References of "Hustinx, Roland"
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See detailQue mesure la neuro-imagerie fonctionnelle: IRMf, TEP & MEG?
Gosseries, Olivia ULg; Demertzi, Athina ULg; Noirhomme, Quentin ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 231-7

Functional cerebral imaging techniques allow the in vivo study of human cognitive and sensorimotor functions in physiological or pathological conditions. In this paper, we review the advantages and ... [more ▼]

Functional cerebral imaging techniques allow the in vivo study of human cognitive and sensorimotor functions in physiological or pathological conditions. In this paper, we review the advantages and limitations of functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and magnetoencephalography (MEG). fMRI and PET measure haemodynamic changes induced by regional changes in neuronal activity. These techniques have a high spatial resolution (a few millimeters), but a poor temporal resolution (a few seconds to several minutes). Electroencephalogram (EEG) and MEG measure the neuronal electrical or magnetic activity with a high temporal resolution (i.e., milliseconds) albeit with a poorer spatial resolution (i.e., a few millimeters to one centimeter). The combination of these different neuroimaging techniques allows studying different components of the brain's activity (e.g., neurovascular coupling, electromagnetic activity) with both a high temporal and spatial resolution. [less ▲]

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See detailMeasuring the effect of amantadine in chronic anoxic minimally conscious state.
Schnakers, Caroline ULg; Hustinx, Roland ULg; Vandewalle, Gilles ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2008), 79(2), 225-7

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See detailPrognostic value of metabolic imaging in non-small cell lung cancers with neoplasic pleural effusion.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule ULg et al

in Nuclear Medicine Communications (2008), 29(11), 982-6

BACKGROUND: The intensity of the [F]fluorodeoxyglucose (F-FDG) uptake is an independent prognostic indicator in non-small cell lung cancer (NSCLC). We evaluate the relationship between the metabolic ... [more ▼]

BACKGROUND: The intensity of the [F]fluorodeoxyglucose (F-FDG) uptake is an independent prognostic indicator in non-small cell lung cancer (NSCLC). We evaluate the relationship between the metabolic activity of the primary and the pleurisy in T4 NSCLC. METHODS: 25 patients (16 males, nine females, mean age 63 years, performance status 1) with pathology-proven, T4 NSCLC and malignant pleurisy were included. All were treated by a platinum salt-based chemotherapy regimen. Positron emission tomography (F-FDG-PET) was performed before treatment, according to a routine procedure. Regions of interest were placed over the primary and the pleural effusion on the transaxial slice showing the highest activity. The maximum pixel standard uptake values (SUVs) were calculated. Overall survival was determined by standard Kaplan-Meier survival analysis. All patients were followed up until death. RESULTS: The median survival for the entire population was 83 days (7-988). The SUVs were higher in the primary than in the pleurisy (9.2+/-5.6 and 5.5+/-2.2, respectively). There was no correlation between primary and pleurisy SUVs (r=0.3, P>0.05). The metabolic activity of the primary tumor did not predict the outcome: the median survival was 77.5 days (range 7-988) and 87 days (19-454) in the groups with SUVs lower and higher than the median value (8.7), respectively (P>0.05). By contrast, the metabolic activity of the pleurisy was significantly correlated with the median survival, which was 196 days (40-988) when the SUVs were lower than the median value (5) and 74 days (7-170) when they were higher (P=0.0096). CONCLUSION: Among patients with T4 NSCLC, those with high metabolic activity in the pleural effusion have a dire prognosis, whereas the metabolic activity of the primary fails to predict the survival. [less ▲]

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See detailFunctional imaging of abdominal aortic aneurysms
Sakalihasan, Natzi ULg; Hustinx, Roland ULg; Gomez, Pierre et al

in Aortic Aneurysms, new insights of an old problem (2008)

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See detailRepérage scintigraphique préopératoire d'une métastase costale unique d'un adénocarcinome prostatique opéré.
Sanjurjo, Sylvia ULg; Hamida, Wissem; Letesson, Gaëtan et al

in Progrès en Urologie (2008), 18(6), 402-5

We present a case of a lonely bone lesion after a prostatic adenocarcinoma with recurrent increased PSA. The localization of the metastasis at the level of a rib is infrequent. The precise localization of ... [more ▼]

We present a case of a lonely bone lesion after a prostatic adenocarcinoma with recurrent increased PSA. The localization of the metastasis at the level of a rib is infrequent. The precise localization of the lesion was made possible by intraoperative scintigraphy. Histology confirmed the complete resection of the lesion with safe margins. [less ▲]

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See detailNoninvasive assessment of Crohn's disease intestinal lesions with F-18-FDG PET/CT
Louis, Edouard ULg; Ancion, Geoffrey; Colard, Arnaud et al

in Journal of Nuclear Medicine (2007), 48(7), 1053-1059

Pilot studies have shown good sensitivity and specificity for F-18-FDG PET in detecting gastrointestinal lesions of Crohn's disease. The combination of F-18-FDG PET with CT may further improve the ... [more ▼]

Pilot studies have shown good sensitivity and specificity for F-18-FDG PET in detecting gastrointestinal lesions of Crohn's disease. The combination of F-18-FDG PET with CT may further improve the localization and characterization of lesions with increased F-18-FDG uptake. Our aim was to assess the use of F-18-FDG PET/CT in evaluating the activity and location of Crohn's disease along the gastrointestinal tract. Methods: After giving informed consent, 22 patients with Crohn's disease were prospectively studied. They underwent F-18-FDG PET/CT, followed by ileocolonoscopy within 1 wk (mean, 2 d). The Crohn's disease activity index (CDAI) was calculated, and serum C-reactive protein (CRP) and fecal calprotectin were measured before endoscopy. The Crohn's disease endoscopy index of severity (CDEIS) was calculated during endoscopy. The global CDEIS score and endoscopic subscores for various ileocolonic segments were used for analysis. Results: Globally, 95 intestinal and colonic segments in 22 patients were analyzed. F-18-FDG PET/CT detected 35 of 48 endoscopically affected segments (sensitivity for the detection of endoscopic lesions, 72.9%). The sensitivity of F-18-FDG PET/CT for the detection of severe endoscopic lesions (deep ulcers and strictures) was 100% (14/14). The global PET/CT score significantly correlated with CDEIS (r = 0.51; 95% confidence interval [Cl], 0.09-0.77; P = 0.017), CDAI (r = 0.58; 95% Cl, 0.17-0.80; P = 0.005), and CRP (r = 0.56; 95% Cl, 0.19-0.81; P = 0.007). Conclusion: F-18-FDG PET/CT was globally well correlated to the clinical, endoscopic, and biologic activity of Crohn's disease. Above all, this technique had a good sensitivity for the detection of intestinal and colonic segments with moderate to severe mucosal lesions. The potential impact of this promising tool on the global management of patients with Crohn's disease should be further evaluated in prospective studies. [less ▲]

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See detailEffect of dementia severity and age on posterior cingulate cortex metabolism in Alzheimer's disease
Withofs, Nadia ULg; Salmon, Eric ULg; Hallet, Claude ULg et al

in Journal of Neurology (2007, May), 254(Suppl. 3), 146

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See detailGossypiboma at PET-CT.
MEDART, L.; WITHOFS, Nadia ULg; HUSTINX, Roland ULg et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailAnother etiology for inflammatory syndrome of unknown origin.
MEDART, L.; WITHOFS, Nadia ULg; HUSTINX, Roland ULg et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailVoxel-based analysis of posterior cingulated cortex metabolism in Alzheimer’s disease : effect of dementia severity and age.
WITHOFS, Nadia ULg; SALMON, Eric ULg; LAUREYS, Steven ULg et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailPET/CT imaging of skull base meningiomas using 1-18F-fluoro-L-tyrosine; initial report.
RUTTEN, I.; CABAY, Jean-Evrard ULg; WITHOFS, Nadia ULg et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailFDG PET/CT for diagnostic arterial prosthetic graft infection : preliminary report.
NAMUR, Gauthier ULg; VAN DAMME, Hendrik ULg; BECKERS, Catherine ULg et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailPET/CT of skull base meningiomas using 2-F-18-fluoro-L-tyrosine: Initial report
Rutten, Isabelle; Cabay, Jean-Evrard ULg; Withofs, Nadia ULg et al

in Journal of Nuclear Medicine (2007), 48(5), 720-725

Precise delineation of the shape of skull base meningiomas is critical for their treatment and follow-up but is often difficult using conventional imaging such as CT and MRI. We report our results with ... [more ▼]

Precise delineation of the shape of skull base meningiomas is critical for their treatment and follow-up but is often difficult using conventional imaging such as CT and MRI. We report our results with PET/CT and 2-(18)F-fluoro-L-tyrosine ((18)F-TYR), a marker of amino acid transport, as part of the yearly follow-up of irradiated patients. METHODS: Eleven patients (mean age, 56.5 y) with skull base meningiomas (n=13 lesions) previously irradiated were included. All patients received 300 MBq of (18)F-TYR and were imaged after 30 min of uptake, using a dedicated PET/CT system. The images were first visually examined, and regions of interest (ROI) were then placed over the transaxial PET slice showing the highest uptake. Another ROI was placed over the normal parietal cortex. Tumor-to-cortex activity ratios were obtained by dividing the maximum pixel value in the tumor ROI by the maximum pixel value in the cortex ROI. The PET/CT images were compared with the MR images obtained as part of routine follow-up. RESULTS: Accumulation of the tracer was higher in all meningiomas than in the surrounding tissue. The tumor-to-cortex activity ratio was 2.53 +/- 0.35 (range, 1.3-6). Nonneoplastic tissue such as hyperemic cavernous sinus did not take up the radionuclide and was therefore easily distinguished from the meningioma. The (18)F-TYR anomalies completely overlapped with the MR image in 54% of the tumors, extended beyond the MRI lesion in 38% of the tumors, and were smaller in 8% of the tumors. CONCLUSION: Meningiomas of the skull base are clearly visualized using (18)F-TYR PET/CT, even after irradiation. In addition to MRI, (18)F-TYR PET/CT images may contribute to the evaluation, delineation, and follow-up of these tumors. [less ▲]

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See detailPrognostic value of metabolic imaging in locally advanced non small cell lung cancers.
DUYSINX, Bernard ULg; LAROCK, Marie-Paule ULg; CORHAY, Jean-Louis ULg et al

in Journal of Nuclear Medicine (The) (2007), 48(SUPPL), 358

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See detailVoxel-based analysis of dementia severity versus age on cerebral metabolic dysfunction in Alzheimer’s disease.
WITHOFS, Nadia ULg; SALMON, Eric ULg; LAUREYS, Steven ULg et al

in Journal of Nuclear Medicine (The) (2007), 48(SUPPL), 172

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See detailAssessment of Crohn’s disease intestinal lesions with FDG PET/CT : A prospective correlation with endoscopy.
HUSTINX, Roland ULg; SPOTE, Véronique ULg; ANCION, G. et al

in Journal of Nuclear Medicine (The) (2007), 48(SUPPL), 66

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See detailPET/CT imaging of skull base meningiomas using 2-18F-fluoro-L-tyrosine : Initial report.
RUTTEN, I.; CABAY, J.; WITHOFS, Nadia ULg et al

in Journal of Nuclear Medicine (The) (2007), 48(SUPPL), 11

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See detailF-18 FDG PET in infectious diseases in children.
Depas, Gisèle ULg; Decortis, Thierry; Francotte, Nadine et al

in Clinical Nuclear Medicine (2007), 32(8), 593-8

PURPOSE: The aim is to report our observations regarding the role of F-18 FDG PET in children's infectious processes. MATERIAL AND METHODS: A presentation is made of 3 neonatal infections unresponsive to ... [more ▼]

PURPOSE: The aim is to report our observations regarding the role of F-18 FDG PET in children's infectious processes. MATERIAL AND METHODS: A presentation is made of 3 neonatal infections unresponsive to treatment, 2 invasive infections in immunocompromised children, and 1 discitis in an immunocompetent child. PET or PET/CT was performed to address a specific question pertaining to the management of the diseases. Results were correlated with the clinical outcome. The impact on patient management is discussed. RESULTS: In 1 neonate, PET localized the infection in a bone which allowed surgical curettage. In another one, it localized the infection in recently renewed exogenous material and led to subsequent removal. It was negative in the third one, whose evolution was rapidly favorable. In the immunocompromised children, treatment of invasive infection was adapted according to the metabolic inflammatory activity of the disease. In a limping child with slight abnormalities on bone scintigraphy but major misleading involvement on MRI, PET/CT demonstrated hypermetabolism limited to a disc, thus avoiding further invasive procedures. CONCLUSIONS: Although not meant as a first choice examination, F-18 FDG PET should be considered in difficult cases of neonatal infection or in challenging diagnoses like discitis in the young child. It provides more accurate staging and treatment monitoring of the inflammatory process in invasive infections of immunocompromised children. [less ▲]

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See detailLe mélanome cutané dans une perspective liégeoise. Actualisation de son épidémiologie et avancées diagnostiques.
Quatresooz, Pascale ULg; Hustinx, Roland ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(Supplément), 52-55

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented ... [more ▼]

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented Neoplasms have scrutenised the epidemiological evolution of this cancer. We have disclosed a sharp increase in the global incidence of melanoma, more particularly in women in the age of procreation. We have also contributed and innovated in terms of clinical diagnosis by introducing dermoscopy and initiating both the ULEV method and the cyanoacrylate skin surface stripping. In the field of dermatopathology we have developed an immunohistological panel allowing to fine tune the diagnosis and to define some histoprognostic criteria. For the checkup of the disease extension, the PET scan method has been particularly refined. [less ▲]

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See detailHepatobiliary disease : primary and metastatic liver tumours
Hustinx, Roland ULg; Detry, Olivier ULg

in Cook, Gary JR; Maisey, Michael M; Britton, Keith (Eds.) et al Clinical Nuclear Medicine (2007)

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion ... [more ▼]

PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, this heavily-illustrated text offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques. [less ▲]

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