References of "Jérôme, Christine"
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See detailSummary of aim and achievements in Work Package 7 "Functional Coatings"
Jérôme, Christine ULg

Conference (2009, December 14)

Detailed reference viewed: 11 (3 ULg)
See detailAdherent functional coatings from readily available acrylates
Cecius, Michaël ULg; Jérôme, Christine ULg

Poster (2009, December 14)

Detailed reference viewed: 21 (9 ULg)
See detailSuperhydrophobic surfaces by electrospinning of polymer mixtures
Grignard, Bruno ULg; Vaillant, Alexandre; De Coninck, Joel et al

Poster (2009, December 14)

Detailed reference viewed: 37 (6 ULg)
See detailAFM-based mechanical testing of electrospun PCL fibers
Croisier, Florence ULg; Duwez, Anne-Sophie ULg; Jérôme, Christine ULg et al

Poster (2009, December 14)

Poly(ε-caprolactone)(PCL forms a part of the aliphatic polyesters; the biodegradable and biocompatible character of these polymers makes them outstanding candidates for short-to medium-term biomedical ... [more ▼]

Poly(ε-caprolactone)(PCL forms a part of the aliphatic polyesters; the biodegradable and biocompatible character of these polymers makes them outstanding candidates for short-to medium-term biomedical applications, especially in the form of nanometric fibers,as their assembly mimics the extracellular matrix structure. However, a prerequisite to their application as nanofibrous biomaterial scaffolds is the investigation of their mechanical strength. In the present study, PCL fibers produced by electrospinning were individually tested using an AFM-based nano-scale three-point bending technique. [less ▲]

Detailed reference viewed: 112 (19 ULg)
See detailCobalt-mediated radical polymerization (CMRP) and coupling reaction (CMRC): mechanistic advances ans synthetic opportunities
Debuigne, Antoine ULg; Poli, Rinaldo; De Winter, Julien et al

Poster (2009, December 14)

Detailed reference viewed: 34 (10 ULg)
See detailSynthesis of novel amphiphilic mikto-arm star-shaped copolymers
Riva, Raphaël ULg; Lazarri, Wenda; Billiet, Leen et al

Poster (2009, December 14)

Detailed reference viewed: 38 (7 ULg)
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See detailCross-linked pH sensitive polymer micelles for drug delivery systems
Cajot, Sébastien ULg; Jérôme, Christine ULg

Poster (2009, December 08)

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block ... [more ▼]

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. In principle, the micelles core is usually constructed with biodegradable hydrophobic polymers such as aliphatic polyesters, e.g. poly(ɛ-caprolactone) (PCL), which serves as a reservoir for the incorporation of various lipophilic drugs. Water soluble poly(ethylene oxide) (PEO) is most frequently used to build the micelle corona because it is very efficient in preventing protein adsorption at surfaces and in stabilizing the micelles in the blood compartment, giving rise to particles invisible to the body defence system (so-called stealthy or long circulating particles). The tumour targeting of a cytotoxic agent refers to the passive accumulation of polymer nanocarriers to solid tumours (EPR effect) followed by active internalization in tumor cells. The internalization of the drug is required for cell death because most cytotoxic drugs act intracellularly. Accordingly, polymer micelles are usually modified by specific ligands. No-specific ligands can be used if their exposition is modulated by the pH decrease typical of tumour tissues. The release of the drug is ruled by diffusion and degradation of the biodegradable polymer used as reservoir. Even if micelles get a high stability in aqueous media thanks to their low critical micellar concentration, the dissociation of micelles is not always preserved when they are injected in the blood compartment. The cross-linking of the core of micelles by disulfide bridges will provide the stability of micelles after the administration and will release the drugs intracellularly by enzymatic breaking of disulfide bridges. This work consists in the development of new macromolecular architectures for the targeting of tumour cells. pH sensitive copolymers able to micellize so as non-specific ligand like biotin is exposed on their surface in response to pH decrease typical for tumour tissues will be synthesized by the incorporation of pH-sensitive linkers, e.g. imine benzoïc linkers. In addition, the core of these new micelles will be cross-linked by disulfide bridges to prevent dissociation around healthy cells and trigger the drug release inside tumour cells. [less ▲]

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See detailSynthesis of glucose-responsive hollow capsules
Alaimo, David ULg; Detrembleur, Christophe ULg; Auzély-Velty, Rachel et al

Poster (2009, December 07)

Detailed reference viewed: 15 (1 ULg)
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Peer Reviewed
See detailAll-in-one strategy for the fabrication of antimicrobial biomimetic films on stainless steel
Charlot, Aurélia; Sciannamea, Valérie; Lenoir, Sandrine et al

in Journal of Materials Chemistry (2009), 19

Here we report on an all-in-one approach to prepare robust antimicrobial films on stainless steel. The strategy is based on the layer-by-layer deposition of polyelectrolytes. A polycationic copolymer ... [more ▼]

Here we report on an all-in-one approach to prepare robust antimicrobial films on stainless steel. The strategy is based on the layer-by-layer deposition of polyelectrolytes. A polycationic copolymer bearing 3,4-dihydroxyphenylalanine units (DOPA, a major component of natural adhesives) was synthesized and co-deposited with precursors of silver nanoparticles as the first layer. The presence of DOPA units ensures a strong anchoring on the stainless steel substrate, and the silver nanoparticles are sources of biocidal Ag+, providing stainless steel with antimicrobial activity. We show that multilayered films, obtained by alternating this nanoparticle-loaded polycationic copolymer with polystyrene sulfonate, a commercial polyanion, results in stainless steel with high antibacterial activity against Gram-negative E. coli bacteria. The polycationic layers are a reservoir of Ag+ that can be reactivated after depletion. The whole process of film formation, including the synthesis of the copolymer, is conducted in aqueous media under very mild conditions, which makes it very attractive for industrial scale-up and sustainable applications. [less ▲]

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See detailTargeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel
Danhier, Fabienne; Vroman, Benoît; Lecouturier, Nathalie et al

in Journal of Controlled Release (2009), 140(2), 166-173

Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our ... [more ▼]

Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our PEGylated PLGA-based nanoparticles grafted with the RGD peptide or RGD-peptidomimetic (RGDp) would target the tumor endothelium and would further enhance the anti-tumor efficacy of PTX. The ligands were grafted on the PEG chain of PCL-b-PEG included in the nanoparticles. We observed in vitro that RGD-grafted nanoparticles were more associated to Human Umbilical Vein Endothelial cells (HUVEC) by binding to αvβ3 integrin than non-targeted nanoparticles. Doxorubicin was also used to confirm the findings observed for PTX. In vivo, we demonstrated the targeting of RGD and RGDp-grafted nanoparticles to tumor vessels as well as the effective retardation of TLT tumor growth and prolonged survival times of mice treated by PTX-loaded RGD-nanoparticles when compared to non-targeted nanoparticles. Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach. [less ▲]

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See detailControlled Synthesis of AB2 amphiphilic triarm star-shaped block copolymers by ring-opening polymerization
Petrova, Svetla; Riva, Raphaël ULg; Jérôme, Christine ULg et al

in European Polymer Journal (2009), 45(12), 3442-3450

This paper describes the synthesis of a novel amphiphilic AB2 triarm star-shaped copolymer with A = non-toxic and biocompatible hydrophilic poly(ethylene oxide) (PEO) and B = biodegradable and hydrophobic ... [more ▼]

This paper describes the synthesis of a novel amphiphilic AB2 triarm star-shaped copolymer with A = non-toxic and biocompatible hydrophilic poly(ethylene oxide) (PEO) and B = biodegradable and hydrophobic poly(ε-caprolactone) (PCL). A series of AB2 triarm star-shaped copolymers with different molecular weights for the PCL block were successfully synthesized by a three-step procedure. α-methoxy-ω-epoxy-poly(ethylene oxide) (PEO-epoxide) was first synthesized by the nucleophilic substitution of α-methoxy-ω-hydroxy-poly(ethylene oxide) (MPEO) on epichlorohydrin. In a second step, the α-methoxy-ω,ω’-dihydroxy-poly(ethylene oxide) (PEO(OH)2) macroinitiator was prepared by the selective hydrolysis of the ω-epoxy end-group of the PEO-epoxide chain. Finally, PEO(OH)2 was used as a macroinitiator for the ring-opening polymerization (ROP) of ε-caprolactone (εCL) catalyzed by tin octoaote (Sn(Oct)2). PEO-epoxide, PEO(OH)2 and the AB2 triarm star-shaped copolymers were assessed by 1H NMR spectroscopy, size exclusion chromatography (SEC) and MALDI-TOF. The behavior of the AB2 triarm star-shaped copolymer in aqueous solution was studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). [less ▲]

Detailed reference viewed: 120 (22 ULg)
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See detailFunctionlization and grafting of polylactide by click chemistry
Riva, Raphaël ULg; Croisier, Florence ULg; Jérôme, Christine ULg et al

Conference (2009, November 19)

Detailed reference viewed: 69 (14 ULg)
See detailNovel pH-responsive copolymers for smart drug carriers
Jérôme, Christine ULg

Conference (2009, November 18)

Detailed reference viewed: 5 (2 ULg)
See detailPreparation of cross-linked chitosan-based nanofibers as wound dressing
Aqil, Abdelhafid ULg; Ziani, K.; Tchemtchoua Tateu, Victor ULg et al

Poster (2009, November 18)

Detailed reference viewed: 51 (19 ULg)