References of "Jérôme, Christine"
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See detailDual anticancer drug/superparamagnetic iron oxide-loaded PLGA-based nanoparticles for cancer therapy and magnetic resonance imaging
Schleich, N.; Sibret, Pierre ULg; Danhier, P. et al

in International Journal of Pharmaceutics (2013), 447(1-2), 94-101

We developed dual paclitaxel (PTX)/superparamagnetic iron oxide (SPIO)-loaded PLGA-based nanoparticles for a theranostic purpose. Nanoparticles presented a spherical morphology and a size of 240 nm. The ... [more ▼]

We developed dual paclitaxel (PTX)/superparamagnetic iron oxide (SPIO)-loaded PLGA-based nanoparticles for a theranostic purpose. Nanoparticles presented a spherical morphology and a size of 240 nm. The PTX and iron loading were 1.84 ± 0.4 and 10.4 ± 1.93 mg/100 mg respectively. Relaxometry studies and phantom MRI demonstrated their efficacy as T2 contrast agent. Significant cellular uptake by CT26 cells of nanoparticles was shown by Prussian blue staining and fluorescent microscopy. While SPIO did not show any toxicity in CT-26 cells, PTX-loaded nanoparticles had a cytotoxic activity. PTX-loaded nanoparticle (5 mg/kg) with or without co-encapulated SPIO induced in vivo a regrowth delay of CT26 tumors. Together these multifunctional nanoparticles may be considered as future nanomedicine for simultaneous molecular imaging, drug delivery and real-time monitoring of therapeutic response. [less ▲]

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See detailDielectric and rheological characterization of polymer/graphene oxide nano composites
Thomassin, Jean-Michel ULg; Trifkovic, Milana; Jérôme, Christine ULg et al

Conference (2013, April 05)

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See detailStudy of the Influence of Pure Ionic Liquids on the Lipase-catalyzed (Trans)esterification of Mannose Based on their Anion and Cation Nature
Galonde, Nadine ULg; Nott, Katherine ULg; Richard, Gaetan ULg et al

in Current Organic Chemistry (2013), 17(7), 763-770

A screening of nine ionic liquids (ILs) has been carried out in order to study the influence of the anion's and cation's nature and structure on the synthesis of mannosyl myristate by (trans ... [more ▼]

A screening of nine ionic liquids (ILs) has been carried out in order to study the influence of the anion's and cation's nature and structure on the synthesis of mannosyl myristate by (trans)esterification catalyzed by Novozym® 435. The best ILs in terms of yield (η) and initial rate (v0) are those based on the TFO- anion. The 24h yield (24h-η) reached 64.9% in [Bmim][TFO] and 70.9% in [Bmpyrr][TFO] by transesterification while it reached 29.7% and 44.5% respectively in each IL by esterification. [Bmpyrr][TFO] based on the pyrrolidinium cation gave the best results although this cation has been rarely used for biocatalysis. This work has thus highlighted a cation that could be further studied in biocatalysis of glycosylated compounds. The study of the relationship between the structure of the ILs and the v0 and η for the biocatalysis of mannosyl myristate showed that the lipase effectiveness is influenced by the anions while the cations have an indirect influence on the interaction strength between Novozym® 435 and the anions. [less ▲]

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See detailA fast and facile synthetic route toward the preparation of nanoparticles of polythiophene and its derivatives
Bozukova, Dimitriya; Jérôme, Robert ULg; Jérôme, Christine ULg

in Journal of Nanoparticle Research (2013), 15(4), 15831-18

A novel photochemical water-based approach for the preparation of nanoparticles of polymerized thiophene (Th), thiophene methanol (ThM), or their mixtures (Th-co/or-ThM) was developed. The influence of 3 ... [more ▼]

A novel photochemical water-based approach for the preparation of nanoparticles of polymerized thiophene (Th), thiophene methanol (ThM), or their mixtures (Th-co/or-ThM) was developed. The influence of 3-[(2-acryloyloxy)methyl] thiophene (ATh) as cross-link agent on the stability of the nanoparticles and on their performances was investigated. The occurrence of a polymerization process was confirmed by Fourier transform infrared (FT-IR), UV and fluorescence emission spectroscopies. Nanoparticles with very narrow size distribution (0.0092–0.105 ATh cross-linked, 0.0635–0.272 uncross-linked) and ideal spherical shape (radius 35–47 nm ATh cross-linked, 49–109 nm uncross-linked) were obtained whatever the reaction composition. The size of the particles was found to depend strongly on the level of ATh-stabilization and to diminish upon increase of the ATh content. In contrast, in the same order, their thermal stability shifted toward higher temperatures. Thermal decomposition of the nanoparticles led to formation of carbon-nanoobjects, as observed by transmission electron microscopy, FT-IR, and RAMAN spectroscopies. The re-dispersibility of the dry Th-co/or-ThM nanoparticles in some conventional monomers and solvents has been estimated. [less ▲]

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See detailChitosan-based biomaterials for tissue engineering
Croisier, Florence ULg; Jérôme, Christine ULg

in European Polymer Journal (2013), 49(4), 780-792

Derived from chitin, chitosan is a unique biopolymer that exhibits outstanding properties, beside biocompatibility and biodegradability. Most of these peculiar properties arise from the presence of ... [more ▼]

Derived from chitin, chitosan is a unique biopolymer that exhibits outstanding properties, beside biocompatibility and biodegradability. Most of these peculiar properties arise from the presence of primary amines along the chitosan backbone. As a consequence, this polysaccharide is a relevant candidate in the field of biomaterials, especially for tissue engineering. The current article highlights the preparation and properties of innovative chitosan-based biomaterials, with respect to their future applications. The use of chitosan in 3D-scaffolds – as gels and sponges – and in 2D-scaffolds – as films and fibers – is discussed, with a special focus on wound healing application. [less ▲]

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See detailMagnetic hybrid materials for triggered drug delivery and optical properties of intraocular lens
Liu, Ji ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg et al

Conference (2013, March 20)

Mesoporous silica nanoparticles have great potential for drug delivery system (DDS) due to their large volume for encapsulation of guest molecules in the porous channels. Due to the specific magnetic ... [more ▼]

Mesoporous silica nanoparticles have great potential for drug delivery system (DDS) due to their large volume for encapsulation of guest molecules in the porous channels. Due to the specific magnetic responsiveness, magnetic nanoparticles can penetrate body tissues under a magnetic guidance, providing a potential platform for magnetic-directed DDS. Furthermore, a sharp local heating can be obtained for superparamagnetic nanoparticles when exposed to an alternating magnetic field (AMF). This specific property opens up the possibility of the application in tumor treatments. Here, we fabricated maghemite/SiO2 mesoporous nanohybrids DDS with phase-changed molecules as gate-keepers. The channels were envisaged to be closed in the biological systems during the delivery; however, opened when exposed to external heating or internal heating from hyperthermia generated by the maghemite cores. Thus the uploaded drug can diffuse into the surrounding medium. MTS assay showed a good cytocompatibility of the vehicles in both mouse L929 cells and cancer MEL-5 cells, and also internalization into MEL-5 cells was confirmed by Fluoresce microscopy, fluoresce-activated cell sorting (FACS) and TEM techniques. The release of drugs can be controlled by varying the concentration of the nanohybrids vehicles, the period of AMF treatment, or both. In-vivo triggered-release of doxorubicin into MEL-5 cells was confirmed by the sharp decrease in cell viability. This DDS can be designed for controlled release to an urgent physiological need via chemotherapy, hyperthermia therapy, or both. [less ▲]

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See detailUse of supercritical carbon dioxide to elaborate drug-loaded polymeric implants
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Jérôme, Christine ULg et al

Poster (2013, March 17)

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See detailPreparation of drug-loaded scaffolds for biomedical applications using supercritical fluid technology
Champeau, Mathilde; Jérôme, Christine ULg; Tassaing, Thierry

Conference (2013, March 17)

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See detailThermally stable bulk heterojunction solar cells based on cross-linkable acrylate-functionalized polythiophene diblock copolymers
Ouhib, Farid ULg; Tomassetti, Mirco ULg; Manca, Jean et al

in Macromolecules (2013), 46(3), 785-795

We report on the synthesis of new thermally cross-linkable all-conjugated diblock copolymers composed of a poly(3-hexylthiophene) (P3HT) block and an acrylate-functionalized polythiophene block. These ... [more ▼]

We report on the synthesis of new thermally cross-linkable all-conjugated diblock copolymers composed of a poly(3-hexylthiophene) (P3HT) block and an acrylate-functionalized polythiophene block. These copolymers are then used in bulk heterojunction (BHJ) solar cells with [6,6]-phenyl C61-butyric acid methyl ester (PCBM), and their photovoltaic performances are compared with standard P3HT/PCBM devices. Thermal cross-linking of the functional copolymers/PCBM blends is performed to improve the thermal stability of the active layer. BHJ photovoltaic cells with cross-linkable copolymers and PCBM show initial power conversion efficiencies slightly lower than that of P3HT devices. However, solar cells with cross-linkable copolymers retain more than 85% of their initial power efficiency value after 165 h of thermal annealing (accelerated aging test), whereas the same devices with P3HT retain less than 65% of their initial power efficiency. This improvement of the thermal stability of BHJ photovoltaic cells is the result of the polymer network that hampers PCBM diffusion and phase separation, as confirmed with TEM and AFM analysis of the microscopic morphology. Such an improvement is mostly observed when using a cross-linkable P3HT with a short spacer between the acrylate group and the polythiophene backbone. [less ▲]

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See detailDrug delivery to inflamed colon by nanoparticles: comparison of different strategies
Coco, Régis; Plapied, Laurence; Pourcelle, Vincent et al

in International Journal of Pharmaceutics (2013), 440(1), 3-12

For inflammatory bowel disease (IBD) treatment, local delivery of molecules loaded in nanoparticles to the inflamed colon could be a promising strategy. The aim of this study was to investigate how drug ... [more ▼]

For inflammatory bowel disease (IBD) treatment, local delivery of molecules loaded in nanoparticles to the inflamed colon could be a promising strategy. The aim of this study was to investigate how drug-loaded polymeric nanoparticles target the site of inflammation and to analyse the influence of different colon-specific delivery strategies. Three different polymeric nanoparticles were formulated using ovalbumin (OVA) as a model drug. pH-sensitive nanoparticles were made with Eudragit® S100. Mucoadhesive nanoparticles were created with trimethylchitosan (TMC). A mix of polymers, PLGA, PEG-PLGA and PEG-PCL, were used to obtain a sustained drug delivery. Furthermore, ligands targeting immune cells (i.e. mannose) or the inflamed colon (i.e. a specific peptide) were grafted on the PEG chain of PCL. Interaction of nanoparticles with the intestinal epithelium was explored using Caco-2 monolayers designed to mimic an inflamed epithelium and then visualized using confocal laser microscopy. TMC nanoparticles had the highest apparent permeability for OVA in the untreated model. However, in the inflamed model, there were no difference between TMC, PLGA-based and Eudragit® nanoparticles. The uptake of nanoparticles in the inflamed mouse colon was assessed in a horizontal diffusion chamber. Mannose-grafted PLGA nanoparticles showed the highest accumulation of OVA in inflamed colon. Based on these results, active targeting of macrophages and dendritic cells may be a promising approach for targeting the colon in IBD. [less ▲]

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See detailCatechols as versatile platforms in polymer chemistry
Faure, Emilie; Falentin-Daudré, Céline; Jérôme, Christine ULg et al

in Progress in Polymer Science (2013), 38(1), 236-270

Catechols represent an important and versatile building block for the design of mussel-inspired synthetic adhesives and coatings. Indeed, their ability to establish large panoply of interactions with both ... [more ▼]

Catechols represent an important and versatile building block for the design of mussel-inspired synthetic adhesives and coatings. Indeed, their ability to establish large panoply of interactions with both organic and inorganic substrates has promoted catechol as a universal anchor for surface modifications. In addition to its pivotal role in adhesive interfaces, the catechol unit recently emerged as a powerful building block for the preparation of a large range of polymeric materials with intriguing structures and fascinating properties. The importance of catechols as efficient anchoring groups has been highlighted in recent excellent reviews partly dedicated to the characterization of their adhesive mechanisms onto surfaces and to their applications. The aim of this paper is to review for the first time the main synthetic approaches developed for the design of novel catechol-based polymer materials. We will also highlight the importance of these groups as versatile platforms for further functionalization of the macromolecular structures, but also surfaces. This will be illustrated by briefly discussing some advanced applications developed from these catechol-modified polymers. The review is organized according to the chemical structure of the functionalized catechol polymers. Chapter 1 discusses polymers bearing catechols embedded into the polymer main chain. Chapter 2 focuses on the attachment of catechol moieties as pendant groups and Chapter 3 describes the different approaches for incorporation of the catechol unit at the extremity of well-defined polymers. [less ▲]

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See detailPhotochemical properties and activity of water-soluble polymer/C60 nanohybrids for photodynamic therapy
Hurtgen, Marie ULg; Debuigne, Antoine ULg; Hoebeke, Maryse ULg et al

in Macromolecular Bioscience (2013), 13(1), 106-115

Water-soluble star-like poly(vinyl alcohol)/C60 and poly{[poly(ethylene glycol) acrylate]-co- (vinyl acetate)}/C60 nanohybrids are prepared by grafting macroradicals onto C60 and are assessed as ... [more ▼]

Water-soluble star-like poly(vinyl alcohol)/C60 and poly{[poly(ethylene glycol) acrylate]-co- (vinyl acetate)}/C60 nanohybrids are prepared by grafting macroradicals onto C60 and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) of the polymeric arms respectively impact the photodynamic activity and the stealthiness of the nanohybrids. The advantages of both nanohybrids are encountered in a third one, poly[(Nvinylpyrrolidone)- co-(vinyl acetate)]/C60, which has linear grafts without hydroxyl groups, and shows a better photodynamic activity. [less ▲]

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See detailEnzymatic synthesis and surface properties of novel rhamnolipids
Nott, Katherine ULg; Richard, Gaetan ULg; Laurent, Pascal ULg et al

in Process Biochemistry (2013), 48

New rhamnolipids were obtained via the development of a synthesis procedure consisting of two biocatalyzed steps. In the first step, naringinase was used to introduce a primary alcohol function onto ... [more ▼]

New rhamnolipids were obtained via the development of a synthesis procedure consisting of two biocatalyzed steps. In the first step, naringinase was used to introduce a primary alcohol function onto rhamnose by glycosylation of 1,3-propanediol. In the second step, immobilized lipase B from Candida antarctica catalyzed the esterification of the primary hydroxyl group with mono- and di-carboxylic fatty acids of increasing chain length (from C8 to C14). For the monoic acids, the initial rate and 24 h yield decreased with increasing chain length. For the dioic acid, the number of carbon atoms of the acid did not influence these parameters. The new rhamnolipid obtained with tetradecanoic acid showed very good surface properties. At pH 5, it had a very low critical aggregation concentration of 1.70 M and it diminished water’s surface tension to 27.6 mN/m. It was also able to form stable insoluble monolayers. On the other hand, the rhamnolipid formed with tetradecanedioic acid showed far less interesting surface properties. [less ▲]

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See detailNovel functional degradable block copolymers for the building of reactive micelles
Cajot, Sébastien; Lecomte, Philippe ULg; Jérôme, Christine ULg et al

in Polymer Chemistry (2013), 4(4), 1025-1037

Amphiphilic biocompatible copolymers are promising materials for the elaboration of nanosystems for drug delivery applications. This paper aims at reporting on the synthesis of new functional amphiphilic ... [more ▼]

Amphiphilic biocompatible copolymers are promising materials for the elaboration of nanosystems for drug delivery applications. This paper aims at reporting on the synthesis of new functional amphiphilic copolymers based on biocompatible and bioeliminable blocks. Poly(ethylene oxide) was selected as the hydrophilic block, whereas an aliphatic polyester, i.e. poly(epsilon-caprolactone), or a polycarbonate, i.e. poly(trimethylene carbonate), were chosen as the degradable hydrophobic block. In order to allow a post-functionalization of the micelles core, azide groups were introduced on the hydrophobic segment to provide reactivity towards functional alkyne derivatives by the copper azide-alkyne cycloaddition (CuAAC). For this purpose, a functional lactone, i.e. alpha-chloro-epsilon-caprolactone was introduced during the polymerization of the hydrophobic block before being converted into azide on the preformed copolymer. Such reactivity of the block copolymers and their self-assemblies is of prime interest for drugs or fluorescent dyes grafting, so as for micelles cross-linking. The influence of the azides distribution along the degradable block on the micelles post-functionalization ability has been studied by using alkyne bearing fluorescent dyes as model for drugs. The hydrophilicity of the dye on the micelles post-functionalization efficiency has also been investigated. [less ▲]

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See detailBiomechanical and optical properties of 2 new hydrophobic platforms for intraocular lenses
Bozukova, Dimitriya; Pagnoulle, Christophe; Jérôme, Christine ULg

in Journal of Cataract & Refractive Surgery (2013), 39(9), 1404-1414

Purpose: To compare the biomechanical and optical properties of 2 new hydrophobic platforms and a series of commercially available foldable intraocular lenses (IOLs). Results: With 1 exception, IOLs ... [more ▼]

Purpose: To compare the biomechanical and optical properties of 2 new hydrophobic platforms and a series of commercially available foldable intraocular lenses (IOLs). Results: With 1 exception, IOLs equilibrated in aqueous medium had a lower glass-transition temperature, higher deformability, lower injection forces, and complete recovery of their initial optical properties after injection. Typical hydrophobic acrylic dry-packaged IOLs required higher injection forces with high residual deformation and lost part of their initial optical quality after injection. Hydrophobic acrylic C-loop, double C-loop, and closed quadripod haptics applied optimum compression forces to the capsular bag with negligible optic axial displacement and tilt compared with plate haptics and poly(methyl methacrylate) haptics. Conclusions: The combination of the C-loop haptic and the bioadhesive glistening-free material, which absorbs a predetermined amount of water, allowed for a biomechanically stable IOL. The same material used in association with a double C-loop haptic design facilitated the perioperative manipulation and placement of the IOL in a smaller capsular bag without impairing the other biomechanical properties of a single C-loop design. [less ▲]

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See detailIn vitro investigations of smart drug delivery systems based on redox-sensitive cross-linked micelles
Cajot, Sébastien; Schol, D.; Dahnier, F. et al

in Macromolecular Symposia (2013), 13(12), 1661-1670

Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly ... [more ▼]

Redox-sensitive micelles are designed by using block copolymers of different architectures composed of a hydrophilic block of poly(ethylene oxide), and hydrophobic blocks of poly(ϵ-caprolactone) and poly(α-azide-ϵ-caprolactone). Stability of these micelles is insured in diluted media by cross-linking their core via the addition of a bifunctional cross-linker, while redox sensitivity is provided to these micelles by inserting a disulfide bridge in the cross-linker. The potential of these responsive micelles to be used as nanocarriers is studied in terms of cytotoxicity and cellular internalization. The release profiles are also investigated by varying the environment reductive strength. [less ▲]

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See detailReusability study of Novozym® 435 for the enzymatic synthesis of mannosyl myristate in pure ionic liquids
Galonde, Nadine ULg; Richard, Gaetan ULg; Deleu, Magali ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013)

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See detailSynthesis and fabrication of polyesters as biomaterials
Lecomte, Philippe ULg; Jérôme, Christine ULg

in Popa, Valentin; Dumitriu, Daniela (Eds.) Polymeric biomaterials: structure and function, volume 1 (2013)

Detailed reference viewed: 69 (9 ULg)