References of "Jérôme, Christine"
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See detailSynthesis and fabrication of polyesters as biomaterials
Lecomte, Philippe ULg; Jérôme, Christine ULg

in Popa, Valentin; Dumitriu, Daniela (Eds.) Polymeric biomaterials: structure and function, volume 1 (2013)

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See detailSynthesis of poly(vinyl acetate)-b-poly(vinyl chloride) block copolymers by cobalt-mediated radical polymerization (CMRP)
Piette, Yasmine; Debuigne, Antoine ULg; Bodart, Vinent et al

in Polymer Chemistry (2013), 4(5), 1685-1693

The synthesis of poly(vinyl acetate)-b-poly(vinyl chloride) (PVAc-b-PVC) block copolymers by Cobalt-Mediated Radical Polymerization (CMRP) is investigated for the first time in this paper. A PVAc–Co(acac ... [more ▼]

The synthesis of poly(vinyl acetate)-b-poly(vinyl chloride) (PVAc-b-PVC) block copolymers by Cobalt-Mediated Radical Polymerization (CMRP) is investigated for the first time in this paper. A PVAc–Co(acac)2 macroinitiator is prepared by CMRP using the V-70/Co(acac)2 binary system or a preformed alkylcobalt(III) compound. Then, the block copolymerization occurs in the bulk at 40 °C by the addition of VC. The addition of water to the polymerization medium or the slow generation of alkyl radicals during the whole polymerization is beneficial to the process by consuming part of the excess of deactivator (Co(acac)2) that blocks the polymer chains into the dormant form. Dynamic light scattering (DLS) measurements and AFM analyses evidence that the PVAc-b-PVC forms core–shell micelles in a selective solvent of the PVAc block, i.e. methanol, evidencing the blocky structure of the copolymer. PVAc-b-P(VC-co-VAc) copolymers are also successfully prepared by initiating the radical copolymerization of VC and VAc at 40 °C from a PVAc–Co(acac)2 macroinitiator. [less ▲]

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See detailFunctional nanogels as platforms for imparting antibacterial, antibiofilm, and antiadhesion activities to stainless steel
Faure, Emilie ULg; Falentin, Céline ULg; Svaldo Lanero, Tiziana ULg et al

in Advanced Functional Materials (2012), 22(24), 5271-5282

In this work, long-term antibacterial, antiadhesion, and antibiofilm activities are afforded to industrial stainless steel surfaces following a green and bio-inspired strategy. Starting from catechol ... [more ▼]

In this work, long-term antibacterial, antiadhesion, and antibiofilm activities are afforded to industrial stainless steel surfaces following a green and bio-inspired strategy. Starting from catechol bearing synthetic polymers, the film cross-linking and the grafting of active (bio)molecules are possible under environmentally friendly conditions (in aqueous media and at room temperature). A bio-inspired polyelectrolyte, a polycation-bearing catechol, is used as the film-anchoring polymer while a poly(methacrylamide)-bearing quinone groups serves as the cross-linking agent in combination with a polymer bearing primary amine groups. The amine/quinone reaction is exploited to prepare stable solutions of nanogels in water at room temperature that can be easily deposited to stainless steel. This coating provides quinonefunctionalized surfaces that are then used to covalently anchor active (bio) molecules (antibiofi lm enzyme and antiadhesion polymer) through thiol/ quinone reactions. [less ▲]

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See detailSmart nanocarriers for pH-triggered targeting and release of hydrophobic drugs
Cajot, Sébastien; Van Butsele, Kathy; Paillard, A. et al

in Acta Biomaterialia (2012), 8(12), 4215-4223

The use of hybrid pH-sensitive micelles mainly based on the PEO129-P2VP43-PCL17 ABC miktoarm star copolymer as potential triggered drug delivery systems has been investigated. Co-micellization of this ... [more ▼]

The use of hybrid pH-sensitive micelles mainly based on the PEO129-P2VP43-PCL17 ABC miktoarm star copolymer as potential triggered drug delivery systems has been investigated. Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (poly-2-vinylpyridine, P2VP) has been considered here in order to impart possible active targeting of the tumor cells. Two architectures have been studied for these labeled copolymers, i.e. a miktoarm star or a linear ABC terpolymer and the respective hybrid micelles have been compared in terms of cytotoxicity (cells viability) and cellular uptake (by using fluorescent dye loaded micelles). Finally, the triggered drug release in the cytosol of tumor cells was investigated by studying on one hand the lysosomal integrity after internalization and on the other hand the release profile in function of the pH. [less ▲]

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See detailRing-opening polymerization of cyclic phosphoesters
Vanslambrouck, Stéphanie ULg; Clement, Benoît ULg; Jérôme, Christine ULg et al

Poster (2012, November 16)

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See detailSynthesis and physico-chemical characterization of fatty esters
Sainvitu, Pauline ULg; Nott, Katherine ULg; Nicks, Francois ULg et al

Poster (2012, November 16)

Specific antioxidant molecules (e.g. phenolics) help to prevent oxidation reaction of the cell membrane. A fatty chain grafted on these compounds should enhance their capacity to interact with the ... [more ▼]

Specific antioxidant molecules (e.g. phenolics) help to prevent oxidation reaction of the cell membrane. A fatty chain grafted on these compounds should enhance their capacity to interact with the membrane lipids. In our study, three fatty esters comprising an aromatic part were synthesized. They differentiate the aromatic substituent and the number of carbons between the aromatic ring and the ester function. A structure-function relationships study was performed to identify the structural pattern affecting the interfacial properties and the membrane interaction properties. The behavior of their monolayer film at an air-water interface was studied. The interactions with membrane were assessed on living cells and were predicted by a computational approach. In the future, we will investigate the effect of the presence of a sugar unit on these molecules. [less ▲]

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See detailSynthesis of new biomimetic and biodegradable polymers for clinical use
Clement, Benoît ULg; Grignard, Bruno ULg; Koole, Leo et al

Conference (2012, November 15)

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See detailSynthesis in scCO2 of nano-hydrogels for proteins delivery
Alaimo, David ULg; Grignard, Bruno ULg; Fustin, Charles-André et al

Conference (2012, November 14)

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See detailCobalt-mediated radical (co)polymerization of vinyl chloride and vinyl acetate
Piette, Yasmine; Debuigne, Antoine ULg; Jérôme, Christine ULg et al

in Polymer Chemistry (2012), 3(10), 2880-2891

The cobalt mediated radical polymerization (CMRP) of vinyl chloride (VC) in the presence of bis(acetylacetonato)cobalt(II) (Co(acac)2) as a controlling agent is presented for the first time. Using an ... [more ▼]

The cobalt mediated radical polymerization (CMRP) of vinyl chloride (VC) in the presence of bis(acetylacetonato)cobalt(II) (Co(acac)2) as a controlling agent is presented for the first time. Using an alkyl-Co(III) compound (R0–(CH2–CHOAc)<4–Co(acac)2; R0 = (H3C)2(OCH3)C–CH2–C(CH3)(CN)–) as an initiator, the bulk polymerization under non-isotherm conditions is controlled. 1H NMR spectra of the resulting PVC show that the CMRP process does not significantly affect the level of defects compared to a PVC prepared by a conventional free radical polymerization at the same temperature. Using the same alkyl-cobalt(III) compound, the copolymerization of VC and VAc is controlled at 40 °C provided that enough VAc (about 40 mol%) is present in the polymerization medium to moderate the VC polymerization. In line with reactivity ratios, VC is preferentially incorporated in the polymer at the early stages of the polymerization, leading to copolymers with a high VC content at moderate conversions. This is the first report of a CMRP of VC and of the synthesis of well-defined statistical PVC-co-PVAc copolymers by this technique. [less ▲]

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See detailImprégnation de polymères par voie CO2 supercritique: suivi in situ par microscopie FTIR
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Jérôme, Christine ULg et al

Conference (2012, September 15)

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See detailEffects of cellular morphology on electricalconductivity of carbon nanotubes containing nanocomposites foams
Tran, Minh Phuong ULg; Detrembleur, Christophe ULg; Thomassin, Jean-Michel ULg et al

Conference (2012, September 13)

In the last few years, polymer carbon nanotubes (CNTs) nanocomposites foams have received increasing attention due to their potential applications in electrostatic dissipation (ESD) and in electromagnetic ... [more ▼]

In the last few years, polymer carbon nanotubes (CNTs) nanocomposites foams have received increasing attention due to their potential applications in electrostatic dissipation (ESD) and in electromagnetic interferences (EMI) shielding. To be efficient, these foams must exhibit appropriate electrical conductivity (> 1 S/m) and dielectric constant. A good understanding of the influence of the foam structural parameters on the electrical properties of the foam will ultimately enable the optimum design of these materials for the targeted applications. A wide range of poly(methyl methacrylate) (PMMA)/CNTs nanocomposites foams were synthesized using the supercritical CO2 technology. Different foaming parameters, such as the temperature, impregnation pressure, time and rate of depressurization were varied to modify the foam structure. The amount of carbon nanotubes in PMMA plays the most important role in increasing the electrical conductivity. Nanocomposite foams show higher electrical conductivity than non-foamed nanocomposites at the same volume content of CNTs. Effects of foam morphology such as cell-density; pore size, volume expansion, and cell-wall thickness on electrical conductivity were comprehensively assessed. High electrical conductivity can be achieved with nanocomposite foams that have high volume expansion, small pore size, high cell density, and thin cell-walls [less ▲]

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See detailStimuli-responsive Magnetic Nanohybrids for Triggered Drug Release and Potential Tumor Treatment via Hyperthermia
Liu, Ji ULg; Detrembleur, Christophe ULg; Mornet, Stéphane et al

Poster (2012, September 13)

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See detailMechanistic investigation and selectivity of the grafting onto C60 of macroradicals prepared by cobalt-mediated radical polymerization
Hurtgen, Marie ULg; Debuigne, Antoine ULg; Gigmes, Didier et al

in Polymer (2012), 53(20), 4353-4358

The grafting mechanism of poly(vinyl acetate) macroradicals prepared by cobalt-mediated radical polymerization onto C60 is investigated. The experimental conditions directly impact the nature and ... [more ▼]

The grafting mechanism of poly(vinyl acetate) macroradicals prepared by cobalt-mediated radical polymerization onto C60 is investigated. The experimental conditions directly impact the nature and stability of the PVAc/C60 adducts. In the presence of residual initiating radicals that can compete with PVAc! macroradicals for addition onto C60, mixtures of PVAc/C60 adducts having between one and eight polymer chains per C60 are formed. PVAc/C60 adducts prepared with low [PVAc]:[C60] ratios may contain weak C60-C60 bonds that further dissociate and account for the instability of the products. The formation of such dimers can be lessened by increasing the temperature from 30 !C to 100 !C. The temperature increase also allows a complete dissociation of the PVAc-Co dormant species into PVAc! macroradicals and an almost quantitative grafting of eight PVAc chains onto C60, leading to well-de!ned C60(PVAc)8 octa-adducts. These results might shed new light on the grafting onto C60 of macroradicals prepared by other CRP techniques. [less ▲]

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See detailThermally induced coupling of poly(thiophene)-based block copolymers prepared by Grignard metathesis polymerization: a straightforward route toward highly regioregular multiblock conjugated copolymers
Ouhib, Farid ULg; Desbief, Simon; Lazzaroni, Roberto et al

in Macromolecules (2012), 45(17), 6796-6806

We report on a convenient and simple process to prepare highly regioregular poly(thiophene)-based multiblock copolymers by a novel thermally induced coupling reaction. Diblock copolymers of 3 ... [more ▼]

We report on a convenient and simple process to prepare highly regioregular poly(thiophene)-based multiblock copolymers by a novel thermally induced coupling reaction. Diblock copolymers of 3-hexylthiophene (3HT) and 2,5-dibromo-3-(2-(2-tetrahydropyranyl-2-oxy)ethyl)thiophene (THPET) end-capped by a nickel complex (Br-P3HT-b-PTHPET-Ni(dppp)Br) are first prepared using Ni(dppp)Cl2 as catalyst at 30 °C by Grignard metathesis polymerization (GRIM process). The coupling of these α-bromo, ω-Ni(dppp)Br telechelic diblock copolymers then occurs by heating the solution of the copolymer at 80 °C for a few hours without adding any additional reagent. Reactions are complete in only 10 min when heating the copolymer at 120 °C using microwaves. The deprotection of the alcohol groups of PTHPET blocks allows further modifications such as the incorporation of acrylates by esterification. AFM analysis on thin films shows the influence of the nature of side chains (protected alcohol or acrylate), the molecular weight, and the architecture (diblock or multiblock) of the copolymer on the supramolecular organization of the polythiophene chains. [less ▲]

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