References of "HUSTINX, Roland"
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See detailOutils isotopiques pour les MICI : PET et PET/CT.
Hustinx, Roland ULg; Louis, Edouard ULg

in Côlon & Rectum (2009), 3

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See detailOutils isotopiques : TEP et TEP/TDM
Hustinx, Roland ULg

in Dupas, Jean-Louis; Louis, Edouard; Marteau, Philippe (Eds.) Maladies inflammatoires chroniques de l'intestin. (2009)

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See detailNuclear (scintigraphic) methods and FDG-PET in rheumatoid osteoarthritis
Ribbens, Clio ULg; Hustinx, Roland ULg

in Bruno, Michael A.; Mosher, Timothy J.; Gold, Gary E. (Eds.) Arthritis in Color. Advance Imaging of Arthritis. (2009)

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See detailLes anticorps monoclonaux en hématologie en 2009
Bonnet, Christophe ULg; Beguin, Yves ULg; De Prijck, Bernard ULg et al

in Revue Médicale de Liège (2009), 64

Directed against the CD20 antigen on B lymphocytes, rituximab (MabThera) is now incorporated in the first line therapy of symptomatic follicular as well as diffuse large B cell non-Hodgkin's lymphoma and ... [more ▼]

Directed against the CD20 antigen on B lymphocytes, rituximab (MabThera) is now incorporated in the first line therapy of symptomatic follicular as well as diffuse large B cell non-Hodgkin's lymphoma and offers superior response and survival rates. 90Y ibritumomab tiuxetan (Zevalin) combines the specificity of rituximab for the CD20 antigen and the therapeutic effect of β irradiation. Given in monotherapy, it constitutes an interesting alternative therapy for follicular lymphomas in second relapse. Alemtuzumab (MabCampath) recognizes the CD52 antigen and offers encouraging results in chronic lymphocytic leukemia resistant to classical chemotherapy. [less ▲]

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See detailFunctional imaging of abdominal aortic aneurysms : can it predict probability of rupture.
Sakalihasan, Natzi ULg; Hustinx, Roland ULg; Gomez, Pierre et al

in VASCULAR ANEURYSMS (2009)

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See detailEvaluation of inflammatory cells in abdominal aortic aneurysmal wall by tomography emission positron
Sakalihasan, Natzi ULg; Hustinx, Roland ULg; Gomez, Pierre et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2009), 33/5

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See detailLiver metastases
Hustinx, Roland ULg; Witvrouw, Nancy ULg; Tancredi, Tino ULg

in PET Clinics (2008), 3

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See detailApport de l'imagerie par tomographie a emission de positons dans la pathologie pleurale. Interet de la TEP en pathologie pleurale.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule et al

in Revue des Maladies Respiratoires (2008), 25(2), 129-38

INTRODUCTION: Positron emission tomography (PET) has a clear role in oncology, particularly in thoracic disease. In the light of our experience and a revue of the literature we define precisely the role ... [more ▼]

INTRODUCTION: Positron emission tomography (PET) has a clear role in oncology, particularly in thoracic disease. In the light of our experience and a revue of the literature we define precisely the role of metabolic imaging in the diagnosis of pleural pathology. BACKGROUND: In particular PET allows characterisation of malignant pleural disease and provides prognostic information in mesothelioma. Metabolic imaging provides clinical information for the staging of pulmonary cancer, in the search for a primary tumour in metastatic pleurisy and also in the follow up of chronic or recurrent pleural pathology. CONCLUSIONS: It is justified, therefore, that PET joins the diagnostic armamentarium of pleural pathology, solid or liquid. [less ▲]

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See detailRisk adaptive treatment in Hodgkin's lympoma: reduction of radiation dose and irradiated volume
Coucke, Philippe ULg; Barthelemy, Nicole ULg; Hustinx, Roland ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2008), 2(2), 85-97

Treatment–related late complications on nontarget normal tissues and appearance of secondary malignancies are well known side-effects induced by effective treatment regimens currently used in the curative ... [more ▼]

Treatment–related late complications on nontarget normal tissues and appearance of secondary malignancies are well known side-effects induced by effective treatment regimens currently used in the curative approach of early and advanced Hodgkin’s lymphoma. Radiotherapy (RT) and chemotherapy (CT) can lead to these late complications. Efforts have been conducted to reduce the morbidity and mortality related to these treatments. In particular there has been a progressive shift from radiotherapy used as sole modality to chemotherapy as first line followed by consolidation radiotherapy. As the side-effects of radiotherapy are linked to dose, volume and interaction with chemotherapy, trials have been launched to assess the impact of modifying the characteristics of the radiation treatment. For early-stage Hodgkin’s lymphoma radiotherapy cannot be avoided but dose and volume can be reduced. In advanced Hodgkin’s lymphoma omitting radiotherapy seems reasonable only in case of complete response (CR). The clinical trials allowing such a paradigm shift are highlighted in this review. [less ▲]

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See detailHighlights of the annual congress of the European Association of Nuclear Medicine, Copenhagen 2007.
Knuuti, Juhani; Hustinx, Roland ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(3), 655-72

INTRODUCTION: The Annual Congress of the European Association of Nuclear Medicine took place in Copenhagen on October 13-17, 2007. The event is the major scientific and professional effort in the field of ... [more ▼]

INTRODUCTION: The Annual Congress of the European Association of Nuclear Medicine took place in Copenhagen on October 13-17, 2007. The event is the major scientific and professional effort in the field of nuclear medicine in Europe. The most important developments in the fields of instrumentation, radionuclide production, radiochemistry, radiotherapy, as well as the clinical imaging fields of neurology, cardiology, oncology, and general sciences were reported. OBJECTIVE: This paper emphasizes the major findings and trends at this important gathering. This review is, however, only a brief summary of the large amount of data discussed. [less ▲]

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See detailQue mesure la neuro-imagerie fonctionnelle: IRMf, TEP & MEG?
Gosseries, Olivia ULg; Demertzi, Athina ULg; Noirhomme, Quentin ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 231-7

Functional cerebral imaging techniques allow the in vivo study of human cognitive and sensorimotor functions in physiological or pathological conditions. In this paper, we review the advantages and ... [more ▼]

Functional cerebral imaging techniques allow the in vivo study of human cognitive and sensorimotor functions in physiological or pathological conditions. In this paper, we review the advantages and limitations of functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and magnetoencephalography (MEG). fMRI and PET measure haemodynamic changes induced by regional changes in neuronal activity. These techniques have a high spatial resolution (a few millimeters), but a poor temporal resolution (a few seconds to several minutes). Electroencephalogram (EEG) and MEG measure the neuronal electrical or magnetic activity with a high temporal resolution (i.e., milliseconds) albeit with a poorer spatial resolution (i.e., a few millimeters to one centimeter). The combination of these different neuroimaging techniques allows studying different components of the brain's activity (e.g., neurovascular coupling, electromagnetic activity) with both a high temporal and spatial resolution. [less ▲]

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See detailMeasuring the effect of amantadine in chronic anoxic minimally conscious state.
Schnakers, Caroline ULg; Hustinx, Roland ULg; Vandewalle, Gilles ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2008), 79(2), 225-7

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See detailTomographie à émission de positons et lymphomes
Hustinx, Roland ULg; Jerusalem, Guy ULg; De Prijck, Bernard ULg

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2008), 32

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See detailIndications cliniques de la radiotherapie metabolique dans les tymphomes.
Witvrouw, Nancy ULg; De Prijck, Bernard ULg; Hustinx, Roland ULg

in Revue Médicale Suisse (2008), 4(168), 1818-22

In their later stages low grade lymphoma are incurable. These lymphomas being radio-sensitive, a treatment of metabolic radioimmunotherapy, using monoclonal antibodies (anti-CD20) as the carrier has been ... [more ▼]

In their later stages low grade lymphoma are incurable. These lymphomas being radio-sensitive, a treatment of metabolic radioimmunotherapy, using monoclonal antibodies (anti-CD20) as the carrier has been developed. The aim of this treatment is to use these antibodies to target radiation to tumor tissues while limiting toxicity to normal cells. Ibritumomab tiuxetan (Zevalin) is currently prescribed for patients with relapsed or refractory low-grade follicular lymphoma after rituximab treatment. This outpatient treatment has a high level of overall response rate including complete response and that for a long period. The side effects are essentially hematological and reversible. In the near future many more indications should become apparent and Zevalin should become an important tool in the B-cell lymphoma (low and high grade). [less ▲]

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See detailPrognostic value of metabolic imaging in non-small cell lung cancers with neoplasic pleural effusion.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule ULg et al

in Nuclear Medicine Communications (2008), 29(11), 982-6

BACKGROUND: The intensity of the [F]fluorodeoxyglucose (F-FDG) uptake is an independent prognostic indicator in non-small cell lung cancer (NSCLC). We evaluate the relationship between the metabolic ... [more ▼]

BACKGROUND: The intensity of the [F]fluorodeoxyglucose (F-FDG) uptake is an independent prognostic indicator in non-small cell lung cancer (NSCLC). We evaluate the relationship between the metabolic activity of the primary and the pleurisy in T4 NSCLC. METHODS: 25 patients (16 males, nine females, mean age 63 years, performance status 1) with pathology-proven, T4 NSCLC and malignant pleurisy were included. All were treated by a platinum salt-based chemotherapy regimen. Positron emission tomography (F-FDG-PET) was performed before treatment, according to a routine procedure. Regions of interest were placed over the primary and the pleural effusion on the transaxial slice showing the highest activity. The maximum pixel standard uptake values (SUVs) were calculated. Overall survival was determined by standard Kaplan-Meier survival analysis. All patients were followed up until death. RESULTS: The median survival for the entire population was 83 days (7-988). The SUVs were higher in the primary than in the pleurisy (9.2+/-5.6 and 5.5+/-2.2, respectively). There was no correlation between primary and pleurisy SUVs (r=0.3, P>0.05). The metabolic activity of the primary tumor did not predict the outcome: the median survival was 77.5 days (range 7-988) and 87 days (19-454) in the groups with SUVs lower and higher than the median value (8.7), respectively (P>0.05). By contrast, the metabolic activity of the pleurisy was significantly correlated with the median survival, which was 196 days (40-988) when the SUVs were lower than the median value (5) and 74 days (7-170) when they were higher (P=0.0096). CONCLUSION: Among patients with T4 NSCLC, those with high metabolic activity in the pleural effusion have a dire prognosis, whereas the metabolic activity of the primary fails to predict the survival. [less ▲]

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See detailIntrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function?
Boly, Mélanie ULg; Phillips, Christophe ULg; Tshibanda, Luaba ULg et al

in Annals of the New York Academy of Sciences (2008), 1129

Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships ... [more ▼]

Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships has been challenged. That altered states of consciousness are a privileged way to study the relationships between spontaneous brain activity and behavior is proposed, and common resting-state brain activity features observed in various states of altered consciousness are reviewed. Early positron emission tomography studies showed that states of extremely low or high brain activity are often associated with unconsciousness. However, this relationship is not absolute, and the precise link between global brain metabolism and awareness remains yet difficult to assert. In contrast, voxel-based analyses identified a systematic impairment of associative frontoparieto-cingulate areas in altered states of consciousness, such as sleep, anesthesia, coma, vegetative state, epileptic loss of consciousness, and somnambulism. In parallel, recent functional magnetic resonance imaging studies have identified structured patterns of slow neuronal oscillations in the resting human brain. Similar coherent blood oxygen level-dependent (BOLD) systemwide patterns can also be found, in particular in the default-mode network, in several states of unconsciousness, such as coma, anesthesia, and slow-wave sleep. The latter results suggest that slow coherent spontaneous BOLD fluctuations cannot be exclusively a reflection of conscious mental activity, but may reflect default brain connectivity shaping brain areas of most likely interactions in a way that transcends levels of consciousness, and whose functional significance remains largely in the dark. [less ▲]

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See detailFunctional imaging of abdominal aortic aneurysms
Sakalihasan, Natzi ULg; Hustinx, Roland ULg; Gomez, Pierre et al

in Aortic Aneurysms, new insights of an old problem (2008)

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