References of "Jérôme, Christine"
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See detailElectrografting method for forming and regulating a strong adherent nanostructured polymer coating
Jérôme, Robert ULg; Jérôme, Christine ULg; Serwas, Harry ULg et al

Patent (2007)

Electrografting method for forming and regulating a strongly adherent nanostructured polymer coating onto an electro-conductive surface profile characterized in that the surface profile is regulated by ... [more ▼]

Electrografting method for forming and regulating a strongly adherent nanostructured polymer coating onto an electro-conductive surface profile characterized in that the surface profile is regulated by electrodeposition of nanometre- and/or micrometre-scale nuclei onto the surface profile prior to or simultaneously to the formation of the polymer coating. [less ▲]

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See detailImproved performances of intraocular lenses by poly(ethylene glycol) chemical coatings
Bozukova, Dimitriya ULg; Pagnoulle, Christophe; Gillet, Marie-Claire ULg et al

in Biomacromolecules (2007), 8(8), 2379-2387

Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of ... [more ▼]

Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of protein adsorption and lens epithelial cell (LEC) adhesion, growth, and proliferation, is the secondary cataract, referred to as posterior capsular opacification (PCO). To avoid PCO formation, a poly(ethylene glycol) (PEG) chemical coating was created on the surface of hydrogel IOLs. Attenuated total reflectance Fourier transform infrared spectroscopy, “captive bubble” and “water droplet” contact angle measurements, and atomic force microscopy analyses proved the covalent grafting of the PEG chains on the IOL surface while keeping unchanged the optical properties of the initial material. A strong decrease of protein adsorption and cell adhesion depending on the molar mass of the grafted PEG (1100, 2000, and 5000 g/mol) was observed by performing the relevant in vitro tests with green fluorescent protein and LECs, respectively. Thus, the study provides a facile method for developing materials with nonfouling properties, particularly IOLs. [less ▲]

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See detailPEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
Garinot, Marie; Fievez, Virginie; Pourcelle, Vincent et al

in Journal of Controlled Release (2007), 120(3), 195-204

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an ... [more ▼]

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an original method called "photografting" which covalently linked RGD peptides mainly on the PEG moiety of the PCL-PEG, included in the formulation. First, three non-targeted formulations with size and zeta potential adapted to M cell uptake and stable in gastro-intestinal fluids, were developed. Their transport by an in vitro model of the human Follicle associated epithelium (co-cultures) was largely increased as compared to mono-cultures (Caco-2 cells). RGD-labelling of nanoparticles significantly increased their transport by co-cultures. due to interactions between the RGD ligand and the I intregrins detected at the apical surface of co-cultures. In vivo studies demonstrated that RGD-labelled nanoparticles particularly concentrated in M cells. Finally, ovalbumin-loaded nanoparticles were orally administrated to mice and induced an IgG response, attesting antigen ability to elicit an immune response after oral delivery. [less ▲]

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See detailOne-step polymer grafting from silicon nitride SPM probes: From isolated chains to brush regime
Gabriel, Sabine ULg; Jérôme, Christine ULg; Jérôme, Robert ULg et al

in Journal of the American Chemical Society (2007), 129(27), 8410

We show that a reactive polymer can be directly grafted from commercial Si3Nx SPM tips, without any intermediate layer. The conditions can be chosen to achieve either an isolated mushroom regime, with ... [more ▼]

We show that a reactive polymer can be directly grafted from commercial Si3Nx SPM tips, without any intermediate layer. The conditions can be chosen to achieve either an isolated mushroom regime, with only one or a few chains accessible at the tip apex, or a brush regime. [less ▲]

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See detailSummary of aim and achievements in Work Package 7 "Functional Coatings"
Jérôme, Christine ULg

Conference (2007, May 11)

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See detailDesign of smart SPM probes by electrografting
Gabriel, Sabine ULg; Jérôme, Christine ULg; Duwez, Anne-Sophie ULg

Conference (2007, May 11)

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See detailSynthesis of adherent hydrophilic polypyrrole coatings onto (semi)conducting surfaces
Gabriel, Sabine ULg; Cecius, Michaël ULg; Fleury-Frenette, Karl ULg et al

in Chemistry of Materials (2007), 19(9), 2364-2371

Hydrophilic and adherent polypyrrole coatings were prepared by a two-step electrochemical method. First, alpha-pyrrole, omega-acrylate polyethylene oxide (Py-PEO-A) dual macromonomer was synthesized by ... [more ▼]

Hydrophilic and adherent polypyrrole coatings were prepared by a two-step electrochemical method. First, alpha-pyrrole, omega-acrylate polyethylene oxide (Py-PEO-A) dual macromonomer was synthesized by anionic polymerization and electrografted onto (semi)conducting substrates by cathodic polymerization of the acrylic end-group. The obtained adherent coating is hydrophilic and thus swells in water and bears a pyrrole ring, a precursor of the conducting polymer. In a second step, the coating is anodically polarized in a mixture of Py and Py-PEO to give the hydrophilic and adherent polypyrrole. Properties such as morphology, adherence, electroactivity, and hydrophilicity of these coatings were investigated by conventional methods and compared to those of pure polypyrrole coatings. These novel coatings exhibit efficient protein adsorption repellency and are thus good candidates for applications in biomaterials and biosensors. [less ▲]

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See detailControlled RAFT synthesis of polyacrylonitrile-b-poly(acrylic acid) diblocks as precursors of carbon nanocapsules with assistance of gold nanoparticles
Aqil, Abdelhafid ULg; Detrembleur, Christophe ULg; Gilbert, Bernard ULg et al

in Chemistry of Materials (2007), 19(9), 2150-2154

A new strategy for the synthesis of carbon nanocapsules has been developed, based on the preparation of well-defined polyacrylonitrile-b-poly(acrylic acid) (PAN-b-PAA) block copolymers followed by their ... [more ▼]

A new strategy for the synthesis of carbon nanocapsules has been developed, based on the preparation of well-defined polyacrylonitrile-b-poly(acrylic acid) (PAN-b-PAA) block copolymers followed by their micellization in basic water to form spherical micelles with a PAN core and PAA shell. The PAN is then cross-linked by the use of gold nanoparticles. After pyrolysis, carbon nanocapsules are produced by graphitization of the PAN core and diffusion of the molten gold nanoparticles out of the nano-objects. [less ▲]

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See detailNew monomers tailored for direct electrografting onto carbon in water
Cecius, Michaël ULg; Jérôme, Robert ULg; Jérôme, Christine ULg

in Macromolecular Rapid Communications (2007), 28(8), 948-954

Electrografting, which is an electropolymerization technique dedicated to the chemisorption of polyacrylates onto conductive surfaces, was actively studied in anhydrous organic media until now. This ... [more ▼]

Electrografting, which is an electropolymerization technique dedicated to the chemisorption of polyacrylates onto conductive surfaces, was actively studied in anhydrous organic media until now. This communication aims at extending this technique to aqueous media for the grafting of polyacrylates onto carbon. The key criterion for the successful electrografting under these not very demanding experimental conditions (water vs. anhydrous organic solvents) is the use of amphiphilic acrylic monomers. The impact of the chemical structure of these new monomers on the coating properties was investigated. Composition of the coatings was analyzed by FT-IR ATR and XPS, whereas film thickness and morphology were analyzed by ellipsometry and AFM, respectively. [less ▲]

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See detailControlled synthesis of carboxylic acid end-capped poly(heptadecafluorodecyl acrylate) and copolymers with 2-hydroxyethyl acrylate
Grignard, Bruno ULg; Jérôme, Christine ULg; Calberg, Cédric ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2007), 45(8), 1499-1506

1H,1H,2H,2H-Heptadecafluorodecyl acrylate (AC8) was polymerized by reversible addition-fragmentation chain transfer and copolymerized with 2-hydroxyethyl acrylate with the formation of random and block ... [more ▼]

1H,1H,2H,2H-Heptadecafluorodecyl acrylate (AC8) was polymerized by reversible addition-fragmentation chain transfer and copolymerized with 2-hydroxyethyl acrylate with the formation of random and block copolymers, respectively. The kinetics of the (co)polymerization was monitored with H-1 NMR spectroscopy and showed that the homopolymerization and random copolymerization of AC8 were under control. As a result of this control and the use of S-1-dodecyl-S-(alpha,alpha'-dimethyl-alpha"-acetic acid)trithiocarbonate as a chain-transfer agent, the copolymer chains were end-capped by an a-carboxylic acid group. Moreover, the controlled polymerization of AC8 was confirmed by the successful synthesis of poly(1H,1H,2H,2H-heptadecafluorodecyl acrylate)-b-poly(2hydroxyethyl acrylate) diblock copolymers, which were typically amphiphilic compounds. [less ▲]

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See detailC-60-containing nanostructured polymeric materials with potential biomedical applications
Stoilova, Olya; Jérôme, Christine ULg; Detrembleur, Christophe ULg et al

in Polymer (2007), 48(7), 1835-1843

Star-shaped polymers with a fullerene (C-60) Core and an unexpanded structure were successfully prepared by reaction Of C60 with amino end-capped polyesters HxC60(NHPCLn)(x) and polyethers HxC60(NHPEG(n ... [more ▼]

Star-shaped polymers with a fullerene (C-60) Core and an unexpanded structure were successfully prepared by reaction Of C60 with amino end-capped polyesters HxC60(NHPCLn)(x) and polyethers HxC60(NHPEG(n))(x), respectively. Upon irradiation of these C-60-derivatives, a large amount of singlet oxygen was released. Compared to previously synthesized star-shaped azafulleroids with an expanded structure, the photosensitivity of HxC60(NHPCLn)(x) is higher as assessed by a higher production of singlet oxygen. The cytotoxicity of the photoactive water-soluble HxC60(NHPEG(n))(x) derivatives was tested against THP-1 cells and expressed in terms of cell viability. Moreover, they were processed as micro-/nanosized fibers by electrospinning, which however required the addition of poly(F-caprolactone) (PCL). The diameter distribution of the fibers was trimodal, where the fraction with the 270 nm average diameter was the major population. Because of their photoactivity, the herein reported star-shaped C-60-derivatives are promising candidates for photodynamic cancer therapy and treatment of multidrug resistant pathogens. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailSynthesis of functional amphiphilic copolymers for the elaboration of third generation drug nanocarriers
Alaimo, David ULg; Freichels, Hélène; Jérôme, Robert ULg et al

Poster (2007, March 08)

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See detailAmphiphilic and biodegradable copolymers for applications in vectorisation
Jérôme, Christine ULg; Van Butsele, Kathy ULg

in Chimie Nouvelle (2007), (94), 8-13

The development of controlled drug delivery systems is today a topic of an intense research activity. In this field, biocompatible and (bio)degradable polymers are particularly studied. The production of ... [more ▼]

The development of controlled drug delivery systems is today a topic of an intense research activity. In this field, biocompatible and (bio)degradable polymers are particularly studied. The production of nanosized particles (polymer micelles, nanoparticles,...) generally requires the elaboration of functional amphiphilic copolymers able to stabilize efficiently these colloidal dispersions. Various strategies to synthesize such copolymers keeping their (bio)degradability are described here. The complexity of these amphiphilic materials will be gradually increased in parallel to the improvement of the nanocarriers properties. [less ▲]

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See detailCombination of ring-opening polymerization and "click chemistry": Toward functionalization and grafting of poly(epsilon-caprolactone)
Riva, Raphaël ULg; Schmeits, Stéphanie; Jérôme, Christine ULg et al

in Macromolecules (2007), 40(4), 796-803

A straightforward strategy is proposed for the derivatization of poly(epsilon-caprolactone) (PCL). First, statistical copolymerization of alpha-chloro-epsilon-caprolactone (alpha-Cl-epsilon-CL) with ... [more ▼]

A straightforward strategy is proposed for the derivatization of poly(epsilon-caprolactone) (PCL). First, statistical copolymerization of alpha-chloro-epsilon-caprolactone (alpha-Cl-epsilon-CL) with epsilon-caprolactone (epsilon-CL) was initiated by 2,2-dibutyl-2-stanna-1,3-dioxepane (DSDOP). In a second step, pendent chlorides were converted into azides by reaction with sodium azide. Finally, duly substituted terminal alkynes were reacted with pendent azides by copper-catalyzed Huisgen's 1,3-dipolar cycloaddition, thus a "click" reaction. According to this strategy, pendent hydroxyl and acrylate groups and atom transfer radical polymerization (ATRP) initiators were successfully attached to PCL. Similarly, amphiphilic graft copolymers were prepared by cycloaddition of an alkyne end-capped poly(ethylene oxide) (PEO) onto the azide substituents of the copolyester. The dependence of the grafting yield on the experimental conditions of the "click" reaction, i.e., temperature, solvent, and catalyst, was investigated. This strategy is very versatile because a large variety of aliphatic polyesters can be easily synthesized from a single precursor, easily prepared from commercially available compounds, merely by changing the alkyne involved in the Huisgen's 1,3-dipolar cycloaddition. Last but not least, PCL subsituted by azide groups does not have to be isolated after substitution of chlorides by sodium azide, and the "click" reaction can be carried out in a "one-pot" process. [less ▲]

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See detailThermoresponsive coatings strongly adhering to (semi)conducting surfaces
Gabriel, Sabine ULg; Duwez, Anne-Sophie ULg; Jérôme, Robert ULg et al

in Langmuir (2007), 23(1), 159-161

Thermoresponsive brushes have been efficiently grafted onto (semi)conductive surfaces by a two-step process. In the first step, poly(N-succinimidyl acrylate) chains have been chemisorbed onto silicon or ... [more ▼]

Thermoresponsive brushes have been efficiently grafted onto (semi)conductive surfaces by a two-step process. In the first step, poly(N-succinimidyl acrylate) chains have been chemisorbed onto silicon or stainless steel by the electrografting method. Then, these modified electrodes were immersed in isopropylamine in order to transform the grafted chains to the thermoresponsive poly(N-isopropyl acrylamide). The thermal response of these brushes has been shown by AFM. This straightforward grafting process is quite attractive for surface modification in confined media and is thus promising for microfludics application. [less ▲]

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See detailPolymeric nanomaterials – synthesis, functionalization and applications in diagnosis and therapy
Rieger, Jutta ULg; Jérôme, Christine ULg; Jérôme, Robert ULg et al

in Kumar, Challa (Ed.) Nanomaterials for Medical Diagnosis and Therapy (2007)

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See detailDEVELOPMENT OF AN INTRAPERITONEAL IMPLANT FOR THE ENDOMETRIOSIS TREATMENT
Krier, Fabrice ULg; Nizet, Dominique; Riva, Raphaël ULg et al

Conference (2007)

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See detailControlled release of drugs from an original multi-component device
Nizet, dominique; Zalfen, Alina; Collard, Laurence ULg et al

Poster (2007)

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