References of "Grandfils, Christian"
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See detailNanocarriers tailored for the delivery of proteinaceous drugs
Grandfils, Christian ULg

Conference (2013, April 09)

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See detailMatériaux médicaux implantables : le point aujourd’hui
Grandfils, Christian ULg

Conference (2013, March 19)

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See detailNew Surface-Enhanced Raman Scattering Platforms: Composite Calcium Carbonate Microspheres Coated with Astralen and Silver Nanoparticles
Stetciura, Inna Y.; Markin, Alexey V.; Ponomarev, Andrei N. et al

in Langmuir (2013), 29

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See detailBiocompatible, Multifunctional, and Well-Defined OEG-based Dendritic Platforms for Biomedical Applications
Simon-Graciaa, L; Pulido, D; Sevrin, Chantal ULg et al

in Organic & Biomolecular Chemistry (2013), 11

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See detailControlled Production of Exopolysaccharides from Enterobacter A47 as a Function of Carbon Source w ith Demonstration of Their Film and Emulsifying Abilities
Freitas, F; Alves, V.D.; Gouveia, A.R. et al

in Applied Biochemistry and Biotechnology (2013)

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See detailIntroduction to advanced biomaterials
Grandfils, Christian ULg

Conference (2012, November 13)

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See detailThe Giant Raman Scattering Platforms on the Basis of Core-Shell Miscrostructures Containing Astralene Nanoparticles and Their Application for Detection of Bioactive Molecules
Stetciura, I.Y.; Markin, A.V.; Ponomarev, A.N. et al

in Proceeding of XVI International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics (2012, September 25)

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See detailThe applications of biodegradable polymers for drug delivery and tissue engineering
Grandfils, Christian ULg

in Proceeding XVI International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics (2012, September 25)

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See detailThe applications of biodegradable polymers for drug delivery and tissue engineering
Grandfils, Christian ULg

in Smart nanocomposite scaffold for tissue engineering (2012, September 25)

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See detailBiodegradable microcarriers based on chitosan and polyesters for tissue engineering
Demina, T; Akopova, T; Sevrin, Chantal ULg et al

Conference (2012, September 03)

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See detailIn vitro hemocompatibility of nanocarriers tailored for biopharmaceutical drugs.
Sevrin, Chantal ULg; Cerda Cristerna, Bernardino Isaac ULg; Lombart, François ULg et al

Poster (2012, May 06)

The optimization of nanoparticles (NP) for drug delivery, in particular to target the BBB, imposes to verify their hemocompatibility both for toxicological and efficiency of targeting perspectives. Indeed ... [more ▼]

The optimization of nanoparticles (NP) for drug delivery, in particular to target the BBB, imposes to verify their hemocompatibility both for toxicological and efficiency of targeting perspectives. Indeed the large surface they are able to expose to the biological environment promotes their interaction with various biochemicals, in particular proteins which can after adsorption elicit the activation of biological cascades either responsible from NP clearance or/and harmful body reaction (inflammatory / coagulation). In the frame of the European Integrated Project : “Nanobiopharmaceutics”, we have the opportunity to compare the hemoreactivity of about 145 different NP samples differing in core and surface chemistry and classified according to their expected difference in hydrophobicity based on the nature of their core materials. According to this classification, PLGA nanoparticles, polyglycidol-polyethyethylene oxide nanoparticles, polyglycidol thyolated or polyacrylamide nanogels, and polyelectrolyte complexes either based on polyamidoamine or poly(N,N-dimethylamino- 2-ethylmethacrylate) have been evaluated within a concentration ranging from 0.3 to 1000 μg/mL. These in vitro tests have been realized for screening purpose adopting normal human bloods and according to Iso 10993. As a summary of this extensive study, our results clearly highlight that most of the polymeric nanoparticles evaluated give rise to some alterations of the blood components. In particular the platelets, intrinsic pathway of coagulation and complement activation are the most reactive biological parameters in the presence of these nanostuctures. Although not strictly related to the surface chemistry our classification has also allowed us to derive some clear correlations between nanomaterial properties and their hemoreactivity. Within the class of polyelectrolyte electrolyte complexes, the modifications brought in the surface chemistry has drastically improved their hemoreactivity [less ▲]

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See detailHemocompatibility of nanocarriers designed to transport biopharmaceutical drugs
Sevrin, Chantal ULg; Cerda, Bernardino; Lombart, François ULg et al

Poster (2012, April 18)

The optimization of nanoparticles (NP) for drug delivery, in particular to target the BBB, imposes to verify their hemocompatibility both for toxicological and efficiency of targeting perspectives. Indeed ... [more ▼]

The optimization of nanoparticles (NP) for drug delivery, in particular to target the BBB, imposes to verify their hemocompatibility both for toxicological and efficiency of targeting perspectives. Indeed the large surface they are able to expose to the biological environment promotes their interaction with various biochemicals, in particular proteins which can after adsorption elicit the activation of biological cascades either responsible from NP clearance or/and harmful body reaction (inflammatory / coagulation). In the frame of the European Integrated Project : “Nanobiopharmaceutics”, we have the opportunity to compare the hemoreactivity of about 145 different NP samples differing in core and surface chemistry and classified according to their expected difference in hydrophobicity based on the nature of their core materials. According to this classification, PLGA nanoparticles, polyglycidol-polyethyethylene oxide nanoparticles, polyglycidol thyolated or polyacrylamide nanogels, and polyelectrolyte complexes either based on polyamidoamine or poly(N,N-dimethylamino-2-ethylmethacrylate) have been evaluated within a concentration ranging from 0.3 to 1000 =g/mL. These in vitro tests have been realized for screening purpose adopting normal human bloods and according to Iso 10993. As a summary of this extensive study, our results clearly highlight that most of the polymeric nanoparticles evaluated give rise to some alterations of the blood components. In particular the platelets, intrinsic pathway of coagulation and complement activation are the most reactive biological parameters in the presence of these nanostuctures. Although not strictly related to the surface chemistry our classification has also allowed us to derive some clear correlations between nanomaterial properties and their hemoreactivity. Within the class of polyelectrolyte electrolyte complexes, the modifications brought in the surface chemistry has drastically improved their hemoreactivity. [less ▲]

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See detailNeuropeptides and endogenous opioids expression during silent chronic inflammation
Chavarria Bolanos, D; de Jesus Pozos Guillén, A; Grandfils, Christian ULg et al

Poster (2012, April 18)

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