References of "Jérôme, Christine"
     in
Bookmark and Share    
See detailElectrospinning of biocompatible polymers for potential biomdical applications
Croisier, Florence ULg; Zalfen, Alina; Aqil, Abdelhafid ULg et al

Poster (2008, June 23)

Detailed reference viewed: 22 (2 ULg)
Full Text
See detailNew pH-sensitive flower micelles for drug delivery systems
Cajot, Sébastien ULg; Van Butsele, Kathy; Jérôme, Christine ULg

Poster (2008, June 23)

Detailed reference viewed: 17 (7 ULg)
Full Text
Peer Reviewed
See detailRecent advances in the synthesis of aliphatic polyesters by ring-opening polymerization
Jérôme, Christine ULg; Lecomte, Philippe ULg

in Advanced Drug Delivery Reviews (2008), 60(9), 1056-1076

Advanced drug delivery systems rely on the availability of biocompatible materials. Moreover, biodegradability is highly desirable in the design of those systems. Consequently, aliphatic polyesters appear ... [more ▼]

Advanced drug delivery systems rely on the availability of biocompatible materials. Moreover, biodegradability is highly desirable in the design of those systems. Consequently, aliphatic polyesters appear as a class of promising materials since they combine both properties. Nevertheless, their use in practical biomedical systems relies on clinical approval which not only depends on the material itself but also on its reproducible synthesis with the absence of residual toxics. The first sections of this review aim at reporting on the evolution of the initiators/catalytic systems and of the synthesis conditions (particularly the use of supercritical CO2 as polymerization medium) in order to produce aliphatic polyesters with controlled macromolecular parameters by still "greener" ways. In addition, the further development of delivery systems also depends on the synthesis of materials exhibiting novel properties, such as amphiphilicity or pH-sensitivity that are emerging from the active research in macromolecular engineering. Functionalizing aliphatic polyesters is quite tedious due to their sensitivity towards hydrolytic degradation. The last section of this review is discussing several strategies to obtain functional (co)polyesters of various architectures providing them with novel properties. [less ▲]

Detailed reference viewed: 32 (7 ULg)
Full Text
See detailSupercritical carbon dioxide, a tool for the dispersion ROP of lactone and PCL foaming: Part A
Grignard, Bruno ULg; Urbanczyk, Laetitia ULg; Stassin, Fabrice et al

Poster (2008, June 02)

Aliphatic polyesters, namely polylactide (PLA) and poly-ε-caprolactone (PCL) are biodegradable and biocompatible materials that find applications as resorbable suture (PLA) and drugs delivery vectors (PCL ... [more ▼]

Aliphatic polyesters, namely polylactide (PLA) and poly-ε-caprolactone (PCL) are biodegradable and biocompatible materials that find applications as resorbable suture (PLA) and drugs delivery vectors (PCL). Nevertheless, these polymers were mainly prepared by ring opening polymerization using aluminum alkoxide or tin alkoxide initiators in organic media. Recently, the use of supercritical carbon dioxide as polymerization medium was proposed as a potential alternative to the use toxic organic solvents. Nevertheless, due to the non-solubility of PCL in this medium, the growing chains rapidly precipitate during their synthesis leading to the formation of a bulky material that is typical of a precipitation polymerization. This work aims at investigating the dispersion ring-opening polymerization (ROP) of ε-caprolactone in the presence of fluoropolymer-based stabilizers, that were prepared by combining the ring opening polymerization of ε-caprolactone and atom transfer radical polymerization of heptadecafluorodecylacrylate (AC8) and so, stabilizing PCL micrometric particles in supercritical carbon dioxide. In practice, the ROP of CL was initiated by dibutyltin dimethoxide in the presence of PCL-b-PAC8 diblock stabilizers of differents molecular weight and composition. After 24h at 40°C, PCL was collected as a powder that consists of small-sized microspheres. Finally, post-polymerization purification of PCL (removal of tin catalyst that may lead to toxicological problems) was demonstrated to be quite feasible by supercritical fluid extraction (SFE) leading to the preparation of PCL with low catalytic residues. The second goal of this work aims at reporting on the use of sc CO2 for the preparation of foams of poly(epsilon-caprolactone) (PCL), that could be useful in the packaging sector and/or the biomedical sector as potential scaffolds for tissue engineering but also as substitutes for polystyrene thermoformed trays. The method that consists of saturating a polymer with a compressed or supercritical fluid, such as carbon dioxide followed by depressurization and polymer expansion was investigated. Indeed, no residual product is left in the foam, no toxic gas is produced and no resort to hydrocarbon solvents is required. Moreover, CO2 is cheap, non-toxic, recyclable, non-flammable and the technology of CO2-assisted foaming can be used in either a batch mode or in a continuous mode within a high-pressure extruder. [less ▲]

Detailed reference viewed: 71 (4 ULg)
See detailSurface coating of hydrogel intraocular lenses toward resistance to posterior capsular opacification
Bozukova, Dimitriya; Pagnoulle, Christophe; Gillet, Marie-Claire ULg et al

Conference (2008, May 23)

Detailed reference viewed: 46 (11 ULg)
See detailKey role of metal-coordination in cobalt mediated radical polymerization
Debuigne, Antoine ULg; Poli, Rinaldo; Jérôme, Christine ULg et al

Poster (2008, May 22)

Detailed reference viewed: 7 (1 ULg)
See detailNovel biodegradable pH-sensitive flower micelle
Cajot, Sébastien ULg; Van Butsele, Kathy; Jérôme, Christine ULg

Poster (2008, May 22)

Detailed reference viewed: 49 (12 ULg)
Full Text
See detailSuperhydrophobic surfaces by electrospinning of polymer mixtures
Grignard, Bruno ULg; Vaillant, Alexandre; De Coninck, Joel et al

Poster (2008, May 22)

Hydrophobic surfaces have found great interest in environment resist coating, antifouling marine structures and low friction devices whereas superhydrophobic materials, with contact angle higher than 150° ... [more ▼]

Hydrophobic surfaces have found great interest in environment resist coating, antifouling marine structures and low friction devices whereas superhydrophobic materials, with contact angle higher than 150°, are of special interest in self-cleaning surfaces and stain resistant textiles. (Super)hydrophobicity is a key property that depends on both the surface chemistry and surface roughness. Numerous methods were reported for the preparation of superhydrophobic surfaces by either increasing the surface roughness of an inherently hydrophobic material or decreasing the surface free energy of a rough surface by post-treatment. For instance, controlled crystallization, lithography , etching were reported in the literature for the production of such surfaces. Nevertheless, all these techniques suffer from some drawback such as high cost, time consuming and expensive processes. As an alternative approach, electrospinning was proposed for the production of superhydrophobic surfaces with controlled roughness, morphology and/or porosity. For instance, Acatay et Al. reported on the preparation of electrospun fibers starting from a poly(AN-co-TMI)/fluorolink-D mixture followed by the annealing of these material in order to enable the reorientation of the perfluorinated groups to the solid-air interface. Rutledge et al. described the preparation of superhydrophobic surfaces by combining electrospinning of PCL and initiated chemical vapor deposition of perfluoroalkyl ethyl methacrylate. Allcock et al. prepared superhydrophibic nanofibers by electrospinning of an organic-soluble poly[bis(2,2,2-trifluoroethoxy)phosphazene]. In order to simplify the experimental protocols described in the literature on the preparation of superhydrophobic surfaces and decrease the cost related to the use of pure fluoropolymers, electrospinning of homopolymer/semifluorinated diblock copolymer mixture, i.e. a polyisobornylacrylate/poly(isobornyl acrylate-b-heptadecafluorodecyl acrylate) mixture, onto aluminum plates is proposed in this study. In practice, a diblock copolymer based on 1H,1H,2H,2H heptadecafluorodecyl acrylate and isobornyl acrylate was prepared by RAFT polymerization. In a second step, electrospinning of PIBA/PAC8-b-PIBA mixtures of different compositions was investigated. At high fluorine content ([PIBA]/[PAC8-b-PIBA] = 50/50), the electrospun mats show high surface roughness (microparticles of undefined morphologies) and a superhydrophic character. By decreasing the fluorine content, the morphology of the films changed from particles to beaded fibers (([PIBA]/[PAC8-b-PIBA] = 70/30) or fibers (([PIBA]/[PAC8-b-PIBA] = 85/15), which is consistent with an increase of the solution viscosity, but the surfaces still demonstrate or tend to superhydrophobicity. [less ▲]

Detailed reference viewed: 120 (2 ULg)
See detailGd(III)-DOTA conjugate with furtive targeting copolymer poly(AMPEO-co-HEA) by click chemistry for magnetic resonance imaging
Grogna, Mathurin ULg; Bémelmans, Stéphanie; Vanasschen, Christian et al

Poster (2008, May 22)

Detailed reference viewed: 60 (11 ULg)
Full Text
See detailNew pH-sensitive flower micelles for potential tumour targeting
Cajot, Sébastien ULg; Van Butsele, Kathy; Jérôme, Christine ULg

Poster (2008, April 16)

Detailed reference viewed: 10 (5 ULg)