References of "Hubert, Philippe"
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See detailResolution Improvement by Use of Carboxymethyl-Beta-Cyclodextrin as Chiral Additive for the Enantiomeric Separation of Basic Drugs by Capillary Electrophoresis
Fillet, Marianne ULg; Bechet, I.; Hubert, Philippe ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1996), 14(8-10), 1107-14

Three beta-cyclodextrin derivatives--carboxymethyl-, dimethyl- and hydroxypropyl-beta-cyclodextrin--were tested as chiral selectors for the enantioseparation of seven basic drugs in free solution ... [more ▼]

Three beta-cyclodextrin derivatives--carboxymethyl-, dimethyl- and hydroxypropyl-beta-cyclodextrin--were tested as chiral selectors for the enantioseparation of seven basic drugs in free solution capillary electrophoresis, using buffers made of 100 mM phosphoric acid adjusted to pH 3.0 with triethanolamine in fused silica capillaries thermostatted at 15 degrees C. The best results with respect to chiral resolution were obtained with carboxymethyl-beta-cyclodextrin (CMCD): the enantiomers of all compounds examined were completely resolved with this beta-cyclodextrin derivative. The influence of the CMCD concentration on the migration times, the apparent electrophoretic mobility difference and the resolution of the drug enantiomers was investigated thoroughly. Particularly impressive resolution values, up to 23.7, were obtained for several compounds in these capillary electrophoretic systems, using CMCD in the 5-15 mM concentration range. [less ▲]

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See detailSFSTP guide on validation of bioanalytical methods : a proposal
Bervoas-Martin, S.; Boulanger, Bruno ULg; Chapuzet, E. et al

Conference (1996)

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See detailDetermination of water-soluble vitamins by capillary zone electrophoresis
Fotsing, Lucas ULg; Bechet, I.; Fillet, Marianne ULg et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailEnantiomeric separation of acidic and basic drugs by capillary electrophoresis using neutral and anionic cyclodextrins
Fillet, Marianne ULg; Bechet, I.; Schomburg, G. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailLC determination of oxprenolol enantiomers in human plasma using dialysis as on-line sample preparation technique
Ceccato, Attilio ULg; Toussaint, B.; Chiap, Patrice ULg et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailMéthodes chromatographiques de dosage dans les milieux biologiques : Stratégie de validation
Bervoas-Martin, S.; Boulanger, Bruno ULg; Chapuzet, E. et al

Conference (1996)

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See detailQuantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis
Bechet, Isabelle; Hubert, Philippe ULg; Crommen, Jacques ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1995), 13(4-5), 497-503

The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of ... [more ▼]

The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the nature and concentration of the anionic and cationic components of the separation buffer. A buffer consisting of 75 mM glycine adjusted to pH 9.1 with triethanolamine was found to provide a very efficient and stable electrophoretic system for the CZE analysis of NSAIDs, giving RSD values of about 0.1 and 0.5% for the within-day reproducibility of migration times and peak areas, respectively at a concentration of 25 micrograms ml-1 (n = 5). Response was linear from 2-100 micrograms ml-1 for both sulindac and tiaprofenic acid, for which the LOQ values were 2.8 and 1.9 micrograms ml-1, respectively, using UV detection at 280 nm. Accuracy for each drug was 102-103%. [less ▲]

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See detailValidation of bioanalytical methods
Hubert, Philippe ULg; Chiap, Patrice ULg; Ceccato, Attilio ULg et al

in Journal de Pharmacie de Belgique (1995), 50

Detailed reference viewed: 12 (3 ULg)