Assessing and improving quality of life of caregivers significantly reduces the risk of new hospitalisation in elderly subjects

Conference (1999)

Le fait d'être fidèle à son médecin généraliste entraîne-t-il une diminution de la consommation de soins ?

Conference (1999)

Case Management dans les différents systèmes d’aide nationaux pour les personnes âgées. Evaluation pour la Belgique

Report (1999)

Etude pilote : Case management intégré dans les hôpitaux belges.

Report (1999)

Established postmenopausal osteoporosis – Assessment of treatment options

in Menopause Review (1999), 1(IV), 39-55

The Effect of Sodium Monofluorophosphate Plus Calcium on Vertebral Fracture Rate in Postmenopausal Women with Moderate Osteoporosis. A Randomized, Controlled Trial

in Annals of Internal Medicine (1998), 129(1), 1-8

BACKGROUND: Fluoride is effective in increasing trabecular bone mineral density (BMD) in the spine, but its efficacy in reducing vertebral fracture rates and its effect on BMD at cortical sites are ... [more ▼]

BACKGROUND: Fluoride is effective in increasing trabecular bone mineral density (BMD) in the spine, but its efficacy in reducing vertebral fracture rates and its effect on BMD at cortical sites are controversial. OBJECTIVE: To study the effect of low-dose fluoride (sodium monofluorophosphate [MFP]) plus a calcium supplement over 4 years on vertebral fractures and BMD at the lumbar spine and total hip in postmenopausal women with moderately low BMD of the spine. DESIGN: Randomized, double-blind, controlled clinical trial. SETTING: Outpatient clinic for osteoporosis at a university medical center. PATIENTS: 200 postmenopausal women with osteoporosis (according to the World Health Organization definition) and a T-score less than -2.5 for BMD of the spine. INTERVENTION: Women were randomly assigned (100 patients per group) to continuous daily treatment for 4 years with 1) oral MFP (20 mg of equivalent fluoride) plus 1000 mg of calcium (as calcium carbonate) or 2) calcium only. MEASUREMENTS: Lateral spine radiographs were taken at enrollment and at each year of follow-up for detection of new vertebral fractures (defined as a reduction > or =20% and > or =4 mm from baseline in any of the heights of a vertebral body). Nonvertebral fractures were also recorded. All analyses were done with the intention-to-treat approach. RESULTS: Radiologic follow-up was possible for 164 of 200 patients (82%). The rate of new vertebral fractures during the 4 years of the study was lower in the MFP-plus-calcium group (2 of 84 patients; 2.4% [95% CI, 0.3% to 8.3%]) than in the calcium-only group (8 of 80 patients; 10% [CI, 4.4% to 18.8%]). The difference between the groups was 7.6 percentage points (CI, 0.3 to 15 percentage points) (P = 0.05). A moderate but progressive increase in BMD of the spine (10.0% +/- 1.5% at 4 years) was found for MFP plus calcium compared with calcium only (P < 0.001), whereas the more modest increase in BMD of the total hip seen with MFP plus calcium (1.8% +/- 0.6%) did not differ from the increase seen with calcium only. CONCLUSIONS: Low-dose fluoride (20 mg/d) given continuously with calcium for prolonged periods can decrease vertebral fracture rates compared with calcium alone in patients with mild to moderate osteoporosis. [less ▲]

Parathyroid hormone plasma concentration in response to low 25-OH vitamin D circulating levels increase with age in elderly women

in Osteoporosis International (1998), 8(S3), 40

Case management : pilootproject case management in Belgische ziekenhuizen. [Case management : pilot study on case management in Belgian hospitals] . Final report, 1998

Report (1998)

Case management : pilootproject case management in Belgische ziekenhuizen. [Case management : pilot study on case management in Belgian hospitals]. Summarizing report, 1998.

Report (1998)

Case Management : a multidisciplinary approach to prevent institutionalization of high-risk elderly

Conference (1998)