References of "Jérôme, Christine"
     in
Bookmark and Share    
Full Text
See detailSynthèse de copolymères amphiphiles originaux par polymérisation radicalaire contrôlée via des complexes de cobalt
Debuigne, Antoine ULg; Hurtgen, Marie ULg; Liu, Ji ULg et al

Conference (2012, June 05)

veuillez consuster le fichier pdf

Detailed reference viewed: 34 (7 ULg)
Full Text
See detailUse of glycosurfactants for the synthesis of polyHIPES in supercritical carbon dioxide
Boyère, Cédric ULg; Favrelle, Audrey; Léonard, Alexandre ULg et al

Poster (2012, June 04)

The abstract is available as a pdf file.

Detailed reference viewed: 26 (4 ULg)
See detailNanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme
Dumont, Janice ULg; pardon, Els; Aumont-Nicaise, Magali et al

Poster (2012, June)

Six variants of human lysozyme (single-point mutatants I56T, F57I, W64R, D67H and double mutants F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidosis. These ... [more ▼]

Six variants of human lysozyme (single-point mutatants I56T, F57I, W64R, D67H and double mutants F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidosis. These proteins form extracellular amyloid fibrils that deposit in a wide range of tissues and organs such as liver, spleen and kidneys where they cause damages [1]. It was shown that the D67H and I56T mutations cause a loss in stability and more particularly a loss of global cooperativity of protein [1]. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. We have also shown that the binding of three variable domain of camelid antibodies (VHHs) - raised against the wild type human lysozyme inhibit in vitro the formation of amyloid fibrils by the lysozyme variants. These three VHHs bind on different regions of lysozyme and act as amyloid fibril inhibitor through different mechanisms [2, 3, and unpublished results]. In the present work, sixteen new VHHs specific of human lysozyme have been generated. Competition experiments have shown that they bind to five non-overlapping epitopes. We have demonstrated that five of these VHHs are able to bind lysozyme in conditions used for amyloid fibril formation, and interestingly two of them recognize two epitopes that are different from those of the three VHHs previously characterized [2, 3, and unpublished results]. The effects of these new VHHs on the properties of lysozyme variants such as stability, cooperativity and aggregation will be discussed. [1] Dumoulin, M., J.R. Kumita, and C.M. Dobson, Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants. Acc Chem Res, 2006, 39(9), 603-610. [2] Dumoulin, M., et al., A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature, 2003, 424, 783-788. [3] Chan, P.H., et al., Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. Biochemistry, 2008, 47, 11041-11054. [less ▲]

Detailed reference viewed: 68 (9 ULg)
Full Text
Peer Reviewed
See detailEasy functionalization of amphiphilic poly(ethylene oxide)-b-poly(ε-caprolactone) copolymer micelles with unprotected sugar: synthesis and recognition by lectins
Freichels, Hélène; Auzély-Velty, Rachel; Lecomte, Philippe ULg et al

in Polymer Chemistry (2012), 3(6), 1436-1145

This paper aims at reporting the end-functionalization of a PEO block of an amphiphilic α-acetal-PEO-b-PCL copolymer. The acetal end-group, which is the fragment of the initiator used in the EO ... [more ▼]

This paper aims at reporting the end-functionalization of a PEO block of an amphiphilic α-acetal-PEO-b-PCL copolymer. The acetal end-group, which is the fragment of the initiator used in the EO polymerization, was first hydrolyzed into an aldehyde that was then reacted with an amine by reductive amination reaction in water. This two-step derivatization was carried out in one pot. In a preliminary study a model amine, i.e. fluorescein amine, was used and the impact of the composition, thus of the Hydrophilic–Lipophilic Balance (HLB) of the amphiphilic copolymer, was studied. The experimental conditions were extended to the coupling of an aminated mannose to the diblock copolymer. The frozen micelles formed by the mannosylated copolymer proved to form complexes with various lectins as shown by Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC). [less ▲]

Detailed reference viewed: 38 (10 ULg)
See detailSynthesis of novel poly(N-vinyl amide)s containing copolymers by cobalt-mediated radical polymerization
Kermagoret, Anthony ULg; Hurtgen, Marie ULg; Liu, Ji ULg et al

Poster (2012, May 10)

Poly(N-vinyl amide)s are found in many applications due to their valued properties including water solubility, biocompatibility, metal-coordination ability, etc. Although N-vinyl amides are easily ... [more ▼]

Poly(N-vinyl amide)s are found in many applications due to their valued properties including water solubility, biocompatibility, metal-coordination ability, etc. Although N-vinyl amides are easily polymerized via radical pathways, their growing radicals are quite reactive due to the lack of stabilizing group, rendering the synthesis of well-defined poly(N-vinyl amide)s challenging. Thus, we explored the organometallic-mediated radical polymerization (OMRP) of a series of N-vinyl amides using bis(acetylacetonato)cobalt(II) as controlling agent in order to develop a platform for the precision synthesis of poly(N-vinyl amide)s. [less ▲]

Detailed reference viewed: 45 (7 ULg)
Full Text
See detailCrosslinking of star-shape PCLs through Diels-Alder reactions for the preparation of shape memory polymers
Defize, Thomas ULg; Riva, Raphaël ULg; Thomassin, Jean-Michel ULg et al

Poster (2012, May 10)

Poly(ε-caprolactone) (PCL), a semi-crystalline polymer, is one of the most widely studied polymers for the development of shape memory materials when chemically cross-linked. PCL presents several ... [more ▼]

Poly(ε-caprolactone) (PCL), a semi-crystalline polymer, is one of the most widely studied polymers for the development of shape memory materials when chemically cross-linked. PCL presents several advantages such as a melting transition temperature close to human body temperature, a high biocompatibility and is (bio)degradable. So, this polymer is highly relevant for both biomedical devices such as stents or resorbable suture wires and also for degradable packaging. However, after cross-linking, the material can not be reprocessed, preventing any reuse/recycling of the material. One of the purposes of this work is to find a solution to this major drawback, which would then allow, for example, to reshape packaging films after use or to recycle trimmings remaining after fabrication. Amongst current trends in the design of new polymer and composite materials, the use of organic reactions that are able to create and reversibly disrupt chemical bonds upon an external stimulus (temperature, irradiation,…) is currently gaining more and more attention as it can lead to applications in various areas such as remendable materials, drug delivery systems, stimulus-degrading materials or recyclable materials. This contribution aims at reporting a new concept for the preparation of well defined and recyclable PCL based reversibly cross-linked shape memory polymer by the formation of reversible carbon-carbon bonds. Amongst all the reversible links described in the literature, thermally (4+2) reversible cycloadditions present interesting features such as the creation of robust bonds and well defined reversibility conditions. As an example, the application of furan/maleimide adducts as covalent link, which cycloreversion is largely favored in the range of temperature (90-120°C), is widely reported. For this purpose, commercially-available star-shaped PCL precursors have been selected and selectively modified at their chain ends either by a diene (furan, anthracene) or a dienophile (maleimide). Typically, PCL-based shape memory materials have been prepared by mixing a stoichiometric amount of diene-bearing and maleimide-bearing PCLs in a twin-screw mini-extruder at a temperature which favors cycloreversion. The polymer blend is then cured at 65°C (just above PCL melting temperature), with the purpose to increase chains mobility and improve the formation of the adducts. Cross-linked PCLs were obtained, as evidenced by swelling experiments. The shape memory properties of the materials have been studied by cyclic tensile thermomechanical analysis. The influence of the nature of the Diels-Alder moieties on the cross-linking rate and on the shape memory properties has been studied. Reversibility of the network formation in the case of furan, used as diene, has been assessed by rheology and by recycling experiment. [less ▲]

Detailed reference viewed: 62 (5 ULg)
See detailStimuli-responsive magnetic nanohybrids designed for controlled drug release application
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stephan et al

Conference (2012, May 10)

Stimuli-responsive organic/inorganic nanohybrids, with an inorganic core and a polymer coating, have been frequently suggested as a promising vehicle for drug or gene delivery and also controlled release ... [more ▼]

Stimuli-responsive organic/inorganic nanohybrids, with an inorganic core and a polymer coating, have been frequently suggested as a promising vehicle for drug or gene delivery and also controlled release, due to their outstanding biocompatibility, versatile surface modification, specific responsive properties to external stimuli, and so on. Magnetic nanoparticles have various applications in biomedical filed, such as magnetic resonance imaging, biosensors, magnetic separation, drug release, hyperthermia therapy and so on. Poly (acrylic acid) copolymers exhibit a sharp conformation transition when exposed to external change in pH. The PAA copolymer was used to form a polymer shell outside the magnetic core, a cationic dye was uploaded by electro-static interaction. The controlled release was achieved by tuning the external pH value. Magnetic/SiO2 mesoporous nanoparticles were prepared as another drug vehicle, in order to obtain a higher drug loading amount. Crystalline molecules were utilized as a gate keeper to control the release of drugs uploaded. [less ▲]

Detailed reference viewed: 79 (9 ULg)
See detailSynthesis of new biomimetic biodegradable materials for clinical use
Clement, Benoît ULg; Grignard, Bruno ULg; Lecomte, Philippe ULg et al

Poster (2012, May 10)

For recent decades, the most commonly biodegradable polymers used in clinical and therapeutic applications are aliphatic polyesters such as polyglycolide, polylactide, polycaprolactone and their ... [more ▼]

For recent decades, the most commonly biodegradable polymers used in clinical and therapeutic applications are aliphatic polyesters such as polyglycolide, polylactide, polycaprolactone and their copolymers, mainly due to their excellent biocompatibility and biodegradability properties. However, the lack of functional groups on the backbone of polyesters, which could otherwise be used for tuning physicochemical properties and for introducing bioactive units, limits their further biomedical applications. Polymers with repeating phosphoester bonds in the backbone are structurally versatile and biodegradable through hydrolysis and possibly enzymatic digestion of phosphates linkages under physiological conditions. An advantage of polyphosphoesters (PPEs) compared to aliphatic polyesters is the possible functionalization of side chains due to the patenvalency of the phosphorous atom, allowing the introduction of bioactive molecules and extensive modification of the physical and chemical properties of final material. The Ring-Opening Polymerization (ROP) of cyclic esters is a well-established process to provide linear polyesters with predictable molecular weight, narrow polydispersity and well-defined end-groups. Up to now, metallic compounds are particularly used as initiators or polymerization catalysts to synthetize these materials but metallic derivatives are cytotoxic and a lack of residual metal contaminants is strongly required in view of biomedical applications. To tackle these drawbacks, we developed synthetic approaches that are metal-free (i.e., organocatalytic) using organocatalysis based on supramolecular recognition. A variety of organocatalysts such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), 1,5,7-triazabicyclo[4.4.0]undec-5-ene (TBD) and a bicomponent thiourea-tertiary amine catalyst were studied. Each of these catalysts is efficient to produce linear polyphosphoesters (PPEs) from cyclic phosphate monomers (CPMs) but with different sensitivity towards transesterification side reactions. Compared with polymerizations carried out with Sn(Oct)2 as a metal catalyst, the control of polymerization is much better so that it is possible to prepare PPEs with molecular weight close to 70000 g.mol-1 and polydispersity index below 1.10. The chain extension experiments through the use of hydroxy end-capped PPEs as macro-initiators confirm the controlled/living nature of organo-catalyzed ROP of CPMs and pave the way to the synthesis of block copolymers based on polyphosphates. Finally, these polymerizations procedures are expected to facilitate the synthesis of well-defined PPEs with various architectures and free of potentially toxic metal remnants. The easy availability of catalysts, the mild conditions of polymerizations and the metal-free nature of the polymerizations makes these catalysts very attractive candidates for the synthesis of PPEs for biomedical applications such as drug and gene delivery, tissue engineering and dental applications. [less ▲]

Detailed reference viewed: 92 (13 ULg)
See detailDesign of sugar-based surface active agents for emulsion polymerization in supercritical carbon dioxide
Boyère, Cédric ULg; Favrelle, Audrey; Broze, Guy ULg et al

Conference (2012, May 10)

The use of aqueous dispersed media, such as emulsions, has many advantages over solution processes for chemical transformations and polymerization reactions, i.e. limited environmental impact, ease of ... [more ▼]

The use of aqueous dispersed media, such as emulsions, has many advantages over solution processes for chemical transformations and polymerization reactions, i.e. limited environmental impact, ease of products recovery and increased reaction rate. Emulsions are usually implemented from a water/organic solvent mixture in the presence of a surfactant. However, supercritical carbon dioxide (scCO2) (Pc =74 bars; Tc = 31°C) constitutes an interesting alternative to the traditional organic solvents in these heterogeneous systems because it is inexpensive, non-toxic, non-inflammable and environmentally friendlier. In this context, we developed a novel class of surfactants for the stabilization of H2O/scCO2 emulsions, i.e. fluorinated modified carbohydrates. The hydrophilic head of the surfactant consists in a sugar moiety whereas a fluorinated tail is specifically located in the scCO2 phase. The strategies for the synthesis of these carbohydrates esters rely on selective lipase-catalyzed modifications of sugars and on the versatile thiol-Michael addition reaction. The ability of these molecules to decrease the H2O/scCO2 interfacial tension and to stabilize such emulsions will be presented. Finally, high internal phase scCO2-in-water emulsion (HIPE) were prepared with these new surfactants and used as template for the acrylamide polymerization. The monomer is polymerized in the continuous aqueous phase before removing the CO2 droplets (at least 70 % of the total volume). The resulting permeable porous polymers, called polyHIPEs, exhibit highly interconnected voids (cfr SEM picture) and should be valuable in many applications including support for catalyst, filtration process, immobilization of proteins, etc. [less ▲]

Detailed reference viewed: 33 (16 ULg)
Full Text
Peer Reviewed
See detailAntibacterial polyelectrolyte micelles for coating stainless steel
Falentin, Céline ULg; Faure, Emilie ULg; Svaldo Lanero, Tiziana ULg et al

in Langmuir (2012), 28(18), 7233-7241

In this study, we report on the original synthesis and characterization of novel antimicrobial coatings for stainless steel by alternating the deposition of aqueous solutions of positively charged ... [more ▼]

In this study, we report on the original synthesis and characterization of novel antimicrobial coatings for stainless steel by alternating the deposition of aqueous solutions of positively charged polyelectrolytes micelles doped with silver based nanoparticles with a polyanion. The micelles are formed by electrostatic interaction between two oppositely charged polymers, a polycation bearing 3,4-dihydroxyphenylalanine units (DOPA, a major component of natural adhesives) and a polyanion (poly(styrene sulfonate), PSS) without using any block copolymer. DOPA units are exploited for their well-known ability to anchor to stainless steel and to form and stabilize biocidal silver nanoparticles (Ag0). The chlorine counter-anion of the polycation forms and stabilizes biocidal silver chloride nanoparticles (AgCl). We demonstrate that two layers of micelles (alternated by PSS) doped by silver particles are enough to impart to the surface a strong antibacterial activity against Gram-negative E. coli. Moreover, micelles that are reservoirs of biocidal Ag+ can be easily reactivated after depletion. This novel water-based approach is convenient, simple and attractive for industrial applications. [less ▲]

Detailed reference viewed: 108 (13 ULg)
Peer Reviewed
See detailElectroinitiated polymerization
Jérôme, Christine ULg

in Matyjaszewski, Krzysztof; Möller, Martin (Eds.) Polymer Science: a comprehensive reference ; volume 4: Ring-Opening Polymerization and Special Polymerization Processes (2012)

Electroinitiated polymerization, a method particularly relevant in coating technology, offers the unique opportunity of imparting permanent functionality/reactivity to a variety of surfaces, provided that ... [more ▼]

Electroinitiated polymerization, a method particularly relevant in coating technology, offers the unique opportunity of imparting permanent functionality/reactivity to a variety of surfaces, provided that the solid substrate is (semi)conducting. By focusing on the electroinitiation of acrylic monomers, basic concepts and some tools dedicated to the analysis of this peculiar polymerization process are discussed in this chapter. The important role of this polymerization method in the field of conjugated polymers is also highlighted. Finally, this chapter concludes with the opportunities and future challenges of this technology. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailPhysicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines
Warnant, Jérôme; Marcotte, N.; Reboul, J. et al

in Analytical and Bioanalytical Chemistry (2012), 403

The physicochemical properties of polyion complex (PIC) micelles were investigated in order to characterize the cores constituted of electrostatic complexes of two oppositely charged polyelectrolytes. The ... [more ▼]

The physicochemical properties of polyion complex (PIC) micelles were investigated in order to characterize the cores constituted of electrostatic complexes of two oppositely charged polyelectrolytes. The pH-sensitive micelles were obtained with double hydrophilic block copolymers containing a poly(acrylic acid) block linked to a modified poly(ethylene oxide) block and various polyamines (polylysine, linear and branched polyethyleneimine, polyvinylpyridine, and polyallylamine). The pH range of micellization in which both components are ionized was determined for each polyamine. The resulting PIC micelles were characterized using dynamic light scattering and smallangle X-ray scattering experiments (SAXS). The PIC micelles presented a core–corona nanostructure with variable polymer density contrasts between the core and the corona, as revealed by the analysis of the SAXS curves. It was shown that PIC micelle cores constituted by polyacrylate chains and polyamines were more or less dense depending on the nature of the polyamine. It was also determined that the density of the cores of the PIC micelles depended strongly on the nature of the polyamine. These homogeneous cores were surrounded by a large hairy corona of hydrated polyethylene oxide block chains. Auramine O (AO) was successfully entrapped in the PIC micelles, and its fluorescence properties were used to get more insight on the core properties. Fluorescence data confirmed that the cores of such micelles are quite compact and that their microviscosity depended on the nature of the polyamine. The results obtained on these core–shell micelles allow contemplating a wide range of applications in which the AO probe would be replaced by various cationic drugs or other similarly charged species to form drug nanocarriers or new functional nanodevices. [less ▲]

Detailed reference viewed: 32 (2 ULg)
See detailInnovative multilayered nanofibers for wound dressing application
Croisier, Florence ULg; Detrembleur, Christophe ULg; Jérôme, Christine ULg

Poster (2012, April 18)

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This ... [more ▼]

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This polysaccharide has shown a great potential for biomedical and pharmaceutical applications, on account of its remarkable compatibility with physiological medium. Besides, it is degraded in a physiological environment into non-toxic products, which make chitosan an outstanding candidate for short- to medium-term applications. In this respect, nanometric fibers are highly interesting as their assembly mimics the skin extracellular matrix structure. Such nanofibrous materials can be prepared by electrospinning (ESP). This technique uses a high voltage to create an electrically charged jet of polymer solution or melt which leads to fibers formation. Depending on the polymer characteristics (a.o. molecular weight, solution viscosity and conductivity) and processing conditions (electric potential, distance between syringe-capillary and collection plate, concentration, flow rate), polymer fibers ranging from nanometers to a few microns in diameter can be obtained and subsequently used as potential scaffolds, a.o. to form a temporary, artificial extracellular matrix. In the present study, electrospinning technique was combined with layer-by-layer deposition method (LBL) - a well-known method for surface coating, based on electrostatic interactions - in order to prepare multilayered chitosan-based nanofibers. The antibacterial properties of the obtained material were then assessed, and the presence of a multilayered deposit was confirmed by several techniques. (Future) possibilities for valorization: These multilayered chitosan-based nanofibers present great prospects for the preparation of new biomedical scaffolds - such as wound dressings that could improve skin regeneration. [less ▲]

Detailed reference viewed: 10 (3 ULg)
Full Text
Peer Reviewed
See detailUse of ionic liquids for biocatalytic synthesis of sugar derivatives
Galonde, Nadine ULg; Nott, Katherine ULg; Debuigne, Antoine ULg et al

in Journal of Chemical Technology & Biotechnology (2012), 87(4), 451-471

Sugar-based compounds are widely used in pharmaceuticals, cosmetics, detergents and food. They are mainly produced by chemical methods, but the use of enzymes as ‘a greener alternative’ to organic ... [more ▼]

Sugar-based compounds are widely used in pharmaceuticals, cosmetics, detergents and food. They are mainly produced by chemical methods, but the use of enzymes as ‘a greener alternative’ to organic synthesis has been investigated for more than 20 years. Due to the low polar substrate solubility in organic solvents compatible with enzymes, research has focused on the application of substitutes for biocatalysis, especially ionic liquids (ILs). After introducing the main properties of ILs and especially their ability to solubilize sugars, this review focuses on one of their applications, the biocatalytic synthesis of carbohydrate derivatives. In this context, they can be used in pure IL systems, in IL/IL systems or in IL/organic solvent systems. Finally, this review provides an update on the environmental fate of ILs. Their exploitation in ‘green’ processes is still limited due to their low degradability but research is currently under way to design new more ‘eco-friendly’ ILs. [less ▲]

Detailed reference viewed: 62 (11 ULg)
Full Text
Peer Reviewed
See detailDevelopment of a biomechanical model of deer antler cancellous bone based on X-ray microtomographic images
de Bien, Charlotte ULg; Mengoni, Marlène ULg; D'Otreppe, Vinciane ULg et al

in Micro-CT User Meeting 2012 - Abstract Book (2012, April)

Finite element models accurately compute the mechanical response of bone and bone-like materials when the models include their detailed microstructure. The aim of this paper is to develop and validate a ... [more ▼]

Finite element models accurately compute the mechanical response of bone and bone-like materials when the models include their detailed microstructure. The aim of this paper is to develop and validate a biomechanical model for deer antler cancellous bone tissue based on X-ray microtomographic images. In order to simulate the mechanical behavior under compressive load using a finite element model, images obtained by X-ray microtomography were exported into Metafor, which is an non-linear finite element software initially developed at University of Liège for metal forming processes. This software has recently found biomedical applications. The ultimate goal is to compare model predictions with the mechanical behavior observed experimentally using the Skyscan material testing stage under compression mode. The creation of the biomechanical model mesh from segmented μCT images, its integration into the software Metafor and the simulation of a compression test are described in this paper. [less ▲]

Detailed reference viewed: 131 (24 ULg)
See detailMagnetic hybrid materials for triggered drug delivery and optical properties of intraocular lens
Liu, Ji ULg; Hurtgen, Marie ULg; Mornet, Stephan et al

Poster (2012, March 30)

Stimuli-responsive nano-materials have been playing increasingly important roles in the biomedical field due to their ability to alter the physico-chemical properties in response to external stimuli, such ... [more ▼]

Stimuli-responsive nano-materials have been playing increasingly important roles in the biomedical field due to their ability to alter the physico-chemical properties in response to external stimuli, such as temperature, pH, ionic strength, magnetic field, etc. Nanohybrids bearing an inorganic core and thermo-responsive polymer shell are particularly applicable in target delivery and controlled drug release. Poly (N-vinylcaprolactam) (PNVCL) and its copolymers, exhibiting lower critical solution temperature (LCST) where the transition between hydrophilic and hydrophobic state happens, is one of the optimal choices for this core/shell structure. Here we present the in-situ fabrication of thermo-responsive gold nanohybrids coated with a novel poly (vinyl alcohol)-b-poly (N-vinylcaprolactam) (PVOH-b-PNVCL) block copolymers, which were prepared by the cobalt-mediated radical polymerization (CMRP). The interaction between both PVOH and PNVCL segments and gold nanoparticles was confirmed by FT-IR spectra. A sharp thermo-induced phase transition with a good reversibility upon change in temperature was detected by DLS and UV/vis spectrometer. Furthermore, the presence of hydrophilic PVOH moieties endows the gold nanohybrids with improved colloidal stability above LCST without any flocculation detected. This kind of gold nanohybrids can be envisaged as a new drug delivery vehicle. [less ▲]

Detailed reference viewed: 78 (4 ULg)
See detailPreparation of drug-loaded scaffolds for biomedical applications using supercritical carbon dioxide technology
Champeau, Mathilde; Jérôme, Christine ULg; Tassaing, Thierry

Conference (2012, March 25)

Detailed reference viewed: 8 (1 ULg)
See detailRadical coupling of polymers formed by cobalt-mediated radical polymerization
Debuigne, Antoine ULg; Hurtgen, Marie ULg; Jérôme, Christine ULg et al

in Matyjaszewski, Krzysztof; Sumerlin, Brent; Tsarevsky, Nicolas V. (Eds.) Progress in controlled radical polymerization: mechanisms and techniques (2012)

Considerable progress has been recently made in cobalt-mediated radical polymerization (CMRP), a controlled radical polymerization system based on the temporary deactivation of the polymer chains by a ... [more ▼]

Considerable progress has been recently made in cobalt-mediated radical polymerization (CMRP), a controlled radical polymerization system based on the temporary deactivation of the polymer chains by a cobalt complex, like the improvement of the mechanistic understanding, the extension to a range of monomers and the preparation of novel architectures. However, the real breakthrough in this field concerns the development of efficient radical coupling methods for polymer precursors preformed by CMRP. This book chapter aims to describe the general principle and main characteristics of such radical coupling techniques involving dienes, nitrones, fullerenes or carbon nanotubes. Well-defined and complex architectures obtained by these techniques are provided in order to illustrate their potential for macromolecular engineering. [less ▲]

Detailed reference viewed: 64 (9 ULg)