References of "Jérôme, Christine"
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See detailGold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Grignard, Bruno ULg et al

in Chemistry : An Asian Journal (2014), 9(1), 275-288

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)- light-sensitive gold-nanorod (GNR) core and a phase-changing poly(e-caprolactone)- b-poly(ethylene glycol ... [more ▼]

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)- light-sensitive gold-nanorod (GNR) core and a phase-changing poly(e-caprolactone)- b-poly(ethylene glycol) polymer corona (GNR@PCL-b-PEG). The underlying mechanism of the drugloading and triggered-release behaviors involves the entrapment of drug payloads among the PCL crystallites and a heat-induced phase change, respectively. A low premature release of the pre-loaded doxorubicin was observed in PBS buffer (pH 7.4) at 37 °C (<10% of the entire payload after 48 h). However, release could be activated within 30 min by conventional heating at 50 °C, above the Tm of the crystalline PCL domain (43.5 °C), with about 60% release over the subsequent 42 h at 37 °C. The NIR-induced heating of an aqueous suspension of GNR@PCL-b- PEG under NIR irradiation (802 nm) was investigated in terms of the irradiation period, power, and concentrationdependent heating behavior, as well as the NIR-induced shape-transformation of the GNR cores. Remotely NIR-triggered release was also explored upon NIR irradiation for 30 min and about 70% release was achieved in the following 42 h at 37°C, with a mild warming (<4 °C) of the surroundings. The cytotoxicity of GNR@PCL-b-PEG against the mouse fibroblastic-like L929 cell-line was assessed by MTS assay and good compatibility was confirmed with a cell viability of over 90% after incubation for 72 h. The cellular uptake of GNR@PCL-b-PEG by melanoma MEL-5 cells was also confirmed, with an averaged uptake of 1250 ( ± 110) particles cell-1 after incubation for 12 h (50 mg mL-1). This GNR@PCL-b-PEG DDS is aimed at addressing the different requirements for therapeutic treatments and is envisaged to provide new insights into DDS targeting for remotely triggered release by NIR activation. [less ▲]

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See detailBiointerface multiparametric study of intraocular lens acrylic materials.
Bertrand, Virginie ULg; Bozukova, Dimitriya; Svaldo Lanero, Tiziana et al

in Journal of cataract and refractive surgery (2014), 40(9), 1536-44

PURPOSE: To compare hydrophilic and hydrophobic acrylic materials designed for intraocular lenses in a multiparametric investigation in a liquid environment to highlight their properties in terms of ... [more ▼]

PURPOSE: To compare hydrophilic and hydrophobic acrylic materials designed for intraocular lenses in a multiparametric investigation in a liquid environment to highlight their properties in terms of adhesion forces, lens epithelial cell (LEC) adhesion, and tissue response as indicators of the risk for posterior capsule opacification (PCO) development. SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: The hydrophobicity and surface adhesion force were assessed using contact-angle and atomic force microscopy measurements. The bioadhesiveness of the disks and the tissue response were determined by in vitro experiments using bovine serum albumin and porcine LECs and by in vivo rabbit subcutaneous implantation, respectively. RESULTS: Increasing surface hydrophobicity led to a greater surface-adhesion force and greater LEC adhesion. After 1 month, the rabbit subcutaneous implants showed a similar thin layer of fibrous capsule surrounding the disks without extensive inflammation. A layer of rounded cells in contact with disks was detected on the hydrophobic samples only. CONCLUSIONS: Hydrophobic acrylic disks that have been associated with a reduced risk for PCO in clinical studies showed increased tackiness. FINANCIAL DISCLOSURES: Proprietary or commercial disclosures are listed after the references. [less ▲]

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See detailChitosan: a versatile platform for pharmaceutical applications
Riva, Raphaël ULg; Jérôme, Christine ULg

in Material Matters: Chemistry Driving Performance (2014), 9(3), 95-98

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See detailNitroxide mediated polymerization of methacrylates at moderate temperature
Detrembleur, Christophe ULg; Jérôme, Christine ULg; De Winter, Julien et al

in Polymer Chemistry (2014), 5(2), 335-340

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide ... [more ▼]

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide precursor. The combination of a low temperature azo-initiator with a hindered nitroso-compound produces a mixture of hindered nitroxides in the polymerization medium that act as efficient polymerization control agents. Results of Electron Spin Resonance (ESR) spectroscopy experiments combined with mass spectrometric studies support the proposed in situ NMP mechanism. The hindered structure of the nitroxides formed in situ is believed to be responsible for the efficiency of the process by allowing it to proceed at low temperature, therefore limiting the side reactions generally observed in NMP of methacrylates. [less ▲]

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See detailDevice-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation
Krier, Fabrice ULg; Riva, Raphaël ULg; Defrère, Sylvie et al

in Journal of Drug Delivery Science and Technology [=JDDST] (2014), 24(2), 198-204

Local treatment using drug loaded implants allows decreasing seric concentrations of the active ingredient with the purpose of limiting side effects and reaching perfect observance. Nowadays, some ... [more ▼]

Local treatment using drug loaded implants allows decreasing seric concentrations of the active ingredient with the purpose of limiting side effects and reaching perfect observance. Nowadays, some diseases are already treated with implants, but generally, by subcutaneous or intra vaginal implantation. In this work, a new implant device dedicated to the intra-peritoneal cavity was developed. For this purpose, a core-membrane polymer implant was selected. We propose an original method to determine the most appropriate membrane to control the release based on the use of Franz cells. The ability of the implant to release a constant quantity of an active ingredient will be assessed by testing implants in vitro. Finally, intra peritoneal cavity and subcutaneous in vivo implantation has been achieved in order to confirm the controlled and local release of the active ingredient. [less ▲]

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See detailPoly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Debuigne, Antoine ULg et al

in Nanoscale (2013), 5(23), 11464-11477

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug ... [more ▼]

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment. [less ▲]

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See detailStimuli-responsive magnetic nanohybrids for triggered drug release and potential tumor treatment via hyperthermia
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Controlled Release (2013, November 28), 172(1), 39

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See detailStraightforward synthesis of symmetrical multiblock copolymers by simultaneous block extension and radical coupling reactions
Debuigne, Antoine ULg; Detrembleur, Christophe ULg; Jérôme, Christine ULg et al

in Macromolecules (2013), 46(22), 8922-8931

In situ combination of a polymerization step with a coupling reaction is demonstrated to accelerate the synthesis protocols for symmetrical multiblock copolymers. Predici simulations and experiments prove ... [more ▼]

In situ combination of a polymerization step with a coupling reaction is demonstrated to accelerate the synthesis protocols for symmetrical multiblock copolymers. Predici simulations and experiments prove on the example of cobalt-mediated radical polymerization and coupling (CMRP/C) reactions that such synthesis strategy can be very effective and easy to conduct. Treatment of a cobalt-terminated poly(acrylonitrile) precursor with a mixture of acrylate and isoprene led to the rapid polymerization of the acrylate before isoprene-assisted radical coupling of the macroradical chains forming a well-defined poly(acrylonitrile)-b-poly(acrylate)-b-poly(acrylonitrile) triblock. The degree of polymerization of the central block, resulting from the balance between propagation and coupling, could be tuned by adjusting the relative concentration and varying the structure of the acrylate and diene. The same convergent strategy also permits the synthesis of ABCBA-type pentablock copolymer starting from a cobalt-functional diblock. Simultaneous radical polymerization and coupling is thus a powerful macromolecular engineering approach for the straightforward design of symmetrical multiblock copolymers. [less ▲]

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See detailUse of supercritical carbon dioxide to prepare drug-loaded polymer implants
Champeau, Mathilde; Tassaing, Thierry; Thomassin, Jean-Michel ULg et al

Conference (2013, November 20)

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See detailRheological characterization of double thermo-responsive block copolymer hydrogels
Thomassin, Jean-Michel ULg; Mathieu, Kevin ULg; Kermagoret, Anthony ULg et al

Poster (2013, November 20)

The ability of double thermoresponsive block copolymers to form hydrogels has been thoroughly studied by rheology. These copolymers having two discrete LCSTs were synthesized following a one-pot strategy ... [more ▼]

The ability of double thermoresponsive block copolymers to form hydrogels has been thoroughly studied by rheology. These copolymers having two discrete LCSTs were synthesized following a one-pot strategy based on the sequential cobalt mediated radical polymeryzation of N-vinylcaprolactam (NVCL) followed by the copolymerization of N-vinylpyrrolidone (NVP) with the residual NVCL.Moreover, the very efficient cobalt mediated radical coupling of the growing chains was advantageously used to design triblock copolymers with similar morphological characteristics than the diblock copolymers (same external block length, copolymer ratio…) allowing direct comparison between their respective gels to be established. Different parameters have been compared such as the block length and the copolymer concentration. Temperature ramps were first performed to distinguish the different states, i.e., solubilized copolymers (below the two LCSTs), micelles (between the two LCSTs) and precipitated polymers (above the two LCSTs). [less ▲]

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See detailReversibly cross-linked polymer micelle as smart drug dellivery device
Lecomte, Philippe ULg; Riva, Raphaël ULg; Cajot, Sébastien et al

Conference (2013, November 20)

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See detailDesign of macroporous poly(ionic liquid)s by CO2/water emulsion templated polymerization
Boyère, Cédric ULg; Favrelle, Audrey; Boury, Frank et al

Poster (2013, November 20)

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See detailOrganocatalyzed ring-opening polymerization of cyclic phosphate monomers
Clement, Benoît ULg; Vanslambrouck, Stéphanie ULg; Koole, Leo H. et al

Conference (2013, November 19)

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See detail« Product-oriented engineering » applied to the development of porous scaffolds for tissue engineering.
de Bien, Charlotte ULg; Ounally, Thameur; Collard, Valérie ULg et al

Poster (2013, November 15)

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire [1]. Parmi les ... [more ▼]

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire [1]. Parmi les différents polymères biosourcés et biodégradables déjà utilisés pour la fabrication de scaffolds, l’acide polylactique (PLA) a été choisi [2]. Des matrices poreuses ont été obtenues par un procédé de moussage par lyophilisation puis leur microstructure 2D/3D a été caractérisée par microtomographie à rayons X avant d’être mise en lien avec les conditions d’élaboration testées [3]. La diminution de la porosité ainsi que l’augmentation de l’épaisseur des parois avec l’augmentation de rapport polymère/solvant ont été confirmées. [less ▲]

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See detailMonocatenary, branched, double-headed and bolaform surface active carbohydrate esters via photochemical thiol-ene/-yne reactions
Boyère, Cédric ULg; Broze, Guy ULg; Blecker, Christophe ULg et al

in Carbohydrate Research (2013), 380

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated ... [more ▼]

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated hydrothiolation reaction involving a thiolated mannose was successfully applied to terminal and internal alkenes, dienes and alkynes, leading to monocatenary, branched, double-headed and bolaform amphiphilic carbohydrate esters,respectively. A surface activity study showed that these new compounds possess valuable properties and display specific behavior at the air-water interface. It also demonstrated the greater flexibility of the thioether moiety in the spacer of the surfactants produced via a thiol-ene reaction in comparison withthe triazole heterocyclic rings in similar glucose-based surfactants synthesized elsewhere by the alkyne-azide 1,3-dipolar addition. [less ▲]

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See detailLe « génie orienté produit » appliqué à l’élaboration de matrices poreuses pour l’ingénierie tissulaire.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Récents Progrès en Génie des Procédés (2013, October 08)

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les ... [more ▼]

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les différents polymères biosourcés et biodégradables déjà utilisés pour la fabrication de scaffolds, l’acide polylactique (PLA) a été choisi. Des matrices poreuses ont été obtenues par un procédé de moussage par lyophilisation puis leur microstructure 2D/3D a été caractérisée par microtomographie à rayons X avant d’être mise en lien avec les conditions d’élaboration testées. La diminution de la porosité ainsi que l’augmentation de l’épaisseur des parois avec l’augmentation de rapport polymère/solvant ont été confirmées. [less ▲]

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See detailDrug delivery systems based on amphiphilic polyphosphate-copolymers
Vanslambrouck, Stéphanie ULg; Clement, Benoît ULg; Riva, Raphaël ULg et al

Poster (2013, September 18)

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In ... [more ▼]

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In contrast to poly--caprolactone and polylactides, PPhos properties and functionality are easily tuned via the nature of the pendant group of the starting cyclic monomer. For example, by varying the length of the alkyl chain the hydrophobicity of the PPhos can be adjusted. In this work, an efficient organo-catalytic system was developed to synthesize a series of amphiphilic diblock copolymers, i.e. poly(ethylene oxide)-b-polyphosphate (PEO-b-PPhos) by ring-opening polymerization of cyclic phosphates. This novel approach prevents metallic residues to polute the final product, and which is highly desirable when biomedical applications are foreseen. For drug delivery application, the micellization of these novel diblock copolymers in aqueous media was investigated, as well as, encapsulation of an hydrophobic drug. Data on, the influence of the polyphosphate nature of the polymer on drug loading will be presented. [less ▲]

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