References of "Guillaume, Michèle"
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See detailUse of food frequency questionnaire to assess relationships between dietary habits and cardiovascular risk factors in NESCAV study: validation with biomarkers
Sauvageot, Nicolas ULg; alkerwi, alaa; Albert, Adelin ULg et al

in Nutrition Journal (2013), 12(143),

Abstract Background: Validation of Food frequency questionnaire (FFQ) is particularly important element, as incorrect information may lead to false associations between dietary factors and diseases. The ... [more ▼]

Abstract Background: Validation of Food frequency questionnaire (FFQ) is particularly important element, as incorrect information may lead to false associations between dietary factors and diseases. The aim of the study was to evaluate the validity of the FFQ used in NESCAV (Nutrition, Environment and Cardiovascular Health) study, by comparing the estimated intakes of fruits and vegetables and of several micro-nutrients with corresponding nutritional biomarkers. Methods: Relative validity was assessed in a sample of 922 subjects (452 men and 470 women). Comparisons between FFQ-estimates and their corresponding biomarkers were performed through correlation and cross classification into quintiles by using both crude and energy-adjusted FFQ-estimates. Correlations adjusted for confounders were also computed. All analyses were performed separately for men and women. Results: Concerning micro-nutrients, significant correlations were found for vitamin B9, D, E, B12 β -carotene and iodine in both men and women. Energy-adjustment led to an increase of all correlations cited previously. However, after excluding supplement users, correlations for vitamin D were not significant anymore. Concerning fruits and vegetables, all correlations were significant. Vegetables alone and fruits and vegetables correlated better in men (r around 0.2) than in women (r around 0.1). In men, correlation was also better for vegetables alone and fruits and vegetables than fruits alone. Conclusion: These data demonstrate that this FFQ is a reasonable tool to assess intakes of fruits and vegetables and of several micro-nutrients. We conclude that our FFQ is suitable to be used in NESCAV study, although protein and vitamin D estimates should be interpreted with caution [less ▲]

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See detailValidation par biomarqueurs d’un FFQ permettant d’étudier le lien entre alimentation et risques cardiovasculaires
Sauvageot, Nicolas ULg; Alkerwi, Alaa; Donneau, Anne-Françoise ULg et al

Poster (2012, September)

Introduction La recherche sur l'alimentation et son lien avec les maladies nécessite une collecte rigoureuse des données nutritionnelles permettant d'estimer avec précision l'apport nutritionnel. Le « ... [more ▼]

Introduction La recherche sur l'alimentation et son lien avec les maladies nécessite une collecte rigoureuse des données nutritionnelles permettant d'estimer avec précision l'apport nutritionnel. Le « Food Frequency Questionnaire (FFQ) » a été choisie pour étudier le lien entre alimentation et risques cardiovasculaires dans un échantillon représentatif de la Grande région recruté pour l’étude NESCAV (Nutrition, environnement et santé cardio-vasculaire). Objectif Valider le FFQ utilisé à l’aide de biomarqueurs afin d’évaluer son habilité à estimer correctement les habitudes alimentaires. Méthodes Afin de prendre en compte les spécificités de la Grande région et le volet cardio-vasculaire, la liste d’items d’un FFQ existant a été modifiée et élargie. Tous les nutriments calculés à partir du FFQ ont été ajustés par rapport à l’énergie par la méthode des résidus. La comparaison des nutriments calculés par le FFQ et les bio-marqueurs correspondants a été faite par le calcul des coefficients de corrélation avec ajustement sur plusieurs facteurs confondants. L’accord entre les deux méthodes a été estimé par le calcul des pourcentages de concordance et du coefficient Kappa. Résultats La validation s’est effectuée sur un échantillon de 466 sujets (236 hommes et 241 femmes). Des corrélations significatives ont été observées pour les folates, le β-carotène dans les deux sexes et pour la vitamine B12 et l’iode chez les femmes. Discussion Ces résultats sont comparables à ceux d’études précédentes. Les corrélations sont souvent expliquées par le fait que les nutriments du FFQ représentent la quantité ingérée alors que les biomarqueurs représentent la quantité absorbée par le corps. [less ▲]

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See detailContribution of violaxanthin, neoxanthin, phytoene and phytofluene to total carotenoid intake: Assessment in Luxembourg
Biehler, E; Hoffmann, L; Krause, E et al

in Journal of Food Composition and Analysis (2012), 25

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See detailDietary, behavioural and socio-economic determinants of the metabolic syndrome among adults in Luxembourg: findings from the ORISCAV-LUX study.
Alkerwi, Ala'a; Donneau, Anne-Françoise ULg; Sauvageot, Nicolas et al

in Public Health Nutrition (2012), 15(5), 849-59

OBJECTIVE: The purpose of the present research was to investigate the epidemiological profile of the metabolic syndrome (MetS) and to explore its potential dietary, behavioural and socio-economic ... [more ▼]

OBJECTIVE: The purpose of the present research was to investigate the epidemiological profile of the metabolic syndrome (MetS) and to explore its potential dietary, behavioural and socio-economic determinants among European adults residing in Luxembourg. DESIGN: Cross-sectional, population-based ORISCAV-LUX survey. SETTING: European adults aged 18-69 years residing in Luxembourg. SUBJECTS: A total of 1349 Europid adults, who participated in the ORISCAV-LUX survey, were included in the study. The prevalence of MetS was estimated according to the Revised-Adult Treatment Panel (R-ATPIII) criteria. Multivariate logistic regression was used to identify the dietary, behavioural and socio-economic factors independently associated with MetS. RESULTS: The overall prevalence of MetS was 24.7 % with significant gender difference (18.5 % for women v. 30.8 % for men, P < 0.0001). Age, male gender, primary level of education, physical inactivity, family history of diabetes and hypertension and inadequate protein intake were identified as significant determinants of MetS, after adjusting for other socio-economic, family medical history and lifestyle factors. CONCLUSIONS: MetS is a common condition among Europid adults in Luxembourg and increases dramatically with age, in both genders. Several dietary, socio-economic and behavioural factors explain the disparity observed. These findings highlight the importance of a comprehensive approach to MetS encompassing dietary, lifestyle and socio-economic aspects, both in clinical and community settings. [less ▲]

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See detailPopulation compliance with national dietary recommendations and its determinants: findings from the ORISCAV-LUX study.
Alkerwi, A; Sauvageot, N; Nau, A et al

in British Journal of Nutrition (2012)

The objective of the present study was to determine the proportion of adults meeting national recommendations for food and nutrient intake and to identify the demographic, socio-economic and behavioural ... [more ▼]

The objective of the present study was to determine the proportion of adults meeting national recommendations for food and nutrient intake and to identify the demographic, socio-economic and behavioural factors that may contribute to weaken dietary compliance. ORISCAV-LUX is a cross-sectional study that took place in Luxembourg (2007-8). A representative stratified random sample of 1352 adults aged 18-69 years participated in the nationwide cardiovascular health survey. A FFQ was used to estimate food intake. Radar charts were built to compare graphically the compliance of the participants with different key dietary guidelines on the same set of axes. The thirteen food- and nutrient-based recommendations were scored and summed to create a recommendation compliance index (range - 0.5 to 14). Ordinal logistic regression analyses were performed to determine the factors contributing to poor dietary compliance. Several food- and nutrient-based guidelines were insufficiently respected compared with others. The greatest gaps occurred in the adherence to grain and dairy product consumption guidelines, as well as to total fat and notably to SFA recommendations. Age, country of birth, economic status, smoking status and subject's awareness of the importance of balanced meals emerged as independently associated with weak dietary compliance. Obese subjects conformed more to dietary recommendations compared with normal-weight subjects. The findings underscore the need for specific nutrition education messages along with targeted interventions. Efforts should be continued to increase population awareness of the importance of a healthy lifestyle and a balanced diet. [less ▲]

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See detailDiabète et Ramadan : représentations et pratiques de santé des patients et des soignants et intérêts de l'éducation thérapeutique du patient
Smaoui, N; Böhme, P; Collin, JF et al

in Diabètes & Métabolism (2012), 38(2), 47-48

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See detailCampagnes de sensibilisation au dépistage du diabète de type 2 dans les pharmacies. Comparaison de deux approches : glycémie capillaire et grille Findrisc
Böhme, P; Agrinier, N; Badia, M et al

in Diabètes & Métabolism (2012), 38(2), 7

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See detailBNP et NT-proBNP: valeurs de référence et seuils décisionnels
TEIXEIRA, Jelda ULg; Guillaume, Michèle ULg; NELLESSEN, Eric ULg et al

in Revue Médicale de Liège (2012), 67(1), 38-43

Les peptides natriurétiques, en particulier BNP et NT-proBNP, sont de plus en plus utilisés comme tests de screening chez les patients avec suspicion d’insuffisance cardiaque (IC), afin d’éviter de ... [more ▼]

Les peptides natriurétiques, en particulier BNP et NT-proBNP, sont de plus en plus utilisés comme tests de screening chez les patients avec suspicion d’insuffisance cardiaque (IC), afin d’éviter de recourir d’emblée à des examens spécialisés coûteux tels que l’échocardiographie. Très performants pour la valeur prédictive élevée d’un résultat négatif, permettant ainsi d’exclure l’IC chronique avec une forte probabilité, ces biomarqueurs sont également reconnus pour leur intérêt diagnostique dans cette pathologie. Des taux élevés de peptides natriurétiques sont corrélés avec un risque accru d’hospitalisation pour cause cardiovasculaire et de décès. La stratification du risque chez les patients présentant une insuffisance cardiaque est facilitée par l’utilisation de seuils décisionnels «bas» et «élevé», pour lesquels différentes valeurs ont été proposées dans la littérature. Le présent article a pour objet de faire le point sur le positionnement des seuils décisionnels eu égard aux valeurs de référence de NT-proBNP déterminées dans la population résidant en Province de Liège (Belgique). Les données ont été analysées en fonction de l’âge et du sexe des sujets, deux des facteurs majeurs de variation des concentrations plasmatiques des peptides natriurétiques. [less ▲]

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See detailNESCAV - Premiers résultats
Streel, Sylvie ULg; Donneau, Anne-Françoise ULg; Hoge, Axelle ULg et al

Conference (2011, December 02)

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See detailEpidemiology of the metabolic syndrome in Luxembourg findings from ORISCAV-LUX study
Alkerwi, A; Sauvageot, N; Donneau, Anne-Françoise ULg et al

Conference (2011)

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See detailPrevalence of the metabolic syndrome in Luxembourg according to the Joint Interim Statement definition estimated from the ORISCAV-LUX study.
Alkerwi, Ala'a; Donneau, Anne-Françoise ULg; Sauvageot, Nicolas et al

in BMC Public Health (2011), 11(1), 4

ABSTRACT: BACKGROUND: The prevalence of the metabolic syndrome (MS) has been determined in many countries worldwide but never in Luxembourg. This research aimed to 1) establish the gender- and age ... [more ▼]

ABSTRACT: BACKGROUND: The prevalence of the metabolic syndrome (MS) has been determined in many countries worldwide but never in Luxembourg. This research aimed to 1) establish the gender- and age-specific prevalence of MS and its components in the general adult population of Luxembourg, according to the most recent Joint Interim Statement (JIS) definition, by using both the high and low cut-off points to define abdominal obesity, and 2) compare and assess the degree of agreement with the Revised National Cholesterol Education Programme-Adult Treatment Panel III (R-ATPIII) and the International Diabetes Federation (IDF) definitions. METHODS: A representative stratified random sample of 1349 European subjects, aged 18-69 years, participated to ORISCAV-LUX survey. Logistic regression and odds ratios (OR) were used to study MS prevalence with respect to gender and age. The Framingham risk score (FRS) to predict the 10-year coronary heart disease (CHD) risk was calculated to compare the proportion of MS cases below or above 20%, according to both high and low waist circumference (WC) thresholds. Cohen's kappa coefficient (kappa) was utilized to measure the degree of agreement between MS definitions. RESULTS: The prevalence of the MS defined by the JIS was 28.0% and 24.7% when using the low (94/80) and the high (102/88) WC cut-off points, respectively. The prevalence was significantly higher in men than in women (OR = 2.6 and 2.3 for the low and high WC thresholds), as were all components of the MS except abdominal obesity measured by both thresholds. It also increased with age (OR values in age categories ranging from 2.7 to 28 when compared to the younger subjects for low WC and from 3.3 to 31 for the high WC cut-offs). The 10-year predicted risk of CHD by FRS did not depend on the threshold used. Globally, excellent agreement was observed between the three definitions of MS (kappa= 0.89), in particular between JIS and IDF (kappa = 0.93). Agreement was significantly higher in women than in men, and differed between age groups. CONCLUSION: Regardless of the definition used, the adult population of Luxembourg reveals a high MS prevalence. Our findings contribute to build evidence regarding the definitive construct of the MS, to help selecting the waist circumference thresholds for Europid populations, and to support the need to revise the guidelines for abdominal obesity levels. [less ▲]

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See detailCardiometabolic Syndrome
Alkerwi, A; Albert, Adelin ULg; Guillaume, Michèle ULg

in Gasparyan, AY (Ed.) Cardiovascular Risk Factors (2011)

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See detailSCREENIN G AND PREDICTING MALNUTRITION IN lUNG CANCER PATIENTS: DEVELOPING NEW TOOLS.
BARTHELEMY, Nicole ULg; Donneau, Anne-Françoise ULg; Haterte, Stéphanie ULg et al

in Radiotherapy & Oncology (2010, September), 96(supp 1), 378

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See detailNutrition, environment and cardiovascular health (NESCAV): protocol of an inter-regional cross-sectional study.
Alkerwi, Ala'a; Guillaume, Michèle ULg; Zannad, Faiez et al

in BMC Public Health (2010), 10(1), 698

BACKGROUND: Despite the remarkable technological progress in health care and treatment, cardiovascular disease remains the leading cause of premature death, prolonged hospitalization and disability in ... [more ▼]

BACKGROUND: Despite the remarkable technological progress in health care and treatment, cardiovascular disease remains the leading cause of premature death, prolonged hospitalization and disability in most European countries. In the population of the Greater Region (Grand-Duchy of Luxembourg, Wallonia in Belgium, and Lorraine in France), the prevalence of cardiovascular risk factors and disease is among the highest in Europe, warranting the need for a better understanding of factors contributing to this pattern. In this context, the cross-border "Nutrition, Environment and Cardiovascular Health-NESCAV" project is initiated by an inter-regional multi-disciplinary consortium and supported by the INTERREG IV A program "Greater Region", 2007-2013, to fight synergically and harmoniously against this major public health problem. METHODS/DESIGN: The objectives of the three-year planned project are to assess, in a representative sample of 3000 randomly selected individuals living at the Greater Region, 1) the cardiovascular health and risk profile, 2) the association between the dietary habits and the cardiovascular risk, 3) the association of occupational and environmental pollution markers with the cardiovascular risk, 4) the knowledge, awareness and level of control of cardiovascular risk factors, 5) the potential gaps in the current primary prevention, and finally, to address evidence-based recommendations enabling the development of inter-regional guidance to help policy-makers and health care workers for the prevention of cardiovascular disease. DISCUSSION: The findings will provide tools that may enable the Greater Region's decision-makers and health professionals to implement targeted and cost-effective prevention strategies. [less ▲]

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