References of "Jérôme, Christine"
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See detailExtrusion foaming of poly(styrene-co-acrylonitrile)/ clay nanocomposites using supercritical CO2
Urbanczyk, Laetitia; Alexandre, Michaël ULg; Detrembleur, Christophe ULg et al

in Macromolecular Materials and Engineering (2010), 295(10), 915-

Supercritical CO2 has been used as a blowing agent to foam poly(styrene-co-acrylonitrile)-based materials in a single screw extruder specially adapted to allow fluid injection. The cellular morphology ... [more ▼]

Supercritical CO2 has been used as a blowing agent to foam poly(styrene-co-acrylonitrile)-based materials in a single screw extruder specially adapted to allow fluid injection. The cellular morphology depends on foaming temperature, more regular cells being obtained with decreasing extrusion temperature. In a second step, a natural and an organomodified nanoclay have been added for the purpose of imparting some flame resistance to the foamed material. The filler efficiency in reducing sample combustion rate appeared to be dependent on its delamination level inside the matrix and better results were obtained when the organomodified clay was first delaminated in the polymer in an efficient twin screw extruder using water assistance, prior to foaming in the single screw extruder. [less ▲]

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See detailContact-killing polyelectrolyte microcapsules based on chitosan derivatives
Cui, Di; Szarpak, Anna; Pignot-Paintrand, Isabelle et al

in Advanced Functional Materials (2010), 20(19), 3303-3312

A new type of multilayer capsules is designed for use as antibacterial vehicles by taking advantage of the properties of natural polysaccharides. These capsules, prepared by layer-by-layer assembly of ... [more ▼]

A new type of multilayer capsules is designed for use as antibacterial vehicles by taking advantage of the properties of natural polysaccharides. These capsules, prepared by layer-by-layer assembly of hyaluronic acid (HA; see graphic) and quaternized chitosan (QCHI) derivatives onto sacrificial colloidal particles, show distinct killing activities depending on the nature of the polysaccharide on the surface. [less ▲]

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See detailMacromolecular engineering to the service of advanced drug delivery systems
Jérôme, Christine ULg

Conference (2010, September 16)

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See detailA method and an apparatus for separating a first amount of liquid
Vandewalle, Nicolas ULg; Gilet, Tristan; Jérôme, Christine ULg et al

Patent (2010)

The invention relates to a method for separating a first amount of liquid into a plurality of second amounts of liquid, the method comprising the steps of bringing the first amount of liquid (210) into ... [more ▼]

The invention relates to a method for separating a first amount of liquid into a plurality of second amounts of liquid, the method comprising the steps of bringing the first amount of liquid (210) into contact with at least one first fibre (110) being arranged substantially vertical, allowing the first amount of liquid to drain of the first fibre, thereby forming a coating film on the fibre, allowing the coating film to decompose, thereby forming a plurality of second amounts of liquid (220), and allowing the second amounts of liquid to drain of the first fibre and being captured at a crossing point (130) being constituted by the first fibre and at least one second fibre (120) being arranged substantially perpendicular to the first fibre and touching the first fibre. Furthermore, the invention relates to an apparatus for separating a first amount of liquid into a plurality of second amounts of liquid. [less ▲]

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See detailTailor-made copolymers for responsive drug delivery nanosystems
Cajot, Sébastien ULg; Jérôme, Christine ULg

Poster (2010, September 15)

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See detailChitosan-based wound dressings produced by electrospinning
Croisier, Florence ULg; Sorlier, Pierre; Jérôme, Christine ULg

Poster (2010, September 07)

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See detailMacromolecular engineering and stimulus response in the design of advanced drug delivery systems
Jérôme, Christine ULg

in MRS Bulletin (2010), 35(9), 665-672

Extensive research activity is currently devoted to controlled drug delivery systems, mainly as nano-sized particles. Although biocompatible and (bio)degradable polymers play a key role in this field ... [more ▼]

Extensive research activity is currently devoted to controlled drug delivery systems, mainly as nano-sized particles. Although biocompatible and (bio)degradable polymers play a key role in this field, their shaping into colloidal particles (e.g., polymeric micelles and nanoparticles) usually requires the proper design of amphiphilic copolymers as effective stabilizers. Strategies for synthesizing these copolymers that preserve the intrinsic properties of the constitutive polymers are discussed in this article. Synthesis of amphiphilic copolymers with a more complex structure and endowed with functionality is also considered, with the purpose of enhancing the performance of the nanocarriers. The focus is increasingly on nanocarriers of the third generation, which resist coalescence and elimination by the immune system, and which are readily incorporated into chosen target cells. The more recent quest is for smart nanocarriers that exhibit the additional capacity of being stimuli-responsive. [less ▲]

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See detailPolymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties
Grogna, Mathurin ULg; Cloots, Rudi ULg; Luxen, André ULg et al

in Polymer Chemistry (2010), 1

New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b ... [more ▼]

New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents. [less ▲]

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See detailPolymers in modern ophthalmic implants—Historical background and recent advances
Bozukova, Dimitriya; Pagnoulle, Christophe; Jérôme, Robert ULg et al

in Materials Science & Engineering : R (2010), 69(6), 63-83

Cataract surgery is the most frequently performed surgical intervention, pursued by replacement of the opacified natural lens by a polymeric intraocular lens (IOL). This paper, based on an exhaustive ... [more ▼]

Cataract surgery is the most frequently performed surgical intervention, pursued by replacement of the opacified natural lens by a polymeric intraocular lens (IOL). This paper, based on an exhaustive number of scientific references, provides a brief simplified discussion of the surgical advances for cataract treatment, and is mainly focused on the process of IOL discovery, engineering and development. The performances of the polymer materials, used for the IOLs fabrication are discussed in a comparative way, and their properties, such as handling during surgery, biocompatibility, rate of some post-surgical complications (e.g. Posterior Capsular Opacification) and optical properties, are considered. Special attention is paid on the basic scientific approaches for engineering and modification of the IOL surface and bulk properties. Polymer coating techniques like ‘grafting onto’ and ‘grafting from’ are discussed and exemplified by a variety of coating compositions and performances. In another part of the review, modification techniques concerning optimization of the bulk properties of the polymer lens are also discussed and synthetic approaches such as copolymerization and nanocomposite formation are considered. A perspective aspect of this discussion concerns improvement of the performance of the main polymer by the incorporation of in situ formed or preformed nanoparticles. The most attractive perspectives concerning the improvement of the IOL properties by chemical modification approaches are described. [less ▲]

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See detailIn vitro identification of targeting ligands of human M cells by phage display
Fievez, V.; Plapied, L.; Plaideau, C. et al

in International Journal of Pharmaceutics (2010), 394(1-2), 35-42

To improve transport of vaccine-loaded nanoparticles, the phage display technology was used to identify novel lead peptides targeting human M cells. Using an in vitro model of the human follicle ... [more ▼]

To improve transport of vaccine-loaded nanoparticles, the phage display technology was used to identify novel lead peptides targeting human M cells. Using an in vitro model of the human follicle-associated epithelium (FAE) which contains both Caco-2 and M cells, a T7 phage display library was screened for its ability either to bind the apical cell surface of or to undergo transcytosis across Caco-2 cells or FAE. The selection for transcytosis across both enterocytes and FAE identified three different peptide sequences (CTGKSC, PAVLG and LRVG) with high frequency. CTGKSC and LRVG sequences enhanced phage transport across M-like cells. When polymeric nanoparticles were grafted with the sequences CTGKSC and LRVG, their transport by FAE was significantly enhanced. These peptides could therefore be used to enhance the transport of vaccine-loaded nanoparticles across the intestinal mucosal barrier. [less ▲]

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See detailControlled radical polymerization of N-Vinylphthalimide using carboxyl-terminated trithiocarbonate as RAFT agent and preparation of microfibers via electrospinning technique
Chikaoui-Grioune, D.; Aqil, Abdelhafid; Zalfen, Alina M. et al

in Journal of Applied Polymer Science (2010), 117(2), 1005-1012

Reversible addition-fragmentation chain transfer (RAFT) polymerization of N-vinylphthalimide in N,N-dimethylformamide (DMF) solution was carried out using 2-carboxypropan-2-yl dodecyl trithiocarbonate as ... [more ▼]

Reversible addition-fragmentation chain transfer (RAFT) polymerization of N-vinylphthalimide in N,N-dimethylformamide (DMF) solution was carried out using 2-carboxypropan-2-yl dodecyl trithiocarbonate as a reversible chain transfer agent in the presence of 2,2-azobisisobutyronitrile. The molecular weights of the polymers increased linearly with the monomer conversion and the molecular weight distributions were relatively narrow (PDI < 1.2). It is confirmed by chain extension reaction that the polymer prepared via RAFT polymerization can be used as a macro-RAFT agent. The structure of both polymers was characterized and confirmed by size-exclusion chromatography and 1H-NMR techniques. Ultrafine microfibers were prepared by electrospinning of poly(N-vinylphthalimide) in DMF solution. The effects of electrospinning process parameters such as voltage, tip-to-collector distance, and solution concentration on the morphology and the average size of the electrospun fibers were studied. To evaluate the fiber diameters, scanning electron microscope micrographs of the microfibers were performed. [less ▲]

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See detailContribution of "click chemistry" to the macromolecular engineering of aliphatic polyesters
Riva, Raphaël ULg; Schmeits, Stephanie ULg; Croisier, Florence ULg et al

Poster (2010, July 13)

In this work, click chemistry was sucessfully applied to the chemical modification of aliphatic polyesters with the purpose to tailor their physical properties. The developped strategy was then applied to ... [more ▼]

In this work, click chemistry was sucessfully applied to the chemical modification of aliphatic polyesters with the purpose to tailor their physical properties. The developped strategy was then applied to the synthesis of materials, such as smart partially degradable hydrogels or antibacterial polyesters. Last, the synthesis of amphiphilic star-shaped copolyester was investigated. [less ▲]

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