean ULg; Banache, Maryse; Bonnet, Francis et al

in Anesthesiology (1993), 79(3), 532-9

BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which ... [more ▼]

BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which shivering can be controlled. Accordingly, we investigated the efficacy of clonidine, an alpha 2-adrenergic agonist, and ketanserin, a 5-hydroxytryptamine antagonist, in treating postanesthetic shivering. METHODS: First, 54 patients shivering after general anesthesia were allocated randomly to receive an intravenous bolus of saline, 150 micrograms clonidine, or 10 mg ketanserin. A second study explored the dose-dependence of clonidine. Forty shivering patients were given saline or clonidine, 37.5, 75, or 150 micrograms. RESULTS: The duration of shivering was significantly shorter in those given clonidine (2.1 +/- 0.9 min) than in the other two groups and shorter in the ketanserin group (4.3 +/- 0.9 min) than in the saline group (12.0 +/- 1.6 min). Clonidine and ketanserin significantly decreased systolic arterial blood pressure when compared to saline. Core rewarming was significantly slower in the clonidine group. In the second study, 37.5 micrograms clonidine was no more effective than saline. Two minutes after treatment, 150 micrograms obliterated shivering in all patients. Five minutes after treatment, all patients given 75 micrograms had stopped shivering. Systolic arterial pressure and heart rate decreased significantly in patients given 75 and 150 micrograms clonidine. CONCLUSIONS: Clonidine (150 micrograms) and ketanserin (10 mg) both are effective treatment for postanesthetic shivering. The effect of clonidine on shivering is dose-dependent: whereas 37.5 micrograms had no effect, 75 micrograms clonidine stopped shivering within 5 min. [less ▲]

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See detailLaparoscopy, urology, and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailAnalgésie postopératoire après thoracotomie
Joris, Jean ULg

in Conférences d'actualisation 1993 (1993)

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See detailAnalgésie postopératoire par analgésie péridurale autocontrôlée
Joris, Jean ULg

in Douleur et analgésie (1993), 4

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See detailAmiodarone-induced thyrotoxicosis: is there a place for surgery?
Meurisse, Michel ULg; Hamoir, Etienne ULg; D'Silva, Milbhor et al

in World Journal of Surgery (1993), 17(5), 622-6627

Amiodarone-induced hyperthyroidism has on most instances been reported as mild, and thyroid functions return to normal after discontinuation of the drug. Nevertheless, life-threatening amiodarone-induced ... [more ▼]

Amiodarone-induced hyperthyroidism has on most instances been reported as mild, and thyroid functions return to normal after discontinuation of the drug. Nevertheless, life-threatening amiodarone-induced thyrotoxicosis has also been described. Conventional treatments such as antithyroid drugs (thionamide) and corticosteroids are essentially ineffective or fail to alter the dramatic course of the thyroid crisis. This limited effectiveness of medical therapy, particularly in patients with previously neglected or unknown thyroid disease, prompted us to intervene surgically. We report a series of nine patients who underwent total or near-total thyroidectomy as a first-line therapy for five of them. Surgery resulted in rapid resolution of thyrotoxicosis with an uneventful postoperative course. This approach has the advantage of immediate effectivity, low risk of relapse, and appears to be the only treatment that permits continued therapy with amiodarone when the drug appears needed to control a life-threatening arrhythmia. [less ▲]

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See detailLaparoscopic surgery, urology and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailMetabolic and respiratory changes after cholecystectomy performed via laparotomy or laparoscopy.
Joris, Jean ULg; Cigarini, I.; Legrand, Marc ULg et al

in British Journal of Anaesthesia (1992), 69(4), 341-5

We have compared metabolic and respiratory changes after laparoscopic cholecystectomy (n = 15) with those after open cholecystectomy (n = 15). The durations of postoperative i.v. therapy, fasting and ... [more ▼]

We have compared metabolic and respiratory changes after laparoscopic cholecystectomy (n = 15) with those after open cholecystectomy (n = 15). The durations of postoperative i.v. therapy, fasting and hospital stay were significantly shorter in the laparoscopy group. During the first and second days after operation, analgesic consumption but not pain scores (visual analogue scale) were significantly smaller after laparoscopy, while vital capacity, forced expiratory volume in 1 s, and PaO2 were significantly greater. The metabolic and acute phase responses (glucose, leucocytosis, C-reactive protein) were less after laparoscopy compared with laparotomy. Although plasma cortisol and catecholamine concentrations were not significantly different between the two groups, after surgery interleukin-6 concentrations were less in the laparoscopy group. [less ▲]

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See detailPlace des morphiniques en réanimation
Joris, Jean ULg; Lamy, Maurice ULg

(1992)

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See detailAspects chirurgicaux du traitement des affections surrenaliennes.
Meurisse, Michel ULg; Dewandre, J. M.; Pirenne, J. et al

in Acta Chirurgica Belgica (1991), 91(2), 107-11

With the greatly enhanced accuracy of current endocrinologic diagnosis assisted by precise diagnostic imaging, together with greatly enhanced preparation of patients with endocrinopathy for safer ... [more ▼]

With the greatly enhanced accuracy of current endocrinologic diagnosis assisted by precise diagnostic imaging, together with greatly enhanced preparation of patients with endocrinopathy for safer anesthetic and surgical procedure (e.g. adrenal cortical cancers, cortisol and aldosterone producing adenomas and pheochromocytomas), operative procedures can be planned and conducted more precisely. For the surgeon, the strategy for treatment of functional and neoplastic disorders of the adrenal glands has essentially to consider the anatomy of the suprarenal glands, the deleterious effects of hormone excess before and during operation, the presumed nature of incidentally discovered adrenal mass and the size of the tumor. [less ▲]

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See detailInterpleural, intercostal and thoracic epidural analgesia
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1991), 4

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See detailChoice of sedation according to ventilatory mode
Lamy, Maurice ULg; Damas, Pierre ULg; Joris, Jean ULg

in Journal of drug development (1991), 4(Suppl 3), 77-81

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See detailOpiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia
Joris, Jean ULg; Costello, A.; Dubner et al

in Pain (1990), 43

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See detailRelease from inflamed tissue of a substance with properties similar to corticotropin-releasing factor.
Hargreaves, K. M.; Costello, A. H.; Joris, Jean ULg

in Neuroendocrinology (1989), 49(5), 476-82

In response to stressors involving tissue injury, pituitary corticotroph secretion of immunoreactive beta-endorphin (iB-END) could be either due to release of hypothalamic factors such as corticotropin ... [more ▼]

In response to stressors involving tissue injury, pituitary corticotroph secretion of immunoreactive beta-endorphin (iB-END) could be either due to release of hypothalamic factors such as corticotropin-releasing factor (CRF) or to release of a tissue factor from the periphery. In the present experiments, we investigated whether inflamed tissue releases a factor which evokes pituitary secretion of iB-END. In an initial experiment, rats with an inflamed hindpaw due to carrageenan injection had significantly greater levels of circulating iB-END as compared to rats with saline-injected paws. Removal of afferent input, by hindlimb denervation, failed to block the carrageenan-induced increase in iB-END levels. Subcutaneous perfusates were then collected from inflamed and control hindlimbs and applied to rat anterior pituitary cell cultures. Pituitary release of iB-END due to administration of perfusate from inflamed paws was significantly greater than iB-END release due to perfusate from saline-injected paws or to basal release. The releasing activity in the perfusates was blocked in calcium-free medium and was not due to a direct action of carrageenan, bradykinin, substance P or calcitonin gene-related peptide. The results indicate that inflamed tissue releases a CRF-like factor which stimulates iB-END release both in the denervated rat and cultured pituitary cells. [less ▲]

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See detailA new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
Hargreaves, K.; Dubner, R.; Brown, F. et al

in Pain (1988), 32(1), 77-88

A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm uses an automated detection of the behavioral end-point; repeated testing does ... [more ▼]

A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm uses an automated detection of the behavioral end-point; repeated testing does not contribute to the development of the observed hyperalgesia. Carrageenan-induced inflammation resulted in significantly shorter paw withdrawal latencies as compared to saline-treated paws and these latency changes corresponded to a decreased thermal nociceptive threshold. Both the thermal method and the Randall-Selitto mechanical method detected dose-related hyperalgesia and its blockade by either morphine or indomethacin. However, the thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold. [less ▲]

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See detailBradykinin is increased during acute and chronic inflammation: therapeutic implications.
Hargreaves, K. M.; Troullos, E. S.; Dionne, R. A. et al

in Clinical Pharmacology & Therapeutics (1988), 44(6), 613-21

Bradykinin is a potent pain-producing substance, yet little is known about its role in inflammation. The present study measured circulating levels of immunoreactive bradykinin in a clinical model of acute ... [more ▼]

Bradykinin is a potent pain-producing substance, yet little is known about its role in inflammation. The present study measured circulating levels of immunoreactive bradykinin in a clinical model of acute inflammation (oral surgery) and chronic inflammation (rheumatoid arthritis) and in the rat carrageenan model of inflammation. The effects of a kallikrein inhibitor (soybean trypsin inhibitor) on blocking bradykinin synthesis in vitro and its analgesic actions in the rat model were also evaluated. Levels of immunoreactive bradykinin increased threefold to fourfold during oral surgery. Levels were twofold to threefold greater in patients with rheumatoid arthritis compared with control subjects. Levels of immunoreactive bradykinin increased twofold in rats during carrageenan inflammation. Soybean trypsin inhibitor blocked synthesis of bradykinin in vitro and possessed analgesic activity in rats. The results indicate that the bradykinin system is activated during inflammation. Kallikrein inhibitors may represent a new class of analgesic/antiinflammatory drugs. [less ▲]

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See detailOpioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?
Joris, Jean ULg; Dubner, R.; Hargreaves, K. M.

in Anesthesia and Analgesia (1987), 66(12), 1277-81

The peripheral analgesic effects of opiates were evaluated in a rat model of inflammation. The experimental design excluded a potential central nervous system site of action for the observed analgesia ... [more ▼]

The peripheral analgesic effects of opiates were evaluated in a rat model of inflammation. The experimental design excluded a potential central nervous system site of action for the observed analgesia. After the injection of carrageenan (CARRA) in the plantar surface of both hind paws, an opiate was injected into one paw and saline was injected into the other paw. The inflamed paws injected with the mu-agonist, fentanyl (0.3 micrograms) or the kappa-agonist, ethylketocyclazocine (10 micrograms) were significantly less hyperalgesic (P less than 0.001 and P less than 0.01, respectively) than were the contralateral inflamed paws injected with saline. At these doses, fentanyl and ethylketocyclazocine were devoid of systemic effects. Another mu-agonist, levorphanol (20, 40, 80, or 160 micrograms) and dextrorphan (160 micrograms), its dextrorotatory isomer, were used next to evaluate opioid specificity. Levorphanol produced a dose-related blockade of CARRA-induced hyperalgesia (P less than 0.005). In contrast, 160 micrograms of dextrorphan was inactive. These results demonstrate that local administration of opiates into an inflamed paw produces a dose-related, stereospecific analgesia restricted to the injected area. [less ▲]

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See detailPreparation preoperatoire et surveillance postoperatoire d'un patient atteint d'oedeme angioneurotique hereditaire.
Joris, Jean ULg; Lamy, Maurice ULg

in Annales Françaises d'Anesthésie et de Réanimation (1986), 5(3), 312-4

Hereditary angioneurotic oedema is an autosomal dominant disorder associated with serum deficiency of functionally active C1 inhibitor protein. This decrease is characterized by episodic swelling of ... [more ▼]

Hereditary angioneurotic oedema is an autosomal dominant disorder associated with serum deficiency of functionally active C1 inhibitor protein. This decrease is characterized by episodic swelling of subcutaneous tissues, of abdominal viscera and of the upper airway. Attacks of angioneurotic oedema, sometimes fatal when involving the upper airway, can occur during any surgery. It is therefore necessary to prepare affected patients before surgery. This review article describes the various preventive treatments used to avoid attacks during surgery: antifibrinolytic agents, androgens, fresh frozen plasma, C1 esterase inhibitor concentrate. Preoperative management of one patient with angioneurotic oedema using danazol and C1 esterase inhibitor concentrate is reported. [less ▲]

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See detailEtude du marquage de la beta-endorphine (beta-END) et de la beta-lipotropine (beta-LPH) par l'iode 125.
Deby-Dupont, G.; Reuter, A. M.; Joris, Jean ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1983), 177(2), 259-68

5 micrograms of human beta-endorphin were labelled with 2 mCi 125I by the chloramine T technique. After two gel filtrations on Sephadex G-15 and on Sephadex G-50 in phosphate buffer with EDTA, Trasylol ... [more ▼]

5 micrograms of human beta-endorphin were labelled with 2 mCi 125I by the chloramine T technique. After two gel filtrations on Sephadex G-15 and on Sephadex G-50 in phosphate buffer with EDTA, Trasylol and mercapto-ethanol, a pure tracer was obtained with a specific activity about 150 microCi/ug. Kept at + 4 degrees C, the tracer remained utilizable for 30 days without loss of immunoreactivity. The labelling with lactoperoxydase and the use of another gel filtration method (filtration on Aca 202) gave a 125I beta-END tracer with the same immunoreactivity. The binding of this tracer to the antibody of an anti-beta-END antiserum diluted at 1/8000 was 32% with a non specific binding of 2%. 5 micrograms of human beta-lipotropin were labelled with 0.5 mCi 125I by the lactoperoxydase method. After two gel filtrations on Sephadex G-25 and on Sephadex G-75 in phosphate buffer with EDTA, Trasylol and mercapto-ethanol, a pure tracer with a specific activity of 140 microCi/micrograms was obtained. It remained utilizable for 30 days when kept at + 4 degrees C. Gel filtration on Aca 202 did not give good purification, while gel filtration on Aca 54 was good but slower than on Sephadex G-75. The binding to antibody in absence of unlabelled beta-LPH was 32% for an anti-beta-LPH antiserum diluted at 1/4000. The non specific binding was 2.5%. [less ▲]

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