References of "Hustinx, Roland"
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See detailFDG-PET for the routine follow-up in NHL: First prospective evaluation
Jerusalem, Guy ULg; Silvestre, R.; Beguin, Yves ULg et al

in Journal of Clinical Oncology (2006, June 20), 24(18, Part 1 Suppl. S), 439

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See detailF-18-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3
Beckers, Catherine ULg; Jeukens, Xavier; Ribbens, Clio ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(3), 275-280

Purpose: The aim of this study was to assess rheumatoid arthritis (RA) synovitis with positron emission tomography (PET) and F-18-fluorodeoxyglucose (F-18-FDG) in comparison with dynamic magnetic ... [more ▼]

Purpose: The aim of this study was to assess rheumatoid arthritis (RA) synovitis with positron emission tomography (PET) and F-18-fluorodeoxyglucose (F-18-FDG) in comparison with dynamic magnetic resonance imaging (MRI) and ultrasonography (US). Methods: Sixteen knees in 16 patients with active RA were assessed with PET, MRI and US at baseline and 4 weeks after initiation of anti-TNF-alpha treatment. All studies were performed within 4 days. Visual and semi-quantitative (standardised uptake value, SUV) analyses of the synovial uptake of FDG were performed. The dynamic enhancement rate and the static enhancement were measured after i.v. gadolinium injection and the synovial thickness was measured in the medial, lateral patellar and suprapatellar recesses by US. Serum levels of C-reactive protein (CRP) and metalloproteinase-3 (MMP-3) were also measured. Results: PET was positive in 69% of knees while MRI and US were positive in 69% and 75%. Positivity on one imaging technique was strongly associated with positivity on the other two. PET-positive knees exhibited significantly higher SUVs, higher MRI parameters and greater synovial thickness compared with PET-negative knees, whereas serum CRP and MMP-3 levels were not significantly different. SUVs were significantly correlated with all MRI parameters, with synovial thickness and with serum CRP and MMP-3 levels at baseline. Changes in SUVs after 4 weeks were also correlated with changes in MRI parameters and in serum CRP and MMP-3 levels, but not with changes in synovial thickness. Conclusion: F-18-FDG PET is a unique imaging technique for assessing the metabolic activity of synovitis. The PET findings are correlated with MRI and US assessments of the pannus in RA, as well as with the classical serum parameter of inflammation, CRP, and the synovium-derived parameter, serum MMP-3. Further studies are warranted to establish the place of metabolic imaging of synovitis in RA. [less ▲]

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See detailDiagnostic and therapeutic management of carcinoma of unknown primary: radio-imaging investigations.
Jerusalem, Guy ULg; Rorive, Andrée ULg; Ancion, G. et al

in Annals of Oncology (2006), 17 Suppl 10

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See detailIntratissular Lymphaticovenous Anastomoses Demonstrated by Perioperative Intramuscular Injection of 99mtc-Colloids
Heymans, Olivier; Fallais, Charles ULg; Hustinx, Roland ULg

in Lymphatic Research and Biology (2006), 4(1, Spring), 29-33

BACKGROUND: The existence of intratissular lymphaticovenous anastomoses has often been suggested, but it has never been demonstrated. This study aims at demonstrating the presence of such anastomoses ... [more ▼]

BACKGROUND: The existence of intratissular lymphaticovenous anastomoses has often been suggested, but it has never been demonstrated. This study aims at demonstrating the presence of such anastomoses. METHODS AND RESULTS: The free flap model was used to investigate the drainage of radiolabeled colloid particles whose size prevents direct passage to the blood vessels. The tracer was injected into the muscle or the skin during the surgical procedure. Blood samples were sequentially drawn from the venous pedicle over the 30 minutes that followed the tracer injection. The blood samples were counted using a gamma well-counter. In all 14 patients, the venous blood radioactivity steadily increased over time. Radiochemical analyses performed on the blood samples demonstrated that the radioactivity is related to the labeled colloids and not to free pertechnetate. Planar imaging performed 24 hours after the surgical procedure showed a significant liver uptake, and no accumulation in the area of normal lymphatic relays. CONCLUSIONS: As, in the free flap model, there is no lymphatic drainage through the classical pathways whatsoever, and since the size of the radiolabeled particles prevents them from directly entering the blood stream, the results strongly suggest the presence of functional intratissular lymphovenous anastomoses. [less ▲]

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See detailClinical added-value of 18FDG PET in neuroendocrine-merkel cell carcinoma
Belhocine, Tarik; Pierard, Gérald ULg; Frühling, Janos et al

in Oncology Reports (2006), 16(2), 347-352

Merkel cell carcinoma (MCC) is a rare and highly malignant skin cancer with neuroendocrine differentiation. We studied the potential value of 18FDG PET in the management of MCC. Eleven patients with MCC ... [more ▼]

Merkel cell carcinoma (MCC) is a rare and highly malignant skin cancer with neuroendocrine differentiation. We studied the potential value of 18FDG PET in the management of MCC. Eleven patients with MCC were examined by 18FDG PET and PET-CT for staging purpose (n=4) or for detection of recurrence (n=7). Qualitative and quantitative interpretation of PET studies was performed routinely. 18FDG PET observations were compared to clinical and radiological findings. In 6 patients, PET findings were also compared to histology. In 7 patients, the 18FDG tumor uptake was compared to the MCC proliferative activity expressed by the Ki-67 index. 18FDG PET was contributive in 10/11 MCC patients. In 7 patients, 18FDG PET detected focal lesions or a disseminated stage of the disease including dermal, nodal and visceral metastases. In 3 patients, a normal 18FDG PET confirmed complete remission of disease. Most MCC patients exhibited highly 18FDG-avid sites suggestive of increased glucose metabolism. This imaging pattern was related to a high proliferative activity (Ki-67 index >50%). In 1 patient with a weakly proliferative nodal MCC (Ki-67<10%), a false negative result was yielded by metabolic imaging. In 4/11 patients, 18FDG PET revealed an unsuspected second neoplasm in addition to MCC. It is concluded that whole-body 18FDG PET may be useful in the management of MCC patients. However, a normal 18FDG PET aspect cannot rule out MCC with low proliferative activity. [less ▲]

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See detailPET and PET/CT Imaging in Lung Cancer
Rigo, Pierre ULg; Hustinx, Roland ULg; Bury, Thierry ULg

in Valk, PE; Delbeke, D; Bailey, DL (Eds.) et al Positron Emission Tomography - Clnical practice (2006)

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See detailEffect of diazepam on the efficacy of dual-phase FDG PET imaging.
Zhuang, Hongming; Hustinx, Roland ULg; Alavi, Abass

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(2), 228-9230

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See detailLe cas clinique du mois. Colite a clostridium difficile.
Laret, Vinciane ULg; Sion, C.; Bataille, Christian et al

in Revue Médicale de Liège (2006), 61(11), 750-2

A 55-year-old patient with mant e cels underwent a cytotoxic chemotherapy (D.H.A.P. + Rituximab). During the medullar aplasia related to the third cycle, diarrhoea due to Clostridium difficile arised and ... [more ▼]

A 55-year-old patient with mant e cels underwent a cytotoxic chemotherapy (D.H.A.P. + Rituximab). During the medullar aplasia related to the third cycle, diarrhoea due to Clostridium difficile arised and relapsed 15 days later despite normal blood counts. This colitis was very severe with pluribacterial peritonitis, but resolved with intensive medical treatment. The incidence, the patient's risk factors, the iatrogenic and nosocomial characters of cl. difficile colitis are discussed. [less ▲]

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See detailPET imaging of arthritis
Hustinx, Roland ULg; Malaise, Michel ULg

in PET Clinics (2006), 1

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See detailPET imaging in lung cancer
Rigo, Pierre ULg; Hustinx, Roland ULg; Bury, Thierry ULg

in Valk, Peter E.; Delbeke, Dominique; Bailey, Dale L. (Eds.) et al Positron emission tomography (2006)

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See detailPET and PET/CT imaging in lymphomas.
Jerusalem, Guy ULg; Hustinx, Roland ULg; Rigo, Pierre ULg

in Valk, Peter E.; Delbeke, Dominique; Bailey, Dale L. (Eds.) et al Positron emission tomography (2006)

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See detailThe lymphomas. Nuclear Medicine
Jerusalem, Guy ULg; Hustinx, Roland ULg

in Canellos, George P.; Lister, Andrew T.; Young, Brian (Eds.) The lymphomas. (2006)

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See detailSequential positron emission tomography using [18F]fluorodeoxyglucose for monitoring response to chemotherapy in metastatic breast cancer.
Couturier, Olivier; Jerusalem, Guy ULg; N'Guyen, Jean-Michel et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2006), 12(21), 6437-43

PURPOSE: To evaluate the clinical value of positron emission tomography (PET) for monitoring chemotherapy in metastatic breast cancer. EXPERIMENTAL DESIGN: Twenty patients with hormonorefractory or ... [more ▼]

PURPOSE: To evaluate the clinical value of positron emission tomography (PET) for monitoring chemotherapy in metastatic breast cancer. EXPERIMENTAL DESIGN: Twenty patients with hormonorefractory or hormonoreceptor-negative multimetastatic breast cancer were prospectively included. PET studies were done at baseline, at day 21 after the first cycle and at day 21 after the third cycle of chemotherapy. Metabolic response was defined based on visual and various modes of standardized uptake value (SUV) analysis of sequential PET studies. RESULTS: After one cycle, PET indicated a partial response in 12 patients, stable disease in 7 patients, and progressive disease in 1 patient, according to the visual analysis. After three cycles, PET showed a complete response in 5 patients, partial response in 11 patients, stable disease in 3 patients, and progressive disease in 1 patient. Seventy-five percent of the patients showing a metabolic response on visual analysis effectively responded to the treatment. The average SUV decreased on both the second and the third PET study, but only changes measured after three cycles of chemotherapy predicted the clinical response to chemotherapy and the overall survival. All methods for calculating the SUV (normalized for body weight, body surface area, or lean body mass) provided similar results. CONCLUSION: Semiquantitative analysis of [18F]fluorodeoxyglucose-PET studies done after three cycles of chemotherapy is useful for monitoring the response to chemotherapy in metastatic breast cancer. [less ▲]

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See detailIs 3 '-deoxy-3 '-[F-18] fluorothymidine ([F-18]-FLT) the next tracer for routine clinical PET after R [F-18]-FDG?
Couturier, Olivier; Léost, Françoise; Campone, Mario et al

in Bulletin du Cancer (2005), 92(9), 789-798

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its ... [more ▼]

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its uptake mechanism for tumors, or the low avidity of some cancer types such as prostate. Alternative tracers are thus being developed, in order to fill up this void. Proliferation as a biological target is particularly attractive in cancer imaging. From that perspective, fluorothymidine ({F-18}-FLT or FLT) has generated a strong interest among the scientific community, especially since the radiosynthesis process has been improved and simplified, thus making possible to envision a routine use for the tracer. This article aims at summarizing the status of the current scientific data regarding FLT The uptake mechanism of FLT is well known, relying on the thymidine kinase 1 (TK1) enzymatic activity, and thus on DNA synthesis, Preclinical studies have shown a clear relationship between tracer accumulation and level of tumor proliferation, even though DNA salvage pathwayss intervene in the process and may complicate the interpretation of the results. Several clinical studies suggest a good specificity for tumor, albeit with a lower sensitivity than with FDG. In all likelihood however, the future of FLT lies in the evaluation of antitumor response and possibly the pretherapeutic prognostic characterization, rather than in the diagnosis and staging of malignancies. Although the scientific data regarding this issue remain limited, initial results are encouraging. Further significant work remains to he done in order to fully assess the clinical performances of the tracer, on the one hand, and to determine its place relative to FDG and other emerging tracers, on the other hand. Until these studies are completed, FLT should he considered as a promising tracer, hut remaining at an experimental stage of its development. [less ▲]

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See detailDistribution of F-18 fluorodeoxyglucose (F-18 FDG) in abdominal aortic aneurysm: High accumulation in macrophages seen on PET Imaging and immunohistology
Defawe, O. D.; Hustinx, Roland ULg; Defraigne, Jean-Olivier ULg et al

in Clinical Nuclear Medicine (2005), 30(5), 340-341

A 68-year-old man was hospitalized for unstable angina and underwent emergency coronary artery bypass surgery. During the operation, a pulsatile large abdominal aortic aneurysm (AAA) was discovered. To ... [more ▼]

A 68-year-old man was hospitalized for unstable angina and underwent emergency coronary artery bypass surgery. During the operation, a pulsatile large abdominal aortic aneurysm (AAA) was discovered. To define the optimal treatment of the abdominal aneurysm, after bypass surgery, CT scans and positron emission tomography (PET) were performed, as we routinely do. PET imaging combined with immunohistologic examination showed a region of increased F-18 FDG uptake corresponding to an inflammatory infiltrate in the aortic wall in contrast to the thrombus in the aneurysm (devoid of inflammatory cells). The luminal area showed midlevel F-18 FDG uptake corresponding to circulating mediators. [less ▲]

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See detailF-18-FDG PET in children with lymphomas
Depas, Gisèle ULg; De Barsy, Caroline; Jerusalem, Guy ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging (2005), 32(1), 31-38

Purpose: The aim of this study was to retrospectively evaluate the performance of positron emission tomography (PET) with F-18-fluorodeoxyglucose (F-18-FDG) in children with lymphomas, at various stages ... [more ▼]

Purpose: The aim of this study was to retrospectively evaluate the performance of positron emission tomography (PET) with F-18-fluorodeoxyglucose (F-18-FDG) in children with lymphomas, at various stages of their disease. Methods: Twenty-eight children (mean age 12.5 years, 14 girls, 14 boys) with Hodgkin's disease (HD, n=17) or non-Hodgkin's lymphoma (NHL, n= 11) were evaluated. Patients were investigated at initial staging (n=19), early in the course of treatment (n=19), at the end of treatment (n=16) and during long-term follow-up (n=19). A total of 113 whole-body PET studies were performed on dedicated scanners. PET results were compared with the results of conventional methods (CMs) such as physical examination, laboratory studies, chest X-rays, computed tomography, magnetic resonance imaging, ultrasonography and bone scan when available. Results: At initial evaluation (group 1), PET changed the disease stage and treatment in 10.5% of the cases. In early evaluation of the response to treatment (group 2), PET failed to predict two relapses and one incomplete response to treatment. In this group, however, PET did not show any false positive results. There were only 4/75 false positive results for PET among patients studied at the end of treatment (group 3, specificity 94%) or during the systematic follow-up (group 4, specificity 95%), as compared with 27/75 for CMs (specificity 54% and 66%, respectively). Conclusion: F-18-FDG-PET is a useful tool for evaluating children with lymphomas. Large prospective studies are needed to appreciate its real impact on patient management. [less ▲]

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See detailPET imaging for differentiating recurrent brain tumor from radiation necrosis
Hustinx, Roland ULg; Pourdehnad, M.; Kaschten, Bruno ULg et al

in Radiologic Clinics of North America (2005), 43(1), 35-47

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See detailFDG-PET imaging for assessing pleural malignancy : a semi-quantitative analysis.
LAROCK, Marie-Paule ULg; DUYSINX, Bernard ULg; NGUYEN, D. et al

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 426

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See detailTime-course study of (F-18)-FDG uptake in psoriatic synovitis.
BECKERS, Catherine ULg; BERNARD, C.; KAISER, Marie-Joëlle ULg et al

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 183

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See detailFDG-PET imaging for diagnosing bone infection.
LETESSON, G.; FOIDART-WILLEMS, Jacqueline ULg; HUSTINX, Roland ULg

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 323

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