References of "Jérôme, Christine"
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See detailStimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Controlled Release (2013, November 28), 172(1), 39

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See detailStraightforward synthesis of symmetrical multiblock copolymers by simultaneous block extension and radical coupling reactions
Debuigne, Antoine ULg; Detrembleur, Christophe ULg; Jérôme, Christine ULg et al

in Macromolecules (2013), 46(22), 8922-8931

In situ combination of a polymerization step with a coupling reaction is demonstrated to accelerate the synthesis protocols for symmetrical multiblock copolymers. Predici simulations and experiments prove ... [more ▼]

In situ combination of a polymerization step with a coupling reaction is demonstrated to accelerate the synthesis protocols for symmetrical multiblock copolymers. Predici simulations and experiments prove on the example of cobalt-mediated radical polymerization and coupling (CMRP/C) reactions that such synthesis strategy can be very effective and easy to conduct. Treatment of a cobalt-terminated poly(acrylonitrile) precursor with a mixture of acrylate and isoprene led to the rapid polymerization of the acrylate before isoprene-assisted radical coupling of the macroradical chains forming a well-defined poly(acrylonitrile)-b-poly(acrylate)-b-poly(acrylonitrile) triblock. The degree of polymerization of the central block, resulting from the balance between propagation and coupling, could be tuned by adjusting the relative concentration and varying the structure of the acrylate and diene. The same convergent strategy also permits the synthesis of ABCBA-type pentablock copolymer starting from a cobalt-functional diblock. Simultaneous radical polymerization and coupling is thus a powerful macromolecular engineering approach for the straightforward design of symmetrical multiblock copolymers. [less ▲]

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See detailUse of supercritical carbon dioxide to prepare drug-loaded polymer implants
Champeau, Mathilde; Tassaing, Thierry; Thomassin, Jean-Michel ULg et al

Conference (2013, November 20)

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See detailRheological characterization of double thermo-responsive block copolymer hydrogels
Thomassin, Jean-Michel ULg; Mathieu, Kevin ULg; Kermagoret, Anthony ULg et al

Poster (2013, November 20)

The ability of double thermoresponsive block copolymers to form hydrogels has been thoroughly studied by rheology. These copolymers having two discrete LCSTs were synthesized following a one-pot strategy ... [more ▼]

The ability of double thermoresponsive block copolymers to form hydrogels has been thoroughly studied by rheology. These copolymers having two discrete LCSTs were synthesized following a one-pot strategy based on the sequential cobalt mediated radical polymeryzation of N-vinylcaprolactam (NVCL) followed by the copolymerization of N-vinylpyrrolidone (NVP) with the residual NVCL.Moreover, the very efficient cobalt mediated radical coupling of the growing chains was advantageously used to design triblock copolymers with similar morphological characteristics than the diblock copolymers (same external block length, copolymer ratio…) allowing direct comparison between their respective gels to be established. Different parameters have been compared such as the block length and the copolymer concentration. Temperature ramps were first performed to distinguish the different states, i.e., solubilized copolymers (below the two LCSTs), micelles (between the two LCSTs) and precipitated polymers (above the two LCSTs). [less ▲]

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See detailReversibly cross-linked polymer micelle as smart drug dellivery device
Lecomte, Philippe ULg; Riva, Raphaël ULg; Cajot, Sébastien et al

Conference (2013, November 20)

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See detailDesign of macroporous poly(ionic liquid)s by CO2/water emulsion templated polymerization
Boyère, Cédric ULg; Favrelle, Audrey; Boury, Frank et al

Poster (2013, November 20)

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See detailOrganocatalyzed ring-opening polymerization of cyclic phosphate monomers
Clement, Benoît ULg; Vanslambrouck, Stéphanie ULg; Koole, Leo H. et al

Conference (2013, November 19)

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See detail« Product-oriented engineering » applied to the development of porous scaffolds for tissue engineering.
de Bien, Charlotte ULg; Ounally, Thameur; Collard, Valérie ULg et al

Poster (2013, November 15)

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire [1]. Parmi les ... [more ▼]

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire [1]. Parmi les différents polymères biosourcés et biodégradables déjà utilisés pour la fabrication de scaffolds, l’acide polylactique (PLA) a été choisi [2]. Des matrices poreuses ont été obtenues par un procédé de moussage par lyophilisation puis leur microstructure 2D/3D a été caractérisée par microtomographie à rayons X avant d’être mise en lien avec les conditions d’élaboration testées [3]. La diminution de la porosité ainsi que l’augmentation de l’épaisseur des parois avec l’augmentation de rapport polymère/solvant ont été confirmées. [less ▲]

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See detailMonocatenary, branched, double-headed and bolaform surface active carbohydrate esters via photochemical thiol-ene/-yne reactions
Boyère, Cédric ULg; Broze, Guy ULg; Blecker, Christophe ULg et al

in Carbohydrate Research (2013), 380

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated ... [more ▼]

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated hydrothiolation reaction involving a thiolated mannose was successfully applied to terminal and internal alkenes, dienes and alkynes, leading to monocatenary, branched, double-headed and bolaform amphiphilic carbohydrate esters,respectively. A surface activity study showed that these new compounds possess valuable properties and display specific behavior at the air-water interface. It also demonstrated the greater flexibility of the thioether moiety in the spacer of the surfactants produced via a thiol-ene reaction in comparison withthe triazole heterocyclic rings in similar glucose-based surfactants synthesized elsewhere by the alkyne-azide 1,3-dipolar addition. [less ▲]

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See detailLe « génie orienté produit » appliqué à l’élaboration de matrices poreuses pour l’ingénierie tissulaire.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Récents Progrès en Génie des Procédés (2013, October 08)

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les ... [more ▼]

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les différents polymères biosourcés et biodégradables déjà utilisés pour la fabrication de scaffolds, l’acide polylactique (PLA) a été choisi. Des matrices poreuses ont été obtenues par un procédé de moussage par lyophilisation puis leur microstructure 2D/3D a été caractérisée par microtomographie à rayons X avant d’être mise en lien avec les conditions d’élaboration testées. La diminution de la porosité ainsi que l’augmentation de l’épaisseur des parois avec l’augmentation de rapport polymère/solvant ont été confirmées. [less ▲]

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See detailDesign of novel polyphosphoesters (co)polymers for improving a drug delivery system based on calcium carbonate particles
Ergül, Zeynep ULg; Boury, Frank; Debuigne, Antoine ULg et al

Poster (2013, October)

Biomedical applications, especially drug delivery systems, often require biodegradable and biocompatible materials that permit safe retention as well as controlled delivery of a drug. CaCO3 particles are ... [more ▼]

Biomedical applications, especially drug delivery systems, often require biodegradable and biocompatible materials that permit safe retention as well as controlled delivery of a drug. CaCO3 particles are safe and biodegradable drug carriers that have excellent properties such as low density, high specific surface areas and porosity for drugs microencapsulation. The encapsulation of a model protein within CaCO3 particles has been successfully investigated by Boury and coworkers but the release profiles still need to be improved. In this project, we would like to slow down the kinetics of protein release. One strategy consists in loading the CaCO3 particles with degradable micelles containing the protein/drug in their core. In this perspective, we have developed a novel class of degradable polyphosphoesters (PPE) (co)polymers able to self-assemble into micelles. Note that the degradation products of PPEs, like phosphates, associated with calcium from the inorganic carrier could favor some reconstruction processes like bone regeneration. Pendant carboxylic acid functions were introduced along the backbone of the copolymers in order to increase their affinity for calcium and facilitate their incorporation in the CaCO3 particles. First, an alkynyl-functionalized phospholane monomer, i.e. butynyl phosphate (BYP), was prepared by condensation of 2-chloro-2-oxo-1,3,2-dioxaphospholane and 3-butyn-1-ol (43 % yield), according to a reported procedure. Then, a series of well-defined (Ɖ < 1.2) alkyne-containing PBYP (co)polymers were synthesized by ring opening polymerization using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and thiourea (TU) as catalysts[5] (see scheme below). The structures of the PPE (co)polymers were characterized by 1H NMR, 31P NMR and size exclusion chromatography (SEC). Next, carboxylic acid functions were introduced along the PPE backbone by click-type thiol-yne addition of mercaptopropionic acid onto the pendant alkynes. The degradability of the PPEs was investigated at different pH. In the future, the self-assembly behavior of the PPE-based copolymers will be studied as well as their drug loading capacity and ability to accumulate within the CaCO3 particles. In addition, the acid-bearing PPE-based copolymers will be tested as templating agents for the synthesis of CaCO3 particles. [less ▲]

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See detailDrug delivery systems based on amphiphilic polyphosphate-copolymers
Vanslambrouck, Stéphanie ULg; Clement, Benoît ULg; Riva, Raphaël ULg et al

Poster (2013, September 18)

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In ... [more ▼]

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In contrast to poly--caprolactone and polylactides, PPhos properties and functionality are easily tuned via the nature of the pendant group of the starting cyclic monomer. For example, by varying the length of the alkyl chain the hydrophobicity of the PPhos can be adjusted. In this work, an efficient organo-catalytic system was developed to synthesize a series of amphiphilic diblock copolymers, i.e. poly(ethylene oxide)-b-polyphosphate (PEO-b-PPhos) by ring-opening polymerization of cyclic phosphates. This novel approach prevents metallic residues to polute the final product, and which is highly desirable when biomedical applications are foreseen. For drug delivery application, the micellization of these novel diblock copolymers in aqueous media was investigated, as well as, encapsulation of an hydrophobic drug. Data on, the influence of the polyphosphate nature of the polymer on drug loading will be presented. [less ▲]

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See detailUse of response surface methodology for the optimization of the lipase-catalyzed synthesis of mannosyl myristate in pure ionic liquid
Galonde, Nadine ULg; Brostaux, Yves ULg; Richard, Gaetan ULg et al

in Process Biochemistry (2013), 48(11), 1914-1920

The purpose of the present study is to find the conditions allowing to reach the highest 24 h-yield(24 h- ) for the synthesis of mannosyl myristate catalyzed by the immobilized lipase B from Candida ... [more ▼]

The purpose of the present study is to find the conditions allowing to reach the highest 24 h-yield(24 h- ) for the synthesis of mannosyl myristate catalyzed by the immobilized lipase B from Candida antarctica (Novozym®435) in the ionic liquid (IL) [Bmpyrr][TFO] (1-butyl-1-methylpyrrolidinium tri-fluoromethanesulfonate). A full factorial design (FFD) was used in order to study the influence of three variables (temperature, mannose/vinyl myristate ratio and total substrate quantity) on the 24 h- . This design led to a model based on a second order polynomial response function. The resulting predicted con-tour plots have shown that the highest 24 h- should be obtained with high temperatures, low sugar/vinylester molar ratio and intermediate total substrate quantities (mmol). The model has been successfully verified and experimentally confirmed at the optimal conditions of 80◦C, substrate molar ratio of 1/10and total substrate quantity of 0.26 mmol leading to the highest predicted 24 h- of 72.2%. [less ▲]

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See detailCarbon nanotubes/polypropylene nanocomposites foams for EMI shielding applications
Tran, Minh Phuong ULg; Detrembleur, Christophe ULg; Thomassin, Jean-Michel ULg et al

Conference (2013, September 12)

In order to reduce the undesired effect of the electromagnetic interference, the developing of the materials with high capacity of electromagnetic interference (EMI) shielding has attracted a great ... [more ▼]

In order to reduce the undesired effect of the electromagnetic interference, the developing of the materials with high capacity of electromagnetic interference (EMI) shielding has attracted a great attention to scientific and industrial communities during last two decades.Indeed, polymer carbon nanotubes (CNTs) nanocomposites foams are addressed due to their high electrical conductivity and a great potential applications in electrostatic dissipation (ESD) and in electromagnetic interferences (EMI) shielding. However, the shortcoming of the addition of CNTs is that it usually leads to an increase of permittivity which results in enhancing undesirably the electromagnetic reflectivity due to the mismatch between the wave impedances for the signal propagating into air and into the absorbing material, respectively. To solve this problem, the introduction of air into these nanocomposites by the formation of foam will be favorable in order to reduce the permittivity of conductive composites. A good understanding of the influence of the foam structural parameters on the electrical properties of the foam will ultimately enable the optimum design of these materials for the targeted applications. A wide range of poly (propylene)/CNTs nanocomposites foams were synthesized using the supercritical CO2 technology. Different foaming parameters, such as the temperature, impregnation pressure will be controlled to modify the foam structure. Nanocomposite foams show higher electrical conductivity than non-foamed nanocomposites at the same volume content of CNTs. Effects of foam morphology such as cell density, pore size, volume expansion, and cell-wall thickness on electrical conductivity were comprehensively assessed. Similarly to our previous study on PMMA foam nanocomposites, the electrical conductivity of foams show higher value when the volume expansion is increased and when the average pore size is decreased. The preliminary EMI performances have highlighted that PP/CNTs foams containing 0.1 vol%CNTs are able to absorb about 90% of the incident radiation in the 25 to 40 GHz frequency range. [less ▲]

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See detailMorphology and electrical conductivity of poly(propylene)/multi-walled carbon nanotubes nanocomposites foams compatibilized by poly(propylene) -graft-maleic anhydride (PP-g-MA)
Tran, Minh Phuong ULg; Detrembleur, Christophe ULg; Alexandre, Michaël et al

Poster (2013, September 09)

The agglomerate of carbon nanotubes (CNTs) in poly(propylene) (PP) matrix often results in low electrical conductivity and poor mechanical properties. In order to improve the dispersion of CNTs, different ... [more ▼]

The agglomerate of carbon nanotubes (CNTs) in poly(propylene) (PP) matrix often results in low electrical conductivity and poor mechanical properties. In order to improve the dispersion of CNTs, different amounts of compatibilizer based on poly(propylene-graft-maleic anhydride) (PP-g-MA) were added in the PP matrix. Carbon nanotubes materbatches pre-dispersed at a high loading in the compatibilizer were used to create the samples used in this study. The nanocomposites of PP/PP-g-MA/CNTs were then foamed in supercritical carbon diozide (scCO2) followed by analysis of the foam morphology and the electrical conductivity. The presence of PPgMA did not significantly change the foam morphology, which exhibits good homogeneity and highly uniform closed-cells with penta-heptagonal cell-form. The expansion volume of the foams is not adversely affected by the addition of the compatibilizer; very high expansion volume (around 15 - 25 times) was achieved. The most interesting point is that the PP-PPgMA - 4wt%CNTs foams show a significantly higher electrical conductivity than the uncompatibilized PP-4wt%CNTs at the same volume percent content of CNTs [less ▲]

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See detail"Product-oriented engineering" applied to the development of porous scaffolds for tissue engineering.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Procedia Engineering (2013, September 02)

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D ... [more ▼]

This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D microstructure was characterized by X-ray microtomography and related to the operating conditions used. Two types of scaffold end-use properties were characterized in relation to their microstructure: the mechanical and the transport properties. Scaffold young's modulus was computed from data measured on tension-compression devices. To evaluate the permeability, Darcy’s experiments were carried out. The obtained results allowed highlighting the quantitative relationships existing between elaboration conditions, microstructure and end use properties of the fabricated PLA scaffolds. [less ▲]

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