References of "Jérôme, Christine"
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See detailA facile and fast electrochemical route to produce functional few-layer graphene sheets for lithium battery anode application
Ouhib, Farid ULg; Aqil, Abdelhafid ULg; Thomassin, Jean-Michel ULg et al

in Journal of Materials Chemistry A (2014), 2(37), 15298-15302

A simple approach for the production of polymer functionalized graphene nanosheets is reported. The resulting polyacrylonitrile chemisorbed on graphene sheets is made of 1 to 2 layers, with a large ... [more ▼]

A simple approach for the production of polymer functionalized graphene nanosheets is reported. The resulting polyacrylonitrile chemisorbed on graphene sheets is made of 1 to 2 layers, with a large majority of graphene single-layers. This novel functionalized graphene exhibits good cycling stability as an anode in Li-ion batteries without a conductive additive or binder. [less ▲]

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See detailTemplating calcium carbonate drug delivery carriers based on polyphosphoester copolymers
Ergül, Zeynep ULg; Debuigne, Antoine ULg; Calvignac, Brice et al

Poster (2014, October)

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See detailBlock, random and palm-tree amphiphilic fluorinated copolymers: controlled synthesis, surface activity and use as dispersion polymerization stabilizers
Alaimo, David ULg; Beigbeder, Alexandre; Dubois, Philippe et al

in Polymer Chemistry (2014), 5(18), 5273-5282

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See detailThermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core–corona nanoparticles as a drug delivery system
Liu, Ji ULg; Detrembleur, Christophe ULg; Hurtgen, Marie et al

in Polymer Chemistry (2014), 5(18), 5289-5299

Core–corona gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) nanoparticles (gold@PVOH-b-PNVCL NPs) were fabricated via an in situ method, where a gold salt was reduced within the macromolecular aqueous ... [more ▼]

Core–corona gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) nanoparticles (gold@PVOH-b-PNVCL NPs) were fabricated via an in situ method, where a gold salt was reduced within the macromolecular aqueous solution. Arrangement of macromolecular chains on the surface of gold cores was studied by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy and infrared spectroscopy. The responsiveness to temperature and the preserved colloidal stability of the gold@PVOH-b-PNVCL NPs above the lower critical solution temperature (LCST) were confirmed by dynamic light scattering and turbidity measurements. The drug loading capacity (DLC of ca. 1.3–2.8 wt%) of the gold@PVOH-b-PNVCL NPs as a drug delivery system (DDS) was tested with Nadolol®, a hydrophilic drug, and the release behaviours were studied at several temperatures. PVOH-b-PNVCL copolymers with an LCST of a few degrees above the biological temperature (37 °C), for example, PVOH180-b-PNVCL110 (LCST of 41 °C), are preferential, due to the slower release at 37 °C, but a faster release at temperatures that are a few degrees higher. The cytocompatibility of the gold@PVOH-b-PNVCL NPs against mouse fibroblastic L929 cells was evaluated via the MTS assay. Cellular uptake within MEL-5 human melanoma cells was studied by confocal laser scanning microscopy, fluorescence-activated cell sorting and TEM techniques and it showed that gold@PVOH-b-PNVCL NPs preferably accumulated within the cellular cytoplasm, with an incubation concentration and period-dependent uptake process. All these results corroborated a general utility of these thermo-responsive gold@PVOH-b-PNVCL NPs for drug delivery and controlled drug release. [less ▲]

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See detailAmphiphilic copolymers containing polyphosphates for drug delivery applications
Vanslambrouck, Stéphanie ULg; Clément, Benoit; Riva, Raphaël ULg et al

Poster (2014, September 19)

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See detailSynthesis of well-defined ethylene-based copolymers: on track using organometallic-mediated radical polymerization
Debuigne, Antoine ULg; Kermagoret, Anthony ULg; Jérôme, Christine ULg et al

Conference (2014, September 19)

Organometallic-Mediated Radical Polymerization (OMRP)1 has received renewed interest in recent years since proving its efficiency for non-activated monomers like vinylacetate (VAc), N-vinylamides, etc ... [more ▼]

Organometallic-Mediated Radical Polymerization (OMRP)1 has received renewed interest in recent years since proving its efficiency for non-activated monomers like vinylacetate (VAc), N-vinylamides, etc. Nevertheless, important mechanistic questions and challenges remained. A major goal in the field of controlled radical polymerization today consists in the design of well-defined ethylene containing (co)polymers. A recent mechanistic study on the impact of head-to-head addition on the course of the VAc polymerization by OMRP provided a strong incentive to evaluate the copolymerization of VAc with ethylene by this technique. Indeed, the latter revealed that dormant chains resulting from inverted head-to-head additions in the VAc polymerization, which mimics a terminal ethylene-cobalt moiety, reactivates at a similar rate compared to the ones resulting from the regular head-to-tail addition. As a result, well-defined statistical and block-like ethylene-based copolymers were prepared. These achievements represent an important step towards a versatile synthetic platform for polyolefine-based materials. [less ▲]

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See detailElectrografting of acrylate monomer, versatile method for coatings and thin films technologies
Aqil, Abdelhafid ULg; Jérôme, Christine ULg

Conference (2014, September)

Among the high research activity in the area of surface modification, electrografting is a very powerful and effective technique. When conducted under appropriate conditions of solvent and cathodic ... [more ▼]

Among the high research activity in the area of surface modification, electrografting is a very powerful and effective technique. When conducted under appropriate conditions of solvent and cathodic potential, the electropolymerization of (meth)acrylic monomers results in the chemisorption of the polymer on the conducting surface. This one-step electrografting technique is very easily implemented, can be applied to a wide range of (semi)-conducting surfaces by keeping the same chemistry and requires commonly used, readily available (meth)acrylate monomers. The wide variety of acrylic monomers suitable for this process makes available a broad range of surface properties including bactericidal, superhydrophobic and proteins repellent coatings. Electrografted smart coatings able to respond to external stimuli are also of interest particularly for sensors and actuators. [less ▲]

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See detailPolymer topology revealed by ion mobility coupled with mass spectrometry
Morsa, Denis ULg; Defize, Thomas ULg; Dehareng, Dominique ULg et al

in Analytical Chemistry (2014), 86(19), 96939700

Hyperbranched and star shaped polymers have raised tremendous interests because of their unusual structural and photochemical properties which provide them potent applications in various domains, namely ... [more ▼]

Hyperbranched and star shaped polymers have raised tremendous interests because of their unusual structural and photochemical properties which provide them potent applications in various domains, namely in the biomedical field. In this context, the development of adequate tools aiming to probe particular three-dimensional features of such polymers is of crucial importance. In this present work, ion mobility coupled with mass spectrometry was used to experimentally derive structural information related to cationized linear and star-shaped poly-ε-caprolactones as a function of their charge state and chain length. Two major conformations were observed and identified using theoretical modeling: (1) near spherical conformations whose size is invariant with the polymer topology for long and lightly charged chains and (2) elongated conformations whose size varies with the polymer topology for short and highly charged chains. These conformations were further confirmed by collisional activation experiments based on the ejection thresholds of the coordinated cations that vary according to the elongation amplitude of the polymer chains. Finally, a comparison between solution and gas-phase conformations highlights a compaction of the structure with a loss of specific chain arrangements during the ionization and desolvation steps of the electrospray process, fueling the long-time debated question related to the preservation of the analyte structure during the transfer into the mass spectrometer. [less ▲]

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See detailOn the use of carbon dioxide and vegetable oil for the synthesis of bio-based cyclic carbonates
Alves, Margot ULg; Tassaing, Thierry; Méreau, Raphaël et al

Conference (2014, August 27)

The uncertain cost of petroleum and its expected depletion in the near future prompted the scientific community to search for new sources of carbon just inexpensive, abundant and easily exploitable ... [more ▼]

The uncertain cost of petroleum and its expected depletion in the near future prompted the scientific community to search for new sources of carbon just inexpensive, abundant and easily exploitable. Combining the use of renewable resources such as vegetable oils and carbon dioxide as a carbon source for the development of a sustainable chemistry is very promising. Thus, this research project fits within the framework of the chemical fixation of CO2 and the utilization of vegetable oils as a substitute for basic petroleum derivatives for the production of new monomers and new bio-based organic polymers. As a first step, the catalytic synthesis of cyclic carbonate monomers from CO2 and epoxidized vegetable oils (and/or the corresponding fatty esters) will be considered. The synthesis of non-isocyanates polyurethanes (NIPUS) will then be performed by reacting in bulk these new monomers with diamines under mild heating. In this talk, we will present the results that we have obtained on the first step of the process. Namely, we have investigated various catalytic platforms enabling the cycloaddition of CO2 on epoxidized oils in the most efficient way under mild conditions. For such task, in situ kinetic follow-up of this reaction has been performed by FT-IR or Raman spectroscopy in order to identify the best catalytic systems and to evaluate the influence of various parameters (pressure, temperature catalyst concentration, nature of epoxidized oil) on the yields and the reaction kinetics. Then, the most efficient catalytic systems have been investigated by molecular modeling in order to identify the key structural parameters of the catalyst that govern its efficiency. [less ▲]

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See detailThiophene derivatives with donor–π–acceptor structures for enhanced light-absorption properties and efficient cationic polymerization upon green-light irradiation
Telitel, Sofia; Ouhib, Farid ULg; Fouassier, Jean-Pierre et al

in Macromolecular Chemistry and Physics (2014), 215(16), 1514-1524

Positively charged thermoresponsive nanogels (NGs) are easily synthesized by precipitation polymerization of N-isopropyl­acrylamide and 2-dimethyl(aminoethyl)­methacrylate crosslinked with dendritic ... [more ▼]

Positively charged thermoresponsive nanogels (NGs) are easily synthesized by precipitation polymerization of N-isopropyl­acrylamide and 2-dimethyl(aminoethyl)­methacrylate crosslinked with dendritic polyglycerol. The NGs are characterized in terms of size, thermoresponsive properties, and Z potential. Their potential applications as drug delivery carriers are evaluated by the encapsulation and release of different anticancer drugs. As model drugs, doxorubicin and methotrexate are studied. [less ▲]

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See detailRole of non-polyQ regions on the aggregation process by polyQ proteins into amyloid fibrils
Huynen, Céline ULg; Willet, Nicolas ULg; Buell, Alexander K et al

Poster (2014, July 28)

Nine neurodegenerative disorders, referred to as polyglutamine diseases and including Huntington’s disease, are associated with the abnormal expansion of a polyglutamine tract inside nine unrelated ... [more ▼]

Nine neurodegenerative disorders, referred to as polyglutamine diseases and including Huntington’s disease, are associated with the abnormal expansion of a polyglutamine tract inside nine unrelated proteins. This polyQ expansion is thought to be the major determinant in the development of neurotoxicity, triggering protein aggregation into amyloid fibrils. A large body of evidence however indicates that non-polyQ regions modulate the aggregation process triggered by polyQ expansions. The interplay between the polyQ tract and non-polyQ regions is complex and still not fully understood. In order to better understand it, we previously designed and characterized model polyQ proteins made of the beta-lactamase BlaP and a 23, 30, 55 or 79Q tract inserted in position 197 or 216. These chimeras recapitulate the aggregation properties of polyQ disease-associated proteins: there is a Q threshold for the formation of amyloid fibrils, and above the threshold, the longer the polyQ, the faster the aggregation. Moreover, the structure of BlaP (native or unfolded) and the position of insertion of the polyQ tract (197 versus 216) influence their aggregation properties. In this work, (i) we will discuss the role of the conformation of the host protein, BlaP, and of the location of the polyQ within BlaP on the different phases of amyloid fibril formation, the nucleation and elongation steps, using mainly quartz crystal microbalance (QCM), atomic force microscopy (AFM) and dynamic light scattering (DLS); and (ii) we will investigate the precise aggregation threshold and the modulating role of the N- and C-terminal polyQ flanking sequences in position 197 of BlaP by creating and characterizing new chimeras containing intermediate length polyQ tracts in position 197, or polyQ tracts inserted between two cleavage sites in position 197, respectively. Our results highlight a linear dependence of the polyQ length on the elongation rate whatever the insertion site and the conformation of BlaP. These two parameters however drastically influence the ability of a polyQ tract to trigger the nucleation and the elongation steps of amyloid fibril formation. Finally, we observed that the propensity to form amyloid fibrils and its rate seems to be largely dependent on the polyQ length and on the polyQ flanking sequences. Altogether our results contribute to identify the important species and elements (polyQ or non-polyQ regions, monomers, oligomers or fibrils) during the aggregation process into amyloid fibrils to interfere with the latter associated with neurotoxicity. [less ▲]

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See detailMicellization of PEO-b-polyphosphate for drug delivery applications
Vanslambrouck, Stéphanie ULg; Clément, Benoit; Riva, Raphaël ULg et al

Conference (2014, July 11)

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See detailSupercritical CO2, impregnation to prepare drug-loaded implants: inpregantion of anti-inflammatory drugs into sutures
Champeau, Mathilde; Tassaing, Thierry; Thomassin, Jean-Michel ULg et al

Conference (2014, July 10)

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See detailSynthesis of degradable polyphosphoester copolymers for templating calcium carbonate drug delivery carriers
Ergül, Zeynep ULg; Debuigne, Antoine ULg; Calvignac, Brice et al

Conference (2014, July 09)

Degradable acid bearing polyphosphoester (PPE) copolymers were prepared by combination of organocatalyzed ring opening polymerization and click chemistry. Their solution behavior and ability to complex ... [more ▼]

Degradable acid bearing polyphosphoester (PPE) copolymers were prepared by combination of organocatalyzed ring opening polymerization and click chemistry. Their solution behavior and ability to complex calcium ions were studied as well as their capacity to template CaCO3 particles dedicated to drug delivery. [less ▲]

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See detailOn the use of carbon dioxide and vegetable oil for the synthesis of bio-based cyclic carbonates
Alves, Margot ULg; Tassaing, Thierry; Mereau, R. et al

Poster (2014, July 03)

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See detailCollapsing and reswelling kinetics of thermoresponsive polymers on surfaces: a matter of confinement and constraints
Willet, Nicolas ULg; Gabriel, Sabine ULg; Jérôme, Christine ULg et al

in Soft Matter (2014), 10

We report on the collapsing and reswelling ability of grafted poly(methyl vinyl ether) chains of different molecular architectures. In order to study the influence of constraints and confinement of the ... [more ▼]

We report on the collapsing and reswelling ability of grafted poly(methyl vinyl ether) chains of different molecular architectures. In order to study the influence of constraints and confinement of the chains, the polymer was grafted onto AFM tips, as a model of a curved nano-sized surface, and onto macroscopic silicon substrates for comparison purposes. AFM-based force spectroscopy experiments were performed to characterise at the nanoscale the temperature-dependent collapsing process and the reversibility to the swollen state on both substrates. The reversible character of the thermoresponsive transition and its kinetics were shown to greatly depend on the polymer architecture and the constraints encountered by the chains. [less ▲]

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See detailStructure-morphology relationship of polyphosphate containing polymer micelles
Vanslambrouck, Stéphanie ULg; Clément, Benoit; Riva, Raphaël ULg et al

Conference (2014, June 18)

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See detailIn situ FTIR micro-spectroscopy to investigate polymeric fibers under supercritical carbon dioxide: CO2 sorption and swelling measurements
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Jérôme, Christine ULg et al

in Journal of Supercritical Fluids (2014), 90

An original experimental set-up combining a FTIR (Fourier Transformed InfraRed) microscope with a high pressure cell has been built in order to analyze in situ and simultaneously the CO2 sorption and the ... [more ▼]

An original experimental set-up combining a FTIR (Fourier Transformed InfraRed) microscope with a high pressure cell has been built in order to analyze in situ and simultaneously the CO2 sorption and the polymer swelling of microscopic polymer samples, such as fibers, subjected to supercritical carbon dioxide. Thanks to this experimental set-up, we have determined as a function of the CO2 pressure (from 2 to 15 MPa) the CO2 sorption and the polymer swelling at T = 40 °C of four polymer samples, namely PEO (polyethylene oxide), PLLA (poly-l-lactide acid), PET (polyethylene terephtalate) and PP (polypropylene). The quantity of CO2 sorbed in all the studied polymers increases with pressure. PEO and PLLA display a significant level of CO2 sorption (20 and 25% respectively, at P = 15 MPa). However, we observe that a lower quantity of CO2 can be sorbed into PP and PET (7 and 8% respectively, at P = 15 MPa). Comparing their thermodynamic behaviors and their intrinsic properties, we emphasize that a high CO2 sorption can be reach if on one hand, the polymer is able to form specific interaction with CO2 in order to thermodynamically favor the presence of CO2 molecules inside the polymer and on the other, displays high chains mobility in the amorphous region. PLLA and PEO fulfilled these two requirements whereas only one property is fulfilled by PET (specific interaction with CO2) and PP (high chains mobility). Finally, we have found that for a given CO2 sorption, the resulting swelling of the polymer depends mainly on its crystallinity. [less ▲]

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