Poly(2-dimethylamino ethylmethacrylate)-based polymers to camouflage red blood cell antigens.

in Biomacromolecules (2012), 13(4), 1172-80

Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane ... [more ▼]

Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane surface of red blood cells (RBCs). The electrostatic self-assembly of PDMAEMA on RBCs membrane can be employed for inducing the formation of a polymeric shield camouflaging blood group antigens on RBCs as a valuable strategy for developing "universal RBCs" for blood transfusion. The purpose of this research was to evaluate the camouflaging ability of PDMAEMA homopolymers and PDMAEMA-co-poly(ethylene glycol) copolymers differing in molecular weight and architecture. Surprisingly, the PDMAEMAs caused a partially masking, no masking, and sensitization of the same RBCs population. The MW and architecture of the polymers as well as temperature of PDMAEMA-RBCs treatment influenced the results observed. Herein, the very particular reactivity of PDMAEMAs and RBCs is analyzed and discussed. [less ▲]

Effect of drug candidates for the treatment of Alzheimer's disorber on hippocampus-dependent learning, glutamate receptors and mitochondria

Conference (2011, November 12)

Characterization of the interaction between nanoformulated drugs and model lipid membranes towards improved drug delivery systems

Poster (2011, October)

Inspired bio- nanobiomaterials for tissue engineering

Conference (2011, September 19)

Why biodegradable polymers for medical applications ? main applications ; list and properties of biodegradable polymers actually accepted for medical applications ; physico-chemical, mechanical factors affecting degradation of polymers.

Conference (2011, July 15)

Biodegradable microcarrier with entrapped peptides for tissue engineering

Conference (2011, May 05)

Structural Rearrangements of Polymeric Insulin-loaded Nanoparticles Interacting with Surface-Supported Model Lipid Membranes

in Journal of Biomaterials and Nanobiotechnology (2011)

Dimebon Enhances Hippocampus-Dependent Learning in Mouse Models of Appetitive Y-Maze and Inhibitory Step-Down Memory Tasks in Mice

Poster (2011, February 23)

Dimebon, a compound recently proposed for a treatment of Alzheimer’s disorder, was suggested to have memory enhancing properties in pre-clinical and clinical studies. We investigated whether dimebon at ... [more ▼]

Dimebon, a compound recently proposed for a treatment of Alzheimer’s disorder, was suggested to have memory enhancing properties in pre-clinical and clinical studies. We investigated whether dimebon at doses acutely (0.1 mg/kg and 0.5 mg/kg) or repeatedly (0.1 mg/kg) administered to mice via i.p. injections, increases memory scores respectively in an appetitive and an inhibitory learning task. Acute treatment with dimebon at the dose 0.1 mg/kg did not affect learning scores in 3-month-old C57BL/6N. Acute treatment with higher dose of dimebon (0.5mg/kg) was found to enhance inhibitory learning in 3-month-old mice as shown in the step-down avoidance paradigm in C57BL/6N mice. In a model of appetitive learning, a spatial version of the Y-maze, repeated treatment with dimebon increased the rate of correct choices and decreased the latency of accessing a water reward after water deprivation. Repeated administration of dimebon also increased the duration of drinking behaviour during training/testing procedures although water consumption behaviour was not altered. Additional behavioural tests were carried out to investigate possible non-specific effects of dimebon on parameters of drinking, anxiety and exploration/locomotion. Our data suggest that dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory tasks in mice. [less ▲]

Design et évaluation de nouveaux biomatériaux pour la construction de tissus

Conference (2011, January 19)

Petit, mais costaud !

in FNRS NEWS (2011)